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Zoological Research(Diversity and Conservation) 2024年第2期1卷 117-120页

作者： Garima Gupta Rahul Kotiyal Isabel l.jones Biological and Environmental Sciences University of StirlingScotland FK94LAUK Baramasa.in Narrating Himalaya 248001India

Climate change and biodiversity loss are pressing global challenges(Pörtner et al.,2021).However,as global energy demand continues to increase(IEA,2021),nations face significant challenges to decarbonization and reaching“net zero”due to trade-offs between the often-competing needs of renewable energy generation and biodiversity *** example,hydropower generates renewable energy(Gibson et al.,2017),yet there are well-documented and severe consequences of dam development for biodiversity(e.g.,Zarfl et al.,2019)and people(e.g.,Bisht,2009)due to reservoir creation and disruption of river *** such potentially damaging ecological and social trade-offs,hydropower currently contributes 70%of global renewable energy and there are at least 3700 large dams planned or under construction globally(Zhang&Gu,2023).

关键词： reservoir consequences globally

Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno Isabel l.jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOlIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams landbridge local extinctions Species-area relationships Species diversity Tropical forests

Ideas speaking and listening activities for upper-intermediate student Teacher's book

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Recent advances in the systemic treatment of gastrointestinal stromal tumors

1984年

作者： l.jones

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Cancer Biology & Medicine 2023年第10期20卷 701-705页

作者： Robin l.jones Marin Golcic Sarcoma Unit The Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchFulham RoadLondon SW36JJUnited Kingdom Clinic for Tumors Clinical Hospital CenterRijeka 51000Croatia

Historical overview of the treatment for advanced gastrointestinal stromal tumors(GISTs)GISTs represent a relatively rare entity;however,GISTs are still the most common mesenchymal neoplasm in the gastrointestinal *** majority of GISTs express the transmembrane receptor,KIT,a product of the KIT proto-oncogene that can lead to uncontrolled cell proliferation and resistance to apoptosis1-3.

关键词： gastrointestinal tumors treatment

Dermatofibrosarcoma protuberans: from translocation to targeted therapy

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Cancer Biology & Medicine 2015年第4期12卷 375-384页

作者： Jonathan Noujaim Khin Thway Cyril Fisher Robin l.jones Sarcoma Unit Royal Marsden NHS Foundation Trust

Dermatofibrosarcoma protuberans(DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity for metastasis. Wide surgical resection or Mohs micrographic surgery(MMS) are the preferred approaches for localized disease, while radiation therapy is warranted for inoperable disease or for cases with positive margins where re-excision is not possible. DFSP is generally regarded as refractory to conventional chemotherapy. Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13)(COl1A1;PDGFB) found in a majority of cases. In recent years, imatinib, a PDGFβR, ABl and KIT inhibitor, has revolutionized systemic therapy in DFSP. In this review, we summarize the epidemiological, clinical, histological and genetic characteristics of DFSP and update the readers on its current management.

关键词： Dermatofibrosarcoma protuberans(DFSP) imatinib Mohs micrographic surgery(MMS) translocation targeted therapy

Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.lee Robin l.jones Paul H.Huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Response of nitrogen fractions in the rhizosphere and bulk soil to organic mulching in an urban forest plantation

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Journal of Forestry Research 2021年第6期32卷 2577-2588页

作者： Xiaodan Sun Gang Wang Yuqian Ye Qingxu Ma Qingwei Guan Davey l.jones College of Biology and the Environment Nanjing Forestry UniversityNanjing 210037People’s Republic of China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing 210037People’s Republic of China School of Natural Sciences Bangor UniversityBangor LL572UWGwyneddUK

Nitrogen is an essential component in forest ecosystem nutrient *** fractions,such as dissolved nitrogen,ammonium,nitrate,and microbial biomass nitrogen,are sensitive indicators of soil nitrogen pools which affect soil fertility and nutrient ***,the responses of nitrogen fractions in forest soils to organic mulching are less well *** rhizosphere is an important micro-region that must be considered to better understand element cycling between plants and the soil.A field investigation was carried out on the effect of mulching soil in a 15-year-old ligustrum lucidum urban *** in total nitrogen and nitrogen fractions in rhizosphere and bulk soil in the topsoil(upper 20 cm)and in the subsoil(20-40 cm)were evaluated following different levels of mulching,in addition to nitrogen contents in fine roots,leaves,and organic *** relationships between nitrogen fractions and other measured variables were *** mulching had no significant effect on most nitrogen fractions except for the rhizosphere microbial biomass nitrogen(MBN),and the thinnest(5 cm)mulching layer showed greater effects than other *** MBN was more sensitive to mulching compared to bulk soil,and was more affected by soil environmental *** and soil depth had more pronounced effects on nitrogen fractions than *** nitrogen and dissolved nitrogen were correlated to soil phosphorus,whereas other nitrogen fractions were strongly affected by soil physical properties(temperature,water content,bulk density).Mulching also decreased leaf nitrogen content,which was more related to soil nitrogen fractions(except for MBN)than nitrogen contents in either fine roots or organic *** applications of small quantities of organic mulch contribute to nitrogen transformation and utilization in urban forests.

