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Micro-Earthquake Seismicity and Tectonic Significance of the 2012 Ms 4.9 Baoying Earthquake,Jiangsu,China

Journal of Earth Science 2023年第3期34卷 900-910页

作者： Yanzhen li Hongyi li Yafen Huang Shengzhong Zhang yuejun lü School of Geophysics and Information Technology China University of GeosciencesBeijing 100083China Information Network Center China University of GeosciencesBeijing 100083China National Institute of Natural Hazards MEMCBeijing 100085China

On July 20,2012,the Ms 4.9 Baoying Earthquake occurred near the junction of Baoying County and Gaoyou City in Jiangsu Province,eastern *** to no obvious surface rupture and limited observation of earthquake sequence,the seismogenic structure of the Ms 4.9 Baoying Earthquake is still *** this study,80 earthquakes provided by China Earthquake Network Center(CENC)are first relocated;and then the relocated 75 events with high signal-to-noise ratios as templates are utilized to scan through continuous waveform data(July 11 to August 31,2012)using graphics processing unit-based match and locate(GPU-M&l)*** the Deep Denoiser,a deeplearning-based noise reduction technique,is used to further confirm some newly detected events;and the double-difference relocation(Hypo DD)algorithm is used to relocate the *** detect and relocate more than twice as many events as the CENC routine catalog,which includes 15 foreshocks and 230 *** results show that the foreshocks are mainly distributed in the NW direction along the extended SE section of the blind Xiagonghe fault(XF),which is orthogonal to the strike of the seismogenic fault of the Ms 4.9 Baoying Earthquake(Yangchacang-Sangshutou fault,named YSF).Most of the aftershocks are generally distributed along the NNE-trending YSF and illuminate a steeply dipping *** study reveals detailed spatiotemporal evolution of the earthquake sequence and suggests that the buried XF extends southeastward and cuts through the NNE-trending seismogenic YSF.

关键词： 2012 Ms 4.9 Baoying Earthquake micro-earthquake seismicity tectonics GPU-M&l Hypo DD Deep Denoiser

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Soft Soil Site Characterization on the Coast of Yantai and Its Effect on Ground Motion Parameters

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Earthquake Research in China 2005年第2期19卷 116-124页

作者： lü yuejun Tang Rongyu Peng Yanju Institute of Crustal Dynamics China Earthquake Administration Beijing 100085 China

According to the Chinese GB50011-2001 code and the recommended provisions of FEMANEHRP and EUROCODE 8, by using shear wave velocity and borehole data, the site classification is evaluated for a typical soft soil site on the Yantai seacoast. The site seismic ground motion effect is analyzed and the influence of the coastal soil on design ground motion parameters is discussed. The results show that the brief site classification can not represent the real conditions of a soft soil site; the soft soil on the coast has a remarkable impact on the magnitude and spectrum of ground motion acceleration. The magnification on peak acceleration is bigger, however, due to the nonlinear deformation of the soil. The magnification is reduced noulinearly with the increase of input ground motion; the spectrum is broadened and the characteristic period elongated on the soft soil site.

关键词： Site classification Shear wave velocity Earthquake ground motion Yantai

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METTl7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs

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International Journal of Oral Science 2024年第3期16卷 528-538页

作者： Yizhou Jin Xiao Han yuejun Wang Zhipeng Fan Beijing Key laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina Beijing laboratory of Oral Health Capital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Bisphosphonate-related osteonecrosis of jaw(BRONJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BMSCs).Corin has recently been demonstrated to act as a key regulator in bone development and orthopedic ***,the role of corin in BRONJ-related BMSCs dysfunction remains unclarified.A m6A epitranscriptomic microarray study from our group shows that the CORIN gene is significantly upregulated and m6A hypermethylated during orofacial BMSCs osteogenic *** knockdown inhibits BMSCs osteogenic differentiation,whereas corin overexpression or soluble corin(sCorin)exerts a promotion ***,corin expression is negatively regulated by bisphosphonates(BPs).Corin overexpression or sCorin reverses BPs-impaired BMSCs differentiation ***,we find altered expression of phos-ERK in corin knockdown/overexpression BMSCs and BMSCs under sCorin ***98059(a selective ERK inhibitor)blocks the corin-mediated promotion *** regard to the high methylation level of corin during osteogenic differentiation,we apply a non-selective m6A methylase inhibitor,Cycloleucine,which also blocks the corin-mediated promotion ***,we demonstrate that METTl7A modulates corin m6A modification and reverses BPs-impaired BMSCs function,indicating that METTl7A regulates corin expression and thus contributes to orofacial BMSCs differentiation *** conclude,our study reveals that corin reverses BPs-induced BMSCs dysfunction,and METTl7A-mediated corin m6A modification underlies corin promotion of osteogenic differentiation via the ERK *** hope this brings new insights into future clinical treatments for BRONJ.

