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Journal of Rare Earths 2022年第1期40卷 29-33页

作者： N.V.Rebrova A.Yu.Grippa I.A.Boiaryntseva P.Berastegui T.E.Gorbacheva Yu.N.Datsko A.l.Rebrov C.Dujardin R.calà l.Martinazzoli E.Auffray V.V.Kononets Institute for Scintillation Materials National Academy of Sciences of UkraineNauky Avenue 6061072KharkovUkraine Department of Chemistry Angstrom LaboratoryInorganic ChemistryUppsala University.PO.Box 583.75121.UppsalaSweden Claude Bernard lyon 1 University CNRSInstitute of Light and MatterUMR 5306F-69100 VilleurbanneFrance The University of Milano-Bicocca Piazza dell'Ateneo Nuovo1-20126Milano.Italy CERN EP DepartmentP.0.Box 1211Geneva 23Switzerland

A series of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3)(0≤x≤0.08)crystals doped with different concentrations of Eu^(2+)were grown using the Bridgman-Stockbarger *** work describes the influence of Eu^(2+)concentration on the luminescent and kinetic properties of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3) crystals,as well as on their scintillation *** maximum in the radioluminescence spectra of these crystals shifts from 439 to446 nm with increasing europium *** scintillation decay times of Cs_(0.2)Rb_(0.8)Ca_(1-x)Eu_(x)Br_(3) lengthen with the Eu^(2+)*** best light output of 33600photons/MeV is obtained for Cs_(0.2)Rb_(0.8)Ca_(0.93)Eu_(0.07)Br_(3),and the best energy resolution of 6.9%is found for Cs_(0.2)Rb_(0.8)Ca_(0.94)Eu_(0.06)Br_(3).

关键词： Inorganic material Crystal growth luminescence Rare-earth doped scintillator X-ray and gamma-ray spectroscopies

Quality of public space and sustainable development goals:analysis of nine urban projects in Spanish cities

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Frontiers of Architectural Research 2023年第3期12卷 477-495页

作者： Raimundo BambóNaya Pablo de la cal Nicolás Carmen Díez Medina Isabel Ezquerra Sergio García-Pérez Javier Monclús Departamento de Arquitectura Universidad de ZaragozaZaragoza 50018Spain Instituto Universitario de Investigación en Patrimonio y Humanidades(IPH) Universidad de ZaragozaZaragoza 50018Spain

The starting point of this research is the urban model promoted by the United Nations through the Sustainable Development Goals(SDGs).The importance of public spaces is especially highlighted in Goal 11.7:“provide universal access to safe,inclusive,and accessible,green,and public spaces.”The quality of public spaces can be properly assessed by reconsidering the quality indicators and investigating their development potential,which is the main focus of our *** study is based on a theoretical and methodological reflection on the quality of public space,considering the contributions of some contemporary urban traditions and a few recent *** this perspective,a variety of public space projects developed in the European sphere have been selected and *** quality parameters identified in this initial analysis were then applied to the analysis of nine representative case studies in three Spanish cities(Madrid,Barcelona,and Zaragoza).The main goal is to propose a methodology that helps to evaluate the quality of those public spaces and determine its relationship with the safety,accessibility,and inclusiveness conditions they offer.

关键词： Safety Inclusiveness Accessibility Design strategy Urban project

Burden, risk assessment, surveillance and management of SARS-CoV-2 infection in health workers:a scoping review

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Infectious Diseases of Poverty 2020年第5期9卷 1-11页

作者： Federica calò Antonio Russo Clarissa Camaioni Stefania De Pascalis Nicola Coppola Department of Mental Health and Public Medicine-Infectious Diseases Unit University of Campania Luigi VanvitelliL.Armanni 580131 NaplesItaly

Background:Health workers(HWs)are at increased risk for severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection and a possible source of nosocomial transmission *** the increased risk,the best surveillance strategy and management of exposed HWs are not yet well *** aim of this review was to summarize and critically analyze the existing evidence related to this topic in order to support public health strategies aimed at protecting HWs in the hospital *** text:A comprehensive computerized literature research from 1 January 2020 up to 22 May 2020 was made to identify studies analyzing the burden of infection,risk assessment,surveillance and management of HWs exposed to *** 1623 citation identified using MEDlINE,Embase,Google Scholar and manual search,we included 43 studies,14 webpages and 5 ongoing *** workers have a high risk of acquiring infection while caring for coronavirus disease 2019(COVID-19)*** particular,some types exposures and their duration,as well as the inadequate or non-use of personal protective equipment(PPE)are associated with increased infection *** infection prevention and control procedures(IPC),adequate training programs on the appropriate use of PPE and close monitoring of HWs with symptom surveillance and testing are essential to significantly reduce the *** the moment there is not enough evidence to provide precise indications regarding pre-exposure prophylaxis(PREP)and post-exposure prophylaxis(PEP).Conclusions:During the spread of COVID-19 outbreak,numerous published papers investigated the epidemiology,risk assessment and prevention and control of ***,more high-quality studies are needed to provide valid recommendations for better management and for the clinical and microbiological surveillance of healthcare personnel.

