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Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

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Journal of Animal Science and Biotechnology 2022年第1期13卷 256-264页

作者： Min-Jin Kwak Min-Young Park Yong-Soon Choi Junghwan Cho Duleepa Pathiraja Jonggun Kim Hanbae Lee In-Geol Choi Kwang-Youn whang Department of Biotechnology Korea University145 Anam-roSeoul 02841Republic of Korea Pathway Intermediates Seoul 02841Republic of Korea

Background:Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign *** strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their ***(SPL),which is a glycolipid biosurfactant,could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal ***,herein,we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota ***:A total of 5401-day-old chicks(Ross 308)were used,and they were immediately allotted into three treatment groups(6 replications with 30 chicks/pen)according to their initial body *** dietary treatments consisted of CON(basal diet),BAM(10 mg/kg bambermycin),and SPL(10 mg/kg SPL).During the experiment,birds freely accessed feed and water,and body weight and feed intake were measured at the end of each *** d 35,birds(one bird/pen)were sacrificed to collect jejunum and cecum ***:Dietary SPL and BAM supplementation significantly accelerated birds’growth and also significantly improved feed efficiency compared to *** microbial community was significantly separated by dietary SPL supplementation from that of CON,and dietary SPL supplementation significantly increased Lactobacillus *** Akkermansia ***,birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment *** morphological analysis showed that dietary SPL significantly increased villus height,ratio of villus height to crypt depth,goblet cell numbers,and the gene expression levels of claudin-1 and mucin ***,dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine,interleukin-6,and increased that of anti-inflammatory cytokine,interleukin-10,compared

关键词： Broilers Gut microbiota Gut morphology Local inflammation Mucus barrier Sophorolipids

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微塑料暴露致小鼠皮质铁死亡的实验研究

环境与健康杂志 2024年第5期41卷 377-382,471页

作者：王朝阳姚雪王丰郝瀚王伟轩张艳淑唐山弘慈医院职业体检科河北唐山063000 华北理工大学公共卫生学院

目的通过建立微塑料暴露小鼠模型探讨微塑料暴露致皮质铁死亡的影响,以期为微塑料暴露致神经损伤的防治提供新的线索。方法SPF级雄性C57小鼠40只按体重随机分为对照组、低微塑料组、中微塑料组、高微塑料组,每组10只。微塑料暴露组小鼠... 详细信息

目的通过建立微塑料暴露小鼠模型探讨微塑料暴露致皮质铁死亡的影响,以期为微塑料暴露致神经损伤的防治提供新的线索。方法SPF级雄性C57小鼠40只按体重随机分为对照组、低微塑料组、中微塑料组、高微塑料组,每组10只。微塑料暴露组小鼠分别以25、50和100 mg/kg纳米聚苯乙烯灌胃,连续染毒8周,对照组每天灌胃相同剂量纯水。染毒结束后,以新物体识别实验检验小鼠的神经行为变化;以HE染色观察小鼠皮质病理变化;以试剂盒检测小鼠皮质组织中二价铁(Fe^(2+))、丙二醛(MDA)和谷胱甘肽(glutathione,GSH)的含量;以Western blot法检测小鼠皮质组织中二价金属铁离子转运体1(DMT1)、铁转运蛋白(ferroportin,FPN1)、转铁蛋白受体1(transferrin receptor 1,TFR1)、谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)和溶质载体家族7成员11(solute carrier family 7 member 11,SLC7A11)蛋白的表达情况。结果染毒期间,低微塑料、中微塑料与高微塑料组小鼠体重与对照组相比无显著差异。新物体识别实验结果显示,与对照组相比,中微塑料组和高微塑料组新物体识别指数显著下降(P<0.05)。HE染色结果显示,与对照组相比,低微塑料组小鼠皮质中出现神经细胞深染,结构模糊,核固缩现象;中微塑料组及高微塑料组小鼠皮质及海马中神经细胞深染,结构模糊,核固缩现象进一步加剧。与对照组相比,各微塑料组小鼠脑皮质中铁含量和MDA含量显著升高(P<0.05),GSH含量在中微塑料组和高微塑料组中显著下降(P<0.05);同时,TFR1表达水平在各微塑料组小鼠脑皮质中均较对照组显著升高(P<0.05),中微塑料和高微塑料组小鼠脑皮质中FPN1表达水平显著降低(P<0.05),DMT1表达水平显著升高(P<0.05);此外,与对照组相比,GPX4与SLC7A11在中微塑料组与高微塑料组小鼠皮质中的表达水平显著降低(P<0.05)。结论微塑料暴露可引起小鼠新物体识别能力下降,其中微塑料引起皮质神经细胞铁稳态失调导致铁死亡是诱导神经损伤的机制之一。

