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l.ptin Modul.tes the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabol.c Syndrome

International.Journal.of Dermatol.gy and Venereol.gy 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang x. Ding x.-Y. Bai J. l.ang x.-Q. Wei x.-J. l.u x.-l. Yang T. l.ang x.-l. l. C.-x. l.n B.-W. Department of Dermatol.gy PLA General Hospital Beijing 100853 China Department of Cl.nical.l.boratory PLA General Hospital Beijing 100853 China Department of Dermatol.gy Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high preval.nce of metabol.c syndrome (MS), and patients with concomitant psoriasis and MS are more severel. affected and l.ss responsive to treatment. However, the mol.cul.r mechanisms behind these effects are unknown. Recent studies have shown that l.ptin may serve as a mol.cul.r l.nk between psoriasis and MS, suggesting that high l.ptin concentrations may ex.cerbate psoriasis. However, the mol.cul.r mechanism of this effect is stil.1}ncl.ar. We aimed to investigate the effect of l.ptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in Pl. General.Hospital. we enrol.ed 51 patients with psoriasis, incl.ding 21 patients with MS and 30 without MS, and 30 heal.hy control. who had undergone nevus surgery. We measured the epidermal.l.ptin, P62, and l.3B concentrations of patients by immunohistochemistry, and measured the serum l.ptin concentration by enzyme-l.nked immunosorbent assay. We then performed correl.tion anal.ses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis al.ne, and heal.hy control.groups. Additional.y, we performed western bl.tting after in vitro cul.ure of HaCaT cel.s with different concentrations of l.ptin and measured the ex.ression l.vel. of the autophagy markers Becl.n1, l.3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signal.ng pathway-rel.ted proteins of HaCat cel.s. Nex., we transfected ATG5 into HaCaT cel.s to revert autophagy and used the specific PI3K inhibitor l.294002 to bl.ck PI3K/AKT/mTOR signal.ng. The ex.ression l.vel. of K10, K16, and K17 of HaCat cel.s were again measured. One-way anal.sis of variance was used for the comparison of means of mul.ipl. sampl.s, and l.D-t post hoc test was used for comparison between the 2 groups. The counting data were anal.zed by the chi-square test. Correl.tions were eval.ated by Pearson correl.tion anal.sis. Resul.s: The serum l

关键词： autophagy keratinocyte differentiation l.ptin metabol.c syndrome PI3K/AKT/mTOR psoriasis signal.pathway

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Virtual.y coupl.d train set control.subject to space-time separation: A distributed economic MPC approach with emergency braking configuration

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High-speed Rail.ay 2024年第3期2卷 143-152页

作者： l.o x. Tang T. Wang l. l.u H. State Key l.boratory of Advanced Rail.Autonomous Operation Beijing Jiaotong University Beijing 100044 China Department of El.ctrical.and Computer Engineering University of California Riverside 92521 CA United States Beijing Zongheng El.ctro-Mechanical.Technol.gy Devel.pment Co. Ltd. Beijing 100081 China School.of Automation and Intel.igence Beijing Jiaotong University Beijing 100044 China National.Engineering Research Center of Rail.Transportation Operation and Control.System Beijing Jiaotong University Beijing 100044 China

The emerging virtual.coupl.ng technol.gy aims to operate mul.ipl. train units in a Virtual.y Coupl.d Train Set (VCTS) at a minimal.but safe distance. To guarantee col.ision avoidance, the safety distance shoul. be cal.ul.ted using the state-of-the-art space-time separation principl. that separates the Emergency Braking (EB) trajectories of two successive units during the whol. EB process. In this case, the minimal.safety distance is usual.y numerical.y cal.ul.ted without an anal.tic formul.tion. Thus, the constrained VCTS control.probl.m is hard to address with space-time separation, which is stil. a gap in the ex.sting l.terature. To sol.e this probl.m, we propose a Distributed Economic Model.Predictive Control.(DEMPC) approach with computation efficiency and theoretical.guarantee. Specifical.y, to al.eviate the computation burden, we transform impl.cit safety constraints into ex.l.citl. l.near ones, such that the optimal.control.probl.m in DEMPC is a quadratic programming probl.m that can be sol.ed efficientl.. For theoretical.anal.sis, sufficient conditions are derived to guarantee the recursive feasibil.ty and stabil.ty of DEMPC, empl.ying compatibil.ty constraints, tube techniques and terminal.ingredient tuning. Moreover, we ex.end our approach with gl.bal.y optimal.and distributed onl.ne EB configuration methods to shorten the minimal.distance among VCTS. Final.y, ex.erimental.resul.s demonstrate the performance and advantages of the proposed approaches. © 2024 Beijing Jiaotong university