关键词： Healthcare worker Health worker Risk assessment Surveillance Management COVID-19

Body and Muscle Growth of Pre-larvae and larvae of Turbot, <i>Scophthalmus Maximus</i>l., Reared at Three Different Temperatures

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Open Journal of Animal Sciences 2015年第4期5卷 402-410页

作者： María Dolores Ayala María Jesús lago Rosa cal Departamento de Anatomía y Anatomía Patológica Comparadas Facultad de Veterinaria Universidad de Murcia Murcia Spain Instituto Espa&ntildeol de Oceanografía (IEO) Centro Oceanográfico de Vigo Subida a Radio Faro Vigo Spain

Three turbot groups were kept at 15℃ - 16℃ (Cold Temperature, T), 17℃ - 18℃ (ambient T) and 21℃ - 22℃(warm T) during the larval development in order to study the thermal influence on muscle growth and larval development in this species. During the early stages (2 - 6 days of post-hatching), the body and the muscle growth was scarce, although the hyperplasia increased slightly, being higher at ambient and at cold T than at warm T. In contrast, the highest value of hypertrophy was found in the warm group. At 15 days of age, the body length and muscle growth increased in all the groups, being significantly higher in the warm than in the rest of groups. Thus, the highest values of both the hypertrophy and the hyperplasia of the white muscle fibres were reached at warm T, although it was only significant for the hyperplasia. The end of the metamorphosis was reached at 29 days of age in the warm group, whereas in the rest of groups it was no observed yet. At this developmental stage, the warm group showed the typical morphological mosaic of the myotome, and it was accompanied by an increase of the transverse area of the white and the red muscles, parallel to an increase of both the hypertrophy and the hyperplasia of the muscle fibres. The hyperplasia of the white fibres was the parameter most significantly increased. Also, the body length increased significantly in this group, reaching ≈ 1.6 cm at this stage.

关键词： Growth Development Temperature Muscle Fibres

Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer

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Genes & Diseases 2023年第4期10卷 1180-1182页

作者： J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-lozano M.Perez R.Perona A.G.Quiroga C.calés I.Sanchez-Perez Dpto.de Bioquímica.Fac.Medicina UAMMadrid 28029Spain Biomedical Research Institute of Madrid CSIC/UAMMadrid 28029Spain Cancer Stem Cell and Fibroinflammatory Microenvironment Group Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Unidad Asociada de Biomedicina UClM-CSIC Madrid 28029 Spain CIBER for Rare Diseases(CIBERER) Instituto de Salud CarlosⅢ Madrid 28029Spain Dpto.de Anatomía Histología y Neurociencia.Fac.Medicina UAMMadrid 28029Spain g Dpto.de Química Inorgánica Fac.Ciencias UAMMadrid 28049Spain

Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic *** have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2l1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.

关键词： MAD2 tumorigenesis Gastric

Depicting the battle between nectarine and Monilinia laxa:the fruit developmental stage dictates the effectiveness of the host defenses and the pathogen’s infection strategies

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Horticulture Research 2020年第1期7卷 619-633页

作者： Marta Balsells-llauradó Christian J.Silva Josep Usall Núria Vall-llaura Sandra Serrano-Prieto Neus Teixidó Saskia D.Mesquida-Pesci Antonieta de cal Barbara Blanco-Ulate Rosario Torres IRTA XaRTA-PostharvestEdifici FruitcentreParc Científic i Tecnològic Agroalimentari de Lleida25003 LleidaCataloniaSpain Department of Plant Sciences University of CaliforniaDavisDavisCA 95616USA Department of Plant Protection INIACtra.de La Coruña Km.728040 MadridCommunity of MadridSpain

