检索结果-南通市图书馆

Flexible Ferroelectric Memory Based on Oxide Heteroepitaxy

在线全文

cnki会议

学校读者我要写书评

暂无评论

Flexible Ferroelectric Memory Based on Oxide Heteroepitaxy

第十四届全国物理力学学术会议

作者：姜杰 HSIEH Y H DO T H liu Q L ZHU X J liu hj MA C H CHU Y H ZHOU Y C School of Materials Science and Engineering Xiangtan University Department of Materials Science and Engineering National Chiao Tung University Institute of Physics Academia Sinica Department of Materials Science and Engineering National Chung Hsing University Institute of Electronics Engineering National Tsing Hua University

The emerging technological demands for flexible electronic devices have compelled researchers to look beyond the current silicon-based electronics.A flexible version of traditional thin lead zirconium titanate(PbZrTiO,PZT)based ferroelectric random access memory(FeRAM)on silicon shows record performance in flexible ***,fabrication of devices

关键词：

A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem T...

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Luan X Guan YY liu hj Lu Q Zhao M Sun D Lovell JF Sun P Chen HZ Fang C Hongqiao International Institute of Medicine Shanghai Tongren Hospital and Department of Pharmacology and Chemical Biology Institute of Medical SciencesShanghai Jiao Tong University School of Medicine (SJTU-SM) Department of Pharmaceutical Sciences College of PharmacyUniversity of Michigan Department of Pharmacy Ruijin HospitalSJTU-SM Department of Pharmacy Shanghai University of Medicine and Health Sciences Department of Biomedical Engineering University at BuffaloState University of New York Department of General Surgery Shanghai Tongren HospitalSJTU-SM

Vascular-targeted photodynamic therapy(VTP) is a recently approved strategy for treating solid ***,the exacerbated hypoxic stress makes tumor eradication challenging with such a single modality ***,a new graphene oxide(GO)-based nanosystem for rationally designed,interlocking trimodal cancer therapy that enables VTP using photosensitizer verteporfin(VP)(1) with codelivery of banoxantrone dihydrochloride(AQ4 N)(2),a hypoxia-activated prodrug(HAP),and HIF-1α siRNA(siHIF-1α)(3) is *** VTP-induced aggravated hypoxia is highly favorable for AQ4 N activation into AQ4(a topoisomerase II inhibitor) for ***,the hypoxia-induced HIF-la acts as a "hidden brake,"through downregulating CYP450(the dominant HAP-activating reductases),to substantially hinder AQ4 N ***-la is rationally adopted to suppress the HIF-1α expression upon hypoxia and further enhance AQ4 N *** trimodal nanosystem significantly delays the growth of PC-3 tumors in vivo compared to the control nanoparticles carrying VP,AQ4 N,or siHIF-la alone or their pairwise *** multimodal nanoparticle design presents,the first example exploiting VTP to actively induce hypoxia for enhanced HAP *** is also revealed that HAP activation is still insufficient under hypoxia due to the hidden downregulation of the HAP-activating reductases(CYP450),and this can be well overcome by GO nanoparticle-mediated siHIF-la intervention.

关键词： A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia VTP

肝细胞生长因子诱导前软骨干细胞向软骨细胞的分化

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2007年第27期11卷 5299-5302页

作者：饶耀剑曹向阳刘慧娟河南省洛阳正骨医院脊柱外科河南省洛阳市471000

目的:探讨肝细胞生长因子诱导前软骨干细胞向软骨细胞分化的机制。方法:实验于2005-12/2006-03在河南省正骨研究院完成。①实验材料:普通级新生兔10只,平均体质量3kg。②实验干预:采用免疫磁珠分离技术分离新生兔长骨干骺端前软骨干细... 详细信息