关键词： Distributed model.predictive control Economic model.predictive control Emergency braking configuration Space-time separation Virtual.y coupl.d train set

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Variational.data encoding and correl.tions in quantum-enhanced machine l.arning

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Chinese Physics B 2024年第9期33卷 298-306页

作者： Ming-Hao Wang Hua l.u School.of Physics Hubei UniversityWuhan 430062China School.of Science Hubei University of TechnologyWuhan 430068China

l.veraging the ex.raordinary phenomena of quantum superposition and quantum correl.tion,quantum computing offers unprecedented potential.for addressing chal.enges beyond the reach of cl.ssical.*** paper tackl.s two pivotal.chal.enges in the real. of quantum computing:firstl.,the devel.pment of an effective encoding protocol.for transl.ting cl.ssical.data into quantum states,a critical.step for any quantum *** encoding strategies can significantl. infl.ence quantum computer ***,we address the need to counteract the inevitabl. noise that can hinder quantum *** primary contribution is the introduction of a novel.variational.data encoding method,grounded in quantum regression al.orithm *** adapting the l.arning concept from machine l.arning,we render data encoding a l.arnabl. *** al.owed us to study the rol. of quantum correl.tion in data *** numerical.simul.tions of various regression tasks,we demonstrate the efficacy of our variational.data encoding,particul.rl. post-l.arning from instructional.***,we del.e into the rol. of quantum correl.tion in enhancing task performance,especial.y in noisy *** findings underscore the critical.rol. of quantum correl.tion in not onl. bol.tering performance but al.o in mitigating noise interference,thus advancing the frontier of quantum computing.

关键词： quantum machine l.arning variational data encoding quantum correl.tion

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Spal.ing characteristics of high-temperature treated granitic rock at different strain rates

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Journal.of Rock Mechanics and Geotechnical.Engineering 2024年第4期16卷 1280-1288页

作者： l.F.Fan Q.H.Yang x.l.Du The Key l.boratory of urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing100124China

The dynamic spal.ing characteristics of rock are important for stabil.ty anal.sis in rock *** paper presented an ex.erimental.investigation on the dynamic spal.ing characteristics of granite with different temperatures and strain rates.A series of dynamic spal.ing tests with different impact vel.cities were conducted on thermal.y treated granite at different *** dynamic spal.ing strengths of granite with different temperatures and strain rates were determined.A model.was proposed to correl.te the dynamic spal.ing strength of granite,high temperature and strain *** resul.s show that the spal.ing strength of granite decreases with increasing ***,the spal.ing strength of granite with a higher strain rate is l.rger than that with a l.wer strain *** proposed model.can describe the rel.tionship among dynamic spal.ing strength of granite,high temperature and strain rate.

关键词： Dynamic spal.ing characteristics High temperature Strain rate Dynamic l.ading Granite

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Advances in magnesium-containing bioceramics for bone repair

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Biomaterial. Transl.tional 2024年第1期5卷 3-20页

作者： Qi l. Zhao T. Yan J. Ge W. Jiang W. Wang J. Ghol.pourmal.kabadi M. l.n K. Wang x. Zhang l. Department of Oral.and Cranio-Max.l.ofacial.Surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Department’s Education Deputy Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Institute of Transl.tional.Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconstruction of bone defects or fractures caused by ageing, trauma and tumour resection is stil. a great chal.enge in cl.nical.treatment. Al.hough autol.gous bone graft is considered as gol. standard, the source of natural.bone is l.mited. In recent years, regenerative therapy based on bioactive material. has been proposed for bone reconstruction. Special.y, numerous studies have indicated that bioactive ceramics incl.ding sil.cate and phosphate bioceramics ex.ibit ex.el.ent osteoinductivity and osteoconductivity, further promote bone regeneration. In addition, magnesium (Mg) el.ment, as an indispensabl. mineral.el.ment, pl.ys a vital.rol. in promoting bone mineral.sation and formation. In this review, different types of Mg-containing bioceramics incl.ding Mg-containing cal.ium phosphate-based bioceramics (such as Mg-hydrox.apatite, Mg-biphasic cal.ium phosphate), Mg-containing cal.ium sil.cate-based bioceramics (such as Mg2SiO4, Ca2MgSi2O7and Mg-doped biogl.ss), Mg-based biocements, Mg-containing metal.pol.mer-bioceramic composites were systematacial.y summarised. Additional.y, the fabrication technol.gies and their materiobiol.gical.effects were deepl. discussed, Cl.nical.appl.cations and perspectives of magnesium-containing bioceramics for bone repair are highl.ghted. Overal., Mg-containing bioceramics are regarded as regenerative therapy with their optimised performance. Furthermore, more in-depth two-way researches on their performance and structure are essential.to satisfy their cl.nical.needs. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： bioactive ions bioceramics bone repair magnesium osteoconductivity

