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Chinese Journal of Chemical Engineering 2020年第4期28卷 1162-1170页

作者： Hongyin Pang Ruifang lu Tao Zhang li lü yanxiao Chen Shengwei Tang State Key laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua 617000China School of Chemical Engineering Sichuan UniversityChengdu 610065China

in order to concentrate the diluted sulfuric acid from the titanium dioxide(TiO2)production of sulphate process,a new concentration process was proposed by coupling chemical dehydration and mul.i-effect *** ferrous sulfate monohydrate(FeSO4·H2O),as the dehydrant,was added to the diluted sulfuric acid to form ferrous sulfate heptahydrate(FeSO4·7H2O)according to the H2SO4-FeSO4-H2O phase diagrams,which partially removes the *** process was named as Chemical Dehydration *** residual water was further removed by two-effect evaporation and finally 70 wt%sulfuric acid was *** FeSO4·H2O can be regenerated through drying and dehydration of FeSO4·*** results show that FeSO4·H2O is the most suitable dehydrant,the optimal reaction time of chemical dehydration process is 30 min,and low temperature is favorable for the dehydration reaction.45.17%of the entire removed water can be removed by chemical dehydration from the diluted sulfuric *** chemical dehydration process is also energy efficient with 24.76%saving compared with the direct evaporation ***,51.21%of the FeSO4 dissolved originally in the diluted sulfuric acid are precipitated out during the chemical dehydration,which greatly reduces the solid precipitation and effectively alleviates the scaling in the subsequent mul.i-effect evaporation process.

关键词： Chemical dehydration Mul.i-effect evaporation Sulfuric acid Titanium

嗜热新芽孢杆菌来源D-阿洛酮糖3-差向异构酶的高效表达和酶学性质

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微生物学通报 2024年第9期51卷 3551-3561页

作者：张苍萍李延啸杨绍青闫巧娟江正强中国农业大学食品科学与营养工程学院北京100083 中国农业大学工学院北京100083 中原食品实验室河南漯河462000 南京财经大学、食品科学与工程学院、江苏省现代粮食流通与安全协同创新中心江苏南京210023

【背景】D-阿洛酮糖具有高甜度、低热量的特性,是一种优良的代糖产品。D-阿洛酮糖3-差向异构酶(D-allulose 3-epimerase,DPEase)可以催化D-果糖异构化生成D-阿洛酮糖,是酶法制备D-阿洛酮糖中的关键酶。【目的】为提高DPEase的工业应用潜... 详细信息

【背景】D-阿洛酮糖具有高甜度、低热量的特性,是一种优良的代糖产品。D-阿洛酮糖3-差向异构酶(D-allulose 3-epimerase,DPEase)可以催化D-果糖异构化生成D-阿洛酮糖,是酶法制备D-阿洛酮糖中的关键酶。【目的】为提高DPEase的工业应用潜力,对其进行异源表达,并研究其酶学性质。【方法】利用甘油醛三磷酸脱氢酶启动子将嗜热新芽孢杆菌(Novibacillus thermophilus)来源的DPEase(NtDPEase)在毕赤酵母(Komagataella phaffii)中组成型表达,并系统研究该酶的酶学性质。【结果】重组菌在5 l发酵罐中经108 h高密度发酵,酶活最高为201.3 U/ml。经过纯化得到电泳纯DPEase,分子量为35 kDa。该酶的最适pH值为7.0,最适温度为60℃,在pH 6.0–8.0和45℃以下具有良好的稳定性。该酶用于转化不同浓度D-果糖(100–500 g/l)制备D-阿洛酮糖,最高转化率达29.0%。【结论】本研究实现了DPEase在毕赤酵母中的高效表达,为D-阿洛酮糖的酶法合成提供了理论和实践依据。

关键词： D-阿洛酮糖3-差向异构酶嗜热新芽孢杆菌组成型表达酶学性质

Chitin oligosaccharides alleviate atherosclerosis progress in ApoE;mice by regulating lipid metabolism and inhibiting inflammation

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Food Science and Human Wellness 2022年第4期11卷 999-1009页

作者： Hongmin Zhen Qiaojuan Yan Yihao liu yanxiao li Shaoqing Yang Zhengqiang Jiang Key laboratory of Food Bioengineering(China National light industry) College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Beijing Advanced innovation Center for Food Nutrition and Human Health College of EngineeringChina Agricultural UniversityBeijing 100083China

