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pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance

Science China Chemistry 2024年

作者： yilin Zhu Liping Zhang Rongyuan Zhang Chenghan He Han yang yong Liu Ryan T.K.Kwok jacky.w.y.lam Jianwei Sun Jing Feng Zheng Zhao Cuiping yao Ben Zhong Tang Institute of Biomedical Photonics and Sensing School of Life Science and Technology Xi'an Jiaotong University Clinical Translational Research Center of Aggregation-Induced Emission The Second Affiliated Hospital School of Medicine School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen (CUHK-Shenzhen) Department of Urology Jining NO.1 People's Hospital AIE Institute Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Biological and Chemical Engineering The Hong Kong University of Science and Technology

Photodynamic therapy(PDT) is a promising cancer treatment that uses photosensitizers(PSs) to generate cytotoxic reactive oxygen species(ROS) under light, but improving its efficacy is crucial for clinical applications. To address this, we propose a smart nanoplatform(P@BAO-DOX) for synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. we designed an aggregation-induced emission(AIE)-based PS(BAO) with effective ROS generation and NIR-II fluorescence. Additionally, BAO as a PS and doxorubicin(DOX) as a chemo drug were encapsulated in pH-responsive nanogels(PNA) to obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs in acidic conditions, leading to cell death. white light irradiation further triggers BAO to produce substantial ROS,enhancing phototoxicity and synergistic chemo-PDT cancer therapy. Thus, P@BAO-DOX nanogels, as a smart nanoplatform,offer precise drug release and efficient ROS generation for imaging-guided chemo-PDT synergistic therapy, showing promise in advancing cancer treatment.

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Fast and robust phase retrieval for masked coherent diffractive imaging

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Photonics Research 2022年第3期10卷 758-768页

作者： Li Song Edmund y.lam Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Conventional phase retrieval algorithms for coherent diffractive imaging(CDI)require many iterations to deliver reasonable results,even using a known mask as a strong constraint in the imaging setup,an approach known as masked *** paper proposes a fast and robust phase retrieval method for masked CDI based on the alternating direction method of multipliers(ADMM).we propose a plug-and-play ADMM to incorporate the prior knowledge of the mask,but note that commonly used denoisers are not suitable as regularizers for complex-valued latent images ***,we develop a regularizer based on the structure tensor and Harris corner *** with conventional phase retrieval methods,our technique can achieve comparable reconstruction results with less time for the masked ***,validation experiments on real in situ CDI data for both intensity and phase objects show that our approach is more than 100 times faster than the baseline method to reconstruct one complex-valued image,making it possible to be used in challenging situations,such as imaging dynamic ***,phase retrieval results for single diffraction patterns show the robustness of the proposed ADMM.

关键词： coherent phase retrieval

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Catalytically active interfaces in titania nanorod-supported copper catalysts for CO oxidation

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Nano Research 2020年第2期13卷 533-542页

作者： wasim U.Khan Season S.Chen Daniel C.w.Tsang wey yang Teoh Xijun Hu Frank L.y.lam Alex C.K.yip Department of Chemical and Process Engineering The University of Canterbury Christchurch 8041New Zealand Department of Civil and Environmental Engineering.The Hong Kong Polytechnic University Hong Kong.China School of Chemical Engineering The University of New South WalesSydneyNSW 2052Australia Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina

One-dimensional titanium dioxide nanorod(TNR)-supported Cu catalysts(2.5 wt.%-12.5 wt.%)were synthesized using deposition-precipitation.X-ray photoelectron spectroscopy,temperature programmed reduction and CO chemisorption measurements showed that Cu doping over TNR offered metal-support interactions and interfacial active sites that had a profound impact on the catalytic *** role of the Cu-TNR interface was investigated by comparing the catalytic activity of Cu-TNR catalysts with that of pure CuO nanoparticles in CO *** presence of highly dispersed copper species,a high number of interfacial active sites,CO adsorption capacity and surface/lattice oxygen were found to be responsible for the excellent activity of 7.5CU-TNR(ie,Cu loading of 7.5 wt.%on TNR).Moreover,the Cu-TNR catalysts followed the Langmuir-Hinshelwood reaction mechanism with 7.5CU-TNR,exhibiting an apparent activation energy of 44.7 kJ/*** TNR-supported Cu catalyst gave the highest interfacial catalytic activity in medium-temperature CO oxidation(120-240℃)compared to other commonly used supports,including titanium dioxide nanoparticles(TiO2-P25),silica(SiO2)and alumina(Al20g)in which copper species were nonhomogeneously *** study confirms that medium-temperature CO oxidation is highly sensitive to the morphology and structure of the supporting material.

