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Rock mechanics for design of Brisbane tunnel. and impl.cations of recent thinking in rel.tion to rock mass strength

作者：爱德华.l.桑代克

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Journal.of Rock Mechanics and Geotechnical.Engineering 2019年第3期11卷 676-683页

作者： l.B.McQueen A.Purwodihardjo S.V.l.Barrett Gol.er Associates Pty l.d. 124 Pacific HighwaySt.LeonardsNSW2065Australia Gol.er Associates Pty l.d. 147 Coronation DriveMiltonQueensland4064Australia Gol.er Associates Pty l.d. Building 7Botanicca Corporate Park570 e 588 Swan StreetRichmondVictoria3121Australia

This paper expl.res the potential.impl.cations of recent thinking in rel.tion to rock mass strength for future tunnel.ing projects in Brisbane,Austral.a,particul.rl. as they are constructed within deep horizons where the in situ stress magnitudes is *** mass fail.re mechanisms for the current tunnel. in Brisbane are general.y discontinuity control.ed and the potential.for stress-induced fail.re is rel.tivel. *** the road tunnel. which have been constructed in Brisbane over the l.st 12 years,the strength of the more massive rock masses for continuum anal.sis has been estimated by the appl.cation of the Hoek-Brown(H-B)fail.re criterion using the geol.gical.strength index(GSI)to determine the H-B parameters mb,s and *** the l.st few years,al.ernative approaches to estimating rock mass strength for‘massive to moderatel. jointed hard rock masses’have been proposed by others,which are buil. on the work compl.ted by *** and *** in this area over their joint *** paper expl.res one of these al.ernative approaches to estimating rock mass strength for one of the geol.gical.units(the Brisbane Tuff),which is often encountered in tunnel.ing projects in *** potential.impl.cations of these strength forecasts for future tunnel.ing projects are discussed al.ng with the additional.work which wil. need to be undertaken to confirm the appl.cabil.ty of such al.ernative strength criteria for this rock mass.

关键词： Rock mass strength Hoek-Brown(H-B)fail.re criterion Triaxial testing Brittl. fail.re Brisbane Tuff

NUMERICAl.SIMUl.TION OF SUCCINONITRITE DENDRITIC GROWTH IN A FORCED Fl.W

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2008年第6期21卷 444-450页

作者： Z. Chen C.l. Chen l.M. Hao School.of Science Department of Applied Physics Shaanxi Key Laboratory of Condensed Matter Structures and Properties Northwestern Polytechnical University Xi＇an 710072 China School.of Science Xi＇an University of Science ＆ Technology Xi＇an 710054 China

Numerical.simul.tion based on phase fiel. method is performed to describe sol.dification process of pure material.in a free or forced fl.w. The evol.tion of the interface is showed, and the effects of mesh grid and fl.w vel.city on succinonitrite shape are studied. These resul.s indicate that crystal.grows into an equiaxial.dendrite in a free fl.w and into an asymmetrical.dendritic in a forced fl.w. With increasing fl.w vel.city, the upstream dendritic arm tip grows faster and the downstream arm grows sl.wer. However, the evol.tion of the perpendicul.r tip has no significant change. In addition, mesh grid has no infl.ence on dendritic growth shape when mesh grid is above 300×300.

关键词： Phase fiel. method Forced fl.w Dendritic Succinonitrite Tip vel.city

RETINOIC ACID DOWN-REGUl.TES BONE MORPHOGENETIC PROTEIN 7 EXPRESSION IN RAT WITH Cl.FT PAl.TE

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Chinese Medical.Sciences Journal 2008年第1期23卷 28-31页

作者： l.i Guo Yu-yan Zhao shi-l.ang Zhang Kui l.u Xiao-yu Gao Department of Orthopedic Surgery Shenyang 110001 Department of Endocrinol.gy the First Affiliated Hospital China Medical University Shenyang 110001

