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Infectious Diseases of Poverty 2014年第1期3卷 128-134页

作者： Seham Fathy Abdel Hameed Azab laila m sherief Safaa H Saleh Wafaa F Elsaeed mona A Elshafie Sanaa m Abdelsalam Faculty of medicine Zagazig UniversityEgypt18 Omar Bin Elkhattab StAl QawmiaZagazig CityAl Sharqia GovernorateEgypt

Background:Community-acquired pneumonia(CAP)is one of the five leading causes of death among children in developing countries,accounting for approximately three million deaths per *** of the modifiable risk factors of CAP may help to reduce the burden of this *** this study,the impact of the socioeconomic status(SES)on the severity and outcome of CAP among Egyptian children was ***:This was a prospective longitudinal cohort study which included 1,470 children diagnosed with CAP,aged two to 15 years(median age 5.4 years).The diagnosis of CAP was based on clinical and radiological findings.A structured questionnaire and the patients’medical records were used for the data *** subjects were divided into two groups:mild and severe *** and demographic variables were compared,and a multivariate logistic regression analysis was ***:The multivariate analysis showed that a low maternal education level(OR:3.8;95%CI:2.12-6.70;P=.0001),unavailability of adequate medical care(OR:3.1;95%CI:1.99-4.88;P=.0001),a low family income(OR:2.2;95%CI:0.99-4.78;P=.047),and parents’smoking habits(OR:2.0;95%CI:1.15-3.55;P=.014)were significant independent predictive risk factors for severe CAP among Egyptian ***:Public health measures against these socio-demographic risk factors should be identified as priorities in order to help reduce the disease burden of deaths from severe CAP among Egyptian children.

关键词： Socioeconomic Community acquired pneumonia Children

Acute lymphoblastic leukemia in a β-thalassemia intermedia child: A case report

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World Journal of Clinical Pediatrics 2020年第1期9卷 1-6页

作者： laila m sherief Esmael Goneim Naglaa m Kamal Amr Ibraheim Fuad Alsofiani Abdulraouf Alawur Department of Pediatric Hematology and Oncology Faculty of MedicineZagazig UniversityZagazig 44511Egypt Department of Pediatrics Faculty of MedicineZagazig UniversityZagazig 44511Egypt Department of Pediatric Oncology Tanta Cancer InstituteTanta 00202Egypt Department of Pediatrics and Pediatric Hepatology Faculty of MedicineCairo UniversityCairo 21121Egypt Fuad A alsofiani Abdulraouf H AlawurDepartment of PediatricsAlhada Armed Forces HospitalTaif 00966Saudi Arabia

BACKGROUNDβ-thalassemia intermedia(βTI)is one of the *** constitutes 10%ofβ-thalassemia cases yet being associated with a better quality of life thanβ-thalassemia major(βTm).CASE SUmmARY We recently reported the first case of acute lymphoblastic leukemia(ALL)from Egypt in a child withβTm,and we herein report the first case of ALL from Egypt in a child withβ*** this report,literature was reviewed for cases of malignancies associated withβTI and the possible factors underling the relationship between the two *** We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.

关键词： Acute lymphoblastic leukemia Thalassemia intermedia Children malignancies Iron overload Hydroxyurea Case report

Effects of dual sofosbuvir/daclatasvir therapy on, chronic hepatitis C infected, survivors of childhood malignancy

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World Journal of Clinical Cases 2019年第16期7卷 2247-2255页

作者： mortada HF El-Shabrawi laila m sherief mostafa Yakoot Naglaa m Kamal mohamed A Almalky manal m AbdElgawad Aml A mahfouz Sherine Helmy Enas m Kamal Dina Attia Hisham R El-Khayat Paediatric Hepatology Department Cairo Faculty of MedicineCairo 11559Egypt Paediatric Hematology-Oncology Department Zagazig Faculty of MedicineZagazig 21121Egypt Internal medicine Pediatrics and HepatologyGreen Clinic and Research CenterAlexandria UniversityAlexandria 21121Egypt Paediatric Hepatology Department Alexandria Faculty of medicineAlexandria 21121Egypt Innovations & Research Pharco CorporationAlexandria 21121Egypt Endemic medicine and Hepatology Department Minia UniversityMinia 22233Egypt Endemic medicine and Hepatology Department Beni-suef UniversityBeni-suef 62511Egypt Gastroenterology and Endemic medicine Department Theodore Research InstituteCairo 23323Egypt