关键词： impaired cor mediated

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Dominance of rock exposure and soil depth in leaf trait networks outweighs soil quality in karst limestone and dolomite habitats

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Forest Ecosystems 2024年第5期11卷 632-641页

作者： Min Jiao Jiawei Yan Ying Zhao Tingting Xia Kaiping Shen yuejun He Forestry College Research Center of Forest EcologyGuizhou UniversityGuiyang550025China

leaf trait networks(lTNs)visualize the intricate linkages reflecting plant trait-functional *** karst vegetation,developed from lithological dolomite and limestone,generally exhibits differential communities,possibly due to habitat rock exposure,soil depth,and soil physicochemical properties variations,leading to a shift from plant trait variation to functional ***,how soil and habitat quality affect the differentiation of leaf trait networks remains *** were constructed for typical dolomite and limestone habitats by analyzing twenty-one woody plant leaf traits across fifty-six forest subplots in karst *** differences between dolomite and limestone lTNs were compared using network *** network association of soil and habitat quality was analyzed using redundancy analysis(RDA),Mantle's test,and a random forest *** limestone lTN exhibited significantly higher edge density with lower diameter and average path length when compared to the dolomite *** indicates lTN differentiation,with the limestone network displaying a more compact architecture and higher connectivity than the dolomite *** specific leaf phosphorus and leaf nitrogen contents of dolomite lTN,as well as the leaf mass and leaf carbon contents of limestone lTN,significantly contributed to network degree and closeness,serving as crucial node traits regulating lTN ***,both habitat lTNs significantly correlated with soil nitrogen and phosphorus,stoichiometric ratios,pH,and organic carbon,as well as soil depth and rock exposure rates,with soil depth and rock exposure showing greater relative *** depth and rock exposure dominate trait network differentiation,with the limestone habitat exhibiting a more compact network architecture than the dolomite habitat.

关键词： leaf trait networks Functional traits Woody plant community Karst Dolomite limestone

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Specialization and Coordination: New Paradigm, Theory, and Path for Regional Development

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China Economist 2024年第1期19卷 76-85页

作者： lu Ming Xiang Kuanhu li Pengfei li Jiewei Zhong yuejun Antai College of Economics&Management Shanghai Jiao Tong UniversityShanghaiChina School of Economics Shanghai UniversityShanghai School of Economics and Management Shanghai Maritime UniversityShanghai Faculty of Economics and Management East China Normal UniversityShanghai

In its new development stage,China seeks to derive new dynamism from reform and opening up at a higher level to boost consumption and *** process coincides with a further differentiation of comparative advantages across *** activity and population will continue to concentrate in clusters in coastal and central cities amid a continuous outflow of population from remote *** expansion from coastal to interior regions and from central cities to the periphery will promote a new regional development paradigm of“dual centers and periphery”.Therefore,China’s regional development strategy should follow the new theory of seeking relative equilibrium amid development,identify regions of population inflow and outflow,and explore a new development path of regional specialization and *** deepening market reforms and increasing central government coordination,the country is poised to improve the spatial allocation of resources and unleash institutional dividends in the process of developing a unified national market.

关键词： Regional development “dual centers-periphery” comparative advantage population migration

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Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

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Nano Research 2024年第5期17卷 4314-4328页

作者： Hongmei liu Jiming Xu Mengjie Ye Hengbo Zhang linlin Han Jingting Wang Peng Xue yuejun Kang Zhigang Xu Key laboratory of luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China Key laboratory of laser Technology and Optoelectronic Functional Materials of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China Yibin Academy of Southwest University Yibin 644000China

Photothermal therapy(PTT)may lead to healthy tissue damage,tumor metastasis,and recurrence,which makes mild photothermal therapy(mild PTT)stand ***,overcoming heat resistance,insufficient therapeutic effect,and poor photothermal conversion efficiency has become new ***,we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan(denoted as SDA),the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine(lND)and NIR-II photothermal agent of IR-1061,producing SDlI with a tighter inner hole,smaller and uniform particle size and excellent stability due to multiple pulling ***,the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity,and the photothermal conversion efficiency(PCE)can reach 48.9%.At the acidic tumor microenvironment of pH 6.5,the controlled release of lND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild ***,SDlI also shows a reasonable tumor inhibition rate,so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress,continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.

关键词： self-shrinkage dynamic supramolecular nanoparticles tumor energy metabolism NIR-II mild photothermal therapy mitochondrial oxidative stress

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Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

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Chinese Chemical letters 2024年第7期35卷 360-366页

作者： Jingting Wang Yuanyuan Chen linlin Han Shasha Xia Xingyao Zhang Peng Xue yuejun Kang Jian Ming Zhigang Xu Key laboratory of luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China College of Food Science Southwest UniversityChongqing 400715China State Key laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side ***(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory ***,it faces problems such as poor water solubility,photothermal instability,and low ***,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant *** vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of *** work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.

