检索结果-南通市图书馆

Novel biomarkers for progression of chronic kidney disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第13期123卷 1789-1792页

作者： liu bi-cheng LU Lin-li Institute of Nephroiogy Zhong Da Hospital Southeast University Nanjing Jiangsu 210009 China

Although there are different initiators of CKD, it is generally recognized that the secondary pathological pathway is quite common to all CKD. CKD may inevitably progress to end stage renal disease （ESRD） due to a vicious cycle of nephron destruction by progressive glomemlosclerosis and tubulointerstitial fibrosis. The chronic processes include kidney resident cell activation,

关键词： chronic kidney disease renal fibrosis disease biomarker proteomics

Urinary biomarkers for Chronic Kidney Disease with a Focus on Gene Transcript

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第18期130卷 2251-2256页

作者： Lin-Li Lyu Ye Feng bi-cheng liu Department of Nephrology School of Medicine Zhongda Hospital Southeast University Nanjing Jiangsu 210009 China

Objective：In the upcoming era of precision medicine,searching for the early,noninvasive biomarkers has been the cornerstone and major challenge in the management of chronic kidney disease （CKD）.Urine contains rich biological information which could be the ideal source for noninvasive biomarkers of *** review will discuss the recent advance in urinary *** Sources：This review was based on data in articles published in the PubMed databases up to June 20,2017,with the following keywords：＂Chronic kidney disease＂,＂biomarker＂,and ＂Urine＂.Study Selection：Original articles and important reviews on urinary biomarker were selected for this ***：Urinary biomarker studies of CKD mainly focused on urine sediment,supernatant,and urinary extracellular *** gene transcript （microRNA [miRNA],messenger RNA [mRNA]） biomarkers have been recently shown with diagnostic potential for CKD reflecting kidney function and histological ***,challenges regarding technique and data analysis need to be resolved before translation to ***：Different fractions of urine contain rich information for biomarker discovery,among which urine （extracellular vesicles） mRNA,miRNA,might represent promising biomarker for CKD.

关键词： biomarkers, Chronic Kidney Disease Extracellular Vesicle Gene Transcript Urine

Current Clinical Research of Acute Kidney Injury in China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第9期128卷 1268-1271页

作者： bi-cheng liu Ri-Ning Tang Zhi-Hong liu Department of Nephrology Institute of Nephrology Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu 210009 China Department of Nephrology Institute of Nephrology Jinling Hospital Nanjing University Nanjing Jiangsu 210002 China

INTRODUCTION Acute kidney injury （AKI） is a common clinical syndrome characterized by an abrupt decline of renal function and has been recognized as a major healthcare problem affecting millions of patients *** is strongly associated with increased resource utilization,mortality,and risk for the development of chronic kidney disease （CKD）.[1-3]

关键词： Acute Kidney Injury China Epidemiology

Magnesium doping to improve the light to heat conversion of OMS-2 for formaldehyde oxidation under visible light irradiation

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 193-198页

作者： Tingting liu Pengfei Sun Wei Zhao Yingshuang Li Lujun cheng Jiahai Fan Xiaohui bi Xiaoping Dong College of Chemistry and Chemical Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China College of Environmental Science and Engineering Nankai UniversityTianjin 300071China Hangzhou Kaiming Catalyst Co. Ltd.Hangzhou 310013China

Mg-doped manganese oxide octahedral molecular sieve(Mg-OMS-2)catalysts were prepared by hydrothermal *** photothermal degradation performance of these catalysts for formaldehyde(HCHO)in batch system and continuous system was *** light absorption of OMS-2 was increased by Mg-doped,especially for near infrared light,which promoted surface temperature reach a maximum of 214.8℃ under xenon *** this temperature,the reinforced surface lattice oxygen and oxygen vacancy that formed by lattice distortion via Mg-doped were *** best HCHO elimination efficiency was achieved over Mg_(0.2)/OMS-2 catalyst with Mg^(2+)/Mn^(2+)=1/5,which could reduce HCHO from 250 ppm to 10 ppm within 20 *** in situ DRIFTS was also carried out to monitor the changes in the content of reaction intermediates and analyze the degradation paths of *** was found the HCHO was attacked by formed·OH and·O^(2-) to generate formate species and carbonate species,and finally transformed to CO_(2) and H_(2)*** photothermal catalytic oxidation process exhibited a high efficiency purification of HCHO without the help of extra energy consumption.