BACKGROUND Childhood cancer survivors are potentially at a higher risk of infection with hepatitis C virus (HCV).The effects of all-oral direct-acting antiviral therapy (DAA) on both the HCV infection as well as the state of cancer remission have not been well investigated in this *** To test the effects of dual sofosbuvir/daclatasvir (SOF/DCV) therapy in the treatment of chronic HCV in survivors of hematologic malignancy in pediatric age *** We conducted a prospective,uncontrolled,open-label multicenter study.A total of 20 eligible,chronic HCV,genotype-4,infected children who had been in continuous complete remission from hematologic cancer (leukemia/lymphoma) for at least one year were included in the *** patients were treated with combined SOF/DCV for 12 *** were monitored throughout the study till 12 wk after end of treatment for safety and efficacy outcomes including the sustained virologic response 12 (SVR12) rate,hematological indices,liver and kidney *** The intent-to-treat SVR12 rate was 20 of 20 (100%;95%CI: 84%-100%).All patients showed normalized liver enzymes from *** hematological indices,liver and kidney functions were kept normal throughout the *** fatalities or treatment-emergent serious or severe adverse events were reported throughout the *** SOF/DCV combined therapy could be used safely and effectively in the treatment of chronic HCV genotype-4 infection in leukemia/lymphoma treated *** relapses were detected during treatment and throughout the follow up period for either the original malignant disease or the HCV infection.

关键词： Chronic hepatitis C Survivors of childhood cancer Sofosbuvir Daclatasvir Efficacy

A new technique of monsplasty as an adjunctive procedure in cases of abdominoplasty:A prospective clinical trial

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 124-129页

作者： laila Ahmed Aboul Nasr sherief Zamer Ahmed Fathy Elsayed mohamed Hatem Elsahar Department of Plastic Surgery Faculty of Medicine Kasr Al-AinyCairo UniversityCairo11562Egypt

Background:No standard monsplasty technique has existed until *** various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative *** that used pubic suspension techniques did not describe exact anatomical landmarks for the mons *** study aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty and provide exact anatomical points to anchor the mons to the rectus ***:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity between December 2017 and September *** surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body mass index≤35 kg/m^(2),and age 18–60 *** patients were followed for up to one year;patient satisfaction was assessed before and after surgery regarding aesthetic results and impact on outfits,hygiene,and sexual ***:The marginal homogeneity test revealed a statistically significant patient satisfaction rate regarding outfits,sexual function,hygiene,and *** postoperative complications,seroma(one case)was managed by aspiration,and one case of wound dehiscence was managed conservatively with ***:This study recommends a quick and reproducible monsplasty technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus *** this technique with abdominal contouring is advisable for optimal aesthetic results and maintained lymphatic drainage in the pubic region.

关键词： Abdominoplasty mons ptosis Pubic suspension Skin redundancy

Deposition of Phosphate Nanoparticles onto Textile Fabrics via Sol-gel method and Their Kinetics Desorption Studies

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Chemical Research in Chinese Universities 2020年第5期36卷 877-884页

作者： mohamed El mESSOUDI Aicha BOUKHRISS laila SADALLAH laila SAJID m'hamed El KOUALI Said GmOUH Laboratory REmTEX ESITHHigher School of Textile and Clothing Industties(ESITH)Kni8Route d'EL JADIDACasablancaMorocco Laboratory LIN1AT Faculty of Sciences Ben M'SikHassan II University of CasablancaB.P 5366 KiaarifCasablancaMorocco Laboratory LCAPCm Faculty of Sciences Ben M'SikHassan II Universityof CasablancaB.P 5366 MaarifCasablancaMorocco Laboratory L3GIE Mohamntadia School of EngineersMohammad V UniversityBP.765 Av.Ibn SinaAgdalRabatMorocco Laboratory LEC Higher School of Textile and Clothing Industries(ESITH)Km 8Route d'EL JADIDACasablancaMorocco

