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cyclopiazonic acid增加SHR和WKY血管平滑肌细胞Ca^(2+)-依赖性外向K^+-电流

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中国药理学通报 1993年第4期9卷 257-260页

作者：关永源 John Zhang lee RMKW Kwan cy Daniel EE 中山医科大学药理教研室 Section of Neurosurgery Medical CenterThe University of ChicagoChicagoIllinois 60637 USA Smooth Musele Research Program Departments of Anacthesia and Biomedical SciencesMcMaster UniversityHamiltonOntario Canada L8N 3Z5

采用全细胞及细胞贴附式斑片钳技术记录自发性高血压大鼠(SHR)和Wistar-Kyoto对照鼠(WKY)培养主动脉平滑肌细胞的Ca^(2+)-依赖性外向K^+电流[I_(k(Ca))],测定肌浆网Ca^(2+)泵抑制剂CPA对其影响.CPA能增加I_K(Ca))单通道开放时间,缩短关... 详细信息

采用全细胞及细胞贴附式斑片钳技术记录自发性高血压大鼠(SHR)和Wistar-Kyoto对照鼠(WKY)培养主动脉平滑肌细胞的Ca^(2+)-依赖性外向K^+电流[I_(k(Ca))],测定肌浆网Ca^(2+)泵抑制剂CPA对其影响.CPA能增加I_K(Ca))单通道开放时间,缩短关闭时间,增加全细胞I_(K(Ca))幅度,这些作用与Ca^(2+)相关并可被K^+通道阻断药glybenclamide阻断。CPA作用在SHR和WKY之间无明显差异。结果提示高血压状态下血管平滑肌的功能改变可能与I_(K(Ca))无关。

关键词： CPA 钾离子通道血管平滑肌细胞

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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy

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World Journal of Gastroenterology 2016年第28期22卷 6484-6500页

作者： Man Fai law Rita Ho Carmen KM Cheung lydia HP Tam Karen Ma Kent cy So Bonaventure Ip Jacqueline So Jennifer lai Joyce Ng Tommy HC Tam Department of Medicine and Therapeutics Prince of Wales HospitalHong Kong China Department of Medicine North District HospitalHong Kong China

Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although ther

关键词： Hepatitis B virus reactivation Hematological malignancies Rituximab Hematopoietic stem cell transplant Prophylactic antiviral therapy

Chinese Herbal Medicine for Chemotherapy Induced Gastrointestinal Side Effects: A Systematic Review of Randomized Controlled Trials

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 31-50页

作者： Chung-Wah Cheng Zhao-Xiang Bian li-Dan Zhong Justin cy Wu Zhi-Xiu lin Eric TC Ziea Vivian CW Wong Hong Kong Chinese Medicine Clinical Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Faculty of Medicine The Chinese University of Hong Kong School of Chinese Medicine The Chinese University of Hong Kong Chinese Medicine Department Hospital Authority

Objective: To determine how safe and effective Chinese Herbal Medicine(CHM) is in alleviating the nausea, vomiting, oral ulceration,diarrhea and constipation for cancer patients with ***: Data sources: A systematic review of Chinese and English articles using Ovid SP, CNKI, VIP Database and Traditional Chinese Medicine Database System. Study selection: Only randomized controlled trials(RCTs) for the prevention or treatment of any one of gastrointestinal side effects, namely nausea, vomiting, oral ulceration, diarrhea and constipation, of CHM with or without western medicine(WM) vs WM, placebo or no treatment were included. Data Extraction: Independent extraction of articles was first performed by four medical students using predefined data fields. Then, all data, including study quality indicators, was checked by two ***: Eighty-six RCTs involving 7076 cancer patients were found and analyzed in this review. Because of the heterogeneity of study design and low overall methodological quality, only descriptive summaries were performed. Beneficial effects were found in some CHM interventions,regardless of being taken alone or taken with WM. Moreover, none of serious adverse effect was reported. However, same intervention had not been repeatedly investigated by different research ***: Implications of the analysis support the efficacy and safety of CHM for the management of gastrointestinal side ***, definite clinical recommendation for particular CHM intervention still cannot be made due to low methodological quality of included studies and lack of duplicated verification. Further large scale and high quality RCTs on the same CHM interventions are suggested.

