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Data-driven mapping-relationship mining between hardness and mechanical properties of dual-phase titanium alloys via random forest and statistical analysis

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Rare Metals 2024年第2期43卷 829-841页

作者： Hai-Chao Gong Qun-Bo Fan Hong-mei Zhang Xing-Wang Cheng Wen-Qiang Xie Kai Chen lin Yang Jun-Jie Zhang Bing-Qiang Wei Shun Xu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China National Key laboratory of Science and Technology on Materials Under Shock and Impact Beijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401135China Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNE68588USA

In order to accelerate the research on the property optimization of titanium alloy based on high-throughput methods,it is necessary to reveal the relationship between hardness and other mechanical properties which is still *** this work,taking Ti20C alloy as research object,almost all the microstructure of dual-phase titanium alloys were covered by traversing over 100 heat treatment ***,massive experiments including microstructure characterization and performance test were conducted,obtaining 51,590 pieces of microstructure data and 3591 pieces of mechanical property ***,based on large-scale data-driven technology,the quantitative mapping relationship between hardness and other mechanical properties was deeply *** results of random forest models showed that the correlation between hardness(H)and Charpy impact energy(A_(k))(or elongation,A)was hardly dependent on the microstructure types,while the relationship between H and tensile strength(R_(m))(or yield strength,R_(p0.2))was highly dependent on microstructure ***,combined with statistical analysis,it was found that the relationship between H and Ak(or A)were negatively ***,the relationship between H and strength was positively linear for equiaxed microstructure,and strength was linked to d^(−1/2)(d,equivalent circle diameter)ofα-grains in the form of classical Hall–Petch formula;but for other microstructures,the relationships were ***,the above rules were nearly the same in the rolling direction and transverse ***,a"four-quadrant partition map"between H and R_(p0.2)/R_(m) was established as a versatile material-screening tool,which can provide guidance for on-demand selection of titanium alloys.

关键词： Dual-phase titanium alloy Data-driven Hardness Mapping relationship

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Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1018-1026页

作者： ZHU Miao SHI Qing-qing NI Jun WU Wei SUN Xing SUN mei XU Kai-lin LIU Yan-qing GU Jian GU Hao Department of Hematology Clinical Medical Col ege Yangzhou University Yangzhou Institute of Hematology Department of Hematology The Affiliated Hospital of Xuzhou Medical University Department of Oncology The Affiliated Hospital of Yangzhou University Yangzhou University Department of Neurology The Affiliated Brain Hospital of Nanjing Medical University

Objective:To investigate the inhibitory effect of Celastrus orbiculatus extracts（COE） on the proliferation of lymphoma cells and the immune regulation ability on inflammation and thrombophilia in ***:The 38B9 lymphoma cells were treated with COE（160μg/mL） and CTX（25 μmol/L）.The apoptosis rate and cell cycle of each group were detected by flow *** secretion of inflammatory factors,including interleukin（IL）-6,IL-10,and tumor necrosis factor α（TNF-α）,in cell supernatant was detected by enzyme-linked immunosorbent assay（ELISA）.In vivo,BALB/c mice were subcutaneously injected with 38B9 lymphoma cells to establish lymphoma ***(3 mg·kg-1·d-1) and CTX(40 mg-kg-1·d-1) were administered to the model mice,*** expression of plasma inflammatory factors（IL-6,IL-10 and TNF-α） and thrombus indexes,including D-dimer（D-D）,von Willebrand factor（vWF） and tissue factor（TF）,were detected by ELISA before tumor bearing（1 d）,after tumor formation（14 d） and after intervention（21 d）.PicoGreen dsDNA was used to detect the level of serum neutrophil extracellular traps（NETs）.Flow cytometry was used to detect the expression of platelet activation marker calcium-dependent lectin-like receptor 2（CLEC-2）.The tumor growth and survival of mice were ***:The 38B9 lymphoma cells were apoptotic after the intervention of COE and *** ratio of G2-M phase cells decreased in COE intervented cells compared with the control cells（P<0.05）,and S phase cells decreased in CTX intervented cells（P<0.05）.Also,the secretion level of IL-6 was significantly reduced after COE or CTX intervention（P<0.05）,and IL-10 was significantly increased（P<0.05）.Furthermore,the tumor mass was reduced,and the median survival time was longer in COE and CTX intervented tumor-bearing mice than in nonintervented *** significantly lower levels of TNF-α,IL-6,NETs,TF,DD and CLEC-2,as well as higher IL-10 were observed in COE and CTX treatment mice in comparision with the control mice（P

