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ang-(1-7)exerts anti-inflammatory and antioxidant activities on high glucose-induced injury by prohibiting NF-κB-IL-1βand activating HO-1 pathways in HUVECs

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BIOCELL 2022年第4期46卷 1053-1066页

作者： FEI CHENG YIQIAN DING QING XU WEI ZHang YULAN ZHEN JING LIU SHICHENG LI CHang TU GUOHUA lai JUN LAN JINGFU CHEN Department of Cardiovascular Medicine Dongguan Songshan Lake Center HospitalDongguan Cardiovascular InstituteDongguan Shilong People’s Hospital Affiliated to Southern Medical UniversityDongguan523326China Department of Ultrasound The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology Huangpu Division of the First Affiliated HospitalSun Yat-sen UniversityGuangzhou510700China Department of Oncology Dongguan Third People’s HospitalDongguan523326China Second Ward of Internal Medicine Dongguan Eighth People’s HospitalDongguan Children’s HospitalDongguan523003China

Previous reports have suggested that ang-(1-7)may have a protective effect in endothelial cells against high glucose(HG)-induced cell injury thanks to a modulatory mechanism in the NF-κB signaling *** this study,we have examined whether NF-κB-IL-1βand Heme oxygenase-1(HO-1)pathways contribute to the protection of ang-(1-7)against hyperglycemia-induced inflammation and oxidative stress in human umbilical vein endothelial cells(HUVECs).Our results indicate that time-varying exposures of HUVECs,from 1 h to 24 h,to high glucose concentrations result in an increased expression of phosphorylated(p)-p65 and HO-1 in a time-dependent *** an inhibitor of NF-κB,pyrrolidinedithiocarbamic acid(PDTC)suppressed IL-1βproduction induced by *** note,HUVECs previously treated with ang-(1-7)(2μM)for 30 min before being exposed to HG concentrations significantly ameliorated the HG-increased in p-p65 and IL-1βexpression;whereas obviously up-regulated the level of HO-1,along with inhibition of oxidative stress,inflammation,and the HG-induced ***,when HUVECs were previously treated either with PDTC or IL-1Ra for 30 min before being exposed to HG,it significantly prevented damages caused by high glucose concentrations mentioned above,while the treatment of HO-1 inhibitor Sn-protoporphyrin(SnPP)before exposure to both HG and ang-(1-7)significantly blocked the protective effect exerted by ang-(1-7)on endothelial cells against injuries induced by HG mentioned *** conclude,the data of this study showed that activation and inhibition of the NF-κB-IL-1βpathway and HO-1 pathway may constitute an important defense mechanism against endothelial cell damage caused by HG *** additionally gave new evidence showing that exogenous ang-(1-7)exerts a protective effect on HUVECs against the HG-induced cell injury via the inhibition and the activation of the NF-κB-IL-1βpathway and the HO-1 pathway,respectively.

关键词： angiotensin-(1-7) High glucose Human umbilical vein endothelial cells NF-κB IL-1β HO-1

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川南东部地区阳新统的地层破裂压力预测

天然气工业 1994年第2期14卷 44-47页

作者：姜子昂张永红赖文洪廖易四川石油管理局川南矿区

碳酸盐岩裂缝性地层破裂压力定量预测目前仍是一道非常复杂的难题。文章应用水力压裂力学原理，紧密结合川南东部地区阳新统碳酸公岩地层特征，探讨了该地区的地层破裂压力机理，认为该区大部分压裂酸化井人工压裂缝是在自然垂缝上延伸... 详细信息

碳酸盐岩裂缝性地层破裂压力定量预测目前仍是一道非常复杂的难题。文章应用水力压裂力学原理，紧密结合川南东部地区阳新统碳酸公岩地层特征，探讨了该地区的地层破裂压力机理，认为该区大部分压裂酸化井人工压裂缝是在自然垂缝上延伸扩展，破裂压力近似等于其垂缝延伸压力。在水平挤压应力和扭剪应力作用下，岩体抗张强度主要受地层破碎系数和应力强度指数控制，文章建立了预测地层破裂压力的物理一数学模型，确定岩体视抗张强度，进而对地层破裂压力进行预测。经实际破裂压力资料验证，绝对误差最大５．０ＭＰａ，一般小于３．０ＭＰａ；相对误差最大５．０％，一般小于２．０％。

