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Aged T cells and cardiovascular disease

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Cellular & Molecular Immunology 2017年第12期14卷 1009-1010页

作者： min kyung Jung Eui-cheol Shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeon 34141Republic of Korea

Memory T cells undergo replicative senescence via repetitive *** in other cells,replicative senescence of T cells is characterized by shortened telomeres.1 Immunophenotypes are also altered in replicative senescent T cells compared to young T *** humans,replicative senescent T cells typically lose expression of CD28,a costimulatory receptor,and acquire the expression of CD57 antigen,a terminally sulfated glycan carbohydrateepitope,1 though the mechanism underlying this regulation has not yet been clearly ***,CD28−or CD57+T cells are considered replicative senescent T cells in humans.

关键词： CD57 cardiovascular typically

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Nanograin network memory with reconfigurable percolation paths for synaptic interactions

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Light(Science & Applications) 2023年第6期12卷 1040-1050页

作者： Hoo-cheol Lee Jungkil Kim Ha-Reem Kim Kyoung-Ho Kim kyung-Jun Park Jae-Pil So Jung min Lee min-Soo Hwang Hong-Gyu Park Department of Physics Korea UniversitySeoul 02841Republic of Korea Department of Physics Jeju National UniversityJeju 63243Republic of Korea Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea

The development of memory devices with functions that simultaneously process and store data is required for efficient *** achieve this,artificial synaptic devices have been proposed because they can construct hybrid networks with biological neurons and perform neuromorphic ***,irreversible aging of these electrical devices causes unavoidable performance *** several photonic approaches to controlling currents have been suggested,suppression of current levels and switching of analog conductance in a simple photonic manner remain ***,we demonstrated a nanograin network memory using reconfigurable percolation paths in a single Si nanowire with solid core/porous shell and pure solid core *** electrical and photonic control of current percolation paths enabled the analog and reversible adjustment of the persistent current level,exhibiting memory behavior and current suppression in this single nanowire *** addition,the synaptic behaviors of memory and erasure were demonstrated through potentiation and habituation *** habituation was achieved using laser illumination on the porous nanowire shell,with a linear decrease in the postsynaptic ***,synaptic elimination was emulated using two adjacent devices interconnected on a single ***,electrical and photonic reconfiguration of the conductive paths in Si nanograin networks will pave the way for next-generation nanodevice technologies.

关键词： electrical percolation network

Protective effects of edible insect protein extracts from Protaetia brevitarsis against H_(2)O_(2)-induced oxidative stress in mouse C2C12 myoblast cells

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Food Bioscience 2023年第2期52卷 435-443页

作者： Jae Hoon Lee Tae-kyung Kim min-cheol Kang Bum-Keun Kim Yun-Sang Choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea

Edible insects have been attracting significant attention not only for their nutritional superiority but also for their excellent bio-functional *** this study,the apoptotic protective effects of water-soluble protein(WPB)and salt-soluble protein(SPB)extracts derived from Protaetia brevitarsis against hydrogen peroxide(H_(2)O_(2))-induced oxidative stress in C2C12 cells were *** and SPB were confirmed to exhibit radical scavenging and ferric-ion reducing *** addition,WPB and SPB treatments effectively restored the decreased cell viability of the C2C12 cells induced by H2O2 treatment,and showcased protective effects against apoptosis and mitochondrial dysfunction by regulating the expressions of pro-and anti-apoptotic ***,our data indicated that protein extracts from Protaetia brevitarsis could be beneficial for the prevention and treatment of diseases associated with apoptosis induced by oxidative stress.

关键词： Edible insect protein extract Protaetia brevitarsis Antioxidant Anti-Apoptosis C2C12 myoblast cells

Densification simulation of compacted Al powders using multi-particle finite element method

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中国有色金属学会会刊：英文版 2009年第B09期19卷 68-75页

作者： kyung-Hun LEE Jung-min LEE Byung-min KIM School of Mechanical Engineering Pu san National University

The powder compaction simulations were performed to demonstrate deformation behavior of particles and estimate the effect of different punch speeds and particle diameters on the relative density of powder by a multi-particle finite element model(MPFEM). Individual particle discretized with a finite element mesh allows for a full description of the contact mechanics. In order to verify the reliability of compaction simulation by MPFEM, the compaction tests of porous aluminum with average particle size of 20 μm and 3 μm were performed at different ram speeds of 5, 15, 30 and 60 mm/min by MTS servo-hydraulic tester. The results show that the slow ram speed is of great advantage for powder densification in low compaction force due to sufficient particle rearrangement and compaction force increases with decrease in average particle size of aluminum.