关键词： Chinese herbal medicine Systematic review Chemotherapy induced side effects Gastrointestinal diseases

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BNIP3 Suppresses PINK1 Proteolytic Cleavage to Promote Mitophagy

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BNIP3 Suppresses PINK1 Proteolytic Cleavage to Promote Mitop...

Cilostazol for Alzheimer′s disease

第十四次全国医学遗传学学术会议

作者： Zhang TM Xue l li l Tang cy Wan ZQ Wang RX Zeng ZT Tan JQ Tang BS W.Andy Tao Zhang ZH The State Key laboratory of Medical Genetics Xiangya Medical SchoolCentral South University Department of Biochemistry Purdue University Department of Neurology Xiangya HospitalCentral South University Collaborative Innovation Center for Brain Science Fudan University

Objective:Mutations in PINK1 gene cause recessive form of Parkinson’s disease(PD).The PINK1 gene encodes a mitochondrial protein kinase that is processed by mitochondrial proteases resulting in two smaller proteolytic *** not only protects cells against mitochondrial dysfunction and apoptosis,but also regulates clearance of damaged mitochondria together with ***2/adenovirus E1B 19kDa interacting protein 3(BNIP3)is a mitochondrial BH3-only protein known to induce *** present study is to explore whether PINK1/Parkin and BNIP3 function in the same pathway to regulate mitochondria ***:The interaction between PINK1 and BNIP3was determined by co-immunoprecipition *** induction was analyzed with parkin and GFP-lC3 ***:Our results reveal that BNIP3 interacts with PINK1 to promote stabilization and accumulation of full-length PINK1 on outer membrane of damaged mitochondria,therefore,to facilitate parkin recruitment to ***:The results suggest that BNIP3 plays an essential role in PINK1/parkinmediated mitophagy and likely contributes to PD pathogenesis.

关键词： Parkinson’s disease PINK1 BNIP3 mitophagy

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中华物理医学与康复杂志 2017年第4期 263-263页

作者： Tai SY Chen CH Chien cy

BACKGROUND AND OBJECTIVE More than 35 million people worldwide suffer from Alzheimer′s disease (AD). No cure currently exists for this disorder. While acetylcholinesterase inhibitors (AChEIs) are frequently prescribed, the benefit is often minor. Cilostazol is a selective inhibitor of cyclic nucleotide phosphodiesterase 3 (PDE3), with multiple activities in the brain including anti-inflammatory, antioxidative, and antiapoptotic. This study examined the therapeutic response of this medication as an add-on in patients with stable *** Subjects were 30 patients with stable AD, all receiving Cilostazol 50 mg twice per day as an add-on therapy with AChEIs. Each subject was matched with one patient with stable AD receiving only AChEIs for at least 12 months. The participants were tested at baseline and every six months thereafter with various neuropsychological assessments, including the Mini-Mental State Examination, the Cognitive Assessment Screening Instrument (CASI) Neuropsychiatric Inventory and Clinical Dementia Rating Sum of Boxes (CDR-SB). In addition, all patients underwent ApoE *** For the primary outcome measure of change in the Mini-Mental State Examination, a favorable response was noted in 50% of those in the Cilostazol group. A logistic regression analysis demonstrated that Cilostazol use was significantly associated with change in MMSE (P=0.024).CONClUSION This study of patients with stable Alzheimer′s disease taking an acetylcholinesterase inhibitor found that an antiplatelet drug, Cilostazol may reduce the odds of deterioration of cognitive function.