Atherosclerosis is driven both by hyperlipidemia and inflammation. Chitin oligosaccharides(NACOS) have shown pharmacological effects on mul.iple diseases via hypolipidemic and/or anti-inflammatory activities. The present study aims to evaluate whether NACOS treatment can prevent atherosclerosis induced by a highfat-diet(HFD) in Apolipoprotein E-knockout(Apo E;) mice. Results showed that 300 and 900 mg/kg b.w./day NACOS supplementation for 14 weeks significantly decreased atherosclerotic lesions up to 45% and 67% in compared with the HFD(P in the valve area of the aortic root. Further, NACOS supplementation significantly reduced the serum hyperlipidemia and circulating proinflammatory cytokines including interleukin-1β, interleukin-6, monocyte chemoattractant protein-1 and tumor necrosis factor-α. NACOS decreased the hepatic Hmgcr to reduce cholesterol synthesis, activated the genes involved in reverse cholesterol transport to enhance cholesterol efflux and excretion, and reduced the intestinal Npc1l1 to lower cholesterol absorption. Additionally, NACOS enhanced cecum short chain fatty acids production and intestinal.integrity. Thus, NACOS supplementation ameliorated atherosclerosis via altering lipid metabolism and reducing inflammation. These findings indicate that NACOS may be a potential functional food material for attenuating atherosclerosis development.

关键词： Chitin oligosaccharides Atherosclerosis lipid metabolism inflammation Apo E-/-mice

Enhanced photocatalytic N2 fixation by promoting N2 adsorption with a co-catalyst

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Science Bulletin 2019年第13期64卷 918-925页

作者： Xiang Gao li An Dan Qu Wenshuai Jiang yanxiao Chai Shaorui Sun Xingyuan liu Zaicheng Sun State Key laboratory of luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100190China Center of Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory of Green Catalysis and Separation Department of Chemistry and Chemical EngineeringSchool of Environmental and EnergyBeijing University of TechnologyBeijing 100124China

Photocatalytic N2 fixation involves a nitrogen reduction reaction on the surface of the photocatalyst to convert N2 into ***,the adsorption of N2 is the limiting step for the N2 reduction reaction on the surface of the *** on the concept of photocatalytic water splitting,the photocatalytic efficiency can be greatly enhanced by introducing a *** this report,we proposed a new strategy,namely,the loading of a NiS co-catalyst on CdS nanorods for photocatalytic N2 *** calculation results indicated that N2 was effectively adsorbed onto the NiS/CdS *** programmed desorption studies confirmed that the N2 molecules preferred to adsorb onto the NiS/CdS *** sweep voltammetry results revealed that the overpotential of the N2 reduction reaction was reduced by loading ***,transient photocurrent and electrochemical.impedance spectroscopy indicated that the charge separation was enhanced by introducing *** N2 fixation was carried out in the presence of the catalyst dispersed in water without any sacrificial *** a result,1.0 wt% NiS/CdS achieved an ammonia production rate of 2.8 and 1.7 mg l-1 for the first hour under full spectrum and visible light(λ>420 nm),*** catalyst demonstrated apparent quantum efficiencies of 0.76%,0.39% and 0.09% at 420,475 and 520 nm,res *** study provides a new method to promote the photocatalytic efficiency of N2 fixation.

关键词： N2 fixation Photocatalyst Co-catalyst N2 adsorption NiS

添加部分水解罗望子胶对酸木瓜果醋品质的影响

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中国酿造 2024年第6期43卷 168-175页

作者：赵玉琪李延啸田嘉欣吕昂江正强闫巧娟中国农业大学食品科学与营养工程学院北京100083 中国农业大学工学院北京100083 南京财经大学食品科学与工程学院/江苏省现代粮食流通与安全协同创新中心江苏南京210023 中原食品实验室河南漯河462000

该研究以酸木瓜(Chaenomeles speciosa)为原料,通过部分水解罗望子胶(PHTG)对6株乳杆菌的增殖活性测定,选用鼠李糖乳杆菌(lactobacillus rhamnosus)与酵母菌混菌进行酒精发酵,并从灵石醋醅中筛选鉴定出一株高产醋酸的巴氏醋杆菌巴士亚种... 详细信息

