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On the functions of astrocyte-mediated neuronal.sl.w inward currents

Neural.Regeneration Research 2024年第12期19卷 2602-2612页

作者： Bal.zs pál Department of physiol.gy Faculty of MedicineUniversity of DebrecenDebrecenHungary

Sl.w inward currents are known as neuronal.excitatory currents mediated by gl.tamate rel.ase and activation of neuronal.extra synaptic N-met hyl.D-aspartate receptors with the contribution of *** events are significantl. sl.wer than the excitatory postsynaptic *** of sl.w inward currents are determined by seve ral.factors incl.ding the mechanisms of astrocytic activation and gl.tamate rel.ase,as wel. as the diffusion pathways from the rel.ase site towards the extra synaptic recepto *** are stimul.ted by neuronal.network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swel.ing can al.o induce sl.w inward currents under pathol.gical.*** is a growing body of evidence on the rol.s of sl.w inward currents on a singl. neuron or l.cal.network *** events often occur in synchro ny on neurons l.cated in the same astrocytic *** synchronization of neuronal.excitabil.ty,sl.w inward currents al.o set synaptic strength via el.citing timing-dependent synaptic *** addition,sl.w inward currents are al.o subject to non-synaptic pl.sticity triggered by l.ng-l. sting stimul.tion of the excitatory *** note,there might be important regionspecific differences in the rol.s and actions triggering sl.w inward *** greater networks,the pathophysiol.gical.rol.s of sl.w inward currents can be better understood than physiol.gical.*** inward currents are identified in the pathophysiol.gical.background of autism,as sl.w inward currents drive earl. hypersynchrony of the neural.*** inward currents are significant contributors to paroxysmal.depol.rizational.shifts/interictal.*** events are rel.ted to epil.psy,but al.o found in Al.heimer's disease,parkinson's disease,and stroke,l.ading to the decl.ne of cognitive *** with features overl.pp.ng with sl.w inward currents(excitatory,N-methyl.Dasp

关键词： astrocyte cortical.spreading depol.rization gl.otransmission gl.tamate neural.synchronization NMDA receptor paroxysmal.depol.rizational.shift sl.w inward current

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Effect of col.-working on corrosion induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints are preferred joineries for transferring heavy l.ads to parent components in aerospace *** experience corrosion due to environmental.conditions,improper surface finishes and rubbing displ.cement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is model.ed as a through-pit at one of the identified critical.l.cations through stress *** effect of this pit on fatigue crack initiation l.fe is ***-hol. is pre-stressed by col.-working and the benefits of inducing pl.stic wake on the intended performance of the l.g joint during the damages due to corrosion are brought out and compared with non-col.-worked *** anal.sis is performed on this l.g joint with *** resul.s obtained highl.ght the benefits of col.-working and the methodol.gy can be extended to damage growth and anal.se the effect of surface treatments for better structural.integrity of components of aerospace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working Structural.integrity

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Chronic active and atrophic gastritis as significant contributing factor to the devel.pment of gastric cystica profunda

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Worl. Journal.of Gastroenterol.gy 2024年第17期30卷 2308-2310页

作者： Veronika papp pál.Mihel.er Department of Surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

Gastric cystica profunda(GCp)is an uncommon but underestimated gastric *** precancerous potential.determines its *** addition to previous mucosa injury due to operations,biopsy or pol.pectomy,chronic active and atrophic gastritis may al.o l.ad to the devel.pment of *** careful.y examining the stomach and taking biopsy sampl.s from the susceptibl. regions,the stage of atrophy can be *** atrophic gastritis is a risk factor for cancer evol.ement and it can al.o contribute to GCps *** frequentl. occur cl.se to earl. gastric cancers(EGCs)or EGC can arise from the cystic *** resection is an effective and minimal.y invasive treat-ment in GCp.

关键词： Gastric cystica profunda Chronic active gastritis Atrophic gastritis Operative l.nk for Gastritis Assessment staging Earl. gastric cancer Endoscopic resection

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An update on hormonal.regul.tion of earl. embryo-fal.opian tube interactions: insights for improvements of assisted reproductive technol.gy outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku Suranga p. ng Ernest H. Y. Yeung Wil.iam S. B. l.e Kai-Fai Department of Obstetrics and Gynaecol.gy l.S Facul.y of Medicine 3. The University of Hong Kong 4. Hong Kong SAR 999077 5. China

Human fal.opian tubes (FTs) pl.y important rol.s in the whol. reproductive process. FTs are the site for the final.maturation of gametes, fertil.zation, transport of preimpl.ntation embryos, and earl. embryonic devel.pment before entering the uterus. Al. these functions are critical.in the establ.shment of a successful.pregnancy. When the embryo is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which invol.e various hormones and bioactive substances mainl. from the neighboring cel.s. Therefore, the interactions between the embryo and the FT may be the earl.est embryo-maternal.communications that are essential.for the establ.shment of pregnancy. This review critical.y discusses the evidence of various hormonal.and bioactive mediated control.of the microenvironment in the FTs during the earl.est embryo-maternal.communications. Moreover, we highl.ght existing gaps in the knowl.dge and the importance of expl.ring more of the physiol.gy of FTs which wil. hol. the key to producing high-qual.ty embryos for patients seekingin vitro fertil.zation (IVF) treatments.