关键词： Celastrus orbiculatus extract immune regulation lymphoma murine lymphoma cells proliferation inhibition thrombotic state tumor inflammation

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RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium

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Journal of Genetics and Genomics 2024年第5期51卷 543-553页

作者： Ting Hu lan Liu He Wang mei Yang Bocheng Xu Hanbing Xie Ziyuan lin Xiaolei Jin Ping Wang Yanyan Liu Huaqin Sun Shanling Liu Department of Medical Genetics West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengduSichuan 610041China Medical College Tibet UniversityLhasaTibet 850000China SCU-CUHK Joint laboratory for Reproductive Medicine West China Second University HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China

Noncompaction of the ventricular myocardium(NVM),the third most diagnosed cardiomyopathy,is characterized by prominent trabeculae and intratrabecular ***,the genetic etiology of 40%–60%of NVM cases remains ***,we identify two infants with NVM,in a nonconsanguineous family,with a typical clinical presentation of persistent bradycardia since the prenatal period.A homozygous missense variant(R223L)of RCAN family member 3(RCAN3)is detected in both infants using whole-exome *** the zebrafish model,marked cardiac dysfunction is detected in rcan3 deficiency(MO-rcan3^(ATG)-injected)and rcan^(−/−) *** dysplasia of both endocardial and myocardial layers is also detected in rcan3-deficient ***3 R223L variant mRNAs can not rescue heart defects caused by rcan3 knockdown or knockout;however,hRCAN3 mRNAs rescue these ***-seq experiments show that several genes involved in cardiomyopathies are significantly regulated through multiple signaling pathways in the rcan3-knockdown zebrafish *** human cardiomyocytes,RCAN3 deficiency results in reduced proliferation and increased apoptosis,together with an abnormal mitochondrial ***,we suggest that RCAN3 is a susceptibility gene for cardiomyopathies,especially NVM and that the R223L mutation is a potential loss-of-function variant.

关键词： Cardiomyopathy NVM RCAN3 Mitochondrial structure Heartdefects

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Storage and redistribution of anthropogenic CO_(2) in the western North Pacific:The role of subtropical mode water transportation

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Fundamental Research 2024年第1期4卷 103-112页

作者： Cheng-long Li Lei Han Wei-dong Zhai Di Qi Xu-chen Wang Hong-mei lin Li-wen Zheng Institute of Marine Science and Technology Shandong UniversityQingdao 266237China China-ASEAN College of Marine Science and Technology Xiamen University MalaysiaSelangorMalaysia Southern Marine Science and Engineering Guangdong laboratory(Zhuhai) Zhuhai 519080China Polar and Marine Research Institute Jimei UniversityXiamen 361021China Key laboratory of Marine Chemistry Theory and Technology and Frontiers Science Center for Deep Ocean Multispheres and Earth SystemMinistry of EducationOcean University of ChinaQingdao 266100China Center for Isotope Geochemistry and Geochronology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Weihai Institute of Marine Ecology and Economy Research Weihai 264400China

Oceanic uptake and storage of anthropogenic CO_(2)(CANT)are regulated by ocean circulation and *** decipher the storage and redistribution of CANT in the western North Pacific,where a major CANT sink develops,we investigated the water column carbonate system,dissolved inorganic radiocarbon and ancillary parameters in May and August 2018,spanning the Kuroshio Extension(KE,35-39°N),Kuroshio Recirculation(KR,27-35°N)and subtropical(21-27°N)*** column CANT inventories were estimated to be 40.5±1.1 mol m^(-2) in the KR zone and 37.2±0.9 mol m^(-2) in the subtropical *** comparison with historical data obtained in 2005,relatively high rates of increase of the CANT inventory of 1.05±0.20 and 1.03±0.12 mol m^(-2) yr^(-1) in the recent decade were obtained in the KR and subtropical zones,*** water-mass-based analyses suggest that formation and transport of subtropical mode water dominate the deep penetration,storage,and redistribution of CANT in those two *** the KE zone,however,both the water column CANT inventory and the decadal CANT accumulation rate were small and uncertain owing to the dynamic hydrology,where the naturally uplifting isopycnal surfaces make CANT penetration relatively *** findings of this study improve the understanding of the spatiotemporal variations of CANT distribution,storage,and transport in the western North Pacific.

