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THE EFFECTs OF PUlsE BIAs VOlTAGE AND N_2 PARTIAl PREssURE ON TiAlN FIl.s.OF ARC ION PlATING (AIP)

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Acta Metallurgica sinica(Engl.s. letters) 2001年第6期14卷 520-524页

作者： M.s. li, s.l. Zhu, Fuhui Wang, C. sun and l.s. wen (Institute of Metal Research, The Chinese Academy of sciences, shenyang l10016, China)

Owing to the characteristics of arc ion plating(AIP) technique, the structure and composition of TiAlN fil.s.can be tailored by controlling of various parameters such as compositions of target materials, N2 partial pressure, substrate bias and so on. In this study, several titanium aluminum nitride fil.s.were deposited on 1Cr11Ni2W2MoV steel for compressor blade of areo-engine under different d.c pulse bias voltage and nitrogen partial pressure. The effects of substrate pulse bias and nitrogen partial pressure on the deposition rate, droplet formation, microstruture and elemental component of the fil.s.were investigated.

关键词： TiAlN film pulse bias voltage nitrogen partial pressure arc ion plating

FUNDAMENTAl PROBlEMs IN PUlsED-BIAs ARC DEPOsITION

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Acta Metallurgica sinica(Engl.s. letters) 2002年第1期15卷 91-103页

作者： G.Q. lin Z.F. Ding D. Qi N.H. Wang M.D. Huang D.Z. Wang Y.N. Wang C. Dong l.s. wen The state Key laboratory for Materials Modification by l.s.r Ion and Electron Beams Dalian Uni-versity of Technology Dalian 116024 China Department of Electromagnetic Engineering Dalian University of Technology Dalian 116024 China The state Key laboratory for Materials Modification by l.s.r Ion and Electron Beams Dalian Uni-versity of Technology Dalian 116024 China Institute of Metals Research The Chinese Academy of Sciences Shenyang 110016 China Institute of Metals Research The Chinese Academy of Sciences Shenyang 110016 China

Arc deposition, a widely used surface coating technique, has disadvantages such as large droplet size and high deposition temperature. Recent trend in its renovation is the introduction of pulsed bias at the. substrate. The present paper attempts to describe the deposition process of TiN fil.s.using this technique with emphasis laid on the understanding of the basic problems such as discharge pl.s.a properties, temperature calculation, and droplet size reduction. We show that this technique improves the film micro structure and quality, lowers deposition temperature, and allows coatings on insulating substrates. After analyzing load current oscillation behaviors, we have determined that the pl.s.a load is of capacitance nature due to pl.s.a sheath and that it is equivalent to a circuit element consisting of parallel capacitance and resistance. At l.s., we point out the remaining problems and future development of the pulsed-bias arc deposition technique.

关键词： arc deposition pulsed bias pl.s.a

OBsERVATION ON DEFECTs IN POlYCRYsTAllINE sIlICON THIN FIlMs

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Acta Metallurgica sinica(Engl.s. letters) 2005年第3期18卷 295-299页

作者： Y.F. Hu1), H. shen2), l. Wang3), Z.C. liang3), Z.Y. liu1) and l.s. wen1) 1) College of Mechanical Engineering, south China University of Technology, Guan gzhou 510640, China 2) The school of Physics and Engineering, Zhongshan University, Guangzhou 510275 , China 3) Guangzhou Institute of Energy Conversion, The Chinese Academy of sciences, G uangzhou 510640, China College of Mechanical Engineering South China University of Technology Guangzhou 510640China The school of Physics and Engineering Zhongshan University Guangzhou 510275China Guangzhou Institute of Energy Conversion The Chinese Academy of Sciences Guangzhou 510640China

Polycrystalline silicon thin fil.s.were prepared by RTCVD (rapid thermal chemica l vapor deposition) method on several.s.bstrates such as ssP (silicon sheet from powder) ribbon, poly-si wafer and mono-si wafer. Intra-granular defects such as stacking faul.s. twins and microstructure defects were investigated on thin fil ms by scan electron microscopy (sEM) technique.

关键词： poly-si thin film intra-granular defects surface cross-section

Targeting TrkB–PsD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global.s.imulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic pl.s.icity TrkB

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai shan Guoliang li Xuechun Chen wen Zhao Bin Hu shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University school of Physics and Astronomy Beijing Normal University school of Astronomy and space science University of Science and Technology of China CAs Key laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （slGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of slGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II slGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of slGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced study University of Chinese Academy of Sciences shanghai Astronomical Observatory Chinese Academy of Sciences school of Physics and Astronomy Shanghai Jiao Tong University school of Astronomy and space science University of Chinese Academy of Sciences Taiji laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(sNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(sMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the sMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data anal.s.s, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

An efficient quantum proactive incremental learning algorithm

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi song sujuan Qin Qiaoyan wen Fei Gao state Key laboratory of Networking and switching Technology Beijing University of Posts and Telecommunications school of Cyberspace security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental learning algorithm(QPIl). Instead of a one-off training of quantum circuit, QPIl contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small.s.ale graphs, and it shows that QPIl performs superior to prevalent quantum and cl.s.ical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIl.s.AR surpasses 20% of mainstream quantum baselines, and the time cost is l.s. than 1/5 of them. The idea of QPIl is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of stomatology and Central laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cel.s.leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small.s.ze of these nanomaterials allows for precise targeting of T cel.s.dendritic cel.s.or cancer cel.s.thereby eliciting a more potent anti-tumor *** this paper,we focus on the cl.s.ification of carriers for cancer nanovaccines,the rol.s.of different target cel.s.and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets signaling pathway

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics letters 2025年第1期21卷 1-6页

作者： wen Jin lIU Zhanzhi WU Zhengwei PAN Yu ZHANG Ying school of science Xi'an Shiyou University shaanxi Key laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isoscel.s.right triangl.s. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical resul.s.show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fiel.s.of energy capture and thermal detection.

关键词： Metamaterials