关键词： Mg doping Photothermal catalysis OMS-2 HCHO Reaction mechanism

Application of systems biology to the study of chronic kidney disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第14期125卷 2603-2609页

作者： CAO Yu-han LU Lin-li ZHANG Jian-dong liu bi-cheng Institute of Nephrology Zhong Da Hospital Southeast UniversityNanjing Jiangsu 210009 China

Chronic kidney disease （CKD） is a major public health problem that affects about 10% of the general population. Current approaches to characterize the category and progression of CKD are normally based on renal histopathological results and clinical parameters. However, this information is not sufficient to predict CKD progression risk reliably or to guide preventive interventions. Nowadays, the appearance of systems biology has brought forward the concepts of ＂-omics＂ technologies, including genomics, transcriptomics, proteomics, and metabolomics. Systems biology, together with molecular analysis approaches such as microarray analysis, genome-wide association studies （GWAS）, and serial analysis of gene expression （SAGE）, has provided the framework for a comprehensive analysis of renal disease and serves as a starting point for generating novel molecular diagnostic tools for use in nephrology. In particular, analysis of urinary mRNA and protein levels is rapidly evolving as a non-invasive approach for CKD monitoring. All these systems biological molecular approaches are required for application of the concept of ＂personalized medicine＂ to progressive CKD, which will result in tailoring therapy for each patient, in contrast to the ＂one-size-fits-all＂ therapies currently in use.

关键词： ' systems biology chronic kidney disease, microarray analysis, genome-wide association study,serial analysis of gene expression

Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu bi Zhang Jianfeng liu College of Life Science and Technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in Science,Zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM

Connective tissue growth factor is associated with the early renal hypertrophy in uninephrectomized diabetic rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2006年第12期119卷 1010-1016页

作者： liu bi-cheng HUANG Hai-quan LUO Dong-dong MA Kun-ling liu Dian-ge liu Hong Institute of Nephrology Zhong Da Hospital Southeast UniversityNanjing 210009 China

Background Renal hypertrophy has been regarded as the early feature of diabetic nephropathy （DN）, which may eventually lead to proteinuria and renal fibrosis. However, the exact mechanism of renal hypertrophy is still unclear. The aim of this study was to investigate the possible association of connective tissue growth factor （CTGF） with renal hypertrophy in uninephrectomized diabetic rats. Methods Seventy-two Sprague-Dawley （SD） rats were randomly divided into two groups： control group （group C, n=32） and diabetic nephropathy （group DN, n=40）. Each group was re-divided into 4 subgroups according to the experimental period. The rats were sacrificed at 1, 2, 4, and 8 weeks respectively after induction of diabetes. Diabetes was induced by intraperitoneal injection of streptozotocin （STZ） after rats had received uninephrectomy. Blood glucose （BG）, body weight （BW）, 24-h urinary albumin excretion （24hUalb）, kidney weight （KW）, KW/BW, glomerular tuft area （AG）, glomerular tuft volume （VG）, proximal tubular area （AT） at each time point, the width of glomerular basement membrane （GBM） and tubular basement membrane （TBM） at week 8 were measured when the rats were sacrificed. Renal expression of CTGF and p27kipl were detected by immnnohistochemical staining. The relationship between CTGF expression and increasing of VG and AT was analyzed. Results There was a significant increase of 24hUalb, KW, and KW/BW from week 1 onward in diabetic rats compared to those in group C （P〈0.05, respectively）, diabetic rats also had a significant increase of AG, VG, and AT from week 1 onward. It was also shown that diabetic rats had a thickening of GBM [（245.7±103.0） nm vs （121.8±19.1） nm, P〈0.01] and TBM [（767.7±331.1） nm vs （293.0±110.5） nm, P〈0.01] at week 8. There was a weak expression for CTGF and p27kipl in normal glomeruli and tubuli, while a significant increasing expression of CTGF and p27kipl was found in glomeruli and tubuli in diabetic kidney from week 1 onward （P〈0.05, respec