该研究以酸木瓜(Chaenomeles speciosa)为原料,通过部分水解罗望子胶(PHTG)对6株乳杆菌的增殖活性测定,选用鼠李糖乳杆菌(lactobacillus rhamnosus)与酵母菌混菌进行酒精发酵,并从灵石醋醅中筛选鉴定出一株高产醋酸的巴氏醋杆菌巴士亚种(Acetobacter pasteuranus subsp. pasteuranus)lS-4用于醋酸发酵制备酸木瓜果醋。以未添加PHTG为对照,考察在酒精发酵阶段添加PHTG对酸木瓜果醋品质的影响。结果表明,添加1.0%PHTG,酒精发酵36 h后酒精度达3.3%vol,比对照组提高17.4%;醋酸发酵72 h后总酸含量达42.0 g/l,比对照组提高8.0%。香气成分分析表明,添加PHTG酸木瓜果醋共检出22种香气成分,其中醇类7种、酯类4种、酸类6种、醛酮类3种、酚类和烯烃类各1种,比对照新增了3种香气成分(正丁酸、2-戊酮和壬醛)。感官评价表明,添加PHTG有效提升酸木瓜果醋的口感和气味评分,改善酸木瓜果醋的感官品质。

关键词：酸木瓜果醋部分水解罗望子胶混菌发酵品质

基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘的分子机制

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中药新药与临床药理 2024年第2期35卷 247-256页

作者：连乐燊孟星汝黄秀芳周谨希谢燕小陶海澜蒋紫云刘小虹广州中医药大学东莞医院广东东莞523000 广州中医药大学第一临床医学院广东广州510405 广州中医药大学第一附属医院广东广州510405 广州中医药大学岭南医学研究中心广东广州510405 广州中医药大学第三临床医学院广东广州510370

目的基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘(NA)的分子机制。方法(1)利用中药系统药理学数据库和分析平台(TCMSP)、文献检索及Swiss ADME、Swiss Target Prediction数据库检索、筛选射麻止喘液的活性成分及其作... 详细信息

目的基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘(NA)的分子机制。方法(1)利用中药系统药理学数据库和分析平台(TCMSP)、文献检索及Swiss ADME、Swiss Target Prediction数据库检索、筛选射麻止喘液的活性成分及其作用靶点。利用OMiM、Gene Cards、Dis Ge NET及Drug Bank数据库检索、筛选NA疾病相关靶点。通过微生信平台对射麻止喘液活性成分作用靶点与NA疾病相关靶点取交集,得到射麻止喘液治疗NA的潜在作用靶点(共有靶点)。采用Cytoscape 3.8软件构建“中药-活性成分-潜在作用靶点”网络。通过STRiNG数据库建立潜在作用靶点蛋白互作(PPi)网络,使用内置Mcode插件分析获得核心靶点。使用Metascape平台对潜在作用靶点进行基因本体(GO)、京都基因和基因组百科全书(KEGG)通路富集分析。(2)将BAlB/C小鼠适应性喂养1周后,随机分为空白组、NA模型组、射麻止喘液低剂量组(2.5 g·kg^(-1))、射麻止喘液高剂量组(10 g·kg^(-1))、地塞米松对照组(1 mg·kg^(-1));通过腹腔注射致敏剂[鸡卵清白蛋白(OVA)+弗氏完全佐剂(CFA)]并通过雾化吸入激发的方法复制NA小鼠模型,第0、7、14天分别腹腔注射OVA+CFA(20μg OVA+75μg CFA,0.3 m l)致敏,第21~30天采用5%OVA混悬液雾化激发(每次8 m l,每次雾化时间40 min,每天1次);雾化激发前1 h各组灌胃给药,地塞米松对照组腹腔注射给药,每天1次。采用HE染色法观察小鼠肺组织病理变化;EliSA法检测肺泡灌洗液中il-8含量;RT-q PCR法检测肺组织中NlRP3、CXCR2 m RNA表达水平;免疫组化法检测肺组织中p-m TOR蛋白表达水平。结果(1)共筛选得到射麻止喘液活性成分作用靶点826个,NA疾病相关靶点154个,取交集后得到射麻止喘液治疗NA的51个潜在作用靶点(共有靶点)。通过“中药-活性成分-潜在作用靶点”网络分析得到槲皮素、木犀草素、山柰酚、豆甾醇、柚皮素等关键活性成分。通过对潜在作用靶点的PPi网络分析得到29个核心靶点,包括AKT1、il6、TNF、EGFR、NlRP3、RElA、MiF、CXCR2、VEGFA等。GO功能富集分析得到882个生物学过程条目、33个细胞组分条目、61个分子功能条目;KEGG通路富集分析得到142条信号通路,主要涉及TNF信号通路、甲型流感信号通路、Toll样受体通路、MAPK信号通路、m TOR信号通路等。(2)动物实验结果:与空白组比较,NA模型组小鼠的气道黏膜损伤明显,结构紊乱,有大量炎性细胞浸润,黏膜充血、水肿,肺泡壁明显增厚,肺泡腔缩小;肺泡灌洗液中的炎症因子il-8水平明显升高(PlRP3、CXCR2 m RNA表达显著上调(Pil-8水平明显降低(PlRP3m RNA表达明显下调(PlRP3、CXCR2等核心靶点,调控TNF信号通路、MAPK信号通路、Toll样信号通路、m TOR等关键信号通路来实现的。

关键词：射麻止喘液中性粒细胞型哮喘网络药理学 NlRP3 CXCR2 mTOR信号通路小鼠

Fine mapping and validation of a stable QTl for thousand-kernel weight in wheat(Triticum aestivum l.)