关键词： supported catalysts nanorod oxygen species interfacial active sites CO oxidation

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Towards creep property improvement of selective laser melted Ni-based superalloy IN738LC

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Journal of Materials Science & Technology 2022年第17期112卷 301-314页

作者： H.y.Song M.C.lam y.Chen S.wu P.D.Hodgson X.H.wu y.M.Zhu A.J.Huang Monash Centre for Additive Manufacturing 15-17 Normanby RdNotting HillVIC 3168Australia Department for of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia Monash Centre for Electron Microscopy 10 Innovation WalkClaytonVIC 3800Australia Institute for Frontier Materials Deakin UniversityVIC 3216Australia

Nickel-based superalloy IN738LC produced by selective laser melting(SLM)exhibits inferior hightemperature creep properties than its cast counterparts due to relatively smaller grain size,particularly for the plane normal to the building *** work studied effects of post heating strategy on the microstructure and especially the grain size to improve the high temperature creep *** asbuilt microstructure exhibited a fine grain size and large quantities of MC carbides that could effectively hinder grain *** was found that unconventional two-step heat treatments could lead to substantial grain growth,and the effect is particularly prominent at a specific *** ease of grain growth was explained after classifying the microstructural evolution(boundary carbide transformation)during each heating step and related to the reduced grain boundary pinning force from MC *** tests validated the effect of the new heat treatment scheme on the SLM-processed IN738LC at 850℃.An extended creep fracture life(1.5 to 4 times improvement)and lower secondary creep rates were achieved with samples subjected to the newly optimized two-step heat *** complete creep curves are also firstly presented for SLM-IN738LC,confirming the effectiveness of grain growth and highlighting the importance of dedicated heat treatment for SLM superalloys.

关键词： Selective laser melting IN738LC alloy Creep properties Heat treatments Grain structure

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5-{[(4′-正戊基氧-4-联苯基基)羰基]氧}-1-戊炔的相转变与相结构

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物理化学学报 2010年第4期26卷 817-821页

作者：余振强朱才镇田赛刘剑洪 lam jacky wing yip 唐本忠深圳大学化学与化工学院深圳市功能高分子重点实验室广东深圳518060 香港科技大学化学系

采用差示扫描量热(DSC)、一维(1D)广角X射线衍射(wAXD)、热台偏光显微镜(PLM-hotstage)等研究手段对含联苯液晶基元的侧链液晶聚炔单体5-{[(4′-正戊基氧-4-联苯基基)羰基]氧}-1-戊炔(A3EO5)的本体相转变和相结构进行了研究.DSC和1D-wAX... 详细信息

采用差示扫描量热(DSC)、一维(1D)广角X射线衍射(wAXD)、热台偏光显微镜(PLM-hotstage)等研究手段对含联苯液晶基元的侧链液晶聚炔单体5-{[(4′-正戊基氧-4-联苯基基)羰基]氧}-1-戊炔(A3EO5)的本体相转变和相结构进行了研究.DSC和1D-wAXD实验结果表明,A3EO5在升温和降温过程中均呈现四个相转变过程,形成双向性液晶.样品从各向同性态降温至室温过程中,首先形成近晶A相,随后进入层内排列具有准长程有序的近晶B相,继续降温将形成层内为正交排列的近晶E相,在此之后样品进入晶相.PLM结果指出样品在各向同性态降温过程中分别形成球状织构、角锥织构和同心圆弧织构.

关键词：液晶相结构相转变 X射线衍射近晶相

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Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 163-172页

作者： wanling Liang Alan y.L.Chan Michael y.T.Chow Fiona F.K.Lo yingshan Qiu Philip C.L.Kwok Jenny K.w.lam Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Advanced Drug Delivery Group Faculty of Pharmacy The University of Sydney

The therapeutic potential of small nucleic acids such as small interfering RNA(siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled *** this study, spray freeze drying was employed to prepare dry powder of small nucleic *** and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope(SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of the formulation. The dry powder formulation containing 2% w/w DNA had a median diameter of 12.5 μm, and the aerosol performance study using next generation impactor(NGI) showed an emitted fraction(EF) and fine particle fraction(FPF) of 91% and 28% respectively. This formulation(5% w/v solute concentration and 2% w/w nucleic acid) was adopted subsequently to produce siRNA powder. The gel retardation and liquid chromatography assays showed that the siRNA remained intact after spray freeze drying even in the absence of delivery vector. The siRNA powder formulation exhibited a high EF of 92.4%and a modest FPF of around 20%. Further exploration of this technology to optimise inhaled siRNA powder formulation is warranted.

