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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi li ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua SU lian-lin YAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(Plites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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MOF衍生碳基材料的电催化应用及其先进表征技术

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新型炭材料（中英文） 2024年第1期39卷 78-99页

作者：陈曦李明轩闫金伦张龙力中国石油大学(华东)化学化工学院山东青岛266580 中国石油大学(华东)重质油国家重点实验室山东青岛266580

鉴于对清洁和可持续能源的需求,来自金属有机框架(MOFs)的纳米炭衍生物正崭露头角,成为电催化能量转化的独特催化剂。这些MOF衍生的纳米炭材料不仅保持了MOFs组成可定制和结构多样性等优势,而且在热解过程中可有效防止金属纳米颗粒和金... 详细信息

鉴于对清洁和可持续能源的需求,来自金属有机框架(MOFs)的纳米炭衍生物正崭露头角,成为电催化能量转化的独特催化剂。这些MOF衍生的纳米炭材料不仅保持了MOFs组成可定制和结构多样性等优势,而且在热解过程中可有效防止金属纳米颗粒和金属氧化物的聚集。因此,它们提高了电催化效率,改善了电导率,并在燃料电池和金属-空气电池等绿色能源技术中发挥了关键作用。该综述以MOF衍生碳基材料的炭化机制为起点,随后深入探讨了固有炭缺陷、金属和非金属原子掺杂,并研究了这些材料的合成策略。此外,全面介绍了先进的表征技术,包括原位映射和原位光谱学。最后,对MOF衍生碳基材料作为电催化剂的研究前景提供了见解。该综述的主要目标是为当前MOF衍生碳基电催化剂的状况提供更清晰的视角,鼓励更高效电催化材料的发展。

关键词：金属-有机框架材料纳米炭材料电催化先进表征方法

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Evaluation of the Interface Between Two Plates by the Lamb Wave

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Chinese Physics Letters 2001年第11期18卷 1483-1486页

作者： WANG Xiao-Min liAN Guo-xuan li ming-xuan Institute of Acoustics Chinese Academy of SciencesBeijing 100080

A new expression of the dispersion equation of the Lamb wave in an adhesive two-layered plate is presented. The bond rigidity of the adhesive plate is accounted for in terms of a spring model. The influence of the variations of the compliance constants of the spring on the dispersion feature of Lamb modes is numerically studied. The numerical results indicate that the deterioration of the bond rigidity may cause the phase velocity decrease and the frequency-shift for a given Lamb mode, thus having a possibility for the evaluation of the bonding state of the adhesive plate by using ultrasonic wave velocity measurements. The phase-tracing method is used to measure the phase velocities experimentally and the results for an adhesive plate of aluminium-aluminium are given to verify the theoretical predictions.

关键词： plate rigidity dispersion

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波纹夹层结构增强的新型罐式集装箱及其设计方法

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石油化工设备 2024年第2期53卷 50-58页

作者：鲍硕李明轩陆晓峰朱晓磊南京工业大学机械与动力工程学院江苏南京211816

罐式集装箱因安全性高、承载量大、性价比高、运输灵活以及可以实现多种运输方式快速切换等特点,成为液体货物点对点运输的主要装备。近年来,大容量、高承载能力成为罐式集装箱发展的主流方向。提出了一种波纹夹层结构增强的新型矩形罐... 详细信息

罐式集装箱因安全性高、承载量大、性价比高、运输灵活以及可以实现多种运输方式快速切换等特点,成为液体货物点对点运输的主要装备。近年来,大容量、高承载能力成为罐式集装箱发展的主流方向。提出了一种波纹夹层结构增强的新型矩形罐式集装箱,并建立了新型罐式集装箱罐体结构的理论设计方法。应用该方法设计了承载能力为1 MPa的新型罐式集装箱罐体,并将设计结果与有限元仿真计算结果进行对比。研究结果表明,相较于传统罐式集装箱,新型罐式集装箱的容量效率提升了17.2%;理论设计方法计算的应力分布特征与有限元计算结果一致,最大误差为6.21%,该理论设计方法可以满足工程需要。理论设计方法可以对任意正交各向异性夹层结构增强的新型罐式集装箱罐体进行设计,具有较高的可移植性。

