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Femtosecond Degenerate Four-Wave-Mixing in ZnO Microcrystallite Thin Films

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Chinese Physics letters 1999年第6期16卷 418-419页

作者： ZhANG Wei-li WANG Qing-yue ChAI lu XING Qi-rong k.S.wong h.Wang Z.k.Tang G.k.l.wong R.Jain Ultrafast laser laboratory School of Precision Instruments&Optoelectronics Engineeringand Optoelectronic Information Science and Technology LaboratoryTianjin UniversityTianjin 300072 School of Science Tianjin UniversityTianjin 300072 Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong Center for high Technology Materials University of New Mexico1313 Goddard SEAlbuquerqueNM 87106USA

Transient third-order optical nonlinearityχ^(3)of ZnO microcrystallite thin films is measured at various temperatures by using femtosecond degenerate ***-temperature excitonic enhancement of is *** magnitude ofχ^(3)ranges between 10^(-4)to 10^(-6)esu from 4.2k to room *** measuredχ^(3)response time ranging from 200 to 300 fs ultrafast for temperature down to 4.2k.

关键词： temperature. crystallite nonlinearity

Effects of 2,3,7,8-TCDD and benzo[a]pyrene on modulating vitellogenin expression in primary culture of crucian carp (Carassius auratus) hepatocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： lIANGYong C.k.C.wong XUYing M.h.wong StatekeylaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong StatekeylaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the precursor of yolk protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was established by measuring Vtg in- duction in cultured primary hepatocytes from crucian carp. Vtg production was detected by biotin-avidin sandwich ElISA method while Vtg and cytochrome P4501A1 (CYP1A1) mRNA induction were measured by semi- quan- titative PCR-primer dropping technique. Vtg and Vtg mRNA were dose-dependently induced by diethylstilbestrol (DES, 0.2—200 ng/ml) in hepatocytes of crucian carp. Co-treatment of the DES-induced hepatocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 pg/ml) or benzo[a]pyrene (B[a]P, 5—1000 ng/ml) resulted in a reduction of Vtg pro- duction and an increment of CYP1A1 mRNA expression both in a dose dependent manner, indicating the anti-estro- genic effects of the compounds. however, at lower tested concentrations, TCDD (0.1, 0.2 pg/ml), B[a]P (5 ng/ml) seemed to have a potentiating effect on Vtg expression and secretion, although by their own these compounds had no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen receptor modulators, 1 nmol/l—1 μmol/l), and β-naphtho-flavone (β-NF, an aryl hydrocarbon receptor inducing compounds, 2.5—1000 ng/ml) also were employed to study the possible interactions in DES-induced Vtg ex- pression. In co-treatment of the DES-induced hepatocytes with β-NF or tamoxifen, the decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tamoxifen inhib- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On the contrary, it was found that in co-treatment of the TCDD-induced hepatocytes with DES, TCDD induced CYP1A1 mRNA production was inhib- ited by DES also. These results implicated a possible cross talk between estrogen receptor- and aryl hydrocarbon re- ceptor-mediated pathways in the hepatocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素

Generation of Electron Traps at high Field in Silicon Oxide Films

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Chinese Physics letters 1995年第7期12卷 420-423页

作者： B.l.Yang h.wong Y.C.Cheng Department of Electronic Engineering City University of Hong KongTat Chee AvenueKowloonHONG KONG

Temperature dependences of the high-field electron trapping in a SiO_(2) thin film for temperature ranging from 100 to 423k are *** is found that in the investigated temperature range,when the temperature decreases the effective surface density of the electron traps in the film decreases;the energy levels of the effective electron traps at high field concentrate at very narrow energy *** thermal generation rate is found to be 1.283x10^(10)/cm^(2).k and its activation energy is *** on these results,a model for the electron traps generated at high field in thin oxide is proposed.

关键词： film Electron energy

Design and fabrication of automated sedimentation-based separation and siphon-based extraction for detection of allergic reaction on a centrifugal microfluidic disc

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Chinese Optics letters 2010年第10期8卷 957-959页

作者： Q. l. Chen h. P. ho k. l. Cheung S. k. kong Y. k. Suen Y. W. kwan C. k. wong Center for Advanced Research in Photonics and Department of Electronic Engineering The Chinese University of Hong Kong Hong Kong China Department of Biochemistry The Chinese University of Hong Kong Hong Kong China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong China

We report the design and fabrication of a novel and fully integrated polymer-based centrifugal microfluidic disc for rapid automatic allergens detection. All essential steps for a single test including flow valving, sequencing, mixing, separation, extraction, and sedimentation for final detection are automatically conducted within 30 min on a centrifugal microfluidic disc. Our design features a siphon-based valving and analyte extraction structure where the released analyte is separated and subsequently extracted by a siphon valve into the detection chamber. Incorporating the siphon valve and a series of capillary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

关键词： Adaptive optics Diffuse optical imaging Photolithography Polydimethylsiloxane Polymethyl methacrylate

The Use of Enzyme-digested Soybean Residue For Feeding Common Carp

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Biomedical and Environmental Sciences 1996年第4期9卷 418-423页

作者： M.h.wong l.Y.TANG 等 DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong DepartmentofAppliedBiologyandChem

This experiment was an attempt to use the soybean residue derived from the production of 'soy milk'. The residue contains about 18% protein, 70% caf bohydrates and 7.5% lipid as fish feed for reafing common carp, Cyrinus carpto. There were 4 types of diets: (1)soybean residue, (2 ) soybean residue digested with Papain, (3) soybean residue (64%)mixed with beef liver (34%) and (4) same mixture as (3) but digested with Papain. The results indicate that the percentage increase in weight and length of fish feeding with beef liver supplemented diets was higher than those feeding with soybean residue alone. This was possibly due to the fact that beef liver was able to supplement the nutrient deficiency in soybean. The two types of feeds (2 and 4) digested with Papain also yielded significantly better fish growth in terms of weight and length gains, than their counterparts without digestion. Furthermore, the water turbidity of the tanks added with digested feeds was significantly less, as papain was able to hyrolyse the protein substrates suspended in the water, and thus lowered the turbidity

关键词： In Res The Use of Enzyme-digested Soybean Residue For Feeding Common Carp

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng haoran Wu Myth T.S.Mok lingyun Zhang Zhixian liang Xiaoyu liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan lu Jingqing li hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong hou heung Man lee Candice C.h.lam howard h.W.leung Anthony W.h.Chan ka Fai To John wong Paul B.S.lai kelvin k.C.Ng Simon k.h.wong Vincent W.S.wong Alice P.S.kong Joseph J.Y.Sung Alfred S.l.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State key laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China lee kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(hCC)that develops from a background of non-alcoholic fatty liver disease(NAFlD).hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in hCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFlD-hCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NkT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NkT cell dysfunction in NAFlD ***,cholesterol-lowering rosuvastatin restored NkT expansion and cytotoxicity to prevent obesogenic diet-promoted hCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NkT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NkT cells,which were supported by findings in people with obesity,NAFlD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NkT dysfunction in the tumor-promoting NAFlD liver microenvironment,providing intervention strategies that invigorating NkT cells to control hCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

Management of cytomegalovirus corneal endotheliitis

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Eye and Vision 2021年第1期8卷 18-30页

作者： Angela h.Y.wong Wee Nie kua Alvin l.Young kelvin h.Wan Department of Ophthalmology Tuen Mun HospitalHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina

Background:Cytomegalovirus(CMV)can manifest as corneal endotheliitis in immunocompetent *** diagnosis is prudent to prevent endothelial cell loss,which could ultimately lead to corneal *** DNA was first detected in an eye with corneal endotheliitis in 2006;since then,clinical evidence from numerous case reports and case series have *** text:In this narrative review,we identified several drugs,including ganciclovir,valganciclovir,and their combination in oral,intravenous,intravitreal,and topical forms in different concentrations,together with the judicious use of topical steroids,have reported variable *** has yet to be any prospective comparative study evaluating the efficacy and safety of these assorted forms of treatment;clinical evidence is based on case reports and case *** endotheliitis presenting with corneal edema can masquerade as other corneal diseases and thus poses a great challenge especially in post-keratoplasty *** awareness is needed before and after keratoplasty to start prompt prophylaxis and ***:There is no consensus on the management of CMV *** studies are much needed to elucidate the optimal treatment modality,regime,and duration in the treatment and prophylaxis of CMV endotheliitis.

关键词： Cytomegalovirus CMV Endotheliitis keratoplasty Corneal transplant Cornea

Is aggregated oviposition by the blow flies lucilia sericata and Phormia regina （Diptera： Calliphoridae） really pheromone-mediated？

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Insect Science 2015年第5期22卷 651-660页

作者： Bekka S. Brodie Warren h. l. wong Sherah Vanlaerhoven Gerhard Gries Simon Fraser University Dept. of Biological Sciences Burnaby BC V5A 1S6 Canada and University of Windsor Windsor ON N9B3P4 Canada

When female blow flies lucilia sericata and Phormia regina （Diptera： Cal- liphoridae） oviposit in aggregations on carrion, even-aged larval offspring reportedly de- velop faster, and fewer are parasitized or preyed upon. The benefits of aggregated ovipo- sition equally affect con- and heterospecific larvae sharing a resource. The benefits imply that female blow flies engage in coordinated, pheromone-mediated oviposition behavior. Yet, repeated attempts to identify oviposition pheromones have failed invoking doubt that they exist. Simply by regurgitating and feeding on carrion, flies may produce attractive semiochemicals. If flies were to aggregate in response to feeding flies rather than oviposit- ing flies, then the semiochemical cue（s） may be associated with the salivary gland. Working with l. sericata and P.. regina and using liver as a surrogate oviposition medium, we test the hypotheses, and present data in their support, that （i） gravid or nongravid females ovipositing and/or feeding on liver enhance its attractiveness to gravid and nongravid fe- males; （ii） females respond to semiochemicals from feeding heterospecific females; （iii） females respond equally well to semiochemicals from feeding con- and heterospecific females; （iv） macerated head tissues of females applied to liver enhance its attractiveness; and （v） females in direct contact with and feeding on liver, but not when next to yet physically separated from liver, enhance attraction of flies. We conclude that oviposition site-seeking females do not respond to an oviposition pheromone. Instead, they appear to coopt semiochemicals associated with feeding flies as resource indicators, taking chances that resources are suitable for oviposition, and that ovipositing flies are present.

关键词： blow flies carrion egg-laying site pheromone saliva semiochemical

A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds

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International Journal of Nursing Sciences 2014年第1期1卷 7-14页

作者： Rainbow l.P.lee Polly h.M.leung Thomas k.S.wong School of Nursing The Hong Kong Polytechnic UniversityHong Kong Department of health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Faculty of health and Social Sciences The Hong Kong Polytechnic UniversityHong Kong

Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound *** tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against *** aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized ***:It was a randomized controlled trial,single-blind *** with stage II or above MRSA-colonized wounds and who had given their informed consent formed the *** determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas *** outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention ***:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil *** control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation *** the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse *** was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation.

关键词： MRSA Topical tea tree preparation Wounds