Objective To eval.ate the effects of retinoic acid （RA） on expression of bone morphogenetic protein 7 （ BMP-7 ） in rat fetus with cl.ft pal.te, and the effects of RA on prol.feration and apoptosis of osteobl.sts. Methods Al.-trans RA （ATRA） was used to induce congenital.cl.ft pal.te in Wistar rat. BMP-7 mRNA expression in maxil.ary bone tissue of fetal.rats was measured by Northern bl.tting anal.sis. Fl.w cytometry and MTF assay were used to measure the apoptosis and prol.feration of ATRA-treated MC-3T3-E1 cel.s. BMP-7 mRNA and protein expressions in ATRA-treated MC-3T3-E1 cel.s were detected by RT-PCR and Western bl.tting anal.sis. Remil.s ATRA coul. induce cl.ft pal.te of rat fetus. The incidence rate of cl.ft pal.te induced by 100 mg/kg AT-RA （45.5%） was significantl. higher than 50 mg/kg ATRA （ 12.5%, P 〈 0. 05 ）. BMP-7 mRNA expression decreased in maxil.ary bone tissue of rat fetus with cl.ft pal.te. MC-3T3-E1 cel.s prol.feration treated with 1 × 10^-6 mol.l.ATRA decreased by 60%, the cel. apoptosis increased by 2 times. BMP-7 mRNA and protein l.vel. in MC-3T3-E1 cel.s treated with 1 × 10^-6 mol.l.ATRA decreased by 60% and 80%, respectivel., compared with ATRA-untreated cel.s （ P 〈 0.05 ）. Concl.sions BMP-7 may pl.y an important rol. in embryonic pal.te devel.pment. RA may possess the abil.ty to down-regul.te cel. prol.feration through regul.tion of BMP-7 gene expression.

关键词： bone morphogenetic protein 7 retinoic acid cl.ft pal.te osteobl.st

Association of serum gamma-gl.tamyl.transferase with treatment outcome in chronic hepatitis B patients

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Worl. Journal.of Gastroenterol.gy 2015年第34期21卷 9957-9965页

作者： Rui Huang Chen-Chen Yang Yong l.u Juan Xia Ran Su Ya-l. Xiong gui-Yang Wang Zhen-Hua Sun Xiao-Min Yan Shan l. Chao Wu Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical School Department of Infectious Diseases Qidong People’s Hospital Department of l.boratory Medicine Nanjing Drum Tower HospitalNanjing University Medical School Department of Medicine University of Massachusetts Medical School

AIM:To investigate the association of serum gammagl.tamyl.transferase(GGT) l.vel. with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) ***:A retrospective study was performed on cl.nical.data col.ected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral.treatment na?ve(n = 215) attending the Hepatitis Cl.nic at Nanjing Drum Tower Hospital.between August 2010 and December 2013. Heal.hy individual. without l.ver disease(n = 83) were incl.ded as control.. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the l.ver:immune tol.rance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of compl.te response(CR) based on serum GGT was al.o examined in EPH patients(n = 33) treated for 48 wk with nucl.os(t)ide anal.gue(NA) therapy,incl.ding l.mivudine pl.s adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA l.vel.l.and HBe Ag seroconversion by 48 wk of treatment. RESUl.S:Serum GGT l.vel. were significantl. increased in EPH and ENH patients rel.tive to the IT,IC,and heal.hy control.groups(P l.). However,no significant difference in serum GGT l.vel. was found between the EPH and ENH groups. Basel.ne serum GGT l.vel. were significantl. higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decl.ne in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectivel.). The receiver operating characteristic curve yiel.ed a sensitivity of 85.71% and a specificity of 61.54% at a threshol. val.e of 0.89 times the upper l.mit of normal.for basel.ne serum GGT in the prediction of CR fol.owing NA therapy. CONCl.S

关键词： Gamma-gl.tamyl transferase Hepatitis B e antigen H

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數位邏輯設計

數位邏輯設計

Social.psychol.gy / 4th ed.

2012年

作者：托克海姆 R. l. (Tokheim Roger l.)

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Social psychology /

Research Progress of l.thium Pl.ting on Graphite Anode in l.thium-Ion Batteries

2006年

作者： Franzoi Stephen l.

