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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

STUDY ON THE THERMODYNAMICS OF CuO/Al IN SITU Al_2O_3 REINFORCED Al MATRIX COMPOSITES

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Acta Metallurgica Sinica(English letters) 2004年第5期17卷 732-740页

作者： Y.Ma Y.Hao S.z.kou X.N.lu StateKeylab.ofAdvancedNonferrousMaterials LanzhouUniversityofTechnologyLanzhou730050China

Based on the experiment and the thermodynamics analysis for CuO/Al system, it is founded that the compounding reaction of CuO/Al under low temperature is available. The general equation of adiabatic temperature of the system is set up, and the influence of resultant concentration and temperature on adiabatic temperature is theoretically analyzed. The values of heat effect of CuO/Al system under different temperature are also caculated.

关键词： composites in situ thermodynamics CuO Al exothermic dispersion

The Coupling Agents' Effects on the BSA Intercalated into Montmorillonite

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Journal of Wuhan University of Technology(Materials Science) 2013年第6期28卷 1236-1241页

作者： lü Yinghai YAN Huaxiao GAO Dengzheng HU Chuanxia kou Xiaoyan College of Chemical and Environmental Engineering Shandong University of Science and Technology

The effects of surface modification on montmorillonite （MMT） were illustrated in order to produce the composite material with premium properties. MMT was treated with two coupling agents： glutaraldehyde （GA） and 7-methacryloxy-propyl-trimethoxy silane （KH570）. The effects of different coupling agents on MMT and protein interaction were investigated by XRD, FT-IR, TGA, UV-Vis, etc. The results of structure characterization indicated that KH570 modification could change the surface crystal structure of MMT. However, GA reacted with amino groups of Bovine serum albumin （BSA） and the ordered layer structures of MMT were not completely destroyed. Coupling agents could greatly increase the amounts of BSA intercalated and the effect of KH570 is better than that of GA. And, the optimum concentrations of KH570 and GA were 2% and 6%, respectively. The rate of weight loss increased by about 12% after MMT was pretreated with coupling agents. The possible reason is that coupling agent treatment makes the structure of MMT more accessible to protein absorption and helps to stabilize the protein structure. Moreover,the presence of coupling agents can reduce the direct chemical interaction between BSA and MMT, which results in increasing protein desorption.

关键词： montmorillonite BSA coupling agents interaction

Pore Size Distribution of High Performance Metakaolin Concrete

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Journal of Wuhan University of Technology(Materials Science) 2002年第1期17卷 42-46页

作者： C.S.Poon S.C.kou l.lam Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hong Kong China

The Compressive strength, porosity and pore size distribution of high performance metakaolin (MK) concrete were investigated. Concretes containing 0,5% , 10% and 20% metakaolin were prepared at a water / cementitious material ratio ( W/C) of 0. 30. In parallel, concrete mixtures with the replacement of cement by 20% fly ash or 5 and 10% silica fume were prepared for comparison. The specimens were cured in water at 27℃ for 3 to 90 days. The results show that at the early age of curing (3 days and 7 days), metakaolin replacements increase the compressive strength, but silica fume replacement slightly reduces the compressive strength. At the age of and after 28 days , the compressive strength of the concrete with metakaolin and silica fume replacement increases. A strong reduction in the total porosity and average pore diameter were observed in the concrete with MK 20% and 10% in the first 7 days.

关键词： high performance concrete metakaolin pore size distribution

RElIABIlITY ANAlYSIS FOR AN AERO ENGINE TURBINE DISK UNDER lOW CYClE FATIGUE CONDITION

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Acta Metallurgica Sinica(English letters) 2004年第4期17卷 514-520页

作者： C.l.liu z.z.lü Y.l.Xu School of Aviation Northwestern Polytechnical University Xi'an 710072 ChinaSchool of Aviation Northwestern Polytechnical University Xi'an 710072 ChinaChina Aviation Research Institute 608 Zhuzhou 412002 China

Reliability analysis methods based on the linear damage accumulation law (lDAl) and load-life interference model are studied in this paper. According to the equal probability rule, the equivalent loads are derived, and the reliability analysis method based on load-life interference model and recurrence formula is constructed. In conjunction with finite element analysis (FEA) program, the reliability of an aero engine turbine disk under low cycle fatigue (lCF) condition has been analyzed. The results show the turbine disk is safety and the above reliability analysis methods are feasible.

