Aged T cells and cardiovascular disease

作     者：Min Kyung Jung Eui-Cheol Shin 

作者机构：Laboratory of Immunology and Infectious DiseasesGraduate School of Medical Science and EngineeringKAISTDaejeon 34141Republic of Korea 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2017年第14卷第12期

页      面：1009-1010页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

主　　题：CD57 cardiovascular typically 

摘      要：Memory T cells undergo replicative senescence via repetitive *** in other cells,replicative senescence of T cells is characterized by shortened telomeres.1 Immunophenotypes are also altered in replicative senescent T cells compared to young T *** humans,replicative senescent T cells typically lose expression of CD28,a costimulatory receptor,and acquire the expression of CD57 antigen,a terminally sulfated glycan carbohydrateepitope,1 though the mechanism underlying this regulation has not yet been clearly ***,CD28−or CD57+T cells are considered replicative senescent T cells in humans.