关键词：微塑料铁死亡神经损伤

Paraaortic lymph node metastasis in patients with intra-abdominal malignancies:CT vs PET

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World Journal of Gastroenterology 2009年第35期15卷 4434-4438页

作者： Mi-Jung Lee Mi Jin Yun Mi-Suk Park Seung Hwan Cha Myeong-Jin Kim Jong Doo Lee Ki whang Kim Department of Diagnostic Radiology Research Institute of Radiological Science and Institute ofGastroenterology Yonsei University College of Medicine 134Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Nuclear medicine Yonsei University College of Medicine 134 Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Diagnostic Radiology Yonsei University Wonju College of Medicine Wonju 220-701South Korea

AIM： To compare the diagnostic accuracy of computed tomography （CT） and positron emission tomography （PET） for the preoperative detection of paraaortic lymph node （PAN） metastasis in patients with intra- abdominal malignancies. METHODS： Sixty-six patients with intra-abdominal malignancies who underwent both CT and PET before lymphadenectomy were included in this study. Histopathologicaliy, 13 patients had metastatic PAN, while 53 had non-metastatic PAN. The CT criteria for metastasis were： short diameter ：）f 〉 8 mm, Iobular or irregular shape, and/or combined ancillary findings, including necrosis, conglomeration, vessel encasement, and infiltration. The PET criterion was positive fluorodeoxyglucose （FDG） uptake. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, and accuracy of both modalities were compared with the pathologic findings, and the false positive and false negative cases with both CT and PET were ***： The sensitivity, specificity, PPV, NPV, and accuracy of CT were 61.5%, 84.9%, 50%, 90% and 80.3%, respectively. For PET, the percentages were 46.2%, 100%, 100%, 88.3%, and 89.4%. Additionally, there were 8 false positive CT cases （8/53, 15.1%） and zero false positive PET cases. Of the 13 metastatic PANs, there were 5 false negative CT scans （38.5%） and 7 （53.9%） false negative PET ***： For detecting PAN metastasis, CT is more sensitive than PET, while PET is more specific.

关键词： Malignancy Paraaortic lymph node Computed tomography Positron emission tomography Sensitivity Specificity

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AC-PDP中等离子体电场的实验研究

核聚变与等离子体物理 2003年第2期23卷 108-112页

作者：周艳 Ki-Woong whang J H Yang D C Jeong C H Ha 核工业西南物理研究院成都610041 国立汉城大学

用激光荧光技术直接测量了AC PDP单元高气压He和He Xe0 1%放电中的电场行为,估算了由放电电场产生的AC PDP单元上的壁电压。选用高气压下寿命较长的氦的亚稳态2s3S,比较主量子数n=8和n=9的Stark分裂谱,使电场的测量精度提高到10%。电场... 详细信息

用激光荧光技术直接测量了AC PDP单元高气压He和He Xe0 1%放电中的电场行为,估算了由放电电场产生的AC PDP单元上的壁电压。选用高气压下寿命较长的氦的亚稳态2s3S,比较主量子数n=8和n=9的Stark分裂谱,使电场的测量精度提高到10%。电场和壁电压的时间分布描述了PDP单元的放电行为。