目的:探讨肝细胞生长因子诱导前软骨干细胞向软骨细胞分化的机制。方法:实验于2005-12/2006-03在河南省正骨研究院完成。①实验材料:普通级新生兔10只,平均体质量3kg。②实验干预:采用免疫磁珠分离技术分离新生兔长骨干骺端前软骨干细胞。利用肝细胞生长因子(浓度分别为0.5,1,2,4μg/L)作用前软骨干细胞;另以2μg/L肝细胞生长因子作用前软骨干细胞,对照用相同剂量的培养基,检测前软骨干细胞Ⅱ型胶原及Ⅱ型胶原mRNA的表达。③实验评估:采用光学显微镜观察前软骨干细胞形态及生长情况;四甲基偶氮唑盐比色法检测前软骨干细胞的增殖;免疫荧光检测Ⅱ型胶原表达;反转录-聚合酶链反应检测Ⅱ型胶原mRNA的表达。结果:①前软骨干细胞形态及生长情况:分离纯化的前软骨干细胞贴壁稳定,在光学显微镜下呈多角和梭形,生长旺盛,曲光度好。②前软骨干细胞增殖情况:细胞增殖率上升,在24,48,72h内呈时间浓度依赖。③Ⅱ型胶原表达:肝细胞生长因子作用第5天前软骨干细胞出现Ⅱ型胶原蛋白的表达。④Ⅱ型胶原mRNA的表达:在肝细胞生长因子刺激3d开始出现表达,并且5d,7d逐渐增加。结论:肝细胞生长因子作用前软骨干细胞后,出现软骨特征标志抗原Ⅱ型胶原的表达,细胞增殖活性上升,表明肝细胞生长因子能诱导前软骨干细胞向软骨细胞方向分化。其机制可能是前软骨干细胞也存在肝细胞生长因子受体。

关键词：肝细胞生长因子干细胞软骨/细胞学细胞分化组织构建

Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model

在线全文

学校读者我要写书评

暂无评论

Integrated Combination Treatment Using a “Smart” Chemother...

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： liu hj Luan X Feng HY Dong X Yang SC Chen ZJ Cai QY Lu Q Zhang Y Sun P Zhao M Chen HZ Lovell JF Fang C Hongqiao International Institute of Medicine Shanghai Tongren Hospital and Department of Pharmacology and Chemical Biology Institute of Medical SciencesShanghai Jiao Tong University School of Medicine (SJTU-SM) Department of General Surgery Shanghai Tongren HospitalSJTU-SM Department of Pharmacy Shanghai University of Medicine and Health Sciences Department of Biomedical Engineering University at BuffaloState University of New York

Mesoporous silica nanoparticles(MSN) can load and deliver potentially synergistic anticancer agents such as small molecule cytotoxics(like doxorubicin,DOX) and nucleic acids(like microRNA,miRNA).However,these cargos have different underlying chemical properties so overcoming respective intracellular delivery barriers is a key *** to deliver DOX from MSN frequently employ pH-driven mechanisms that are restricted to the acidic environment of ***,strategies to deliver miRNA make use of approaches that deliberately compromise lysosomal membrane integrity to enable cytosolic delivery of the *** reconcile these two needs(lysosomal delivery of DOX and intracellular delivery of miRNA),a new methodology by "weaving" polyethylenimine on the MSN surface through disulfide bonds to achieve superior delivery of chemotherapy(DOX) and miRNA therapy(using miRNA-145) is ***,an active targeting strategy based on a peptide ligand with affinity to glucose-regulated protein 78(GRP78),a cell surface protein overexpressed in colorectal carcinoma,is *** active targeting approach results in enhanced synergistic antitumor effect both in vitro and in vivo in an orthotopic murine model of colorectal *** together,this work demonstrates the capability and advantages of "smart" MSN delivery systems to deliver anticancer cargo appropriately to targeted cancer cells.