关键词： Inhalation Pulmonary delivery Small interfering RNA Spray freeze drying

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被分析物在微流体器件中的分散特性

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机械工程学报 2006年第3期42卷 93-98页

作者：赵志文陈兴 lam y C 北京师范大学电子学系北京100875 新加坡-MIT联盟新加坡南洋理工大学机械与航空航天学院新加坡639798

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的y型微流体器件中两种同物性流体的流... 详细信息

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的y型微流体器件中两种同物性流体的流动特性,采用平均分析法,对微型矩形窄缝中的压力流的传质现象进行了初步研究,提出二维分析模型,并导出了其分析解。

关键词：扩散/对流传质微流体器件压力定常流泰勒分散

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5-[4′-正庚基-氧-联苯基-4-氧-羰基]基-1-正戊炔的晶体结构研究

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高等学校化学学报 2005年第7期26卷 1366-1368,M010页

作者：刘雷静耿建新周云春尹丽李杲周恩乐 jacky lam wing yip 唐本忠中国科学院研究生院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 香港科技大学化学系

The crystal structure of 5-{[(4′-heptoxy-biphenylyl-4-yl)oxy]carbonyl}-1-pentyne({A3E′O7}) was investigated by wide angle X-ray diffraction(wAXD), transmission electron microscope(TEM) and atom force microscope(AFM). The structures of A3E′O7 solution-crystal and melt-crystal are the same. The crystals belong to the monoclinic P112/m space group, the cell parameters are {a0.589 nm}, b0^771 nm, c4.75 nm, αβ90° and γ93.8°, the calculated cell density is {1.167 g/cm+3}.

关键词：晶体结构 5-[4′-正庚基-氧-联苯基-4-氧-羰基]基-1-正戊炔透射电镜 X射线衍射

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An unsupervised learning approach to study synchroneity of past events in the South China Sea

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Frontiers of Earth Science 2019年第3期13卷 628-640页

作者： Kevin C. Tse Hon-Chim Chiu Man-yin Tsang yiliang Li Edmund y. lam Department of Earth Sciences The University of Hong KongPokfulamHong KongChina Department of Geography and Centre for Geo-computation Studies Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Earth Sciences University of TorontoCanada Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Unsupervised machine learning methods were applied on multivariate geophysical and geochemical datasets of ocean floor sediment cores collected from the South China Sea. The well-preserved and continuous core samples comprising high resolution Cenozoic sediment records enable scientists to carry out paleoenvironment studies in detail. Bayesian age-depth chronological models constructed from biostratigraphic control points for the drilling sites are applied on cluster boundaries generated from two popular unsupervised learning methods: K-means and random forest. The unsupervised learning methods experimented have produced compact and unambiguous clusters from the datasets, indicating that previously unknown data patterns can be revealed when all variables from the datasets are taken into account simultaneously. A study of synchroneity of past events represented by the cluster boundaries across geographically separated ocean drilling sites is achieved through converting the fixed depths of cluster boundaries into chronological ranges represented by Gaussian density plots which are then compared with known past events in the region. A Gaussian density peak at around 7.2 Ma has been identified from results of all three sites and it is suggested to coincide with the initiation of the East Asian monsoon. Contrary to traditional statistical approach, a priori assumptions are not required for unsupervised learning, and the clustering results serve as a novel data-driven proxy for studying the complex and dynamic processes of the paleoenvironment surrounding the ocean sediment. This work serves as a pioneering approach to extract valuable information of regional events and opens up a systematic and objective way to study the vast global ocean sediment datasets.

关键词： machine learning ocean sediments unsupervised classification

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Unsupervised learning on scientific ocean drilling datasets from the South China Sea

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Frontiers of Earth Science 2019年第1期13卷 180-190页

作者： Kevin C.TSE Hon-Chim CHIU Man-yin TSANG yiliang LI Edmund y.lam Department of Earth Sciences The University of Hong KongPokfulamHong KongChina Department of Geography and Centre for Geo-computation Studies Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Earth Sciences University of TorontoTorontoON M5S 2M8Canada Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Unsupervised learning methods were applied to explore data patterns in multivariate geophysical datasets collected from ocean floor sediment core samples coming from scientific ocean drilling in the South China *** to studies on similar datasets,but using supervised learning methods which are designed to make predictions based on sample training data,unsupervised learning methods require no a priori information and focus only on the input *** this study,popular unsupervised learning methods including K-means,self-organizing maps,hierarchical clustering and random forest were coupled with different distance metrics to form exploratory data *** resulting data clusters were externally validated with lithologic units and geologic time scales assigned to the datasets by conventional methods. Compact and connected data clusters displayed varying degrees of correspondence with existing classification by lithologic units and geologic time scales.K-means and self-organizing maps were observed to perform better with lithologic units while random forest corresponded best with geologic time *** study sets a pioneering example of how unsupervised machine learning methods can be used as an automatic processing tool for the increasingly high volume of scientific ocean drilling data.

关键词： machine learning unsupervised learning ODP IODP clustering

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