pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance
作者机构：Institute of Biomedical Photonics and Sensing School of Life Science and Technology Xi'an Jiaotong University Clinical Translational Research Center of Aggregation-Induced Emission The Second Affiliated Hospital School of Medicine School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen (CUHK-Shenzhen) Department of Urology Jining NO.1 People's Hospital AIE Institute Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscience and Department of Biological and Chemical Engineering The Hong Kong University of Science and Technology
出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))
年 卷 期：2024年
核心收录：
学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学]
基 金：supported by the National Key Research and Development Program of China (2023YFB3810001) the National Natural Science Foundation of China (62175198, 52333007, U22A2092, and 52273197) the Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001) the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, KQTD20210811090142053, JCYJ20220818103007014, and GJHZ20210705141810031) the Innovation and Technology Commission (ITC-CNERC14SC01) the Science and Technology Program of Guangzhou, China (2023A04J0069) the Fundamental Research Funds for the Central Universities (xtr062022002 and xzy022022007)
摘 要：Photodynamic therapy(PDT) is a promising cancer treatment that uses photosensitizers(PSs) to generate cytotoxic reactive oxygen species(ROS) under light, but improving its efficacy is crucial for clinical applications. To address this, we propose a smart nanoplatform(P@BAO-DOX) for synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission(AIE)-based PS(BAO) with effective ROS generation and NIR-II fluorescence. Additionally, BAO as a PS and doxorubicin(DOX) as a chemo drug were encapsulated in pH-responsive nanogels(PNA) to obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs in acidic conditions, leading to cell death. White light irradiation further triggers BAO to produce substantial ROS,enhancing phototoxicity and synergistic chemo-PDT cancer therapy. Thus, P@BAO-DOX nanogels, as a smart nanoplatform,offer precise drug release and efficient ROS generation for imaging-guided chemo-PDT synergistic therapy, showing promise in advancing cancer treatment.
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