Infections by the fungus Monilinia laxa,the main cause of brown rot in Europe,result in considerable losses of stone ***,we present a comprehensive transcriptomic approach to unravel strategies deployed by nectarine fruit and *** during their *** used ***-inoculated immature and mature fruit,which was resistant and susceptible to brown rot,respectively,to perform a dual RNA-Seq *** immature fruit,host responses,pathogen biomass,and pathogen transcriptional activity peaked at 14–24 h post inoculation(hpi),at which point *** appeared to switch its transcriptional response to either quiescence or *** fruit experienced an exponential increase in host and pathogen activity beginning at 6 *** analyses in both host and pathogen highlighted differences in stage-dependent *** example,in immature fruit,*** unsuccessfully employed carbohydrate-active enzymes(CAZymes)for penetration,which the fruit was able to combat with tightly regulated hormone responses and an oxidative burst that challenged the pathogen’s survival at later time *** contrast,in mature fruit,*** was more dependent on proteolytic effectors than CAZymes,and was able to invest in filamentous growth early during the *** analyses of mature fruit infected with *** indicated that,while jasmonic acid activity was likely useful for defense,high ethylene activity may have promoted susceptibility through the induction of ripening ***,we identified *** genes that were highly induced in both quiescent and active infections and may serve as targets for control of brown rot.

关键词： fruit pathogen strategies

Fibrosis assessment using Fibro Meter combined to first generation tests in hepatitis C

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World Journal of Hepatology 2017年第6期9卷 310-317页

作者： Maria Chiara Chindamo Jerome Boursier Ronir Raggio luiz Isabelle Fouchard-Hubert Vera lúcia Nunes Pannain Joao Marcello de Araújo Neto Henrique Sérgio Moraes Coelho Renata de Mello Perez Paul calès Cristiane Alves Villela-Nogueira Departament of Internal Medicine Federal University of Rio de Janeiro Department of Hepatology University Hospital HIFIH laboratory UPRES 3859SFR 4208Bretagne Loire University Institute of Public Health Studies Federal University of Rio de Janeiro Departament of Pathology Federal University of Rio de Janeiro Gastroenterology Department University of the State of Rio de Janeiro D’Or Institute for Research and Education

AIMTo evaluate the performance of FibroMeterVirus3G combined to the first generation tests aspartate aminotransferase-to-platelet ratio index (APRI) or Forns index to assess significant fibrosis in chronic hepatitis C (CHC). METHODSFirst generation tests APRI or Forns were initially applied in a derivation population from Rio de Janeiro in Brazil considering cut-offs previously reported in the literature to evaluate significant fibrosis. FibroMeterVirus3G was sequentially applied to unclassified cases from APRI or Forns. Accuracy of non-invasive combination of tests, APRI plus FibroMeterVirus3G and Forns plus FibroMeterVirus3G was evaluated in the Brazilian derivation population. APRI plus FibroMeterVirus3G combination was validated in a population of CHC patients from Angers in France. All patients were submitted to liver biopsy staged according to METAVIR score by experienced hepatopathologists. Significant fibrosis was considered as METAVIR F ≥ 2. The fibrosis stage classification was used as the reference for accuracy evaluation of non-invasive combination of tests. Blood samples for the calculation of serum tests were collected on the same day of biopsy procedure or within a maximum 3 mo interval and stored at -70 °C. RESUlTSSeven hundred and sixty CHC patients were included (222 in the derivation population and 538 in the validation group). In the derivation population, the FibroMeterVirus3G AUROC was similar to APRI AUROC (0.855 vs 0.815, P = 0.06) but higher than Forns AUROC (0.769, P Virus3G cut-off to discriminate significant fibrosis was 0.61 (80% diagnostic accuracy; 75% in the validation population, P = 0.134). The sequential combination of APRI or Forns with FibroMeterVirus3G in derivation population presented similar performance compared to FibroMeterVirus3G used alone (79% vs 78% vs 80%, respectively, P = 0.791). Unclassified cases of significant fibrosis af

关键词： Chronic hepatitis C Fibrosis liver biopsy Non-invasive methods FibroMeterVirus3G Combination algorithms

MICROSCOPIC KINETICS OF NON-EQUIlIBRIUM SOlIDIFICATION

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Acta Metallurgica Sinica(English letters) 1994年第2期7卷 84-88页

作者： cal Yingwen, MAO Xiemin, lI Jianguo, FU HengzhiNorthwestern Polytechnieal University, Xi’an, China Manuscript received 14 March, 1994

Theoretical model for non -equilibrium solidification is constructed with consideration of diffuse interface and multiphase fluctuation. It can he degenerated to Aziz continuous growth model in the case of mono-atomic approximation. for large undercooling, the change of heat capacity should not he neglected and it usually gives an increase in the interface partition coefficient. Solute trapping may happen at a rather slow growth rate compared with that predicted by other models, because the undercooling and structural relaxation ahead of the S/ l interface lowers the interfacial diffusivity to a great extent. Plase fluctuation has two contending effects, decrease in energy barrier and increase in atomic dragging, therefore exerts dual influences on the partition coefficient.

