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Electrically pumped quantum-dot lasersgrownon 300 mm patterned Si photonic wafers

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light(Science & Applications) 2022年第11期11卷 2698-2705页

作者： Chen Shang Kaiyin Feng Eamonn THughes Andrew Clark Mukul Debnath Rosalyn Koscica Gerald leake Joshua Herman David Harame Peter ludewig Yating Wan john E.Bowers Materials Department University of California Santa BarbaraSanta BarbaraCA 93106USA Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA OQE IncGreensboroNC 27409USA RF SUNY Polytechnic Institute AlbanyNY 12203USA NAsPIII/NV GmbH MarburgGermany

Monolithic integration of quantum dot(QD)gain materials onto Si photonic platforms via direct epitaxial growth is a promising solution for on-chip light *** developments have demonstrated superior device reliability in blanket hetero-epitaxy ofⅡ-Ⅴdevices on Si at elevated ***,thick,defect management epi designs prevent vertical light coupling from the gain region to the Si-on-lnsulator ***,we demonstrate the frst electrically pumped QD lasers grown by molecular beam epitaxy on a 300 mm patterned(001)Si wafer with a buttcoupled *** growth and fabrication challenges imposed by the template architecture have been resolved,contributing to continuous wave lasing to 60℃and a maximum double-side output power of 126.6 mW at 20℃with a double-side wall-plug efficiency of 8.6%.The potential for robust on-chip laser operation and effcient lowloss light coupling to Si photonic circuits makes this heteroepitaxial integration platform on Si promising for scalable and low-cost mass production.

关键词： pumped quantum coupling

Human semen quality and the secondary sex ratio

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Asian Journal of Andrology 2017年第3期19卷 374-381页

作者： Jisuk Bae Sungduk Kim Zhen Chen Michael l Eisenberg Germaine M Buck louis Department of Preventive Medicine Catholic University of Daegu School of Medicine Daegu 42472 Korea Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Rockvilie MD 20852 USA Department of Urology Obstetrics and Gynecology Stanford University School of Medicine Stanford CA 94305-5118 USA.

The aim of this study was to evaluate the association between semen quality and the secondary sex ratio （SSR）, defined as the ratio of male to female live births. Our study cohort comprised 227 male partners who were enrolled prior to conception in Michigan and Texas between 2005 and 2009, and prospectively followed through delivery of a singleton birth. The male partners provided a baseline and a follow-up semen sample a month apart. Semen analysis was conducted to assess 27 parameters including five general characteristics, six sperm head measures, 14 morphology measures, and two sperm chromatin stability assay measures. Modified Poisson regression models with a robust error variance were used to estimate the relative risk （RR） and 95% confidence interval （95% CI） of a male birth for each semen parameter, after adjusting for potential confounders. Of the 27 semen parameters, only the percentage of bicephalic sperm was significantly associated with the SSR （2nd VS Ist quartile, RR, 0.65, 95% CI, 0.45-0.95, P= 0.03; 4TM vs 1St quartile, RR, 0.61, 95% CI, 0.38-1.00, P 〈 0.05 before rounding to two decimal places）, suggestive of a higher percentage of bicephalic sperm being associated with an excess of female births. Given the exploratory design of the present study, this preconception cohort study suggests no clear signal that human semen quality is associated with offspring sex determination.

关键词： fertility prospective studies reproduction semen analysis sex ratio sperm

光动力疗法不能预防器官移植受者皮肤鳞状细胞癌的发生:一项随机对照试验结果

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 16-17页

作者： De Graaf Y.G.l. kennedy C. Wolterbeek R. J.N.B. Bavinck 吴佳纹 Department of Dermatology Leiden University Medical Center PO Box 9600 2300 RC Leiden Netherlands Dr.