关键词： AC-PDP 等离子体电场实验研究激光荧光技术壁电压放电等离子体显示器

Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2020年第9期26卷 904-917页

作者： Ezekiel Maloney Yak-Nam Wang Ravneet Vohra Helena Son Stella whang Tatiana Khokhlova Joshua Park Kayla Gravelle Stephanie Totten Joo Ha Hwang Donghoon Lee Department of Radiology University of WashingtonSeattleWA 98195United States Applied Physics Laboratory University of WashingtonSeattleWA 98195United States Division of Gastroenterology University of WashingtonSeattle 98195WAUnited States Division of Gastroenterology&Hepatology Stanford University School of MedicineRedwood CityCA 94063United States

BACKGROUND The robust fibroinflammatory stroma characteristic of pancreatic ductal adenocarcinoma(PDA)impedes effective drug *** focused ultrasound(pFUS)can disrupt this stroma and has improved survival in an early clinical ***-invasive methods to characterize pFUS treatment effects are desirable for advancement of this promising treatment modality in larger clinical *** To identify promising,non-invasive pre-clinical imaging methods to characterize acute pFUS treatment effects for in vivo models of *** We utilized quantitative magnetic resonance imaging methods at 14 tesla in three mouse models of PDA(subcutaneous,orthotopic and transgenic-KrasLSLG12D/+,Trp53LSL-R172H/+,Cre or“KPC”)to assess immediate tumor response to pFUS treatment(VIFU 2000 Alpinion Medical Systems;475 W peak electric power,1 ms pulse duration,1 Hz,duty cycle 0.1%)vs sham therapy,and correlated our results with histochemical *** pFUS treatment parameters were previously shown to enhance tumor permeability to chemotherapeutics.T1 and T2 relaxation maps,high(126,180,234,340,549)vs low(7,47,81)b-value apparent diffusion coefficient(ADC)maps,magnetization transfer ratio(MTR)maps,and chemical exchange saturation transfer(CEST)maps for the amide proton spectrum(3.5 parts per million or“ppm”)and the glycosaminoglycan spectrum(0.5-1.5 ppm)were generated and analyzed pre-treatment,and immediately post-treatment,using *** were sacrificed immediately following post-treatment *** whole-tumor was selected as the region of interest for data analysis and subsequent statistical analysis.T-tests and Pearson correlation were used for statistical *** Mean high-b value ADC measurements increased significantly with pFUS treatment for all *** glycosaminoglycan CEST and T2 measurements decreased significantly post-treatment for the KPC *** MTR and amide CEST values increased significantly for the KPC *** acid focal int

关键词： Pancreatic adenocarcinoma Multiparametric magnetic resonance imaging Focused ultrasound

A Study on Biological Half-life of Radioiodine in Thyroid Glands on Korean Adult Male

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A Study on Biological Half-life of Radioiodine in Thyroid Gl...

Thalidomide effect in endothelial cell of acute radiation proctitis

The Second Asian and Oceanic Congress for Radiation Protection

作者： Junghoon Kim Jooho whang Department of Nuclear Engineering Kyunghee UniversityKiheungYonginKyunggi449-701Republic of Korea Department of Nuclear Engineering Kyunghee UniversityKiheungYonginKyunggi449-701Republic of Korea

In this study,biological half-life of radioiodine（131I）in thyroid glands was calculated with 10 Korean adult males as the target in order to evaluate radiation does to suit the physiological characteristics of the *** the method of experiment,131I was orally administered on ***,measurements were taken in intervals at the 2nd,4th,6th and 24th hour for the first 24 hours and continuously in the 2nd and the 3rd *** then on,radioactivity of 131I accumulated in thyroid glands was measured in the interval of 10 days up to the 60th day to calculate the biological half-life of 131I in thyroid *** result indicated that the biological half-life of radioiodine was 37 *** is different from the existing data of ICRP-56 and 67,which suggest biological half-life of radioiodine in thyroid glands as 80 days and the result of the study by ***,et al.,which evaluates the biological half-life as 66 *** can be interpreted that such result was produced firstly by the fact that the target of experiment in this study was healthy male adults whereas the existing studies were targeted on hospitalized patients and middle-aged people as the test group and secondly by the fact that,unlike the Westerners,Korean people have the dietary habit of taking in large quantities of iodine,etc.