关键词：粉末压实粉末粒子多孔铝有限元法模拟致密化平均粒径有限元模型

维普期刊数据库

Activation or exhaustion of CD8^(+) T cells in patients with COVID-19

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Cellular & Molecular Immunology 2021年第10期18卷 2325-2333页

作者： min-Seok Rha Eui-cheol Shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKorea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Otorhinolaryngology Yonsei University College of MedicineSeoulRepublic of Korea.3 The Center for Epidemic PreparednessKAISTDaejeonRepublic of Korea

In addition to CD4^(+)T cells and neutralizing antibodies,CD8^(+)T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019(COVID-19),an ongoing pandemic *** patients with COVID-19,CD8^(+)T cells exhibiting activated phenotypes are commonly observed,although the absolute number of CD8^(+)T cells is *** addition,several studies have reported an upregulation of inhibitory immune checkpoint receptors,such as PD-1,and the expression of exhaustion-associated gene signatures in CD8^(+)T cells from patients with ***,whether CD8^(+)T cells are truly exhausted during COVID-19 has been a controversial *** the present review,we summarize the current understanding of CD8^(+)T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8^(+)T cells in the context of activation and *** also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8^(+)T cells and discuss long-term SARS-CoV-2-specific CD8^(+)T-cell memory.

关键词： CD8^(+)T cell Activation T-cell exhaustion SARS-CoV-2 COVID-19

Effectiveness of pulsed radiofrequency on the medial cervical branches for cervical facet joint pain

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World Journal of Clinical Cases 2022年第22期10卷 7720-7727页

作者： min cheol Chang Seoyon Yang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityTaegu 42415South Korea Department of Rehabilitation Medicine School of MedicineEwha Woman's University Seoul HospitalSeoul 07804South Korea

BACKGROUND Cervical facet joint pain(CFP)is one of the most common causes of neck pain and *** CFP deteriorates the quality of life of patients and reduces their productivity at *** To investigate the effectiveness of pulsed radiofrequency(PRF)stimulation of cervical medial branches in patients with chronic *** We retrospectively included 21 consecutive patients(age=50.9±15.3 years,range 26-79 years;male:female=8:13;pain duration=7.7±5.0 mo)with chronic CFP,defined as≥4 on the numeric rating scale(NRS).We performed PRF stimulation on the cervical medial *** outcomes of the PRF procedure were evaluated by comparing the NRS scores for CFP before treatment and 1 and 3 mo after *** pain relief was defined as a≥50%reduction in the NRS score at 3 mo when compared with the pretreatment NRS *** No patient had immediate or late adverse effects following *** average NRS score for CFP decreased from 5.3±1.1 at pre-treatment to 2.4±0.6 at the 1 mo follow-up,and 3.1±1.1 at the 3 mo *** to the NRS scores before PRF stimulation,those at 1 and 3 mo after PRF stimulation had significantly *** of the 21 patients(52.4%)reported successful pain relief 3 mo after the PRF *** stimulation on cervical medial branches may be a useful therapeutic option to control chronic *** PRF stimulation of the cervical medial branches may be used as an alternative treatment method in patients with *** can effectively alleviate CFP,and is safe to perform.

关键词： Pulsed radiofrequency treatment Zygapophyseal joint Chronic pain Pain Neck pain Pain management

Reliable high temperature, high humidity flexible thin film encapsulation using Al2O3/MgO nanolaminates for flexible OLEDs

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Nano Research 2020年第10期13卷 2716-2725页

作者： Ki Suk Kang So Yeong Jeong Eun Gyo Jeong kyung cheol Choi School of Eetrical Enginerng Korea Advanced lstute of Sciencp and Tchcnoloy(KAIST) 291 Daehak roYuscong guDaejeon 34141Republic of Korea Department of Clothing and Textiles Chormam National University77 Yongbong.roBuk guGwangjiu 61186Republic of Korea

Since most organic materials are very sensitive to moisture and oxygen, organic light emitting diodes (OLEDs) require an encapsulation layer to protect the active layer from these gases. Since light, flexible and portable OLEDs are being employed in more diverse climates and environmental conditions, the OLED encapsulation layer must retain robust mechanical properties and stability in high temperature/high humidity conditions. Al2O3 films have demonstrated excellent barrier performance, but they readily hydrolyze when exposed to prolonged harsh environments. In this study, we fabricated a thin film encapsulation (TFE) film that was resistant to hydrolysis, using Al2O3/MgO (AM) nanolaminates. MgO has superior resistance to harsh environments, and the aluminate phase generated by the chemical reaction of Al2O3 and MgO provided excellent barrier performance, even after storage in harsh conditions. A multi-barrier fabricated using the AM nanolaminate showed excellent barrier performance, close to the level required by OLEDs. It did not significantly deteriorate even after a bending test of 1,000 iterations at 0.63% strain. After 1,000 cycle of bending, the electrical properties of the passivated OLEDs were not significantly degraded at shelf-lifetime test where the fabricated device was stored for 50 days in a harsh environment of 60℃, 90% relative humidity. The multi-barrier shows the best performance compared to previous studies on flexible encapsulation that can be used in harsh environments.

关键词： thin film encapsulation nanolaminate structure Al2O3 MgO flexible organic light emitting diode(OLED)