关键词： Oral administration Astaxanthin Nanocarrier Anti-oxidant activity Colon targeting

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Study of Canada’s Economic System from a System Thinking Perspective

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Proceedings of Business and Economic Studies 2024年第3期7卷 179-187页

作者： Wei Zhang yuejun Cui China Foreign Affairs University Beijing 102206China

This article analyzes Canada’s economic system from a systems thinking *** content includes patterns of public choice(party system and power distribution),organizational framework of decision-making arrangements,information provision and coordination mechanisms,property rights system,incentive system,and welfare ***’s economic system significantly influences the development of the Canadian economy,and its economic system arrangements hold reference significance for other developed and developing countries.

关键词： Canada Economic system Party system Power distribution Property rights system

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Provenance and paleogeographic evolution of the Upper Paleozoic–lower Mesozoic strata in northern laos

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Journal of Earth Science 2024年

作者： Jingjie Jin Xin Qian Vongpaseuth Senebouttalath Yuzhi Zhang yuejun Wang Guangdong Provincial Key lab of Geodynamics and Geohazards， School of Earth Sciences and Engineering， Sun Yat-sen University， and Southern Marine Science and Engineering Guangdong laboratory (Zhuhai) Ministry of Energy and Mines， Department of Geology and Minerals

The late Paleozoic–Early Mesozoic sedimentary system of the luang Prabang Paleotethyan back-arc basin in northern laos is important for investigating sedimentary provenance， paleogeographic patterns， and the tectonic evolution of the Eastern Paleotethyan Ocean. This study presents systematic stratigraphy， petrology， geochemistry， and detrital zircon U–Pb–Hf isotopic analyses for the late Carboniferous–Jurassic sedimentary strata on both sides of the luang Prabang basin. Based on distinct stratigraphic ages and provenance characteristics， the clastic rock samples can be divided into four groups. The Group 1 late Carboniferous–Early Permian samples from the western part of the basin yield detrital zircon age-peaks of ～348 and ～1425 Ma， with corresponding εHf(t) values ranging from -2.0 to +15.5 and +1.5 to +14， respectively. The age spectrum of Group 2 late Carboniferous–Early Permian samples from the eastern part of the basin shows major age-peaks of ～287 and ～1860 Ma， with εHf(t) values of -5.9–-0.9 and -3.6–+4.2， respectively. Group 3 late Permian–Triassic samples exhibit age-peaks of ～242 and ～1853 Ma， along with εHf(t) values of -0.7–+14.4 and -5.4–-1.8， respectively. Group 4 Middle–late Jurassic samples yield age-peaks of ～237，～431，～813，～1833， and ～2460 Ma， lacking late Devonian (413–345 Ma) detrital zircons. All these data collectively suggest that the Group 1 sample primarily originated from the Sukhothai Arc in western Indochina， Group 2 was from the Kontum and Truong Son in eastern Indochina， and Group 3 has a combined provenance of the Sukhothai， Kontum， and Truong Son. Regional comparisons suggest that the Jurassic provenance was mainly derived from South China， which was imported through the northern river system. Our data， combined with the regional angular unconformities between Jurassic continental strata and pre-Jurassic marine strata， suggest that the luang Prabang basin transformed into a superimposed collisional retroforeland basin during the Ju

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Review on the Usage of Synchronous and Asynchronous FIFOs in Digital Systems Design

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Engineering（科研） 2024年第3期16卷 61-82页

作者： Dongwei Hu yuejun lei linan Wang The 54th Research Institute of CETC Shijiazhuang China MUC School of Information Engineering Beijing China

First-Input-First-Output (FIFO) buffers are extensively used in contemporary digital processors and System-on-Chips (SoC). There are synchronous FIFOs and asycnrhonous FIFOs. And different sized FIFOs should be implemented in different ways. FIFOs are used not only for the pipeline design within a processor, for the inter-processor communication networks, for example Network-on-Chips (NoCs), but also for the peripherals and the clock domain crossing at the whole SoC level. In this paper, we review the interface, the circuit implementation, and the various usages of FIFOs in various levels of the digital design. We can find that the usage of FIFOs could greatly facilitate the signal storage, signal decoupling, signal transfer, power domain separation and power domain crossing in digital systems. We hope that more attentions are paid to the usages of synchronous and asynchronous FIFOs and more sophististicated usages are discovered by the digital design communities.

关键词： First-Input-First-Output System-on-Chip Network-on-Chip Advanced eXtensible Interface Asynchronous

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