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Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris

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那是必须的——快速掌握Android系统手机实用技巧

第六次全国中西医结合变态反应学术大会

作者： Hong li l Gao Z Shen cy li K li M li YJ lv CX li TW Gao YF liu Departments:Institute of Dermatology of Chinese PlA Xijing HospitalFourth Military Medical University

Nuclear factor kappa-beta(NF-κB)is a critical transcription factor responsible for modulating the expression of many genes involved in the pathogenesis ***4 is a negative regulator ofNF-κB in the process of cell signaling *** functional single nucleotide polymorphisms(SNP),-94ins/delATTG in NFKB 1gene and the rs237025 A>G in SUMO4 *** been found to be the risk of some autoimmune *** their correlation with the susceptibility of psoriasis vulgaris,a newly-defined autoimmune-related disease,remained unknown *** we genotyped the two polymorphisms in 5 1 9 patients with psoriasis vulgaris and 541 healthy *** found that the ins/ins genotype frequency in NFKB 1 were significant differences among the psoriasis cases and the controls(x2test P=0.01 8).By stratified analysis,the frequency of the ins/ins genotype Was statistically higher among the patients of onset age≤40,PASI>20,male patients and sporadic patients than among *** no statistically significant association has been found between the rs237025A>G polymorphism in SUMO4 gene and the susceptibility ofpsoriasis vulgaris even stratified analysis by the age of onset,family history,PASI score and gender.

关键词： psoriasis NF-κB NFKB1 SUMO4 genetic association SNP

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电脑爱好者(普及版) 2010年第12期 74-77页

作者： cy

说到机器人,相信大家都不会陌生。但与大家印象中的人形机器人不同,我们今天要介绍的是安家在手机中的Android"机器人"。Android是一款以linux平台为基础的手机操作系统,这款移动软件由操作系统、中间件、用户界面以及应用软件组成。之... 详细信息

说到机器人,相信大家都不会陌生。但与大家印象中的人形机器人不同,我们今天要介绍的是安家在手机中的Android"机器人"。Android是一款以linux平台为基础的手机操作系统,这款移动软件由操作系统、中间件、用户界面以及应用软件组成。之所以称Android手机操作系统为"机器人",是因为它不仅让手机智能化,而且Android还可以不断改进、不断成长。因此,从Google公司2007年11月宣布Android至今,这款手机系统已经被

关键词：手机机器人应用程序人工智能应用软件 Android 浏览器

区别对待——FAT32、NTFS、exFAT

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电脑爱好者(普及版) 2010年第11期 74-75页

作者： cy

如今,移动存储设备可谓层出不穷,几乎每一个使用电脑的人都有一个移动存储设备。从最初的软盘,到如今的U盘、移动硬盘等。这些移动存储设备的外观设计日趋多元化,体积也越来越小,而存储容量则在不断的增大。我们在日常对这些存储设备进... 详细信息

如今,移动存储设备可谓层出不穷,几乎每一个使用电脑的人都有一个移动存储设备。从最初的软盘,到如今的U盘、移动硬盘等。这些移动存储设备的外观设计日趋多元化,体积也越来越小,而存储容量则在不断的增大。我们在日常对这些存储设备进行格式化时,都会发现"FAT32"、"NTFS"、"exFAT"的字样,它们都代表了什么,各自又有什么独特之处?相信很多人都有这样的疑问,那么,今天我们就来详细地探究一下"FAT32"、"NTFS"和"exFAT"之间的区别。

关键词： exFAT NTFS 文件分配表

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不速之客请走开——教你赶走“蹭网者”

电脑爱好者(普及版) 2010年第11期 71-73页

作者： cy 天唯创造

如今,很多时尚一族都非常热衷于无线网络的使用。无线网络有着其他网络不能媲美的便捷性,也正是这样,短短的几年时间,无线网络走进了我们的家居生活,普及程度惊人。但是,和很多IT产品相同,无线网络越完善,安全问题也就越严峻,其中最令... 详细信息

如今,很多时尚一族都非常热衷于无线网络的使用。无线网络有着其他网络不能媲美的便捷性,也正是这样,短短的几年时间,无线网络走进了我们的家居生活,普及程度惊人。但是,和很多IT产品相同,无线网络越完善,安全问题也就越严峻,其中最令我们烦心的就是那些无孔不入的"蹭网族"。这些"蹭网族"不仅让我们在流量上受到损失,还会影响我们的网络速度。那有没有一些方法可以让我们摆脱这些不速之客的困扰呢?当然有,今天我们就来介绍一些方法,让这些"蹭网族"远离我们的网络。

关键词：蹭网管理界面 IP 无线网络无线网路由器无线网卡 MAC SSID 地址池