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Bioactivity‑Guided Isolation of Totarane‑Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3‑Deoxy‑2α‑hydroxynagilactone E

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Natural Products and Bioprospecting 2019年第2期9卷 157-163页

作者： P.Annécie Benatrehina Wei-lun Chen Austin A.Czarnecki Steven Kurina Hee-Byung Chai Daniel D.lantvit Tran N.Ninh Xiaoli Zhang Djaja D.Soejarto Joanna E.Burdette A.Douglas Kinghorn l.harinantenaina rakotondraibe Division of Medicinal Chemistry and Pharmacognosy The Ohio State UniversityCollege of PharmacyColumbusOHUSA Center for Biostatistics The Ohio State UniversityColumbusOHUSA College of Pharmacy University of Illinois at ChicagoChicagoILUSA John G.Searle Herbarium of the Field Museum of Natural History ChicagoILUSA Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology HanoiHanoiVietnam

Bioactivity-guided phytochemical investigation of Podocarpus neriifolius ***.(Podocarpaceae)has led to the isolation of one new(2)and three known(1,3,and 4)B-type podolactones,along with three totarane-type diterpenes(5-7).Their structures were determined by interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry(HRESIMS)and 1D and 2D NMR data,and comparison with the values reported in the *** structure of compound 1,previously identifed as 3-deoxy-2α-hydroxynagilactone E(8),was revised as its 2β-epimer,which has been reported recently as a new *** of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines,namely,ovarian(OVCAR3),breast(MDA-MB-231),colon(HT-29),and melanoma(MDA-MB-435),and compounds 1 and 3 were found to be cytotoxic with IC_(50) values in the low micromolar range for most of the cell lines *** major compound,inumakilactone A(3),was further tested in vivo using the HT-29,MDA-MB-435,and OVCAR3 cells in a murine hollow fber model,for the frst time.

关键词： Podocarpus neriifolius Nagilactone G-2β-O-β-d-glucoside Hollow fber assay 3-Deoxy-2αhydroxynagilactone E Antiproliferative B-type podolactone

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Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis(Baker)***

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Natural Products and Bioprospecting 2016年第5期6卷 261-265页

作者： Vincent E.Rasamison Peggy J.Brodie Emilio F.Merino Maria B.Cassera Michel A.Ratsimbason Stephan Rakotonandrasana Andriamalala Rakotondrafara Elie Rafidinarivo David G.I.Kingston harinantenaina l.rakotondraibe Centre National d’Application de Recherches Pharmaceutiques B.P.702101 AntananarivoMadagascar Department of Chemistry and the Virginia Tech Center for Drug Discovery M/C 0212Virginia TechBlacksburgVA 24061USA Department of Biochemistry and the Virginia Tech Center for Drug Discovery M/C 0308Virginia TechBlacksburgVA 24061USA Institut Superieur de Technologie B.P.8122101 AntananarivoMadagascar Division of Medicinal Chemistry and Pharmacognosy College of PharmacyThe Ohio State UniversityColumbusOH 43210USA

Melicope madagascariensis(Rutaceae)is an endemic plant species of Madagascar that was first classified as a member of the genus Euodia J.R.&***(Rutaceae)under the scientific name Euodia madagascariensis *** on morphological characteristics,Thomas Gordon Hartley taxonomically revised *** Baker to be ***(Baker)*** studies have long been used to help the identification and confirmation of taxonomical classification of plant species and *** to find more evidences to support the taxonomical revision performed on ***,we carried out phytochemical investigation of two samples of the *** of the ethanol extracts prepared from two stem bark samples of ***(Baker)*** led to the isolation of seven known furoquinoline alkaloids 1–7 and two known methoxyflavones 8 and *** presence of furoquinoline alkaloids and methoxyflavones in the title species is in agreement with its taxonomic transfer from Euodia to *** evaluation of the isolated compounds showed that 6-methoxy-7-hydroxydictamnine(heliparvifoline,3)showed weak antimalarial activity(IC_(50)=35μM)against the chloroquine-resistant strain Dd2 of Plasmodium ***(4)displayed moderate cytotoxicity with IC_(50)value of 1.5 lM against HT-29 colon cancer cell line whereas 3,5-dihydroxy-30,40,7-trimethoxyflavone(9)was weakly active in the same assay(IC_(50)=13.9μM).

关键词： Chemotaxonomy Furoquinoline alkaloids Methoxyflavones Antimalarial activity Cytotoxicity Melicope madagascariensis(Rutaceae)

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