关键词：地层破裂压力采油井压裂

Knock out Fall Incidence

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Journal of Health Science 2014年第9期2卷 405-427页

作者： Magdalene Ng Kim Choo Juweita Bte Arba'in Heng Lili Joline NurJannah Zhong Tan Sue Ching Mardielene Cunanan Mercado Nur Amelia Binte Azman Jayanthi d/o Sivam Pillay Israel Jimenez Bernal Connie Besas Oepulango Chong lai Ling ang Shin Yuh Ward 53C Department of Internal Medicine Singapore General Hospital 169608 Republic of Singapore Ward 77H Department of Haematology Singapore General Hospital 169608 Republic of Singapore Nursing Division Singapore General Hospital 169608 Republic of Singapore Nursing Quality Department Singapore General Hospital 169608 Republic of Singapore

Fall is an event in which a person unintentionally descends onto the floor. It may lead to physical injuries, psychological harm and/or financial loses. Over the last three Financial Years 2009-201 l, there had been increasing fall incident rate at the unit level, Department of Internal Medicine and Haematology. The hospital fall performance target was set at 〈 one fall per 1000 patient days. Hence, there was a pressing need for improvement with an emphasis of focused analysis to prevent fall. The aim of the study was to reduce fall incidents by at least 50% at W53C and W77H in Financial Year 2012. The baseline fall incident data was collected from February 2011 to March 2012 for both wards. A total number of 33 falls with a median of 2.5 and 1.1 falls per 1000 patient days respectively were collected. The verification of root causes to fall incidences was identified in Pareto Chart. The 3 root causes were： Delayed elimination round, underestimated patients＇ risk for falls and lack of care coordination among team members. The solution implementations were： Cessation ofhardcopy of elimination chart and daily assessment of patient＇s fall risk using modified Morse Fall Scale was changed from paper to electronic. Conducting root cause analysis post fall and sharing near miss incidences were another two implementations to draw the learning points from the incidents to prevent the similar occurrence. Reallocation of staffassignment without increasing manpower to ensure better care coordination was the 5th solution. With the above stated multi-factorial interventions, a significant fall incidence rate was achieved. It had achieved 7% more than the target set for the project.

关键词： Falls patient safety quality improvement.

Oxidative stress-mediated effects of angiotensin Ⅱ in the cardiovascular system

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World Journal of Hypertension 2012年第4期2卷 34-44页

作者： Hairuo Wen Judith K Gwathmey lai-Hua Xie Department of Cell Biology and Molecular Medicine UMDNJ-New Jersey Medical School Newark NJ 07103 United States GwathmeyInc. CambridgeMA02138 United States School of Optometry Massachusetts CollegeofPharmacyandHealthSciences WorcesterMA01608 United States

angiotensin Ⅱ(ang Ⅱ), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. ang Ⅱ is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species(ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in ang Ⅱ-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of ang Ⅱ in the cardiovascular system. In particular, the involvement of ang Ⅱ-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca2+/calmodulin-dependent protein kinase Ⅱ is an important molecule linking ang Ⅱ, ROS and cardiovascular pathological conditions.

关键词： angiotensinⅡ Oxidative stress Mitochondria Arrhythmias Ischemia-reperfusion Hypertrophy Hypertension

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硬脂酸锌对车用聚丙烯复合材料性能影响

工程塑料应用 2020年第9期48卷 133-137页

作者：程文超付伟陈胜杰赖昂陈瑶杨波上海金发科技发展有限公司上海201714 武汉金发科技有限公司武汉430109 金发科技股份有限公司企业技术中心广州510663

采用双螺杆挤出机熔融共混挤出制备不同硬脂酸锌含量的40%滑石粉填充聚丙烯(PP)复合材料,研究了硬脂酸锌含量对复合材料加工性能、力学性能、气味等级、挥发性有机化合物(VOC)含量、总挥发性有机化合物(TVOC)含量及耐划伤性能的影响,并... 详细信息