关键词：罐式集装箱波纹夹层结构矩形罐体设计

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Bonding Interface Imaging and Shear Strength Prediction by Ultrasound1

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Chinese Physics Letters 2010年第6期27卷 118-121页

作者： li Yong-An MAO Jie li ming-xuan WANG Xiao-Min AN Zhi-Wu ZHUANG Qiao State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences Beijing 100190

The propagation of a longitudinal ultrasonic wave normally incident upon an adhesively bonded structure is stud- ied. The structure consists of adherend and adhesive layers with finite thickness. Interfaces between adherend and adhesive are regarded as distributed springs. Theoretical and experimental results show that resonant frequencies of the bonded structure vary sensitively with the interface stiffness constants and adhesive thickness, and these interface characteristics are inversed by the simulation annealing （SA） method. Furthermore, the distribution image of interface stiffnesses is compared with the state of fracture interface, and quantitative prediction of shear strength is achieved based on the distribution of interface stiffnesses and adhesive thicknesses by using a back- propagation neutral network. The average relative error of the shear strength from prediction to real value is 10.7%.

关键词： Ultrasonics Fractures Waves Adhesives Ultrasound imaging Numerical simulations

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机动车制动颗粒物测试技术研究综述

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内燃机与配件 2024年第3期 109-112页

作者：刘志伟李腾腾钟祥麟李明宣中汽研汽车检验中心(天津)有限公司天津300300

非尾气颗粒物排放已超过车辆尾气颗粒物排放,但限制非尾气排放的法规仍不完善。本文综述了机动车制动颗粒物排放的试验方法和粒径分布特征。制动磨损颗粒物的测试方法主要包括销盘法、惯性制动台架法、底盘测功机法和实际道路法。研究发... 详细信息

非尾气颗粒物排放已超过车辆尾气颗粒物排放,但限制非尾气排放的法规仍不完善。本文综述了机动车制动颗粒物排放的试验方法和粒径分布特征。制动磨损颗粒物的测试方法主要包括销盘法、惯性制动台架法、底盘测功机法和实际道路法。研究发现,受制动摩擦片材质、制动运行特征、制动力、温度、路况和测试工况等多种因素影响,制动颗粒物的粒径分布没有典型的统一特征,具有单峰、双峰和多峰等多种粒径分布形态。

关键词：非尾气颗粒物制动颗粒物排放测试方法粒径分布

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An approximate analytical model for unconventional reservoir considering variable matrix blocks and simultaneous matrix depletion

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Petroleum Science 2024年第1期21卷 352-365页

作者： Kai-xuan Qiu Jia li Dong Feng Shi-ming Wei Gang Lei Jiangmen Laboratory of Carbon Science and Technology Jiangmen529100GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou511400GuangdongChina China University of Geosciences(Beijing) Beijing100083China China University of Petroleum(Beijing) Beijing102249China China University of Geosciences(Wuhan) Wuhan430074HubeiChina Shenzhen Research Institute China University of GeosciencesShenzhen518063GuangdongChina

In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture *** has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture *** addition,most of the existing models are solved analytically based on Laplace transform and numerical ***,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix *** simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the ***,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by ***,a relationship between oil rate and production time in real-time space is *** new model is verified against classical analytical *** the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,***,the new model also has an excellent agreement with the numerical *** model is then applied to two actual tight oil wells completed in western Canada sedimentary *** identifying the flow regime,the solution suitably matches the field production data,and the model parameters are *** these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.

