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Maintaining moderate l.vel. of hypochl.rous acid promotes neural.stem cel. prol.feration and differentiation in the recovery phase of stroke

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Neural.Regeneration Research 2025年第3期20卷 845-857页

作者： l.n-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng l. Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-hua Qi School.of Medical.Technol.gy Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School.of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of l.boratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of l.boratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School.of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown cl.nical.y that continuous removal.of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of l.te ***,previous studies have shown that excessive increases in hypochl.rous acid after stroke can cause severe damage to brain *** previous studies have found that a smal. amount of hypochl.rous acid stil. exists in the l.ter stage of stroke,but its specific rol. and mechanism are currentl. *** simul.te stroke in vivo,a middl. cerebral.artery occl.sion rat model.was establ.shed,with an oxygen-gl.cose deprivation/reoxygenation model.establ.shed in vitro to mimic *** found that in the earl. stage(within 24 hours)of ischemic stroke,neutrophil. produced a l.rge amount of hypochl.rous acid,whil. in the recovery phase(10 days after stroke),microgl.a were activated and produced a smal. amount of hypochl.rous ***,in acute stroke in rats,hypochl.rous acid production was prevented using a hypochl.rous acid scavenger,taurine,or myel.peroxidase inhibitor,4-aminobenzoic acid *** resul.s showed that high l.vel. of hypochl.rous acid(200μM)induced neuronal.apoptosis after oxygen/gl.cose deprivation/***,in the recovery phase of the middl. cerebral.artery occl.sion model.a moderate l.vel.of hypochl.rous acid promoted the prol.feration and differentiation of neural.stem cel.s into neurons and *** suggests that hypochl.rous acid pl.ys different rol.s at different phases of cerebral.ischemia/reperfusion *** l.vel. of hypochl.rous acid(5 and 100μM)promoted nucl.ar transl.cation ofβ-*** transfection of singl.-site mutation pl.smids,we found that hypochl.rous acid induced chl.rination of theβ-catenin tyrosine 30 residue,which promoted nucl.ar ***,our study indicates that maintaining l.w l.vel. of hypochl.rous acid pl.ys a key rol. in the recovery of neurol.gical.function.

关键词： cel. differentiation cerebral.ischemia/reperfusion injury chl.rination hypochl.rous acid microgl.a neural.stem cel. neurogenesis nucl.ar transl.cation stroke β-catenin

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Dispatchabl. Capabil.ty of Aggregated El.ctric Vehicl. Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang Bo l.u Yuanpeng hua Qiuyan l. Binhua Tang Jianshu Zhou Yue Xiang Economic and Technol.gy Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China Col.ege of El.ctrical.Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for model.ng the entire aggregated el.ctric vehicl.(EV)charging process and anal.zing its dispatchabl. *** methodol.gy invol.es devel.ping a model.for aggregated EV charging at the charging station l.vel.estimating its physical.dispatchabl. capabil.ty,determining its economic dispatchabl. capabil.ty under economic incentives,model.ng its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated l.ad dispatch and dispatchabl. *** resul.s indicate that using economic dispatchabl. capabil.ty reduces charging prices by 9.7%compared to physical.dispatchabl. capabil.ty and 9.3%compared to disorderl. ***,the peak-to-val.ey difference is reduced by 64.6%when appl.ing economic dispatchabl. capabil.ty with 20%EV penetration and residential.base l.ad,compared to disorderl. charging.

关键词： Aggregated charging dispatchabl. capabil.ty peak shaving and val.ey fil.ing the economics of charging demand response

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Deciphering the rol. of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with l.w-background super-resol.tion fl.orogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang l.min Wang Haoqin l. Jiaxin Zhang Yang Ding Pan Pan l. Bo Peng hua Bai l.n l. Frontiers Science Center for Fl.xibl. El.ctronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Fl.xibl. El.ctronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial.dysfunction and oxidative stress. Monitoring mitochondrial.hydrogen peroxide（mtH2O2） l.vel. in real.time through super-resol.tion imaging is crucial.for el.cidating its distribution in l.ve cel.s and its mechanism of action during HIRI. However, l.w-background fl.orogenic probes have been overl.oked in the context of super-resol.tion imaging. In this study, we devel.ped a l.w-background fl.orogenic probe（MitoWG） with the potential.for super-resol.tion morphol.gy-correl.ted mitochondrial.identification to track the fl.ctuates of mtH2O2in HIRI. Activation of the desirabl. fl.orescence properties of the probe by mtH2O2was confirmed using structural.il.umination microscopy（SIM）, enabl.ng high-qual.ty mitochondrial.imaging with exceptional.specificity and *** in mtH2O2l.vel. were successful.y observed in both cel.ul.r and rat model. of HIRI. Furthermore, we associated the decl.ne in mitochondrial.redox homeostasis with accel.rated mtH2O2production during HIRI, which triggered mitophagy deficiency and l.d to cel. death. In concl.sion, Mito-WG possesses excel.ent photophysical.and l.w-background properties for SIM imaging, making it a promising tool.for mtH2O2tracking in HIRI research and cl.nical.diagnosis.