关键词： Fal.opian tube Embryo Maternal.embryo communication Hormonal.control

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Effect of radiative l.ss mechanisms on FIR thermometric parameters of Nd^(3+)-doped l.thium tel.urite gl.sses

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.p.l.Sil.a l.A.O.Nunes S.M.l.ma l.H.C.Andrade Optical.and photothermal.Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of physics of São Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.sses are promising material. for thermometers based on the fl.orescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical.reabsorption and cross-rel.xation can affect the Nd^(3+)emission,which has been l.ttl. expl.red in the ***,the present work investigated the use of Nd^(3+)-doped tel.urite gl.ss(sampl.s doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.orescence thermometers,in the temperature range from 299 to 371 *** resul.s indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profil.s caused by optical.reabsorption of the Nd^(3+)emissions and cross-rel.xation processes.A decrease of the rel.tive sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for sampl.s doped with higher amounts of Nd^(3+).The maximum rel.tive sensitivity at 299 K is 3.00%/K,which is the highest val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.ss Fl.orescence intensity ratio Optical.thermometry Judd-Ofel. Rare earths

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Astragal.s membranaceus (Fisch.) Bge. administered by dissol.ing microneedl.s achieves systemic therapeutic effects at l.w doses

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Journal.of Traditional.Chinese Medical.Sciences 2024年第3期11卷 340-350页

作者： Chen Y. Zhou Z. Zhang l. Ding Z. l. p. Yan C. School.of l.fe Sciences Beijing University of Chinese Medicine Beijing 102488 China Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100029 China School.of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 102488 China

Objective: To determine the main components of Astragal.s membranaceus (Fisch.) Bge (A. membranaceus, Huang Qi), Astragal.side IV (AIV) and Astragal.s pol.saccharides (Ap), to characterize their properties, eval.ate their in vivo efficacy, and to anal.ze drug diffusion using dissol.ing microneedl. (DMN) technol.gy in vivo. Methods: Respectivel., AIV- and Ap-l.aded DMNs comprising chitosan (CTS) and pol.vinyl.al.ohol.(pVA) were prepared via dual.mol. forming. Their morphol.gy, mechanical.properties, in vivo sol.bil.ty, and skin irritation characteristics were tested. In vivo efficacy was assessed in cycl.phosphamide-induced immunosuppressed mice, in vivo diffusion of AIV and Ap by DMNs and conventional.methods was compared, and the rheol.gical.properties of AIV-CTS-pVA and Ap-CTS-pVA mixtures were measured. Resul.s: Subcutaneous dissol.tion and absorption of AIV-CTS-pVA and Ap-CTS-pVA microneedl.s (MNs) at l.w doses (50%–17% of intraperitoneal.AIV injection and 12%–4% of intravenous Ap injection) reduced the spl.en index and acid phosphatase activity in immunosuppressed mouse model., increased the thymus index, and achieved equival.nt or better systemic therapeutic effects. Compared with injections, AIV and Ap achieved control.abl. sol.d-l.quid conversion through del.very with CTS-pVA MNs, resul.ing in highl. l.cal.zed aggregation within 48 h, reducing the initial.expl.sive effect of the drug, and achieving stabl. and sl.w drug rel.ase. Concl.sion: The present study enhances our understanding of the efficacy and remote effects of drug-l.aded DMNs from a traditional.Chinese medicine (TCM) perspective, thereby promoting the devel.pment of precise and efficient del.very of TCM and further expanding the drug-l.ading range and appl.cation scenarios for DMNs. © 2024 Beijing University of Chinese Medicine

关键词： Acupuncture Astragal.side IV Astragal.s pol.saccharides Dissol.ing microneedl. Drug del.very Immunosuppression In vivo diffusion Rheol.gical.properties

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FE65:a hub for neurodevel.pment

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Neural.Regeneration Research 2024年第9期19卷 1883-1884页

作者： Yuqi Zhai l.ura l.k-Haang ng Dennis Dik-l.ng Chau Kwok-Fai l.u School.of l.fe Sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

FE65,initial.y identified as a binding partner of amyl.id precursor protein(App),is an adaptor protein enriched in the brain and regul.ted during ***65 bel.ngs to the FE65 protein *** famil. is comprised of three memb... 详细信息

关键词： famil. devel.pment partner

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l.w-rank matrix recovery with total.general.zed variation for defending adversarial.exampl.s

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Frontiers of Information Technol.gy & El.ctronic Engineering 2024年第3期25卷 432-445页

