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Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： lan yang Lai-Yu Kwok Zhihong Sun Heping Zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

Experimental and numerical flutter analysis of a folding fin with multiple asymmetric free-plays

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Chinese Journal of Aeronautics 2024年第5期37卷 332-348页

作者： Chenyu LIU Chao AN Changchuan XIE Xin ZHANG lan yang School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Experimental folding fin models with an adjustable free-play are tested in a wind *** fin structure is modeled using the free-interface component mode synthesis method,and its free-play is modeled as four independent nonlinear springs with asymmetric stiffness.A nonplanar unsteady vortex-lattice method considering compressibility is employed to address nonlinear deformation and high subsonic *** spline interpolation is improved through projection and *** aeroelastic characteristics of folding fins with different free-play magnitudes,initial conditions and elastic-axis positions are analyzed using an established time-marching method because of its relatively small computation scale and high *** results show good consistency among the presented method,the wind tunnel test and the harmonic balance *** is a negative correlation between the critical speed of divergent motion and the ratio of the initial condition to the free-play *** either the free-play magnitude or the initial condition is extreme(tiny or vast),the system nonlinearity degenerates to ***,the flutter prevention design of a linear model can be applied to a nonlinear model,such as moving the elastic-axis position *** presented fin configuration exhibits an unstable limit cycle oscillation because the orders of coupled flutter modes do not change with variations in equivalent linear stiffness.

关键词： Free-play Limit cycle oscillation Flutter Component mode synthesis Vortex-lattice method

Three-stage niobium mineralization at Bayan Obo, China

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National Science Review 2024年第4期11卷 102-110页

作者： Yan Yu yang Li Yu Liu Xiao-Xiao Ling Li-Guang Wu Li yang lan yang Bo yang Yong-Gang Zhao Xian-Hua Li State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Science University of Chinese Academy of Sciences Ministry of Education Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking University Mining Research Institute Baotou Iron and Steel(Group) Co.LTD State Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization

The Chinese Bayan Obo deposit is a world-class rare earth element(REE) deposit with considerable niobium(Nb) and iron(Fe) resources. A complete genetic understanding on all metals is fundamental for establishing genetic models at Bayan Obo. With extensive research being focused on REE enrichment, the timing and controls of Nb enrichment remain unresolved at Bayan Obo, which is mainly due to the challenges in dating, i.e. multistage thermal events, fine-grained minerals with complex textures and the rare occurrence of uranium-enriched minerals with mature dating methods. Based on robust geological and petrographic frameworks, here we conducted ion probe uranium-lead(U-Pb) dating of ferrocolumbite to unravel the timing, hence the genesis of Nb mineralization. Three types of hydrothermal ferrocolumbites—key Nb-bearing minerals—are identified based on their textures and mineral assemblages. They yield U-Pb ages of 1312 ± 47 Ma(n = 99), 438 ± 7 Ma(n = 93), and 268 ± 5 Ma(n = 19), respectively. In line with deposit geology, we tentatively link the first, second and third stage Nb mineralization to Mesoproterozoic carbonatite magmatism, ubiquitous early Paleozoic hydrothermal activity, and Permian granitic magmatism, respectively. While quantifying the contribution of metal endowment from each stage requires further investigation, our new dates highlight that multi-stage mineralization is critical for Nb enrichment at Bayan Obo, which may also have implications for the enrichment mechanism of Nb in REE deposits in general.

关键词： niobium mineralization U-Pb dating ferrocolumbite Bayan Obo

Lateral root elongation in maize is related to auxin synthesis and transportation mediated by N metabolism under a mixed NO_(3)^(–) and NH_(4)^(+) supply

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Journal of Integrative Agriculture 2024年第3期23卷 1048-1060页

作者： Peng Wang lan yang Xichao Sun Wenjun Shi Rui Dong Yuanhua Wu Guohua Mi Key Laboratory of Tobacco Biology and Processing of Ministry of Agriculture and Rural Affairs Tobacco Research InstituteChineseAcademy of Agricultural SciencesQingdao 266101China Department of Plant Nutrition College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China College of Resources Hunan Agricultural UniversityChangsha 410128China Agro-Environmental Protection Institute Ministry of Agriculture and Rural AffairsTianjin 300191China

A mixed nitrate (NO_(3)^(–)) and ammonium (NH_(4)^(+)) supply can promote root growth in maize (Zea mays),however,the changes in root morphology and the related physiological mechanism under different N forms are still ***,maize seedlings were grown hydroponically with three N supplied in three different forms (NO_(3)^(–)only,75/25 NO_(3)^(–)/NH_(4)^(+)and NH_(4)^(+)only).Compared with sole NO_(3)^(–)or NH_(4)^(+),the mixed N supply increased the total root length of maize but did not affect the number of axial *** main reason was the increased total lateral root length,while the average lateral root (LR) length in each axle was only slightly *** addition,the average LR density of 2nd whorl crown root under mixed N was also *** with sole nitrate,mixed N could improve the N metabolism of roots (such as the N influx rate,nitrate reductase (NR) and glutamine synthase (GS)enzyme activities and total amino content of the roots).Experiments with exogenously added NR and GS inhibitors suggested that the increase in the average LR length under mixed N was related to the process of N assimilation,and whether the NR mediated NO synthesis participates in this process needs further ***,an investigation of the changes in root-shoot ratio and carbon (C) concentration showed that C transportation from shoots to roots may not be the key factor in mediating lateral root elongation,and the changes in the sugar concentration in roots further proved this ***,the synthesis and transportation of auxin in axial roots may play a key role in lateral root elongation,in which the expression of ZmPIN1B and ZmPIN9 may be involved in this *** study preliminarily clarified the changes in root morphology and explored the possible physiological mechanism under a mixed N supply in maize,which may provide some theoretical basis for the cultivation of crop varieties with high N efficiency.