关键词： Oceanic CO_(2)uptake Anthropogenic CO_(2)storage Subtropical mode water Kuroshio extension Kuroshio recirculation Western North Pacific

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基于Deeplab v3+的PIV误矢量修复

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工程热物理学报 2024年第6期45卷 1722-1729页

作者：陈建豪林梅西安交通大学能源与动力工程学院西安710049

在PIV图像后处理过程中,修正其误矢量对获取准确速度矢量场起到关键作用。本研究在模拟和实验矢量图数据库中人为添加误矢量,通过标注添加误矢量图像,用Deeplab v3+算法来识别分割误矢量,并同时生成用于修正的掩膜(mask),其识别分割的... 详细信息

在PIV图像后处理过程中,修正其误矢量对获取准确速度矢量场起到关键作用。本研究在模拟和实验矢量图数据库中人为添加误矢量,通过标注添加误矢量图像,用Deeplab v3+算法来识别分割误矢量,并同时生成用于修正的掩膜(mask),其识别分割的损失控制在0.001。对于修复,使用了DeepFill v2算法,用正确矢量图像训练网络,将损失稳定于0.05。将识别生成的mask和原始待修正的PIV图像,放入修正图像,靠输入指令即可实现PIV矢量图像中的误矢量自动识别与修正。结果表明,此方法,可批量处理PIV矢量图像,简单方便且自动化,具有较高的识别分割与修正精度。

关键词： PIV矢量图像深度学习误矢量识别与修复 Deeplab v3+ DeepFill v2

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Clinicopathological features,psychological status,and prognosis of 33 patients with occult breast cancer

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World Journal of Psychiatry 2024年第1期14卷 76-87页

作者： Hong-mei Wang Ao-Yang Yu lin-lin Li Lu-Yao Ma Meng-Han Cao Yu-Le Yang Xiao-Bing Qin Juan-JuanTang Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Graduate School Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Pathology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast *** to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been *** To investigate the clinicopathological features,psychological status and prognostic features of patients with *** The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively *** psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression ***’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),*** survival was calculated using the Kaplan-meier method,and survival curves were plotted for analysis with the log-rank *** and multivariate survival analyses were performed using the Cox regression *** The 33 OBC patients included 32 females and 1 *** the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant *** 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psycho

关键词： Occult breast cancer Breast cancer Perceived Stress Scale Axillary lymph node dissection

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Weak Merging Scenario of ClaSH Cluster A209

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Research in Astronomy and Astrophysics 2024年第4期24卷 174-182页

作者： Wen-Cheng Feng Heng Yu Hai-Hui Zhao Xiao-lan Hou Shu-mei Jia Cheng-Kui Li Yu-lin Cheng Paolo Tozzi Ming Sun Yong Chen Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy Yunnan UniversityKunming 650091China INAF—Osservatorio Astrofisico di Arcetri Largo E.Fermi50122 FirenzeItaly Department of Astronomy University of VirginiaP.O.Box 400325CharlottesvilleVA 22904-4325USA

We study the structural and dynamical properties of A209 based on Chandra and XMM-Newton *** obtain detailed temperature,pressure,and entropy maps with the contour binning method,and find a hot region in the NW *** X-ray brightness residual map and corresponding temperature profiles reveal a possible shock front in the NW direction and a cold front feature in the SE *** with the galaxy luminosity density map we propose a weak merger scenario.A young sub-cluster passing from the SE to NW direction could explain the optical subpeak,the intracluster medium temperature map,the X-ray surface brightness excess,and the X-ray peak offset together.

关键词： X rays:galaxies:clusters galaxies:clusters:intracluster medium galaxies:clusters:Abell 209

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Research on perturbation of neutron fluence rate in a closed thermal neutron field due to medium materials

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-11页

作者： Yang, Jun-Kai Wang, Ping-Quan Hu, Zhi-Meng Li, Fan Zeng, Jun-mei Xiao, lin Guo, Hong-Yu Zhang, Jian Gorini, Giuseppe Zhang, Hui Chu, Chungming Paul Nanjing Univ Coll Engn & Appl Sci Nanjing 210093 Peoples R China Natl Inst Metrol Beijing 100029 Peoples R China Nanjing Univ Aeronaut & Astronaut Dept Nucl Sci & Technol Nanjing 210093 Peoples R China Univ Milano Bicocca Dept Phys I-20126 Milan Italy

