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Non-pancreatic hyperlipasemia:A puzzling clinical entity

World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： Krisztina Eszter Feher David Tornai Zsuzsanna Vitalis l.szl. davida Nora Sipeki Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPHl)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPHl condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPHl in a large prospective patient cohort with an assessment of parameters determining disease *** A Hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(UlN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EASY trial(ISRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPHl was established based on≥3×UlN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×UlN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPHl with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPHl(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/l(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury Sepsis Mortality

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IMAGING REDOX STATE HETEROGENEITY WITHIN INDIVIDUAl EMBRYONIC STEM CEll COlONIES

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 279-288页

作者： HE N.XU RUSSEll C.ADDIS davida F.GOINGS SHOKO NIOKA BRITTON CHANCE JOHN D.GEARHART lIN Z.lI Molecular Imaging laboratory Department of Radiology University of PennsylvaniaSchool of Medicine PhiladelphiaPA 19104USA Institute for Regenerative Medicine and Department of Cell and Developmental Biology University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Britton Chance laboratory of Redox Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPA 19104USA

Redox state mediates embryonic stem cell(ESC)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem *** redox ratio(NADH/(Fp t NADH)),where NADH is the reduced form of nicotinamide adenine dinucleotide and Fp is the oxidizedflavoproteins,has been established as a sensitive indicator of mitochondrial redox *** this paper,we report our redox imaging data on the mitochondrial redox state of mouse ESC(mESC)colonies and the implications *** low-temperature NADH/Fp redox scanner was employed to image mESC colonies grown on a feeder layer of gamma-irradiated mouse embryonicfibroblasts(MEFs)on glass cover *** result showed significant heterogeneity in the mitochondrial redox state within individual mESC colonies(size:~200-440μm),exhibiting a core with a more reduced state than the *** more reduced state positively correlates with the expression pattern of Oct4,a well-established marker of *** observation is thefirst to show the heterogeneity in the mitochondrial redox state within a mESC colony,suggesting that mitochondrial redox state should be further investigated as a potential new biomarker for the stemness of embryonic stem cells.

关键词： Redox imaging pluripotency NADH flavoproteins redox ratio

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家族性精神分裂症的定量性状与1号染色体的连锁分析

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中华医学遗传学杂志 2002年第4期19卷 281-284页

作者：蔡贵庆伍新尧李涛 davida.Collier 刘协和冯炳建邓红童大跃李建金区敬华中山大学中山医学院法医学系广州510080 Institute of Psychiatry 四川大学华西医院心理卫生研究所中山大学肿瘤研究所

目的　探讨家族性精神分裂症的定量性状位点与 1号染色体的分子遗传学关系。方法　在32个家族性精神分裂症家系中 ,选择以下量表对精神分裂症患者的性状进行定量 ,包括 :阳性和阴性综合征量表、功能全面评定量表、病前分裂样和分裂型特... 详细信息

目的　探讨家族性精神分裂症的定量性状位点与 1号染色体的分子遗传学关系。方法　在32个家族性精神分裂症家系中 ,选择以下量表对精神分裂症患者的性状进行定量 ,包括 :阳性和阴性综合征量表、功能全面评定量表、病前分裂样和分裂型特质量表、病前社会适应量表 ,结合 1号染色体上 2 9个DNA多态标记位点的扫描数据 ,进行数量性状的遗传分析。结果　精神分裂症的阴性症状在 14 7.6 4 c M位置得到最大 Trad H- E l od值为 1.73、最大 EH H- E l od值为 1.6 5 ,此区域与质量性状连锁分析在 1q2 1- 2 3的峰值区域重叠。结论　提示精神分裂症阴性症状在 1q2 1- 2

关键词：家族性精神分裂症连锁分析精神分裂症定量性状位点 1号染色体分子遗传学

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Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease

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World Journal of Gastroenterology 2015年第22期21卷 6952-6964页