In this paper,phosphate nanoparticles were coated on cotton(CO)and polyester(PES)textile surfaces by sol-gel method using tetraethylorthosilicate(TEOS)and chloropropyltriethoxysilane(CPTS)as silica *** deposited nanoparticles were observed with scanning electronic microscopy energv-dispersive X-ray spectroscopy(SEm-EDX).The release kinetics of phosphorus(P)from these textiles into the aqueous medium(Aq),acid(Ac),and basic(Ba)artificial sweats were then *** released amount of phosphorus was evaluated by the inductively coupled plasma(ICP)according to ISO NF EN 16711-2 *** results revealed that the release of P into the aqueous medium is lower than in the artificial *** kinetics data[the phosphoras desorption amount(mg/g)as a iunction of time]were modeled according to five models:the first order,the second order,the third order,simple Elovich and parabolic *** suitable model was chosen based on the coefficient of determination(R2)and the calculation of the sum of the absolute errors(EABS),which describes the error between the theoretical and experimental *** observations were also carried out on the fabrics after desorption in order to show the impact of desorption on their ***,the impact of P release on the tensile strength of CO and PES fabrics was investigated using a uniaxial tensile *** thennal stability of all samples before and after desorption was assessed by thermogravimetric aiialysis(ATG).

关键词： Sol-gel Coating Kinetic Desorption Phospliate nanoparticle

Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 459-464页

作者： Amal A.El Gohary laila Hassan m.Elshazly Department of Ocular Physiology Research Institute of Ophthalmology Department of Ophthalmology Memorial Institute of Ophthalmology

AIm: To determine whether the photopic negative response(Ph NR) elicited by transient white flash on white background is characterizing for glaucoma model in ***: Glaucoma was induced in twelve rabbits by subconjunctival injection of 0.05 m L of betamethasone in right eyes(each 1 m L contain betamethasone dipropionate5 mg and betamethasone sodium phosphate 2 mg).The intraocular pressure(IOP), electroretinogram(ERG) and visual evoked potential(VEP) were measured successively prior and on the 3, 7d, two weeks and four weeks postglaucoma induction. After four weeks, the animals were sacrificed and the globes were histopathologically ***: The IOP increased significantly after one week(P =0.0001), then it gradually returned to the control level. In ERG examination, the means of a and b wave amplitude and latency were not affected *** NR amplitude decreased significantly within one week(P =0.0001), but its latency was not affected significantly(P =0.132). The means of VEP latency and amplitude were significantly affected after two weeks and four weeks of glaucoma induction(P =0.0001 and 0.02,respectively). The histopathologic examination of the globes showed reduced number of cells in the retinal ganglion cell layer with multiple vacuoles in the retinal nerve fibre *** was significant positive correlation between ganglion cell layer cells and Ph NR amplitude( r =0.8, P =0.002).CONCLUSION: The rise in IOP resulted in irreversible changes or incomplete recovery of VEP and Ph NR amplitude. Both Ph NR and VEP represented good additional tools in early diagnosis of glaucoma.

关键词： glaucoma electrophysiology photopic negative response rabbits

Threshold-Based Software-Defined Networking(SDN)Solution for Healthcare Systems against Intrusion Attacks

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1469-1483页

作者： laila m.Halman mohammed J.F.Alenazi Department of Computer Engineering College of Computer ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The healthcare sector holds valuable and sensitive *** amount of this data and the need to handle,exchange,and protect it,has been increasing at a fast *** to their nature,software-defined networks(SDNs)are widely used in healthcare systems,as they ensure effective resource utilization,safety,great network management,and *** this sector,due to the value of thedata,SDNs faceamajor challengeposed byawide range of attacks,such as distributed denial of service(DDoS)and probe *** attacks reduce network performance,causing the degradation of different key performance indicators(KPIs)or,in the worst cases,a network failure which can threaten human *** can be significant,especially with the current expansion of portable healthcare that supports mobile and wireless devices for what is called mobile health,or *** this study,we examine the effectiveness of using SDNs for defense against DDoS,as well as their effects on different network KPIs under various *** propose a threshold-based DDoS classifier(TBDC)technique to classify DDoS attacks in healthcare SDNs,aiming to block traffic considered a hazard in the form of a DDoS *** then evaluate the accuracy and performance of the proposed TBDC *** technique shows outstanding performance,increasing the mean throughput by 190.3%,reducing the mean delay by 95%,and reducing packet loss by 99.7%relative to normal,with DDoS attack traffic.