关键词： miRNA Integrated Combination Treatment Using a Smart Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model

应用3.0T MRI评价缺血性脑血管病与鼻窦炎性病变的关系

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2007年第48期11卷 9722-9725页

作者：李晖刘怀军朱清风杨冀萍张强河北医科大学第二医院医学影像科河北省石家庄市050000

目的:应用3.0TMRI从影像学角度探讨缺血性脑血管病与鼻旁窦炎性病变的关系及鼻旁窦炎性病变的MRI表现。方法:①分组及检测:2006-10/2007-08河北医科大学第二医院收治经临床及影像学证实为缺血性脑血管病患者218例为病例组,健康体检者21... 详细信息

目的:应用3.0TMRI从影像学角度探讨缺血性脑血管病与鼻旁窦炎性病变的关系及鼻旁窦炎性病变的MRI表现。方法:①分组及检测:2006-10/2007-08河北医科大学第二医院收治经临床及影像学证实为缺血性脑血管病患者218例为病例组,健康体检者218例为对照组,应用美国GE公司Signa Excite HD 3.0T高场强MR扫描仪常规行MRI及MRA检查。②评估指标:MRI图像观察以轴位T2-FSE、轴位T1-FLAIR序列为主,辅以轴位T2-FLAIR、矢状位T1-FLAIR序列,观察并记录脑实质MRI表现、鼻旁窦有无炎性病变。MRA图像观察以MIP重组后图像为主,辅以MRA源图像,观察并记录颅内血管异常情况。主要观察指标包括额窦、筛窦、蝶窦、上颌窦受累情况,各窦病变类型(黏膜增厚、炎性积液、黏膜下囊肿)及相应的MRI表现。结果:①病例组所有患者前循环及后循环系统血管均存在不同程度的动脉粥样硬化改变,143例患者脑实质出现缺血性病变;对照组脑实质及脑血管均未见异常改变。②病例组鼻旁窦有病变者123人次(56.4%),上颌窦病变96例,筛窦病变58例,蝶窦病变30例,额窦病变15例;对照组鼻旁窦有病变者54人次(24.8%),上颌窦病变8例,筛窦病变34例,蝶窦病变2例,额窦病变4例。病例组鼻旁窦炎性病变明显较对照组多(χ2=45.281,P=0.000)。相关系数C=0.91。结论:缺血性脑血管病患者鼻旁窦炎性病变发病率高,缺血性脑血管病与鼻旁窦炎性病变间有一定的相关性。

关键词：缺血性脑血管病鼻旁窦炎症磁共振成像

在线全文

学校读者我要写书评

暂无评论

胆道闭锁早期诊断方法的研究进展

临床小儿外科杂志 2017年第2期16卷 113-116,158页

作者：刘洪江张明满重庆医科大学附属儿童医院肝胆外科儿童发育疾病研究教育部重点实验室儿童发育大疾病国家际科技合作基地儿科学重庆市重点实验室重庆400014

胆道闭锁（biliaryatresia，BA）是一种以肝外胆管炎症及肝纤维化导致胆汁淤积，进行性胆汁性肝硬化为特征的疾病，约50％的患儿需行肝移植手术。本病的发病率在台湾地区和日本约为1：5000～10000，在欧美地区发病率约为1：15000～2000... 详细信息

胆道闭锁（biliaryatresia，BA）是一种以肝外胆管炎症及肝纤维化导致胆汁淤积，进行性胆汁性肝硬化为特征的疾病，约50％的患儿需行肝移植手术。本病的发病率在台湾地区和日本约为1：5000～10000，在欧美地区发病率约为1：15000～20000。如不能及时进行有效的治疗，胆道闭锁患儿将最终死于肝硬化和肝衰竭，其病程约2年。ChardotC等研究表明，在患儿生后1个月、2个月、3个月及以后行Kasai手术，

关键词：胆道闭锁诊断方法胆汁性肝硬化肝移植手术地区发病率早期胆汁淤积肝纤维化

不同孔径纳米羟基磷灰石人工骨修复兔桡骨缺损效果比较

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2007年第48期11卷 9641-9645页

作者：王大平韩云朱伟民陆伟刘浩江江捍平熊建义刘健全欧阳侃刘伟军深圳市第二人民医院创伤骨科广东省深圳市518035 深圳市卫生局广东省深圳市518000

目的:纳米级的羟基磷灰石材料与人体内组织成分更为相似,具有更佳的生物性能。评价不同孔径的多孔纳米羟基磷灰石人工骨的骨缺损修复能力,从而筛选出适合的孔径以达到骨传导功能与生物力学性能的良好统一。方法:实验于2005-10/2006-10... 详细信息