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作物学报:英文版 2023年第5期11卷 1491-1500页

作者： Deyuan Meng Aamana Batool Yazhou Xuan Ruiqing Pan Na Zhang Wei Zhang liya Zhi Xiaoli Ren Wenqing li Jijie li yanxiao Niu Shuzhi Zheng Jun Ji Xiaoli Shi l.i Wang Hongqing ling Chunhua Zhao Fa Cui Xigang liu Junming li liqiang Song Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesShijiazhuang 050022HebeiChina Ministry of Education Key laboratory of Molecular and Cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024HebeiChina State Key laboratory of North China Crop improvement and Regulation College of AgronomyHebei Agricultural UniversityBaoding 071000HebeiChina State Key laboratory of Plant Cell and Chromosome Engineering Chinese Academy of SciencesBeijing 100101China Key laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong School of AgricultureLudong UniversityYantai 264025ShandongChina Hebei Collaboration innovation Center for Cell Signaling Shijiazhuang 050024HebeiChina College of life Science University of Chinese Academy of SciencesBeijing 100049China

Thousand-kernel weight(TKW)is a measure of grain weight,a target of wheat *** object of this study was to fine-map a stable quantitative trait loci(QTl)for TKW and identify its candidate gene in a recombinant inbred line(Ril)population derived from the cross of Kenong 9204(KN9204)and Jing411(J411).On a high-density genetic linkage map,24,26 and 25 QTl were associated with TKW,kernel length(Kl),and kernel width(KW),respectively.A major and stable QTl,QTkw-2D,was mapped to an8.3 cM interval on chromosome arm *** saturation of polymorphic markers in its target region,QTkw-2D was confined to a 9.13 Mb physical.interval using a secondary mapping population derived from a residually heterozygous line(F6:7).This interval was further narrowed to 2.52 Mb using QTkw-2D near-isogenic lines(Nils).Nils~(KN9204)had higher fresh and dry weights than NilsJ411at various grain-fil.ing *** TKW and KW of Nils~(KN9204)were much higher than those of NilsJ411in field *** comparison of both DNA sequence and expression between KN9204 and J411,TraesCS2D02G460300.1(TraesKN2D01HG49350)was assigned as a candidate gene for *** was confirmed by RNA sequencing(RNA-seq)of QTkw-2D *** results provide the basis of map-based cloning of QTkw-2D,and DNA markers linked to the candidate gene may be used in marker-assisted selection.

关键词： Wheat Thousand-kernel weight Fine mapping Candidate gene

低角与均角安氏Ⅱ类1分类错牙合肌激动器治疗前后软硬组织变化

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实用口腔医学杂志 2017年第5期33卷 689-694页

作者：张延晓陈瑛徐庆无锡牙病防治所 214001

目的:探讨肌激动器对不同骨面型的安氏Ⅱ类1分类患者矫治前后软硬组织变化的影响。方法:纳入22例骨性安氏Ⅱ类1分类患者[(男12例,女10例,平均年龄(11.5±0.67)岁],根据其骨面型分为低角组(n=15)和均角组(n=7)。肌激动器矫治前后拍摄头... 详细信息

目的:探讨肌激动器对不同骨面型的安氏Ⅱ类1分类患者矫治前后软硬组织变化的影响。方法:纳入22例骨性安氏Ⅱ类1分类患者[(男12例,女10例,平均年龄(11.5±0.67)岁],根据其骨面型分为低角组(n=15)和均角组(n=7)。肌激动器矫治前后拍摄头颅侧位定位片,头影测量分析治疗前后软硬组织的变化。用SPSS 13.0软件,t检验分析治疗结果差异。结果:所有患者治疗前后Co-Pg、ANB、Wits、NA-Pg、l1-APg和l6-MP值差异具有统计学意义(Pits值变化分别为1.34°±1.82°和3.50°±1.77°,NA-Pg值变化分别为(3.06±2.00)mm和(5.80±3.17)mm,牙齿项目中l1-APg变化值分别为(-1.16±1.74)mm和(-2.83±1.48)mm,组间差异均具有显著统计学意义(P0.05)。结论:肌激动器矫治低角和均角骨性安氏Ⅱ类1分类患者均能取得较理想的治疗效果,均角患者对矫治器的反映效果好于低角患者。