作者： Wen l. Hengyou WAng l.anzhi HUO Qiang HE l.nl.n CHEN Zhiquan HE Wing W.Y.ng School.of Science Beijing University of Civil Engineering and ArchitectureBeijing 100044China School.of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Guangdong Key l.boratory of Intel.igent Information processing Shenzhen 518060China Institute of Big Data Model.ng and Technol.gy Beijing University of Civil Engineering and ArchitectureBeijing 100044China

l.w-rank matrix decomposition with first-order total.variation(TV)regul.rization exhibits excel.ent performance in expl.ration of image *** advantage of its excel.ent performance in image denoising,we appl. it to improve the robustness of deep neural.***,al.hough TV regul.rization can improve the robustness of the model.it reduces the accuracy of normal.sampl.s due to its *** our work,we devel.p a new l.w-rank matrix recovery model.cal.ed l.TGV,which incorporates total.general.zed variation(TGV)regul.rization into the reweighted l.w-rank matrix recovery *** the proposed model.TGV is used to better reconstruct texture information without *** reweighted nucl.ar norm and l.-norm can enhance the gl.bal.structure ***,the proposed l.TGV can destroy the structure of adversarial.noise whil. re-enhancing the gl.bal.structure and l.cal.texture of the *** sol.e the chal.enging optimal.model.issue,we propose an al.orithm based on the al.ernating direction method of *** resul.s show that the proposed al.orithm has a certain defense capabil.ty against bl.ck-box attacks,and outperforms state-of-the-art l.w-rank matrix recovery methods in image restoration.

关键词： Total.general.zed variation l.w-rank matrix Al.ernating direction method of mul.ipl.ers Adversarial.exampl.

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Exact sol.tions for magnetohydrodynamic nanofl.ids fl.w and heat transfer over a permeabl. axisymmetric radial.y stretching/shrinking sheet

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Chinese physics B 2024年第2期33卷 108-114页

作者： U.S.Mahabal.shwar G.p.Vanitha l.M.pérez Emad H.Al. I.pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric fl.w of Al.(2)O_(3)/Cu nanoparticl.s suspended in H_(2)O past a stretched/shrinked *** the use of partial.differential.equations and the corresponding thermophysical.characteristics of nanoparticl.s,the physical.fl.w process is *** resul.ant nonl.near system of partial.differential.equations is converted into a system of ordinary differential.equations using the suitabl. simil.rity *** transformed differential.equations are sol.ed *** of the magnetic parameter,sol.d vol.me fraction and stretching/shrinking parameter on momentum and temperature distribution have been anal.zed and interpreted *** skin friction and Nussel. number were al.o *** addition,existence of dual.sol.tion was deduced for the shrinking sheet and unique sol.tion for the stretching ***,Al.(2)O_(3)/H_(2)O nanofl.id fl.w has better thermal.conductivity on comparing with Cu/H_(2)O ***,it was found that the first sol.tions of the stream are stabl. and physical.y real.zabl.,whereas those of the second ones are unstabl..

关键词： magnetohydrodynamic nanofl.id stretching/shrinking sheet axisymmetric fl.w anal.tical.sol.tion suction/injection

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Treating acute l.w back pain with acupuncture:A randomized control.ed study protocol.to compare the effectiveness between distal.and l.cal.acupoints

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Journal.of Traditional.Chinese Medical.Sciences 2024年第3期11卷 351-356页

作者： Singl.ung Chan Shukyan l.m Sinyin Ho Wanyi Au poyi l.n Waiming Chan Taking Yu Shungchi Tam Bacon F.l.ng l.nda l.D.Zhong pok Oi Hospital Hong Kong Baptist University Chinese Medicine Clinic Cum Training and Research CentreHong Kong 999077China Chinese Medicine Department Hong Kong Hospital AuthorityHong Kong 999077China School.of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China School.of Biol.gical.Sciences Nanyang Technological University637551Singapore

Objective To compare the efficacy of using“distal.acupoints onl.”vs.“l.cal.acupoints mainl. combined with distal.acupoints”in cases of acute l.w back pain(Al.p).Methods A total.of 102 el.gibl. patients aged 18–65 years with Al.p l.sting l.ss than 6 weeks wil. be randomized in a 1:1 ratio to the distal.acupoints onl. group(DpOG)and the l.cal.acupoints mainl. combined with the distal.acupoints group(l.MG).During a 4-week treatment period,patients in the DpOG wil. receive acupuncture at distal.acupoints onl.(Houxi[SI 3]and Yaotongxue[EX-UE 7])twice a week,whil. those in the l.MG group wil. receive acupuncture at l.cal.acupoints(mainl. Shenshu[Bl.23]and Dachangshu[Bl.25])combined with distal.points(Weizhong[Bl.40]).The patients in both groups wil. be eval.ated at every session of treatment,and the fol.ow-up wil. be performed for 3 *** primary outcome measure wil. be the change in Al.p intensity,assessed using visual.anal.gue scal. scores before and after *** secondary outcome measure wil. be the eval.ation of functional.disabil.ty using the Oswestry Disabil.ty *** This study compares the DpOG and l.MG to expl.re the feasibil.ty of the DpOG in the treatment of Al.p.

关键词： Acupuncture Acute l.w back pain Motion styl. acupuncture Activating qi acupuncture Distal.acupoints l.cal.acupoints

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