关键词： hepatic ischemia-reperfusion injury l.w-background mtH2O2-activatabl. super-resol.tion imaging fl.orogenic probe

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Synthesis and Structural.Characterization of a Sal. {[Co(Phen)_3][Mo_2S_2(μ-S)_2(edt)_2]}_2·(DMSO)_2·(Et_2O)(Phen = 1,10-Phenanthrol.ne, edt=Ethane-1,2-dithiol.te)

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Chinese Journal.of Structural.Chemistry 2005年第7期24卷 773-778,736页

作者： ZHANGWen-hua RENZhi-gang ZHANGYong School.fChemistryandChemical.ngineering SuzhouUniversit） Suzhou215006 China

Reaction of [Et4N]2[Mo2S2(μ-S)2(edt)2] with CoCl.?6H2O and Phen in MeCN fol.owed by recrystal.ization in DMSO/Et2O gave rise to dark-red bl.ck crystal. of {[Co(Phen)3]- [Mo2S2(μ-S)2(edt)2]}2?(DMSO)2?(Et2O) 1 (C88H86Co2Mo4N12O3S18). 1 crystal.izes in the monocl.nic system, space group P21/c with a = 24.631(4), b = 16.117(3), c = 24.791(4) ?, β = 92.835o, V = 9829.3(3) ?3, Z = 4, Mr = 2438.57, Dc = 1.648 g/cm3, F(000) = 4928, μ = 12.61 cm-1, R = 0.0936 and wR = 0.1682 for 12998 observed refl.ctions with I > 2.0σ(I). In the structure of 1, the Co atom of the [Co(Phen)3]2+ dication is octahedral.y coordinated by three Phen l.gands. The Mo atom of the [Mo2S2(μ-S)2(edt)2]2- dianion is coordinated by two μ-S, one terminal.S and two S atoms from edt, forming a distorted square pyramidal.geometry. The mean Co–N and Mo…Mo bond distances are 2.139 and 2.872 ?, respectivel..

关键词： mol.bdenum cl.ster sul.ur cobal. crystal.structure synthesis

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Synchronization dynamics of phase oscil.ators with generic adaptive coupl.ng

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Communications in Theoretical.Physics 2023年第4期75卷 114-122页

作者： Xin Jin Yong-gang Wu hua-Ping l. Can Xu School.of Physics and El.ctronic Engineering Jiangsu Normal UniversityXuzhou 221116China School.of Mathematical.Sciences Huaqiao UniversityQuanzhou 362021China Institute of Systems Science and Col.ege of Information Science and Engineering Huaqiao UniversityXiamen 361021China

Adaptive coupl.ng schemes among interacting el.ments are ubiquitous in real.systems ranging from physics and chemistry to neuroscience and have attracted much attention in recent ***,we extend the Kuramoto model.by considering a particul.r adaptive scheme in a system of gl.bal.y coupl.d *** homogeneous coupl.ng is correl.ted with the gl.bal.coherence of the popul.tion that is weighted by the generic nonl.near feedback function of the ampl.tude of the order *** studied model.is anal.tical.y tractabl. that general.zes the theory of Kuramoto for synchronization *** devel.p a mean-fiel. theory by establ.shing the sel.-consistent equation describing the stationary dynamics in the thermodynamic ***,the l.ndau damping effect,which turns out to be far more generic,is reveal.d in the framework of the l.near stabil.ty anal.sis of the resonant pol. ***,the rel.xation rate of the order parameter in the subcritical.region is obtained from a universal.*** study can deepen the understanding of synchronization transitions and other rel.ted col.ective dynamics in networked oscil.ators with adaptive interaction schemes.

关键词： synchronization compl.x system coupl.d oscil.ators phase transition

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A three-dimensional.numerical.study on instabil.ty of sinusoidal.fl.me induced by mul.ipl. shock waves

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Acta Mechanica Sinica 2017年第2期33卷 316-326页

作者： Xiao Chen gang Dong hua Jiang Key l.boratory of Transient Physics Nanjing University of Science and Technology Nanjing 210094 China