作者： Nora Sipeki l.szl. davida Eszter Palyu Istvan Altorjay Jolan Harsfalvi Peter Antal Szalmas Zoltan Szabo Gabor Veres Zakera Shums Gary l Norman Peter l lakatos Maria Papp Division of Gastroenterology Department of Internal Medicine Faculty of Medicine University of Debrecen Clinical Research Center Faculty of MedicineUniversity of Debrecen Department of laboratory Medicine Faculty of Medicine University of Debrecen Division of Emergency Medicine Department of Internal Medicine Faculty of Medicine University of Debrecen 1~(st) Department of Medicine Semmelweis University Inova Diagnostics Inc. San Diego California

AIM: To assess the prevalence and stability of different antiphospholipid antibodies(APlAs) and their association with disease phenotype and progression in inflammatory bowel diseases(IBD) ***: About 458 consecutive patients [Crohn's disease(CD): 271 and ulcerative colitis(UC): 187] were enrolled into a follow-up cohort study in a tertiary IBD referral center in Hungary. Detailed clinical phenotypes were determined at enrollment by reviewing the patients' medical charts. Disease activity, medical treatment and data about evolvement of complications or surgical interventions were determined prospectively during the follow-up. Disease course(development f complicated disease phenotype and need for surgery),occurrence of thrombotic events, actual state of diseaseactivity according to clinical, laboratory and endoscopic scores and accurate treatment regime were recorded during the follow-up,(median, 57.4 and 61.6 mo for CD and UC). Sera of IBD patients and 103 healthy controls(HC) were tested on individual anti-β2-Glycoprotein-I(anti-β2-GPI IgA/M/G), anti-cardiolipin(ACA IgA/M/G)and anti-phosphatidylserine/prothrombin(anti-PS/PT IgA/M/G) antibodies and also anti-Saccharomyces cerevisiae antibodies(ASCA IgA/G) by enzyme-linked immunosorbent assay(ElISA). In a subgroup of CD(n = 198) and UC patients(n = 103), obtaining consecutive samples over various arbitrary timepoints during the disease course, we evaluated the intraindividual stability of the APlA status. Additionally,we provide an overview of studies, performed so far, in which significance of APlAs in IBD were ***: Patients with CD had significantly higher prevalence of both ACA(23.4%) and anti-PS/PT(20.4%) antibodies than UC(4.8%, p lence of anti-β2-GPI between different groups(7.2%-9.7%). In CD, no association was found between APlA and ASCA status of the *** of a

关键词： Crohn's disease Ulcerative colitis Diseaseprogression Antiphospholipid antibodies Anti-β2-Glycoprotein-I antibodies Anti-phosphatidylserine/prothrombin Anti-cardiolipin antibodies Thrombosis

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应用紫外光辐照尾蚴在小鼠体内对曼氏血吸虫的抵抗力

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中国兽医科学 1985年第11期 5-6页

作者： davida.Dean,K.Darwin Murrell,许绶泰,Beverly l.Mangolel 美国海军医学研究所美国农业部寄生虫学研究所中国农科院上海家畜血吸虫病研究所

在较早研究中指出,辐照虫体存活到成虫期在引起抵抗方面有作用的可能性并未被排除。并指出在体内成熟或用高剂量丙种射线处理后阻止其成熟的血吸虫能引起基本上不同类型的抵抗力。Tromba氏认为致弱蠕虫幼虫所需的紫外光辐照剂量和波长... 详细信息

在较早研究中指出,辐照虫体存活到成虫期在引起抵抗方面有作用的可能性并未被排除。并指出在体内成熟或用高剂量丙种射线处理后阻止其成熟的血吸虫能引起基本上不同类型的抵抗力。Tromba氏认为致弱蠕虫幼虫所需的紫外光辐照剂量和波长的变化大有关系。我们决定将幼虫暴露于比我们较早工作中所用的限度更严的紫外光辐照光谱,这一研究证明:曼氏血吸虫尾蚴暴露给阻止成熟的紫外光辐照能引起的抵抗力的程度,可与X射线或丙种射线辐照的尾蚴引起的抵抗力相媲美。

关键词：抵抗力丙种射线辐照曼氏血吸虫小鼠小家鼠

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赖型钩体pD C 38核酸序列测定及其与流感伤寒型钩体外膜蛋白基因om pl 1核酸序列的类似性匹配

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华西医科大学学报 1999年第3期30卷 236-240页