采用双螺杆挤出机熔融共混挤出制备不同硬脂酸锌含量的40%滑石粉填充聚丙烯(PP)复合材料,研究了硬脂酸锌含量对复合材料加工性能、力学性能、气味等级、挥发性有机化合物(VOC)含量、总挥发性有机化合物(TVOC)含量及耐划伤性能的影响,并采用扫描电子显微镜(SEM)分析了滑石粉在PP中的分散效果。结果表明,随着硬脂酸锌的含量从0份增加到3.0份,复合材料的加工性能和力学性能均得到改善。SEM测试显示,滑石粉在PP中的分散更加均匀。随着硬脂酸锌含量的增加,降低了复合材料中VOC和TVOC含量,复合材料的耐划伤性能明显提升,当硬脂酸锌含量为3.0份时,复合材料的TVOC含量为38.27μg/g,气味等级为3.0级,划伤前后的变化值ΔL为2.0,较无硬脂酸锌的复合材料,TVOC降低了51.3%,ΔL降低了57.4%。

关键词：润滑剂硬脂酸锌聚丙烯复合材料耐划伤气味

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鲍曼不动杆菌生物被膜与耐药性的相关性分析

国际检验医学杂志 2016年第2期37卷 153-154页

作者：赖其伟黄丽芳韶关市第一人民医院检验科广东韶关512000

目的探讨鲍曼不动杆菌生物被膜与其耐药性的相关性。方法对2011年6月至2014年8月该院分离的鲍曼不动杆菌临床分布、生物膜形成情况及生物膜形成与耐药性的关系进行研究。结果标本来源主要为痰液、分泌物、腹腔积液等;强度为"+"生物膜菌... 详细信息

目的探讨鲍曼不动杆菌生物被膜与其耐药性的相关性。方法对2011年6月至2014年8月该院分离的鲍曼不动杆菌临床分布、生物膜形成情况及生物膜形成与耐药性的关系进行研究。结果标本来源主要为痰液、分泌物、腹腔积液等;强度为"+"生物膜菌株56株,占66.67%(56/84);强度为"-"生物膜菌株3株,占3.57%(3/84),所占比例最低,96.43%鲍曼不动杆菌具有较强的生物膜形成能力;具有生物膜的菌株耐药性明显高于不具有生物膜的菌株,差异有统计学意义(P0.05)。结论鲍曼不动杆菌生物膜与其耐药性密切相关,但不同强度生物膜与其耐药性无明显相关性,值得对生物膜与其耐药性的关系进行更加深入的研究。

关键词：鲍氏不动杆菌生物膜药物耐受性

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基于业务抽象规划的分布式动态服务组合算法

计算机工程 2014年第4期40卷 37-41,47页

作者：赵明雷赵文栋彭来献成昂轩解放军理工大学通信工程学院南京210007 南京军区空军指挥自动化工作站南京210018

异构系统间难以实现计算资源的灵活共享,制约分布式信息系统性能的提升,基于面向服务架构的Web服务技术,为异构系统计算资源共享提供了有效手段。为此,针对Web服务组合在集中式发布架构下单点故障和性能瓶颈问题,提出一种基于业务抽象... 详细信息

异构系统间难以实现计算资源的灵活共享,制约分布式信息系统性能的提升,基于面向服务架构的Web服务技术,为异构系统计算资源共享提供了有效手段。为此,针对Web服务组合在集中式发布架构下单点故障和性能瓶颈问题,提出一种基于业务抽象规划的分布式动态服务组合算法。该算法根据组合规划结果对业务抽象规划库进行动态扩充,快速组合出满足需求的服务,逐步提高服务组合响应率。仿真结果表明,该算法在分布式环境下可减少服务请求过程中交互的信息量,降低请求响应时间,提高服务组合效率。

关键词：面向服务架构分布式信息系统业务抽象规划动态服务组合服务代理

CYP2J2-derived EETs attenuated angiotensin Ⅱ-induced adventitial remodeling via reduced inflammatory response

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中国病理生理杂志 2016年第8期32卷 1507-1508页

作者： ZHOU Chi HUang Jin CHEN Jun-xiong lai Jin-sheng ZHU Fa-sheng XU Xi-zhen Wang Dao-wen Department of Internal Medicine and The Institute of Hypertension Tongji HospitalTongji Medical College of Huazhong University of Science and Technology