关键词：垂直骨面型肌激动器功能矫治器头影测量安氏Ⅱ^1

Efficient production of poly-γ-glutamic acid by Bacillus velezensis via solid-state fermentation and its application

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Food Bioscience 2022年第2期46卷 631-638页

作者： Hong liu Qiaojuan Yan Yuchuan Wang yanxiao li Zhengqiang Jiang Key laboratory of Food Bioengineering(China National light industry) College of EngineeringChina Agricultural UniversityBeijing100083China Beijing Advanced innovation Center for Food Nutrition and Human Health College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijing100083China

A novel glutamate-dependent poly-γ-glutamic acid(γ-PGA)-producing strain Bacillus velezensis CAU263 isolated from Chinese traditional Douchi was *** efficient method ofγ-PGA production was performed by this strain via solid-state fermentation(SSF)using guar *** maximal yield ofγ-PGA reached 158.5 g/kg dry weight(DW)in 250 ml flasks and 155.1 g/kg DW in shallow tray,*** molecular weight ofγ-PGA was 3.8×106 Da,the ratio of l/D-glutamic acid was 26.1%and 73.9%.Additionally,γ-PGA significantly improved the operating characteristics of wheat dough,the specific volume of bread was increased by 15.8%and the bread hardness was reduced by 44.2%owing to the addition of 0.3 g/kgγ-***,γ-PGA could be produced by Bacillus velezensis CAU263 at high level using guar meal and might have potential application prospect in food industry.

关键词： Bacillus velezensis Poly-γ-glutamic acid Guar meal Solid-state fermentation Bread quality

长三角地区景观生态风险与人类活动强度的响应及其时空关联

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农业工程学报 2022年第22期38卷 210-219,F0003页

作者：方林方斌刘艳晓蔡俊李灿锋安徽农业大学经济管理学院合肥230036 南京师范大学地理科学学院南京210023 东北师范大学地理科学学院长春130024 中国地质调查局昆明自然资源综合调查中心昆明650100

人类活动是诱发区域生态风险的重要因素,但生态风险与人类活动在不同尺度下的表征效果不一,响应程度不同,从多尺度科学地研究区域景观生态风险与人类活动强度的关联特征对于协调区域人地关系地域系统矛盾,推动地区可持续发展具有重要意... 详细信息

人类活动是诱发区域生态风险的重要因素,但生态风险与人类活动在不同尺度下的表征效果不一,响应程度不同,从多尺度科学地研究区域景观生态风险与人类活动强度的关联特征对于协调区域人地关系地域系统矛盾,推动地区可持续发展具有重要意义。该研究以长三角地区为研究对象,基于1990—2020年4期土地利用、夜间灯光、人口空间分布数据,建立市域、县域、格网三级尺度,构建景观生态风险及人类活动强度评估模型,刻画不同尺度下二者的时空响应特征,并基于Copula函数、双变量空间自相关及耦合协调度模型,揭示景观生态风险与人类活动强度的时空关联性。结果表明:1)1990—2020年间不同尺度下长三角地区景观生态风险均呈现北高南低的空间分布格局,且高风险地区持续减少,低风险区均呈增加趋势,其中市域尺度下高风险地区的减势最明显,而县域尺度下,低及中低风险区总体增势最为显著;2)1990—2020年间不同尺度下长三角地区人类活动强度均呈现东北高西南低的空间分布格局且高强度区域均呈现显著上升趋势,而低强度区域均明显下降,其中格网尺度下高强度区域增幅最大,达13.42个百分点,市域尺度下低强度区域的减幅最为明显,达9.76个百分点;3)1990—2020年间长三角地区人类活动强度与景观生态风险呈现正向相关性,但人类活动强度对于景观生态风险的影响正在削弱。空间上高-高(H-H)集聚区域呈现持续减少趋势,而低-低(l-l)呈现先增后减的变化趋势,低-高(l-H)及高-低(H-l)在2010年后增势明显。研究结果可为长三角地区国土空间优化及生态安全维护提供理论依据,为区域生态风险防范和生态修复提供参考。

关键词：土地利用景观生态人类活动尺度响应 Copula函数长三角地区