关键词： maize NO_(3)^(–)/NH_(4)^(+)ratio lateral root elongation N assimilation indole-3-acetic acid

Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu lan yang Min Li Haozhou Shu Na Jia Yunzhen Gao Rongying Shi Xiaojia yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate from<5%by 5-FU alone to~80.1%.This nanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

Generative Models for the Evolution of Transportation Systems

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Yixu He Hongyi Lin lan yang yang Liu School of Information Engineering Chang'an University School of Vehicle and Mobility Tsinghua University Department of Architecture and Civil Engineering Chalmers University of Technology

As the development of big data and artificial intelligence accelerates， many studies have begun to incorporate methods of machine learning and deep learning to address multifaceted challenges within the field of transportation. Generative models， garnering increasing attention in recent years， are gradually bolstering the progression of intelligent transportation systems. This paper conducts an extensive investigation into the applications and potential of generative models in the evolution of transportation systems. It specifically delves into three primary areas: trajectory generation， traffic flow prediction， and autonomous driving. While generative models have already made significant contributions， their full capabilities remain underexplored. Consequently， this paper introduces promising avenues for future exploration， such as the potential integration of diffusion models in autonomous driving， harnessing generative models for infrastructure planning， and leveraging generative models to enhance traffic safety. It is anticipated that this paper will serve as a comprehensive and insightful reference for researchers and scholars engaged in generative models and their applications in the transportation domain.

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Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

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Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru LI Jiali WANG Zheng WU Xiao JIN Zhong ZHU Song LI Hongfei ZHANG Delai HU Wangming XU Huan yang lan SHI Liangqin WANG Yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

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马克思与蒲鲁东关于世界秩序的政治哲学交锋

思想理论教育导刊 2024年第3期 56-63页

作者：兰洋中国人民大学马克思主义学院中国人民大学当代政党研究平台

现代世界秩序的本质及其未来出路是马克思与蒲鲁东政治哲学交锋的重要论题,也是过去长期被忽视的理论问题。在马克思看来,蒲鲁东虽然对资产阶级的世界秩序方案进行了深刻揭露,但却陷入了抽象人性论、无政府主义和目的论的泥潭。与此相对... 详细信息

现代世界秩序的本质及其未来出路是马克思与蒲鲁东政治哲学交锋的重要论题,也是过去长期被忽视的理论问题。在马克思看来,蒲鲁东虽然对资产阶级的世界秩序方案进行了深刻揭露,但却陷入了抽象人性论、无政府主义和目的论的泥潭。与此相对,马克思则在与蒲鲁东的反复论战中,开创了阐释世界秩序的历史唯物主义范式,即从物质生产的历史性过程出发考察世界秩序的演变过程,进而以社会主义运动引领超越资本逻辑的新型世界秩序。面对前所未有的世界之变、时代之变、历史之变,进一步挖掘马克思批判蒲鲁东的深刻意涵,既有助于加深我们对马克思思想的理解,也有助于透视现实问题、回应时代之需。

关键词：马克思蒲鲁东世界秩序政治哲学历史唯物主义无政府主义

马克思恩格斯关于“波兰问题”的评论及当代启示

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马克思主义理论学科研究 2024年第3期10卷 58-66页

作者：兰洋中国人民大学马克思主义学院北京100872 中国人民大学当代政党研究平台北京100872

马克思、恩格斯对“波兰问题”的研究贯穿了历史唯物主义的视野和方法,具有独特的理论内涵。他们始终关注波兰人民的命运,广泛而深入地探讨了“波兰问题”的历史演变、战略价值、复杂层次、时代特征和未来出路,并将这些看似无关紧要的... 详细信息

马克思、恩格斯对“波兰问题”的研究贯穿了历史唯物主义的视野和方法,具有独特的理论内涵。他们始终关注波兰人民的命运,广泛而深入地探讨了“波兰问题”的历史演变、战略价值、复杂层次、时代特征和未来出路,并将这些看似无关紧要的对象视作理解世界总体性变革的切入点。面对世界经济复苏艰难曲折、国际和地区热点问题频发的局面,更加需要我们继承马克思、恩格斯评价“波兰问题”的思想精髓,进一步梳理其中蕴含的宽广的历史视野、科学的分析方法和进步的价值向度,以总体性、辩证性、阶段性、超越性思维科学地处理复杂国际问题,全力战胜前进道路上的各种困难和挑战,建构解决世界难题的“中国方案”。

关键词：波兰问题历史唯物主义百年未有之大变局