Chinese Herbal Medicine for Chemotherapy Induced Gastrointestinal Side Effects: A Systematic Review of Randomized Controlled Trials

作     者：Chung-Wah Cheng Zhao-Xiang Bian Li-Dan Zhong Justin CY Wu Zhi-Xiu Lin Eric TC Ziea Vivian CW Wong 

作者机构：Hong Kong Chinese Medicine Clinical Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Faculty of Medicine The Chinese University of Hong Kong School of Chinese Medicine The Chinese University of Hong Kong Chinese Medicine Department Hospital Authority 

出 版 物：《World Journal of Traditional Chinese Medicine》 (世界中医药杂志（英文）)

年 卷 期：2017年第3卷第2期

页      面：31-50页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Hospital Authority(HA/09-10/02-CANCER) Hong Kong SAR 

主　　题：Chinese herbal medicine Systematic review Chemotherapy induced side effects Gastrointestinal diseases 

摘      要：Objective: To determine how safe and effective Chinese Herbal Medicine(CHM) is in alleviating the nausea, vomiting, oral ulceration,diarrhea and constipation for cancer patients with ***: Data sources: A systematic review of Chinese and English articles using Ovid SP, CNKI, VIP Database and Traditional Chinese Medicine Database System. Study selection: Only randomized controlled trials(RCTs) for the prevention or treatment of any one of gastrointestinal side effects, namely nausea, vomiting, oral ulceration, diarrhea and constipation, of CHM with or without western medicine(WM) vs WM, placebo or no treatment were included. Data Extraction: Independent extraction of articles was first performed by four medical students using predefined data fields. Then, all data, including study quality indicators, was checked by two ***: Eighty-six RCTs involving 7076 cancer patients were found and analyzed in this review. Because of the heterogeneity of study design and low overall methodological quality, only descriptive summaries were performed. Beneficial effects were found in some CHM interventions,regardless of being taken alone or taken with WM. Moreover, none of serious adverse effect was reported. However, same intervention had not been repeatedly investigated by different research ***: Implications of the analysis support the efficacy and safety of CHM for the management of gastrointestinal side ***, definite clinical recommendation for particular CHM intervention still cannot be made due to low methodological quality of included studies and lack of duplicated verification. Further large scale and high quality RCTs on the same CHM interventions are suggested.