A randomized-controlled trial with paired observations was performed with 40 organ-transplant recipients to assess the preventive effect of photodynamic therapy (PDT) on the development of new squamous-cell carcinomas and to evaluate the effect of PDT on the number of keratotic skin lesions. The treatment area consisted of a randomly assigned forearm and the corresponding hand, whereas the other forearm and hand served as the control area. After the initial visit, follow-up visits were scheduled at 3-monthly intervals during 2 years. No statistically significant difference was found in the occurrence of new squamous-cell carcinomas between the treated and untreated arms: after 2 years of follow up, we observed 15 squamous-cell carcinomas in nine out of 40 PDT-treated arms and 10 squamous-cell carcinomas in nine out of 40 control arms. The number of keratotic skin lesions increased in both arms, but was less pronounced in the PDT-treated arm. After 1 year of follow-up, a trend in favor of the PDT-treated arm was observed, but statistical significance was not reached. Nearly 80% of the patients reported mild to severe adverse effects consisting of pain and a burning sensation, immediately after the treatment. No long-term adverse events were noted. In conclusion, PDT does not appear to prevent the occurrence of newsquamous-cell carcinomas in organ-transplant recipients, but to some degree, reduces the increase of keratotic skin lesions.

关键词：皮肤鳞状细胞癌光动力疗法器官移植受者随机对照试验皮损数目角化性随访调查灼热感不良反应

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男性避孕:回顾与展望

英国医学杂志中文版 2022年第7期25卷 393-398页

作者： john Joseph Reynolds-Wright Richard A Anderson 王涛(译) 李铮(校) MRC Centre for Reproductive Health The Queen's Medical Research InstituteUniversity of EdinburghEdinburghUK 华中科技大学同济医学院附属同济医院泌尿外科上海交通大学医学院附属第一人民医院泌尿中心男科

新型可逆性男用避孕药的研发进展缓慢。虽然研究已充分表明激素类药物具备有效和可逆的避孕作用,但仍然没有此类药物应用于临床。目前,正在研发一种睾酮和孕激素的自用凝胶Nestorone@,而以往研究更多采用的是注射给药方法。具有雄激素... 详细信息

新型可逆性男用避孕药的研发进展缓慢。虽然研究已充分表明激素类药物具备有效和可逆的避孕作用,但仍然没有此类药物应用于临床。目前,正在研发一种睾酮和孕激素的自用凝胶Nestorone@,而以往研究更多采用的是注射给药方法。具有雄激素和孕激素活性的新型长效类固醇制剂,也正在进行早期临床试验。非激素疗法作用于精子发生的潜在位点,或干扰附睾或输精管中的精子成熟,具有某些潜在的优势,但仍处于临床前试验阶段。调查表明男性及其伴侣更愿意尝试新的男性避孕方法,只是没有相关产品上市。

关键词：避孕作用药物应用激素类药物注射给药孕激素精子发生男性避孕雄激素

Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

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Bone Research 2015年第1期3卷 40-45页

作者： Douglas J DiGirolamo Vandana Singhal Xiaoli Chang Se-Jin lee Emily l Germain-lee Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Bone & Osteogenesis Imperfecta Department Kennedy Krieger Institute Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University School of Medicine

Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.

关键词： bone Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATlAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios l. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.l. Alberghi J. Albert P. Albicocco G.l. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo l. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines l. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli l.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal l. Barak M. Barakat E.l. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATlAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATlAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATlAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATlAS JET QUARK GlUON TAGGING

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流行病学研究中的测量问题

国际结核病与肺部疾病杂志 2006年第3期1卷 149-152页

作者： D. A. Enarson S. M. kennedy D. l. Miller 贺晓新（译）屠德华（校）张立兴（审） Scientific Activities Unit International Union Against Tuberculosis and Lung Disease Paris France University of British Columbia Vancouver British Columbia Canada Emeritus Professor of Public Health Medicine Imperial College University of London London United Kingdom 不详

数据(信息)是流行病学研究中的基础性资料。对信息的认真测量、记录及处理是研究过程的重要步骤。必须对数据的特征给予准确的描述,而数据的收集则需要可靠的工具。对测量过程中的定义和程序进行标准化可保证不同来源数据的可比性。在... 详细信息