关键词： low cycle fatigue life reliability analysis load-life interference model recurrence method aero engine turbine disk

RANDOM-FUzzY SAFETY ANAlYSIS FOR AN AERO ENGINE TURBINE DISK

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Acta Metallurgica Sinica(English letters) 2004年第4期17卷 509-513页

作者： z.z.lü C.l.liu Y.l.Xu z.F.Yue School of Aviation Northwestern Polytechnical University Xi'an 710072 ChinaSchool of Aviation Northwestern Polytechnical University Xi'an 710072 ChinaChina Aviation Research Institute 608 Zhuzhou 412002 ChinaSchool of Mechanics Civil Engineering and Architecture Northwestern Polytechnic University Xi'an 710072 China

A numerical simulation method is presented for the random-fuzzy safety analysis of an aero engine disk. Based on the equivalent transformation from a fuzzy variable to a random variable, the equivalent random Probability Density Functions(PDFs) are got from their corresponding Fuzzy Possibility Distributions(FPDs) for the fuzzy variables. In that case the perfect numerical simulation method for the random uncertainty is employed to solve the fuzzy uncertainty. For the complex structure such as the aero engine disk with implicit relationship between the input basic variable and the response variable, the equivalent PDFs of the input basic variables are delivered simultaneously to the response variable by an empirical PDF, which is simulated by Finite Element Method(FEM). Then, in view of the fuzzy application requirement occurring in engineering usually, the reliability definition and calculation are discussed for the aero engine disk with multiple fuzzy failure modes. On the other hand, through the inverse transformation of the fuzzy variable to the random variable, the FPDs of the response variables can be calculated from their empirical PDFs as well.

关键词： random fuzzy turbine disk reliability

NUMERICAl SIMUlATION OF TEMPERATURE FIElDS IN ElECTROSlAG REMElTING SlAB INGOTS

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Acta Metallurgica Sinica(English letters) 2008年第4期21卷 253-259页

作者： l.z. Chang B.z. li Department of Metallurgical Technology Central Iron ＆ Steel Research Institute Beijing 100081 China

The method based on transient heat transfer model is adopted to simulate electro-slag remelting process. The calculated results of the model show that the process is in the quasi-steady state, and the shape of pool remains unchanged when the height of ingot is approximately 2.5-3 times the thickness of slab ingot. The change in the shape of pool is found to be strongly dependent on the pattern of melting rate, and hence, the power input; the depth of the molten pool increases with the increase in melting speed. It is concluded that a transient heat transfer model has to be used to obtain reliable input information for the entire, operatina time.

关键词： ESR Slab ingot Mathematical model Shape of molten metal pool

Synergetic deformation mechanisms in an Mg-zn-Y-zr alloy with intragranular lPSO structures

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Journal of Magnesium and Alloys 2023年第5期11卷 1754-1768页

作者： z.z.Peng X.H.Shao z.M.liang D.l.Wang l.W.Wang X.l.Ma Hebei Key laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050018China Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Whenua RoadShenyang 110016China

Deformation kink is one of the important strengthening mechanisms of the long-period-stacking-ordered(lPSO)phase containing magnesium(Mg)alloys,while the deformation twin is generally *** optimize the mechanical properties of lPSO containing Mg alloy by simultaneously exciting kink and twin,we successfully prepared the Mg-zn-Y-zr alloy featuring intragranular lPSO phase and free grain boundary lPSO phase by *** unraveled the corresponding strengthening and toughening mechanisms through transmission electron microscopy characterization and theoretical *** high strength and good plasticity of the homogenized alloy benefit from the synergistic deformation mechanism of multiple kinking and twining in the *** the activation of kinking and twinning depends on the thicknesses of lPSO lamellae and their relative *** results may shed light on optimizing the design of Mg alloys regulating the microstructure of lPSO phases.

关键词： Mg alloy lPSO distribution Kink Twin Transmission electron microscopy

SpyStapler-mediated assembly of nanoparticle vaccines

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Nano Research 2023年第2期16卷 2821-2828页

作者： Songzi kou Weitao Chen Chenbo Sun Fei Sun Biomedical Research Institute Shenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhen 518132China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has wreaked havoc around the globe,with no end in *** rapid emergence of viral mutants,marked by rapid transmission and effective immune evasion,has also posed unprecedented challenges for vaccine development,not least in its speed,mass production,and *** we report a versatile“plug-and-display”strategy for creating protein vaccines,including those against malaria parasites and SARS-CoV-2,through the combined use of the intrinsically disordered protein ligase SpyStapler and computationally designed viral-like *** resulting protein nanoparticles harboring multiple antigens induce potent neutralizing antibody responses in mice,substantially stronger than those induced by the corresponding free *** modular vaccine design enabled by SpyStapler furnishes us with a new weapon for combatting infectious diseases.

关键词： subunit vaccine SpyTag SARS-CoV-2 malaria