关键词： diffuse interface multiphase fluctuation interface partition coefficiem

Interaction between hydrogen sulfide/cystathionine γ-lyase and carbon monoxide/heme oxygenase pathways in aortic smooth muscle cells

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Acta Pharmacologica Sinica 2006年第12期27卷 1561-1566页

作者： Hong-fang JIN~2 Jun-bao DU~(2,4)Xiao-hui lI~2 Yan-fei WANG~2 Yin-fang lIANG~2 Chao-shu TANG~3 2 Department of Pediatrics,Peking University First Hospital,Beijing 100034,China 3 Institute of Cardiovascular Research,Peking University First Hospital,Beijing 100034,China Department of Pediatrics Peking University First Hospital Beijing China Institute of Cardiovascular Research Peking University First Hospital Beijing China

Aim:To investigate the interaction between hydrogen sulfide（H2S）/cystathion-ine γ-lyase（CSE）and carbon monoxide（CO）/heme oxygenase（HO）pathways inaortic smooth muscle cells（ASMC）.Methods:The ASMCs were divided into thefollowing groups:（1）the control group;（2）the zinc protoporphyrin（ZnPP）20μmol/l group;（3）the propargylglycine（PPG）2 mmol/l,4 mmol/l and 10 mmol/lgroups;and（4）the sodium hydrosulfide（NariS）1×10-5mol/l,1×10-4mol/l and1×10-3mol/l *** of the groups was further divided into 6h,12h,18hand 24h *** CO level,represented by carboxyhemoglobin（HbCO）content was measured using a spectrophotometric method and H2S content wasdetected by a sensitive electrode *** and HO-1 expressions were de-tected by Western ***:The H2S content in the medium and CSEexpression by ASMC were markedly increased by ZnPP compared with the con-trol *** content in the medium and HO-1 expression by the ASMCstarted strengthening following 24h treatment with PPG at 2 mmol/l,but werefurther strengthened following 18h and 24h treatment with PPG at 4 mmol/lcompared with the controls（Pl/l increased the HbCO levelin the medium following 18h treatment and increased HO-1 expression by theASMC following 12h ***,NariS at 1×10-5mol/l and 1×10-4mol/ldecreased the HbCO level in the medium and HO-1 expression by the ASMC after6h and 12h treatment,while NariS at 1×10-3mol/l decreased them at all timepoints of the ***:The results suggested that endogenousCO/HO and H2S/CSE pathways inhibited each other in ASMC under physiologi-cal conditions.

关键词： hydrogen sulfide cystathionine γ-lyase carbon monoxide heme oxygenase

左房消融与双心房消融治疗持续性和永久性房颤的前瞻性、随机对比研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 49-50页

作者： calòl. lamberti F. loricchio M.l. 马超 Division of Cardiology Policlinico Casilino ASL RM B Rome Italy Dr.

Objectives: The aim of this study was to compare-in patients with persistent and permanent atrial fibrillation(AF)-the efficacy and safety of left atrial ablation with that of a biatrial approach. Background: left atrium-based catheter ablation of AF, although very effective in the paroxysmal form of the arrhythmia, has an insufficient efficacy in patients with persistent and permanent AF. Methods: Eighty highly symptomatic patients(age, 58.6±8.9 years) with persistent(n=43) and permanent AF(n=37), refractory to antiarrhythmic drugs, were randomized to two different ablation approaches guided by electroanatomical mapping. A procedure including circumferential pulmonary vein, mitral isthmus, and cavotricuspid isthmus ablation was performed in 41 cases(left atrial ablation group). In the remaining 39 patients(biatrial ablation group), the aforementioned approach was integrated by the following lesions in the right atrium: intercaval posterior line, intercaval septal line, and electrical disconnection of the superior vena cava. Results: During follow-up(mean duration 14±5 months), AF recurred in 39%of patients in the left atrial ablation group and in 15%of patients in the biatrial ablation group(p=0.022). Multivariable Cox regression analysis showed that ablation technique was an independent predictor of AF recurrence during follow-up. Conclusions: In patients with persistent and permanent AF, circumferential pulmonary vein ablation, combined with linear lesions in the right atrium, is feasible, safe, and has a significantly higher success rate than left atrial and cavotricuspid ablation alone.

关键词：永久性房颤治疗持续性二尖瓣峡部线性消融抗心律失常药物静脉电隔离导管消融标测消融方法