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ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice

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中国药理学与毒理学杂志 2018年第9期32卷 713-714页

作者： XIAO Kuo SUN Zhi-ming JIN Xue-qin MA Wei-ning SONG Yan lai shi-rong FAN Ming-hua ZHANG Jing-liang YUE Wei-hua HUANG Zhuo State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Department of Neurology Shengjing Hospital affiliated to China Medical UniversityShenyang 110000China Peking University Sixth Hospita(Institute of Mental Health) Beijing 100191China National clinical Research Center for Mental Disorders&Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China Key Laboratory for Neuroscience Ministry of EducationBeijing 100191 china

The input-output relationship of neuronal networks depends heavily on the intrinsic properties of their neuronal *** changes in intrinsic properties have been observed in various physiological and pathological processes,such as learning,memory and ***,the cellular and molecular mechanisms underlying acquired changes in intrinsic excitability are still not fully ***,we demonstrate that ERG3 channels are critically involved in the regulation of intrinsic excitability in hippocampal CA1 pyramidal neurons and DG granule ***-down of ERG3 channels significantly increases neuronal intrinsic excitability,which is mainly caused by decreased fast afterhyperpolarization,delayed time to the generation of an action potential and enhanced summation of somatic excitatory post-synaptic ***,the expression level of ERG3 protein is significantly reduced in human and mouse brain tissues with temporal lobe ***,ERG3 channel knock-down in hippocampus significantly enhanced seizure susceptibility,while mice treated with ERG3 channel activator NS1643 were less prone to *** together,our results suggest ERG3 channels play an important role in determining the excitability of hippocampal neurons and dysregulation of these channels may be involved in the generation of ***3 channels may thus be a novel therapeutic target for the prevention of epilepsy.

关键词： ERG3 channels intrinsic property dysregulation epilepsy

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内蒙古草甸草原羊草和尖嘴薹草空间分布格局对坡位的响应

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草地学报 2024年第12期32卷 3897-3904页

作者：赖仕蓉梁宏余国杰韩瑞鑫平晓燕北京林业大学草业与草原学院北京100083 北京林业大学草地资源与生态研究中心北京100083

点格局分析常用来解释不同尺度上种群空间分布格局与环境的关系及生态学过程,但当前对草甸草原坡位影响下的物种空间分布格局还缺乏深入系统的认识。因此,本研究选取内蒙古科右前旗山地草甸草原为研究对象,通过点格局分析的g(r)函数统... 详细信息

点格局分析常用来解释不同尺度上种群空间分布格局与环境的关系及生态学过程,但当前对草甸草原坡位影响下的物种空间分布格局还缺乏深入系统的认识。因此,本研究选取内蒙古科右前旗山地草甸草原为研究对象,通过点格局分析的g(r)函数统计方法和3种零模型,探究三个坡位群落优势种羊草(Leymus chinensis)和伴生种尖嘴薹草(Carex leiorhyncha)的空间分布格局及种间关联性。结果表明羊草和尖嘴薹草种群在不同坡位均呈现出先聚集分布,随尺度增加逐渐转变为随机分布和均匀分布的趋势。在下坡位尖嘴苔草聚集程度最大,随着坡位的升高聚集效应逐渐减弱。各坡位羊草和尖嘴薹草种群都基本符合异质泊松模型和泊松聚块模型,即生境异质性和扩散限制显著影响种群空间分布格局。下坡位的羊草和尖嘴薹草种群间存在显著的正关联,而上坡位和中坡位的羊草和尖嘴薹草种群的种间关联基本表现为负关联和无关联。研究结果可为深入理解不同坡位内蒙古山地草甸草原群落结构和功能提供参考依据。

关键词：羊草尖嘴薹草零模型坡位空间分布格局

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亚健康的生理学特征与运动处方的研究

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四川体育科学 2003年第4期22卷 14-16页

作者：周君来史绍蓉湖南师范大学体育学院湖南长沙401002

近年来,全球处于亚健康状态的人越来越多,亚健康被社会广泛关注。本文采用文献综述研究的方法,提出合理运动,科学健身,以运动处方的形式指导人们健身锻炼,达到治疗疾病和增进健康的目的。

关键词：亚健康生理学运动处方发生机制慢性疲劳现代身心疾病运动形式运动强度运动时间运动频率

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang shijie Su Weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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广东省韶关市近5年地中海贫血防治效果分析

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湖南师范大学学报（医学版） 2018年第2期15卷 183-186页

作者：杨学煌陈亚军曾宪琪方莎赖世荣韶关市妇幼保健院韶关512026

目的:回顾性分析2012年1月~2016年6月韶关市在地中海贫血防治中取得的成效。方法:利用韶关市的出生缺陷防控网络,对韶关市所有参加婚前医学检查以及产前检查的夫妇双方进行地中海贫血筛查。地中海贫血筛查阳性患者进一步进行α和β地中... 详细信息