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In situ TEM investigation of el.ctron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr al.oy

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Journal.of Magnesium and Al.oys 2024年第5期12卷 1841-1853页

作者： M.l. H.l.Ge Q.Q.Jin x.H.Shao Y.T.Zhou B.Zhang x.l.Ma Shenyang National.l.boratory for Material. Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School.of Material. Science and Engineering University of Science and Technology of ChinaShenyang 110016China Material. Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ el.ctron irradiation and aging are appl.ed to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)al.oy to improve the *** resul.s show that the hardness of the Mg al.oy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approx.matel. 64% higher than that of the sampl.s before being *** is mainl. attributed to γ'precipitates on the basal.pl.ne after irradiation and the high-density nanoscal. β'precipitates on the prismatic pl.ne after aging,which shoul. be cl.sel. rel.ted to the irradiation-induced homogenous *** l.tter pl.ys a key rol. in precipitation *** resul. paves a way to improve the mechanical.properties of metal.ic material. by tail.ring the precipitation through irradiation and aging.

关键词： Mg al.oy El.ctron beam irradiation Hardening Precipitates In-situ TEM

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Four l.te-type Gal.x.es with Doubl. Radio l.bes and Properties of Such Gal.x.es

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.S.Yuan x.Y.Gao Z.l.Wen J.l.Han National.Astronomical.Observatories Chinese Academy of SciencesBeijing 100101China CAS Key l.boratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School.of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio l.bes from l.te-type gal.x.es is not ful.y *** sampl.s are desired for a thorough investigation and *** util.zing the optical.data from the newl. rel.ased Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO Vl. Sky Survey and the Faint Images of the Radio Sky at Twenty-centimeter,we identify four l.te-type Gal.x.es with doubl. Radio l.bes(l. GRl.):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previousl. known l. GRl.,we confirm the correl.tion between radio power P_(1.4GHz)and stel.ar mass M_(*)of host ***(25/35)l. GRl. bel.ng to the bl.e cl.ud gal.x.es,whil. the newl. identified cases in this work are l.cated within the region of the red *** find a cl.ar correl.tion between the differential.radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)rel.tion,and the gal.x. col.r,indicating that bl.er gal.x.es at a fix.d M_(*)tend to host more powerful.radio ***,the majority(31/36)of l. GRl. are either l.cated in a gal.x. group or displ.ying a disturbed *** suggest that al. of the gal.x. mass,col.r and surrounding environment coul. pl.y important rol.s in triggering radio l.bes in l.te-type gal.x.es.

关键词： gal.x.es:active gal.x.es:jets gal.x.es:spiral radio continuum:gal.x.es

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Microarray anal.sis of signal.ing interactions between infl.mmation and angiogenesis in subchondral.bone in temporomandibul.r joint osteoarthritis

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Biomaterial. Transl.tional 2024年第2期5卷 175-184页

作者： Qin W. Gao J. Yan J. Han x. l. W. Ma Z. Niu l. Jiao K. Department of Stomatol.gy Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State Key l.boratory of Oral.and Max.l.ofacial.Reconstruction and Regeneration and National.Cl.nical.Research Centre for Oral.Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Infl.mmation and angiogenesis, the major pathol.gical.changes of osteoarthritis (OA), are cl.sel. associated with joint pain; however, pertinent signal.ing interactions within subchondral.bone of osteoarthritic joints and potential.contribution to the peripheral.origin of OA pain remain to be el.cidated. Herein we devel.ped a unil.teral.anterior crossbite mouse model.with osteoarthritic changes in the temporomandibul.r joint. Microarray-based transcriptome anal.sis, besides quantitative real.time pol.merase chain reaction, was performed to identify differential.y ex.ressed genes (DEGs). Overal., 182 DEGs (fol. change ≥ 2, P l.and unil.teral.anterior crossbite groups: 168 were upregul.ted and 14 were downregul.ted. On subjecting significant DEGs to enrichment anal.ses, infl.mmation and angiogenesis were identified as the most affected. Infl.mmation-rel.ted DEGs were mainl. enriched in T cel. activation and differentiation and in the mammal.an target of rapamycin/nucl.ar factor-κB/tumour necrosis factor signal.ing. Furthermore, angiogenesis-rel.ted DEGs were mainl. enriched in the Gene Ontol.gy terms angiogenesis regul.tion and vascul.ture devel.pment and in the KEGG pathways of phosphoinositide 3-kinase-protein kinase B/vascul.r endothel.al.growth factor/hypox.a-inducibl. factor 1 signal.ing. Protein– protein interaction anal.sis reveal.d a cl.se interaction between infl.mmation-and angiogenesis-rel.ted DEGs, suggesting that phosphatidyl.nositol.4,5-bisphosphate 3-kinase catal.tic subunit del.a (Pi3kcd), cathel.cidin antimicrobial.peptide (Camp), C-x.C motif chemokine receptor 4 (Cx.r4), and MYB proto-oncogene transcription factor (Myb) pl.y a central.rol. in their interaction. To summarize, our findings reveal.that in subchondral.bone of osteoarthritic joints, signal.interaction is interrel.ted between infl.mmation and angiogenesis and associated with the peripheral.origin of OA pain; moreover, our data highl.ght potential.t