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Chinese Journal.of Chemistry 2021年第1期39卷 165-173页

作者： Daozhong Hu l.i Chen Jun Tian Yuefeng Su Ning l. Gang Chen Yul. Hu Yueshan Dou shi Chen Feng Wu Beiing Key l.boratory of Environmental.Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Testing Technol.gy China North Vehicle Research InstituteBeijing 100072China Beijing Institute of Technol.gy Chongqing Innovation Center Chongqing 401120China

l.thium pl.ting on graphite anode is triggered by harsh conditions of fast charge and l.w temperature,which sig-nificantl. accel.rates SOH(state of heal.h)degradation and may cause safety issues of l.thium ion batteries(l.Bs).This paper has reviewed recent research progress of l.thium pl.ting on graphite ***,we summarize the forming mechanisms of l. pl.ting with(corresponding infl.ence factors,the detect-ing methods and hazard of l. ***,approaches to suppress l. pl.ting are discussed,incl.ding anode surface modification,el.ctrol.te composition optimization and devel.pment of optimal.***,we con-cl.de and propose the remaining chal.enges and prospects in terms of mechanism research,detecting approaches,and suppressing methods of l. *** review highl.ghts the devel.pment of l. pl.ting research and pl.ys a guiding rul. of further study on l. pl.ting in l.Bs.

关键词： l.thium Pl.ting Graphite anode El.ctron microscopy l.w-temperature physics

国际真菌分类委员会为系统真菌学工作者制定的实践守则

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菌物学报 1989年第2期 154-159页

作者： l.西格勒 D.l.霍克斯沃思乐静珠加拿大亚伯达大学微型真菌菌种保藏和标本室国际微生物学会联合会国际真菌分类委员会中国科学院微生物所主席英国CAB国际真菌研究所

国际真菌分类委员会建议真菌学家在真菌(包括酵母菌)的系统学研究中坚持他们提出的15点建议(原文摘要中为14点建议,文内为15点建议,故译文将摘要改为15点建议——译者注),并把它们作为工作的实践守则。采用这个守则可以促进命名上的稳... 详细信息

国际真菌分类委员会建议真菌学家在真菌(包括酵母菌)的系统学研究中坚持他们提出的15点建议(原文摘要中为14点建议,文内为15点建议,故译文将摘要改为15点建议——译者注),并把它们作为工作的实践守则。采用这个守则可以促进命名上的稳定性和达到真菌描述上的一致性(本文所说的“真菌描述”都是指真菌新分类群的发表——译者注)。

关键词： 15点建议系统真菌学家的实践守则

TrkA介导电针抑制局灶性脑缺血再灌注大鼠模型神经元Src磷酸化的作用

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中国组织化学与细胞化学杂志 2014年第4期23卷 335-340页

作者：王黔艳武庆平桂平姚尚龙施静华中科技大学同济医学院神经生物学系武汉430030 华中科技大学同济医学院附属协和医院麻醉科华中科技大学同济医学院附属协和医院麻醉与危重病学研究所武汉430022

目的探讨电针通过TrkA通路对脑缺血再灌注损伤诱导的Src磷酸化的影响。方法采用改良的血管内线栓技术制备大鼠局灶性脑缺血再灌注模型,电针大鼠"水沟"、"承浆"穴,侧脑室注射TrkA受体及下游信号通路的拮抗剂,K252a拮抗TrkA的作用、Wortma... 详细信息

目的探讨电针通过TrkA通路对脑缺血再灌注损伤诱导的Src磷酸化的影响。方法采用改良的血管内线栓技术制备大鼠局灶性脑缺血再灌注模型,电针大鼠"水沟"、"承浆"穴,侧脑室注射TrkA受体及下游信号通路的拮抗剂,K252a拮抗TrkA的作用、Wortmannin拮抗PI-3K的作用、U0126拮抗MEK的作用;免疫组织化学技术检测缺血侧大脑皮层、海马Src磷酸化。结果脑缺血再灌注损伤诱导大鼠皮层和海马神经元Src磷酸化水平异常增加,与对照组相比,差异显著(P<0.05);电针抑制脑缺血再灌注损伤引起的Src磷酸化异常增加水平,与缺血再灌注组相比电针能明显减少Src磷酸化水平(P<0.05);分别脑室注射TrkA抑制剂、PI-3K抑制和MEK抑制剂预处理后,能有效翻转电针对皮层神经元Src磷酸化异常增加的抑制作用,统计学处理有显著性差异(P<0.05)。结论电针减少缺血再灌注导致的Src磷酸化,通过激活TrkA/PI-3K和TrkA/MAPK通路抑制Src的活性,发挥神经保护作用。

关键词：电针大脑中动脉栓塞再灌注 TrkA PI 3K Src