目的:回顾性分析2012年1月~2016年6月韶关市在地中海贫血防治中取得的成效。方法:利用韶关市的出生缺陷防控网络,对韶关市所有参加婚前医学检查以及产前检查的夫妇双方进行地中海贫血筛查。地中海贫血筛查阳性患者进一步进行α和β地中海贫血基因检测,筛选出携带同型地中海贫血基因的高危夫妇。在孕期对高危夫妇行地贫产前诊断,诊断为严重类型的地贫胎儿在知情同意选择的情况下终止妊娠。结果:45316例人群筛查出11482例阳性疑似地中海贫血基因携带者,阳性率26.38%,其中10475例筛查阳性患者α和β地中海贫血基因检测,共检测出7297例地贫携带者,群体携带率16.76%(7297/45316);其中α地贫携带者4792例,群体携带率11.01%(4792/45316);β地贫携带者2505例,群体携带率5.75%(2505/45316);筛选出携带同型地贫基因夫妇392对,其中携带同型α地贫基因夫妇316对,携带同型β地贫基因夫妇76对。392对高危夫妇产前诊断后诊断出中间型α地贫胎儿22例(Hb H),重型α地贫胎儿56例,重型β地贫胎儿16例。结论:通过对韶关市大规模人群的地中海贫血防控措施,有效减少了严重类型地中海贫血患儿的出生,提高了本地区出生人口素质,也为本地区出生缺陷防治的策略方案研究提供了依据。

关键词：地中海贫血产前诊断防治效果

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Coupled effects of climate change and human activities on vegetation dynamics in the Southwestern Alpine Canyon Region of China

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Journal of Mountain Science 2024年第10期21卷 3234-3248页

作者： lai Jinlin QI shi School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China

The driving effects of climate change and human activities on vegetation change have always been a focal point of ***,the coupling mechanisms of these driving factors across different temporal and spatial scales remain *** Southwestern Alpine Canyon Region of China(SACR),as an ecologically fragile area,is highly sensitive to the impacts of climate change and human *** study constructed a vegetation cover dataset for the SACR based on the Enhanced Vegetation Index(EVI)from 2000 to *** autocorrelation,Theil-Sen trend,and Mann-Kendall tests were used to analyze the spatiotemporal characteristics of vegetation cover *** main drivers of spatial heterogeneity in vegetation cover were identified using the optimal parameter geographic detector,and an improved residual analysis model was employed to quantify the relative contributions of climate change and human activities to interannual vegetation cover *** main findings are as follows:Spatially,vegetation cover exceeds 60%in most areas,especially in the southern part of the study ***,the border area between Linzhi and Changdu exhibits lower vegetation *** factors are the primary drivers of spatial heterogeneity in vegetation cover,with temperature having the most significant influence,as indicated by its q-value,which far exceeds that of other ***,the interaction q-value between the two factors significantly increases,showing a relationship of bivariate enhancement and nonlinear *** terms of temporal changes,vegetation cover shows an overall improving trend from 2000 to 2020,with significant increases observed in 68.93%of the study *** these,human activities are the main factors driving vegetation cover change,with a relative contribution rate of 41.31%,while climate change and residual factors contribute 35.66%and 23.53%,*** thoroughly exploring the coupled mechanisms of vegetation change,this

关键词： Enhanced vegetation index Climate change Human activities Spatial heterogeneity Coupled mechanisms

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All-atom Molecular Dynamic Simulations and NMR Spectra Study on Intermolecular Interactions of N,N-dimethylacetamide-Water System

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Chinese Journal of Chemical Physics 2008年第3期21卷 221-226页

作者： rong Zhang Zai-you Tan San-lai Luo Lab of Physical Chemistry College of Pharmacy Guangdong Pharmaceutical University Guangzhou510006 China

N,N-dimethylacetamide （DMA） has been investigated extensively in studying models of peptide bonds. An all-atom MD simulation and the NMR spectra were performed to investigate the interactions in the DMA- water system. The radial distribution functions （RDFs） and the hydrogen-bonding network were used in MD simulations. There are strong hydrogen bonds and weak C-H…O contacts in the mixtures, as shown by the analysis of the RDFs. The insight structures in the DMA-water mixtures can be classified into different regions by the analysis of the hydrogen-bonding network. Chemical shifts of the hydrogen atom of water molecule with concentration and temperatures are adopted to study the interactions in the mixtures. The results of NMR spectra show good agreement with the statistical results of hydrogen bonds in MD simulations.

关键词： All-atom simulation NMR spectrum DMA-water system Hydrogen bond

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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