作者：戴保民陈庄 davida.Haake 游自立方之茂华西医科大学基础医学院钩端螺旋体病研究室成都610041 UniversityofCalifornialosAngels SchoolofMedicineU.S.A

为了探讨赖型钩体ｐＤＣ３８插入片段基因组ＤＮＡ编码、位置与ｏｍｐＬ１基因的关系，作者采用在流感伤寒型钩体外膜蛋白基因ｏｍｐＬ１首尾区段设计一对引物，以ｐＤＣ３８插入片段作模板进行ＰＣＲ扩增、测定... 详细信息

为了探讨赖型钩体ｐＤＣ３８插入片段基因组ＤＮＡ编码、位置与ｏｍｐＬ１基因的关系，作者采用在流感伤寒型钩体外膜蛋白基因ｏｍｐＬ１首尾区段设计一对引物，以ｐＤＣ３８插入片段作模板进行ＰＣＲ扩增、测定和类似性匹配（ａｌｉｇｎｍｅｎｔ）。结果发现：ｐＤＣ３８含有２．７ｋｂ和３．０ｋｂ两个插入片段，３．０ｋｂ片段含有１个ｏｍｐＬ１基因全拷贝。结论：类似性匹配表明，ｐＤＣ３８和ｏｍｐＬ１相同碱基８６４个（９０％），碱基变异（不配对）９６（１０％）个，ｐＤＣ３８可用于钩体诊断、分类、鉴定、疫苗和发病机理的研究。

关键词：钩端螺旋体病重组质粒外膜蛋白基因 DNA

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美国耐甲氧西林金黄色葡萄球菌感染治疗临床治疗指南(一)

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今日药学 2011年第8期21卷 465-467页

作者：罗明琍吴新荣 Catherine liu Arnold Bayer Sara E.Cosgrove Robert S.Daum Scott K.Fridkin Rachel J.Gorwitz Sheldon l.Kaplan Adolf W.Karchmer Donald P.levine Barbara E.Murray MichaelJ.Rybak davida.Talan Henry F.Chambers 广州军区广州总医院药学部广东广州510010 Department of Medicine Division of Infectious DiseasesUniversity of California-San Francisco Division of Infectious Diseases Harbor-UCLA Medical Center Department of Medicine David Geffen School of Medicine at University of California Los Angeles Division of Infectious Diseases Johns Hopkins Medical Institutions Department of Pediatrics Section of Infectious DiseasesUniversity of Chicago Division ofHealthcare Quality Promotion Center for Emerging and Zoonotic Infectious DiseasesCenters for Disease Control and Prevention Department of Pediatrics Section of Infectious DiseasesBaylor College of Medicine Division of Infectious Diseases Beth Israel Deaconess Medicine CenterHarvard Medical School Department of Medicine Division of Infectious DiseasesWayne State UniversityDetroit Receiving Hospital and University Health Center Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens University of Texas Medical School Deparment of Pharmacy Practice Wayne State University Divisions of Emergency Medicine and Infectious Diseases Olive View-UCLA Medical Center Division of Infectious Diseases San Francisco General Hospital

美国感染病学会（IDSA）制订了治疗耐甲氧西林金黄色葡萄球菌（MRSA）患者的循证指南。该指南用于指导MRSA感染患者的治疗。该指南就多种与MRSA疾病相关的临床症状的治疗进行了论述,包括：皮肤和软组织感染（SSTI）、菌血症和感染性心... 详细信息

美国感染病学会（IDSA）制订了治疗耐甲氧西林金黄色葡萄球菌（MRSA）患者的循证指南。该指南用于指导MRSA感染患者的治疗。该指南就多种与MRSA疾病相关的临床症状的治疗进行了论述,包括：皮肤和软组织感染（SSTI）、菌血症和感染性心内膜炎、肺炎、骨和关节感染、中枢神经系统（CNS）感染等。该指南重点介绍了关于万古霉素用量及监测,以及对万古霉素低敏的耐甲氧西林金黄色葡萄球菌菌株感染的治疗方案及治疗失败的处置。

关键词：耐甲氧西林金黄色葡萄球菌感染临床治疗指南美国感染性心内膜炎中枢神经系统感染患者 MRSA 万古霉素

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