数据(信息)是流行病学研究中的基础性资料。对信息的认真测量、记录及处理是研究过程的重要步骤。必须对数据的特征给予准确的描述,而数据的收集则需要可靠的工具。对测量过程中的定义和程序进行标准化可保证不同来源数据的可比性。在测量过程中认真负责,对测量人员进行严格培训可保证测量的精确性。还要特别注意数据记录过程中的完整性和准确性。可以利用常规或专门设计的表格来收集数据,也可以利用死亡或病例计数或失能测量数据进行评价。调查问卷是一种常用的数据收集工具。调查问卷包括研究对象基础信息和关于疾病及其影响因素调查问题两个部分。要想使问卷调查有意义,必须对问卷进行精心设计。关于疾病的比较常常使用“率”或“危险度”指标,从而涉及到分母(人群)和分子(病例数或事件数)的问题。患病率和发病率是标准的“危险度”测量指标。收集高质量的信息,并据此计算出“危险度”或“危险度比”,这就构成了流行病学的基础。

关键词：研究方案肺教育

Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study

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World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 471-479页

作者： Alexander R Robertson Nicholas A kennedy James A Robertson Nicholas I Church Colin l Noble Department of Gastroenterology Western General Hospital Centre for Genomic and Experimental Medicine University of Edinburgh Department of Gastroenterology University of Exeter School of life Sciences University of Nottingham Royal Infirmary of Edinburgh

AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus *** A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in lothian health board hospitals between July 2013 and January *** quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to *** study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the *** There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P l intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONClUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid.

关键词： Gastrointestinal endoscopy Colonoscopy Caecal intubation Benzodiazepine Polyp detection Nitrous oxide Entonox Midazolam Sedation Unsedated

Relevance of placental type I interferon beta regulation for pregnancy success

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Cellular & Molecular Immunology 2018年第12期15卷 1010-1026页

作者： Ja-Young Kwon Paulomi Aldo Yuan You Jiahui Ding Karen Racicot Xiaoyan Dong john Murphy Guy Glukshtad Michelle Silasi Jian Peng li Wen Vikki MAbrahams Roberto Romero Gil Mor Division of Reproductive Sciences Department of ObstetricsGynecology and Reproductive SciencesYale School of MedicineNew HavenCTUSA Department of Obstetrics and Gynecology Institute of Women’s Life Medical ScienceYonsei University College of MedicineSeoulKorea Department of Obstetrics Gynecology&Reproductive BiologyCollege of Human MedicineMichigan State University400 Monroe Avenue NEGrand RapidsMI 49503USA Department of Pulmonary Shanghai Children’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Division of Endocrinology Department of Internal MedicineYale School of MedicineNew HavenCTUSA Perinatal Research Branch NICHD/NIHDetroitMIUSA

Pregnancy is a unique immunologic and microbial condition that requires an adequate level of awareness to provide a fast and protective response against pathogens as well as to maintain a state of tolerance to paternal *** of inflammatory pathways in the placenta triggered by pathogens is one of the main factors responsible for pregnancy *** I IFNs are key molecules modulating immune responses at the level of the placenta and are crucial for protection of the pregnancy via their antiviral and immune modulatory *** this study,we elucidate the mechanisms controlling the basal expression of IFNβand its negative *** in vitro and in vivo animal models,we found that TlR signaling maintains basal IFNβlevels through the TlR4-MyD88-independent TBK/IRF3 signaling *** describe the role of the TAM receptor Axl in the regulation of IFNβfunction in human and mouse trophoblast *** absence of TAM receptors in vivo is associated with fetal demise due to dysregulation of IFNβexpression and its pro-apoptotic downstream ***,our data describe a feedback signaling pathway controlling the expression and function of IFNβin the trophoblast that is essential for an effective response during viral and microbial infections.

关键词： trophoblast immune regulation cytokine TAM receptors type I interferon Interferon beta ISGs