关键词： biological half-life thyroid glands radiation does.

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World Journal of Gastroenterology 2008年第30期14卷 4779-4783页

作者： Ki-Tae Kim Hiun-Suk Chae Jin-Soo Kim hyung-Keun Kim Young-Seok Cho whang Choi Kyu-Yong Choi Sang-Young Rho Suk-Jin Kang Department of Radiology College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Department of Pathology College of Medicine The Catholic University of Korea St. Vincent Hospital

AIM: To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats. METHODS: Fourteen female Wistar rats were used: six in the radiation group, six in the thalidomide group, and two in normal controls. The radiation and thalidomide groups were irradiated at the pelvic area using a single 30 Gy exposure. The thalidomide (150 mg/kg) was injected into the peritoneum for 7 d from the day of irradiation. All animals were sacrificed and the rectums were removed on day 8 after irradiation. The microvessels of resected specimens were immunohistochemically stained with thrombomodulin (TM), von Willebrand Factor (vWF), and vascular endothelial growth factor (VEGF). RESULTS: The microscopic scores did not differ significantly between the radiation and thalidomide groups, but both were higher than in the control group. Expression of TM was significantly lower inthe endothelial cells (EC) of the radiation group than in the control and thalidomide groups (P < 0.001). The number of capillaries expressing vWF in the EC was higher in the radiation group (15.3 ± 6.8) than in the control group (3.7 ± 1.7), and the number of capillaries expressing vWF was attenuated by thalidomide (10.8 ± 3.5, P < 0.001). The intensity of VEGF expression in capillaries was greater in the radiation group than in the control group and was also attenuated by thalidomide (P = 0.003). CONCLUSION: The mechanisms of acute radiation- induced proctitis in the rats are related to endothelial cell injury of microvessel, which may be attenuated with thalidomide.

关键词： Radiation proctitis Von Willebrand factor Thrombomodulin Vascular endothelial growth factor Thalidomide

Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor

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World Journal of Gastroenterology 2003年第12期9卷 2832-2835页

作者： Chun-Pin Li Fa-Yauh Lee Shinn-Jang Hwang Rei-Hwa Lu Wei-Ping Lee Yee Chao Sung-Sang Wang Full-Young Chang Jacqueline whang-Peng Shou-Dong Lee Division of Gastroenterology Department of MedicineTaipei Veterans General Hospital and Institute of Clinical MedicineNational Yang-Ming University School of MedicineTaipeiTaiwanChina Cancer Center Taipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwanChina Cancer Research Division National Health Research Institutes and Institute of Clinical MedicineNational Yang-Ming University School of MedicineTaipeiTaiwanChina

AIM: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated wibh spider angiomas in patients wibh liver cirrhosis. METHODS: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. RESULTS: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=-0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95% confidence interval[CI]=2.02-21.79, P=0.002; OR=4.35, 95% CI=1.35-14.01,P=0.014; OR=5.66, 95% CI=1.72-18.63, P=0.004, respectively). CONCLUSION: Plasma VEGF and bFGF are elevated inpatients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.

关键词：血管内皮生长因子基质纤维原细胞生长因子肝硬化蛛形血管瘤作用机制

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煤矿采掘计划计算机仿真系统实现

煤炭技术 2013年第10期32卷 39-41页

作者：王倩淄博职业学院山东淄博255000

在煤矿生产管理过程中,一项十分关键的环节就是编制采掘接替计划,其对煤矿企业经济效益具有重要意义,对依托于计算机的煤矿采掘计划已经有所研究。文章首先介绍了煤矿采掘计划计算机仿真系统的整体思路及系统的技术解决方案,并对系统功... 详细信息

在煤矿生产管理过程中,一项十分关键的环节就是编制采掘接替计划,其对煤矿企业经济效益具有重要意义,对依托于计算机的煤矿采掘计划已经有所研究。文章首先介绍了煤矿采掘计划计算机仿真系统的整体思路及系统的技术解决方案,并对系统功能列表进行了阐述。

关键词：煤矿生产管理计算机仿真系统采掘接替计划