The neutron radiation field has vital applications in areas such as biomedicine, geology, radiation safety, and many others for neutron detection and neutron metrology. Correcting neutron fluence rate perturbation accurately is an important yet challenging problem. This study proposes a correction method that analyzes three physical processes. This method, which transforms the detection process from point detection to area detection, is based on a novel physical model and has been validated through theoretical analyses, experiments, and simulations. According to the average differences between the calculated and experimental results, the new method (1.67%) demonstrated better accuracy than the traditional simulation (2.17%). In a closed thermal neutron radiation field, the detector or strong neutron absorption material significantly perturbs the neutron fluence rate, whereas its impact on the energy spectrum shape and neutron directionality is relatively minor. Furthermore, based on the calculation results of the perturbation rate formula for medium materials with different compositions and sizes, the larger the volume and capture cross section of the medium, the higher the perturbation rate generated in the closed radiation field.

关键词： Perturbation rate Area detection Three-dimensional neutron energy spectrum Closed radiation field INFINITE-PlaNE ABSORBERS FLUX PERTURBATIONS SPECTRUM

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知识视域下中小学教师深度学习的定位与发生机制研究

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中国电化教育 2024年第8期 110-117,125页

作者：林美华南师范大学教育科学学院广东广州510631

当前教师工作充满的“不确定性”要求教师走出“惰性知识”“秘诀知识”等知识学习的实践困境而走向深度学习。该研究以重审教师工作的内在属性为逻辑起点,借助学习科学探明作为深度学习之过程条件及结果的知识所需具备的良好结构特征,... 详细信息

当前教师工作充满的“不确定性”要求教师走出“惰性知识”“秘诀知识”等知识学习的实践困境而走向深度学习。该研究以重审教师工作的内在属性为逻辑起点,借助学习科学探明作为深度学习之过程条件及结果的知识所需具备的良好结构特征,并基于此揭示教师深度学习的定位及发生机制。知识视域下中小学教师深度学习的定位在于实现“深度”的知识结构与知识应用的一体化,使教师在具备“具体性”、系统性等良好知识结构的同时,能深度理解知识并能将知识运用于新情境,解决复杂的新问题,实现知识的高通路迁移。指向知识迁移的教师深度学习过程可归纳为直觉投入、解释说明、理论化与整合、内化与迁移四个要素,同时需具备起始于有价值问题的“具身”探究,探究过程中的理论知识指导与“理智”在场,个体学习与组织学习的互动等内在逻辑特征。

关键词：深度学习知识迁移教师知识学习实践智慧理论理性

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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation

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Rare Metals 2024年第10期43卷 5186-5201页

作者： Wen-Jing Zhang Li-Guo Jin Shui-lin Wu Chao-Feng Wang Yu-Feng Zheng Zhao-Yang Li Zhen-Duo Cui Hui Jiang Sheng-Li Zhu Xiang-mei Liu School of Materials Science and Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin University Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei University School of Materials Science and Engineering Peking University School of Health Science and Biomedical Engineering Hebei University of Technology

Deep tissue infections caused by pathogenic bacteria seriously threat the lives of *** this study a smart heterostructured Au/Cu-BTA （BTA=1,2,4,5-benzenetetramine） with microwave （MW） response is synthesized via NaBH4reduction of HAuCl4on the ***/Cu-BTA exhibits excellent hyperthermy and dynamics under MW *** MW thermal mechanism of Au/Cu-BTA is attributed to the excellen dielectric loss and polarization of the heterogeneous ***,the surface energy levels of the Cu-BTA interface alleviate the difficulty of electron hopping through multistage ***,MW can excite Cu-BTA to produce free ***,Au nanoparticles rapidly increase electron transfer and inhibit electron-hole ***,the yields of reactive oxygen species can be enhanced for MW dynamic therapy Consequently,under 10 min of MW irradiation,Au/Cu-BTA killed 99.998%±0.001% of Gram-positive Staphylococcus aureus,99.966%±0.014% of methicillin-resistant Staphylococcus aureus,and 96.871%±0.831% of Gram-negative Pseudomonas *** effective MW bacteria-killing strategy designed in this study shows significant potential for application in the MW-responsive treatment of deep tissue infections without antibiotics.

关键词： Anti-infection Antibacterial Microwave therapy

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