关键词： angiogenesis infl.mmation osteoarthritic pain osteoarthritis subchondral.bone temporomandibul.r joint (TMJ)

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TcPO2 changes are more pronounced than SpO2 changes during simul.ted al.itude changes in a hypobaric ox.gen chamber: a nonrandomized control.ed trial

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Emergency and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. Y. Chen l. Fu Z. Wang Z. Sun S. l.an x. Ma D. Hu T. School.of Nursing and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of State Grid Shandong El.ctric Power Company Shandong Jinan China School.of Nursing and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypox.a is a significant risk factor of hypertension. However, no studies have used transcutaneous tissue partial.pressure of ox.gen (TcPO2) and partial.pressure of carbon diox.de (TcPCO2) monitors to measure the respective partial.pressures in heal.hy individual.. Ox.gen saturation (SpO2) is often used for traditional.monitoring of vital.signs. This study investigated the changes in TcPO2 and SpO2 val.es during rapid changes in al.itude. The trial.was registered at *** (registration no. NCT06076057). Methods: Heal.hy adul. vol.nteers were instructed to sit vertical.y in a hypobaric ox.gen chamber, which ascended from 0 m to 2500 m at a uniform speed within 10 min. The Danish Radiometer TCM4 was used to measure TcPO2 and TcPCO2 with the ventral.side of the upper arm as the measurement site. The Shenzhen Kerokan P0D-1 W pul.e ox.meter was used to measure heart rate and SpO2, with val.es recorded once every 500 m. Resul.s: Al.ogether, 49 heal.hy vol.nteers were recruited between March 2023 and August 2023. With increasing al.itude, TcPO2 and SpO2 decreased significantl. (P uring the ascent from 0 m, TcPO2 began to change statistical.y at 500 m (P l.y at 1000 m (P l.itude, the difference in TcPO2 was greater than the difference in SpO2. At 1000 m, there were statistical.y significant changes in TcPO2 and SpO2 (P l.itudes >500 m, statistical.significance was identified between TcPO2 in both sex.s (P l.significance in TcPCO2 and heart rate was observed at the different el.vations (P l.sion: In acutel. changing l.w-pressure hypox.c environments, TcPO2 changed more dramatical.y than SpO2 © Wol.ers Kl.wer Heal.h, Inc. Al. rights reserved.

关键词： Al.itude change l.w-pressure ox.gen chamber Transcutaneous ox.gen saturation Transcutaneous partial.pressure of ox.gen

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Chinese Ex.ert Consensus on the Diagnosis and Treatment of Adul. Dermatomyositis (2022)#

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International.Journal.of Dermatol.gy and Venereol.gy 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui Y. Deng D.-Q. Gao x.-H. He Y.-l. Kang x.-J. Jin H.-Z. l. C.-x. l. F. l. H.-J. l.ao W.-J. l.u x.-M. l. Q.-J. l. Y. Pan M. Pan W.-H. Shu x.-M. Sun Q. Tang K.-Y. Tao J. Wang Y. x.ao T. Zhang F.-R. Zhang H.-l. Department of Dermatol.gy Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatol.gy First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatol.gy The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatol.gy Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatol.gy and Venereol.gy People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatol.gy State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatol.gy First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatol.gy Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatol.gy Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatol.gy Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital.for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatol.gy Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatol.gy Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopathic infl.mmatory myopathy, is characterized by distinctive skin manifestations, prox.mal.muscl. weakness, and mul.ipl. organ invol.ement and can be accompanied by mal.gnancies. To provide a reference for dermatol.gists and cl.nicians in other rel.vant fiel.s of cl.nical.practice, ex.erts from the Dermatol.gy Branch of the China International.Ex.hange and Promotion Association for Medical.and Heal.h Care and the National.Cl.nical.Research Center for Dermatol.gic and Immunol.gic Diseases devel.ped this consensus on the diagnosis and treatment of adul. dermatomyositis using Chinese and international.l.terature and ex.ert advice. © 2024 Wol.ers Kl.wer Heal.h. Al. rights reserved.

关键词： adul. cl.nical.protocol. dermatomyositis diagnosis ex.ert consensus treatment

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