关键词： connective tissue growth factor p27kip1 diabetic nephropathies hypertrophy

Influence of irbesartan on the urinary excretion of cytokines in patients with chronic kidney disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第6期125卷 1147-1152页

作者： NI Jie HUANG Hai-quan LÜLin-li ZHENG Min liu bi-cheng Institute of Nephroiogy Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Background The non-hemodynamic effects of angiotensin receptor blocker （ARB） in the delay of progression of chronic kidney disease （CKD） remain unclear. In this study, we investigated the influence of irbesartan on the urinary excretion of cytokines in patients with CKD. Methods In this randomized perspective clinical trial, different doses of irbesartan （150 mg/d and 300 mg/d） were given to two groups of patients in a cross-over design. Blood pressure （BP）, creatinine clearance （Ccr） and 24-hour proteinuria were examined. Urinary excretion of cytokines was determined by human inflammatory cytokine antibody array. A two-fold change in spot intensity was considered significant. Results Urinary excretion of cytokines （granulocyte colony stimulating factor （GCSF）, intercellular cell adhesion molecule-1 （ICAM-1）, interferon y （IFN-y）, interleukin 1β （IL-1β）, IL-2, IL-6, IL-8, IL-11, IL-15 and macrophage inflammatory protein 1δ （MIP-Iδ） in group B （irbesartan 300 mg/d） was significantly decreased in comparison to group A （irbesartan 150 mg/d） after 8-week treatment. In group A, 8 weeks of treatment induced a two- to nine-fold reduction in urinary cytokine levels （GCSF, GM-CSF, IFN-γ, IL-1α, IL-11, IL-12p40, MCP-2, MIP-1α）, while increasing the dosage to 300 mg/d further decreased the excretion of GCSF, GM-CSF, IL-12p40, MCP-2 and MIP-1α by week 18. There was no significant difference in BP or Ccr between the two groups. However, 24-hour proteinuria was significantly reduced in both groups, and in group A the reduction was dose *** Irbesartan offers additional renoprotection in a dose-dependent manner by reducing pro-inflammatory cvtokines excretion in the urine of CKD patients.

关键词： angiotensin receptor antagonists kidney diseases cytokines protein array analysis urine

Formation mechanism of Fe-based amorphous powders produced by spark erosion

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第3期170卷 33-46页

作者： Chekai liu Ran Li Jiazi bi Ding Ma Xiaobin liu Tao Zhang School of Materials Science and Engineering Key Laboratory of Aerospace Materials and Performance(Ministry of Education)Beihang UniversityBeijing 100191China

Spark erosion is a convenient,flexible,and low-cost method to quickly produce fine powders of metals,alloys,and semiconductors in size ranging from nearly a hundred micrometers to submicrometer by repetitive spark *** to the complexity of the powder-forming journey,normally accompanied by high temperature,high pressure,decomposition,diffusion and rapid quenching caused by discharge plasma,the mechanisms of powder formation and possible contaminant infiltration are still controversial,posing a significant challenge to control particle size and chemical composition of the powder produced by this *** this study,Fe-based amorphous powders in different particle-size distributions with high sphericity were fabricated by spark erosion under different discharge-energy *** max-imum particle size of the resultant powders can be correlated with discharge parameters,crater depth,and crater radius,respectively.A multi-ring-breakup model is proposed to reveal the particle-size distribution of the powder formed from the electrode melt under a single-pulse ***,a dielectric-element infiltration model is provided to quantitatively evaluate the infiltration mass ratio of the contaminant elements,stemming from the decomposed products of dielectric liquid,in the resultant powder with different particle *** models verified through the experimental data are significant for the development of high-performance fine Fe-based amorphous powder with controlled particle size and chemical composition.

关键词： Amorphous alloy Particle Spark erosion Infiltration Modeling