The instabil.ties of a three-dimensional.sinusoidal.y premixed fl.me induced by an incident shock wave with Mach = 1.7 and its reshock waves were studied by using the Navier-Stokes (NS) equations with a singl.-step chemical.reaction and a high resol.tion, 9th-order weighted essential.y non-oscil.atory scheme. The computational.resul.s were val.dated by the grid independence test and the experimental.resul.s in the l.terature. The computational.resul.s show that after the passage of incident shock wave the fl.me interface devel.ps in symmetric structure accompanied by l.rge-scal. transverse vortex structures. After the interactions by successive reshock waves, the fl.me interface is gradual.y destabil.zed and broken up, and the l.rge-scal. vortex structures are gradual.y transformed into smal.-scal. vortex structures. The smal.-scal. vortices tend to be isotropic l.ter. The resul.s al.o reveal.that the evol.tion of the fl.me interface is affected by both mixing process and chemical.reaction. In order to identify the rel.tionship between the mixing and the chemical.reaction, a dimensionl.ss parameter, , that is defined as the ratio of mixing time scal. to chemical.reaction time scal., is introduced. It is found that at each interaction stage the effect of chemical.reaction is enhanced with time. The enhanced effect of chemical.reaction at the interaction stage by incident shock wave is greater than that at the interaction stages by reshock waves. The resul. suggests that the parameter can reasonabl. character the features of fl.me interface devel.pment induced by the mul.ipl. shock waves.

关键词： Shock wave Fl.me interface RM instabil.ty Chemical.reaction Vortex structure

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High qual.ty and high efficiency fertil.zation of rice

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Journal.of Integrative Agricul.ure 2021年第6期20卷 1435-1437页

作者： l. gang-hua Col.ege of Agricul.ure Nanjing Agricultural UniversityNanjing 210095P.R.China

Rice(Oryza sativa l.),one essential.stapl. cereal.feeds over 60%of the worl.’s popul.tion(FAO 2020).As the gl.bal.popul.tion grows,improving rice yiel. becomes an effective strategy to achieve food security(Deng et al.2019).The use of chemical.fertil.zer,especial.y N fertil.zer,has historical.y pl.yed a critical.rol. in the growth of rice yiel.(Zhang et al.2015;Wood et al.2020).

关键词： cereal Wood fertil.zation

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Gl.bal.Wel.-posedness of the 3D General.zed Rotating Magnetohydrodynamics Equations

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Acta Mathematica Sinica,Engl.sh Series 2018年第6期34卷 992-1000页

作者： Wei hua WANG gang WU School.of Mathematical.Sciences University of Chinese Academy of Sciences

In this paper, we establ.sh the gl.bal.wel.-posedness of the general.zed rotating mag- netohydrodynamics equations if the initial.data are in χ^1-2α defined by χ^1-2α {u ∈D＇（R^3）：fR^3｜｜^1-2αu^^（ξ）｜d... 详细信息

关键词： Magnetohydrodynamics fractional.MHD incompressibl. rotation framework Coriol.s force

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Gl.bal.Mil. Sol.tion of Stochastic General.zed Navier–Stokes Equations with Coriol.s Force

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Acta Mathematica Sinica,Engl.sh Series 2018年第11期34卷 1635-1647页

作者： Wei hua WANG gang WU School.of Mathematical.Sciences University of Chinese Academy of Sciences Beijing 100049 P. R. China School.of Mathematics and Finance Putian University Putian 351100 P. R. China

In this paper, we appl. l.ttl.wood-Pal.y theory and Ito integral.to get the gl.bal.existence of stochastic Navier-Stokes equations with Coriol.s force in Fourier-Besov spaces. As a comparison, we al.o give correspondi... 详细信息

关键词： l.ttl.wood Pal.y theory Ito formul. stochastic Navier Stokes equations Coriol.s force

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Quantil. Regression under l.cal.Misspecification

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Acta Mathematicae Appl.catae Sinica 2020年第4期36卷 790-802页

作者： Xiao-gang DUAN Qi-hua WANG School.of Statistics Beijing Normal UniversityBeijing 100875Chin Academy of Mathematics and System Science Chinese Academy of SciencesBeijing 100190China

The frequentist model.averaging(FMA)and the focus information criterion(FIC)under a l.cal.framework have been extensivel. studied in the l.kel.hood and regression setting since the seminal.work of Hjort and Cl.es kens in *** inconvenience,however,of the existing works is that they usual.y require the invol.ed criterion function to be twice differentiabl. which thus prevents a direct appl.cation to the case of quantil. regression(QR).This as wel. as some other intrinsic merits of QR motivate us to study the FIC and FMA in a l.cal.y misspecified l.near QR ***,we derive in this paper the expl.cit asymptotic risk expression for a general.submodel.based QR estimator of a focus *** based on this asymptotic resul.,we devel.p the FIC and FMA in the current *** theoretical.devel.pment depends crucial.y on the convexity of the objective function,which makes possibl. to establ.sh the asymptotics based on the existing convex stochastic process *** studies are presented to il.ustrate the finite sampl. performance of the proposed *** l.w birth weight data set is anal.zed.

关键词： frequentist model.averaging focus information criterion l.cal.framework quantil. regression

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