关键词： Network resilience network management attack prediction software defined networking(SDN) distributed denial of service(DDoS) healthcare

Pillararene-based supramolecular systems for theranostics and bioapplications

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Science China Chemistry 2021年第5期64卷 688-700页

作者： Huangtianzhi Zhu Qi Li laila E.Khalil-Cruz Niveen m.Khashab Guocan Yu Feihe Huang State Key Laboratory of Chemical Engineering Key Laboratory of Excited-State Materials of Zhejiang ProvinceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Smart Hybrid materials Laboratory(SHms) Advanced Membranes and Porous Materials CenterKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and ***-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising *** to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional *** one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of *** the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and *** this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,*** introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are *** challenges and directions of this field are also outlined.

关键词： pillararenes self-assembly theranostics drug delivery supra-amphiphiles

Effect of the Si/Al ratio of HZSm-5 zeolite on the production of dimethyl ether before and after ultrasonication

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燃料化学学报 2017年第5期45卷 581-588页

作者： Sameh m.K.Aboul-Fotouh laila I.Ali mona A.Naghmash Noha A.K.Aboul-Gheit Chemistry Department Faculty of ScienceNorthern Boder UniversityArar 91431Kingdom of Saudi Arabia Chemistry Department Faculty of EducationAin Shams UniversityRoxyCairo 11757Egypt Egyptian Petroleum Research Institute Nasr CityCairo 11787Egypt

A series of as-synthesized HZSm-5 zeolites with different Si/Al ratios(25,90,120,240 and 400)were post-treated by ultrasonication for an optimum time of 60 *** morphology,acidity and textural properties of HZSm-5 were characterized with XRD,SEm,N_2 adsorption and NH3-TPD *** catalytic performance was evaluated by dehydration of methanol to dimethyl ether(DmE),which is a promising gaseous automotive fuel in *** was found that the Si/Al ratio of HZSm-5 had considerable impacts on its catalytic performance for dehydration of methanol to *** activity increased with decreasing Si/Al ratio from 400 to *** of HZSm-5 could significantly improve its catalytic performance.

关键词： Ultrasonication-HZSm-5-dimethyl ether-Si/Al 比率

Safety of intravitreal triamcinolone acetonide:an electrophysiologic and histopathological study in rabbits

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 790-795页

作者： laila Hassan m.El-Shazly Amal Ahmad El-Gohary Ghada Ghanem El-Hossary Department of Ophthalmology Memorial Institute of Ophthalmology Department of Physiology Research Institute ofOphthalmology Department of Pharmacology Research Institute ofOphthalmology

AIm:To evaluate the retinal safety of various doses of intravitreal triamcinolone acetonide(TA)in ***:Thirty New Zealand albino rabbits were divided into five groups(six animals each).In group 1(control group),each animal received a single intravitreal injection of 0.1 mL phosphate buffered *** groups2,3,4 and 5,each rabbit received a single intravitreal injection of 4,8,16 and 32mg of TA,*** dose was contained in 0.1 mL phosphate buffered *** ocular examinations were performed before the injection and on the 1st,3rd,10th and 17th postinjection days.A standard dark adapted electroretinogram(ERG)was obtained before injection and on the 3rd,10th and 17th post-injection ***17d,animals were sacrificed and their eyes prepared for pathological ***:By monitoring ERG as a functional index for the retina,intravitreal injection of 4mg TA showed no significant ERG *** doses of 8,16 and 32,hyper-abnormal responses in a-and b-waves of ERG were detected on the 3rd post-injection *** changes gradually returned back to normal limits *** examination of the retina of all animals showed no pathological ***:High doses of intravitreal TA seemed to have enhancing effects on the retinal function with gradual return to normal limits with no pathological changes detected in examined eyes.

关键词： triamcinolone acetonide intravitreal injection electroretinogram