目的:纳米级的羟基磷灰石材料与人体内组织成分更为相似,具有更佳的生物性能。评价不同孔径的多孔纳米羟基磷灰石人工骨的骨缺损修复能力,从而筛选出适合的孔径以达到骨传导功能与生物力学性能的良好统一。方法:实验于2005-10/2006-10在深圳市第二人民医院中心实验室完成。①实验材料:纳米羟基磷灰石人工骨以硝酸钙和磷酸二氢铵为原料,采用溶胶-絮凝法制备粉体,运用压力成型、木模成型和浸渍成型分别制得孔隙分布均匀的孔径分别为50～150μm、100～250μm和300～500μm的多孔纳米羟基磷灰石人工骨。②实验动物:雄性新西兰大白兔60只随机分为植入50～150μm孔径材料组、植入100～250μm孔径材料组、植入300～500μm孔径材料组、空白对照组,每组15只。实验过程中对动物处置符合动物伦理学要求。③实验方法:制备双侧桡骨骨缺损动物模型,然后用3种不同孔径的纳米羟基磷灰石人工骨材料植入骨缺损处进行修复,空白对照组不植入任何材料。④实验评估:术后4,8和12周分别行大体标本观察、X射线片观察、扫描电镜观察及生物力学测试,比较各组材料修复骨缺损的能力。结果:实验动物均进入结果分析。①X射线片检查结果:术后4周、8周、12周,植入100～250μm孔径材料组X射线评分高于植入50～150μm,300～500μm孔径材料组,差异有显著性意义(P<0.05)。②生物力学检测结果:术后4周、8周、12周,植入100～250μm孔径材料组生物力学强度高于植入50～150μm,300～500μm孔径材料组,差异有显著性意义(P<0.05)。③扫描电镜观察结果:植入100～250μm孔径材料组成骨效果明显优于植入50～150μm,300～500μm孔径材料组和空白对照组。结论:纳米羟基磷灰石人工骨具有良好的成骨能力,但其骨修复能力受孔径因素的影响,孔径100～250μm的纳米羟基磷灰石人工骨材料成骨能力较好。

关键词：孔径羟基磷灰石纳米人工骨骨缺损

Application of carbazole compounds in study of hydrocarbon migration

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第23期42卷 1970-1974页

作者： liu, LF Xu, XD Mao, DF Yu, hj Univ Petr Beijing 102200 Peoples R China

IN recent years, studies on nitrogen compounds have been widely carried out by overseas schol-are, and achievements have been obtained spec1ally in the application of carbazoles to thestudy of hydrocarbon migration. B... 详细信息

关键词： carbazole compound hydrocarbon migration Tarim Basin.

Heteroaggregation between porphyrin and phthalocyanine bearing oppositely charged substituents

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1995年第3期13卷 223-230页

作者： MAO, HF TIAN, hj XU, hj CHINESE ACAD SCI INST PHOTOG CHEMBEIJING 100101PEOPLES R CHINA

Heteroaggregates composed of cationic porphyrin, meso-tetra(p-trimethylamino)porphyrin iodide, its sine complex and anionic phthalocyanine sodium hydroxygallium 4,4',4 '',4 ''-tetrasulfonated phthalocyanine have been investigated by absorption and fluorescence spectroscopy. It has been found that both free base cationic porphyrin and its zinc complex can form very stable heterodimers with anionic phthalocyanine in water, methanol and dimethylformamide. The stability of the aggregate depends on the polarity as well as the ligation ability of the solvent. No evidence of higher aggregates was detected. Besides axial coordination, steric hindrance which influences the relative orientation of the macrocycles are considered.

关键词： PORPHYRIN PHTHALOCYANINE HETEROAGGREGATION