BACKGROUND: Cytochrome P450( CYP) epoxygenases metabolize arachidonic acids( AA) to form epoxyeicosatrienoic acids (EETs),which exert beneficial roles in the treatment of cardiovascular diseases,but little is known about its role on adventitial remodeling. METHODS: We used C57 BL /6J mice in vivo and primary rat adventitial fibroblasts( AFs) in vitro treated with angiotensin II(ang II) to investigate the effects of CYP2J2 gene delivery and exogenous EETs administration on adventitial remodeling. RESULTS:CYP / s EH system was found to exist in human adventitia,and involved in adventitial remodeling process. Exogenous EETs administration significantly inhibited ang II-induced AFs activation,characterized by differentiation,proliferation,migration,and collagen synthesis. These protective effects were partially reversed by PPARγ antagonist GW9662 pretreatment or SOCS3 si RNA transfection. EETs suppressed ang II-induced IκBα phosphorylation,subsequent NF-κB nuclear translocation via PPARγ dependent signaling pathway in AFs. Additionally,EETs reduced ang II-induced JAK2,STAT3 phosphorylation and subsequent phosphor-STAT3 nuclear translocation,which were mediated by SOCS3 induction but independent of PPARγ activation. Furthermore,r AAV-CYP2J2 gene delivery reduced vessel wall thickening,AFs differentiation,proliferation and collagen deposition in aortic adventitia induced by ang II infusion,which were mediated by NF-κB and SOCS3 / JAK / STAT signaling pathways in blood pressure-dependent and-independent manners,respectively. CONCLUSION: We concluded that CYP2J2 overexpression attenuated ang II-induced adventitial remodeling via PPARγ-dependent NF-κB and PPARγ-independent SOCS3 / JAK / STAT inflammatory signaling pathways.

关键词： CYP2J2-derived EETs attenuated angiotensin induced adventitial remodeling via reduced inflammatory response PPAR SOCS

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基于大黄鱼基因组的微卫星标记开发与验证

浙江海洋大学学报（自然科学版） 2020年第5期39卷 394-400页

作者：谢斐昂赵若苹何其 MAO Jun-lai Wang Yi-fan JIang Li-hua SENANAN Wansuk 陈永久浙江海洋大学海洋科学与技术学院浙江舟山316022 中国科学院昆明动物研究所遗传资源与进化国家重点实验室云南昆明650203 National Research Center for Marine Facility Aquaculture Engineering Technology Zhoushan 316022China Department of Aquatic Science Faculty of ScienceBurapha UniversityBangsaenChonburi 20131Thailand

大黄鱼及其姐妹种小黄鱼属鲈形目,石首鱼科,都是中国沿海重要的经济鱼类。在本研究中,我们从大黄鱼的基因组序列中开发了499,638个微卫星DNA位点,并选取了其中22个四碱基重复的微卫星在大黄鱼(n=21)和小黄鱼(n=3)中评估了基因座的多态... 详细信息

大黄鱼及其姐妹种小黄鱼属鲈形目,石首鱼科,都是中国沿海重要的经济鱼类。在本研究中,我们从大黄鱼的基因组序列中开发了499,638个微卫星DNA位点,并选取了其中22个四碱基重复的微卫星在大黄鱼(n=21)和小黄鱼(n=3)中评估了基因座的多态性。在大黄鱼中共获得了220个等位基因,每个基因座平均有10±5.58个等位基因(NA)。有效等位基因数(NE),观测杂合度(HO),期望杂合度(HE)和多态信息含量(PIC)分别为5.40±3.68、0.64±0.25、0.71±0.22和0.67±0.22。在小黄鱼中交叉扩增共产生了66个等位基因(NA=3±1.51),每个基因座平均的NE,HO,HE和PIC分别为2.65±1.40、0.52±0.38、0.60±0.34和0.45±0.26。所选微卫星DNA标记可以在2个物种间实现交叉扩增,有助于对大黄鱼和小黄鱼,特别是人工繁育、养殖的杂交后代开展深入的群体遗传学和种群评估研究。此外,这一方法可以进一步促进其他缺乏有效遗传标记的非模式海洋鱼类在基因组水平上开发、研究微卫星标记。

关键词：大黄鱼小黄鱼基因组序列微卫星DNA 交叉扩增