关键词： Rhizosphere Nitrogen fraction Organic mulching Soil–plant interaction Urban plantation forest

Organic mulching promotes soil organic carbon accumulation to deep soil layer in an urban plantation forest

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Forest Ecosystems 2021年第1期8卷 11-21页

作者： Xiaodan Sun Gang Wang Qingxu Ma Jiahui liao Dong Wang Qingwei Guan Davey l.jones College of Biology and Environment Nanjing Forestry UniversityNanjing 210037China Co-Innovation Center of Sustainable Forestry in Southern China Nanjing 210037China School of Natural Sciences Bangor UniversityGwynedd LL572UWUK College of Environmental Science and Engineering China West Normal UniversityNanchong 637000China UWA School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia

Background:Soil organic carbon(SOC)is important for soil quality and fertility in forest *** SOC fractions are sensitive to environmental changes,which reflect the impact of short-term internal and external management measures on the soil carbon *** mulching(OM)alters the soil environment and promotes plant ***,little is known about the responses of SOC fractions in rhizosphere or bulk soil to OM in urban forests and its correlation with carbon composition in ***:A one-year field experiment with four treatments(OM at 0,5,10,and 20 cm thicknesses)was conducted in a 15-year-old ligustrum lucidum *** in the SOC fractions in the rhizosphere and bulk soil;the carbon content in the plant fine roots,leaves,and organic mulch;and several soil physicochemical properties were *** relationships between SOC fractions and the measured variables were ***:The OM treatments had no significant effect on the SOC fractions,except for the dissolved organic carbon(DOC).OM promoted the movement of SOC to deeper soil because of the increased carbon content in fine roots of *** were significant correlations between DOC and microbial biomass carbon and SOC and easily oxidised organic *** OM had a greater effect on organic carbon fractions in the bulk soil than in the *** thinnest(5 cm)mulching layers showed the most rapid carbon decomposition over *** time after OM had the greatest effect on the SOC fractions,followed by soil ***:The frequent addition of small amounts of organic mulch increased SOC accumulation in the present *** is a potential management model to enhance soil organic matter storage for maintaining urban forest productivity.

关键词： Soil organic carbon labile organic carbon fractions Rhizosphere Urban plantation forest Organic mulching

Structural and microstructural description of relaxor-ferroelectric transition in quenched Na_(1/2)Bi_(1/2)TiO_(3)-BaTiO_(3)

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Journal of Materiomics 2022年第4期8卷 823-832页

作者： Andreas Wohninsland Ann-Katrin Fetzer Rachel Broughton Jacob l.jones K.V.lalitha Department of Materials-and Geosciences Technical University of Darmstadt64287DarmstadtGermany Department of Materials Science and Engineering North Carolina State UniversityRaleighNC27695USA

Quenching lead-free Na_(1/2)Bi_(1/2)TiO_(3)-based ceramics from sintering temperature is established to increasethe depolarization temperature,Td and the lattice *** situ synchrotron X-ray diffractionmeasurements were carried out on furnace cooled and quenched Na_(1/2)Bi_(1/2)TiO_(3)-BaTiO_(3)(NBT-BT)with 6and 9 mol.%BT to discern the field-induced ferroelectric *** fractions were determined fromfull pattern Rietveld refinements and utilized together with the change in unit cell volume to calculatevolumetric strain resulting from phase ***-6BT demonstrates a cubic symmetry in thefurnace cooled state but quenching stabilizes the rhombohedral R3c phase and delays the formation of afield-induced,long range-ordered tetragonal phase,thereby shifting the onset of macroscopic strain tohigher fields.A field-induced phase transition from a weakly distorted rhombohedral to tetragonal phasecan be observed in furnace cooled ***,this phase transition cannot be detected inquenched NBT-9BT,since the ferroelectric tetragonal P4mm phase is stabilized in the initial *** to the furnace cooled materials,both the quenched compositions exhibit overall negligiblevolumetric strain as a function of electric ***,scanning electron micrographs of chemi-cally etched,poled and unpoled samples reveal an increased lamellar domain contrast in the *** these findings strengthen the hypothesis of a stabilized ferroelectric order resulting in theabsence of a field-induced phase transformation in quenched NBT-BT.

关键词： lead-free Quenching Na_(1/2)Bi_(1/2)TiO_(3)-BaTiO_(3) Synchrotron diffraction Ferroelectric

Effects of 7 years of field weathering on biochar recalcitrance and solubility

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Biochar 2019年第3期1卷 237-248页

作者： Elizabeth K.Williams Davey l.jones Hannah R.Sanders Gabriel V.Benitez Alain F.Plante University of Pennsylvania PhiladelphiaPAUSA Bangor University BangorUK The University of Western Australia PerthAustralia University of Minnesota MinneapolisMNUSA

How weathering affects the physiochemical properties of biochar and its long-term carbon(C)sequestration potential remains *** this study,we measured changes in biochar recalcitrance and solubility after 7 years of weathering in a cultivated *** recalcitrance and biodegradability of weathered and unweathered hardwood biochar mixtures were determined by thermal analysis(differential scanning calorimetry)and evolved gas *** in biochar solubility and the chemical composition of biochar-derived dissolved organic carbon(DOC)were determined by repeated laboratory leaching and UV-Vis *** surface carbon-oxidation state(Cox)of biochar increased by 117.6-158.2%with weather-ing in the field,and there was an average of 0.9-1.2%decrease in biochar C contents per ***,thermal indices of biochar recalcitrance and biodegradability,which suggested intermediate C sequestration potential,were not significantly different between weathered and unweathered *** O:C ratio increased with weathering suggesting an increase in biodegradability,however,both weathered and unweathered biochars were still estimated to have half-lives of over 1000 ***-soluble organic carbon(WSOC)concentrations from the unweathered biochar rapidly decreased during laboratory leaching to levels similar to the field-weathered biochars,and aromaticity(SUVA_(254))of WSOC increased from 5.9%in the unweathered biochar to 42%aromaticity in the biochars weathered for 7 *** conclude that during short-term(years)weathering under field conditions,there is continued solubilization of increasingly aromatic biochar-C compounds,however,this accounts for a relatively small proportion of biochar C such that there is little-to-no change in biochar stability or C sequestration potential after field application.

关键词： Biochar Pyrogenic organic matter Thermal analysis Carbon sequestration Dissolved pyrogenic organic matter