关键词： Analytical solution Unconventional reservoir Variable matrix Simultaneous flow

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Integrating machine learning and CALPHAD method for exploring low-modulus near-β-Ti alloys

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Rare Metals 2024年第1期43卷 309-323页

作者： Hao Zou Yue-Yan Tian li-Gang Zhang Ren-Hao Xue Zi-xuan Deng ming-ming Lu Jian-Xin Wang li-Bin liu School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Traditional theoretical and empirical calculation methods can guide the design of β-and metastable β-alloys for bio-titanium. However, it is still difficult to obtain novel near-β-Ti alloys with low modulus. This study developed a method that combines machine learning with calculation of phase diagrams(CALPHAD) to facilitate the design of near-β-Ti alloys. An elastic modulus database of Ti–Nb–Zr–Mo–Ta–Sn system was constructed first, and then three features(the electron to atom ratio, mean absolute deviation of atom mass, and mean electronegativity) were selected as the key factors of modulus by performing a three-step feature selection. With these features, a highly accurate model was built for predicting the modulus of near-β-Ti alloys. To further ensure the accuracy of modulus prediction, machine learning with the elastic constants calculated was leveraged by CALPHAD database. The root mean square error of the well-trained model can be as low as 6.75 GPa. Guided by the prediction of machine learning and CALPHAD, three novel near-β-Ti alloys with elastic modulus below 50 GPa were successfully designed in this study. The best candidate alloy(Ti–26Nb–4Zr–4Sn–1Mo–Ta) exhibits an ultra-low modulus(36.6 GPa) after cold rolling with a thickness reduction of 20%. Our method can greatly save time and resources in the development of novel Ti alloys, and experimental verifications have demonstrated the reliability of this method.

关键词： Near-β-Ti alloy Machine learning Calculation of phase diagram Low-modulus alloy Feature selection

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Effective Activation of Melamine for Synchronous Synthesis of Catalytically Active Nanosheets and Fluorescence-Responsive Quantum Dots

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Transactions of Tianjin University 2024年第3期30卷 284-296页

作者： Jie xuan Guijian Guan ming-Yong Han Institute of Molecular Plus Tianjin UniversityTianjin 300072China

Because of the low reactivity of cyclic nitrides,liquid-phase synthesis of carbon nitride introduces challenges despite its favorable potential for energy-efficient preparation and superior *** this study,we demonstrate a strong interaction between citric acid and melamine through experimental observation and theoretical simulation,which eff ectively activates melamine-condensation activity and produces carbon-rich carbon nitride nanosheets(CCN NSs)during hydrothermal *** a large specific surface area and increased light absorption,these CCN NSs demonstrate significantly enhanced photocatalytic activity in CO_(2) reduction,increasing the CO production rate by approximately tenfold compared with hexagonal melamine(h-Me).Moreover,the product selectivity of CCN NSs reaches up to 93.5%to generate CO from CO_(2).Furthermore,the annealed CCN NSs exhibit a CO conversion rate of up to 95.30μmol/(g h),which indicates an 18-fold increase compared with traditional carbon *** the CCN NS synthesis,nitrogen-doped carbon quantum dots(NDC QDs)are simultaneously produced and remain suspended in the supernatant after *** QDs disperse well in water and exhibit excellent luminescent properties(QY=67.2%),allowing their application in the design of selective and sensitive sensors to detect pollutants such as pesticide 2,4-dichlorophenol with a detection limit of as low as 0.04μmol/***,the simultaneous synthesis of CCN NSs and NDC QDs provides a cost-eff ective and highly efficient process,yielding products with superior capabilities for catalytic conversion of CO_(2) and pollutant detection,respectively.

关键词： Carbon nitride Hydrothermal reaction Photocatalysis Carbon dioxide Quantum dots

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Oxidative Methylation of Toluene with Methane overK-exchanged Y Type Zeolite Catalyst Promoted with Alkali Metal Bromide and Alkali Metal Oxide

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Chemical Research in Chinese Universities 1996年第1期12卷 120-124页

作者： ZHOU ling-ping TAO Ke-yi li Wei SU ming and li He-xuan(Department of Chemistry, Nakai University, Tianjin, 300071 )Hideshi Hattori(Hokkaido University, Sapporo, Japan) NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA HOKKAIDO UNIV SAPPOROHOKKAIDO 060JAPAN

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