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EXPERIMENTAL ESTIMATION OF A SCALING EXPONENT FOR TIP VORTEX CAVITATION VIA ITS INCEPTION TEST IN FULL-AND MODEL-SHIP

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Journal of Hydrodynamics 2012年第5期24卷 658-667页

作者： LEE Jeung-Hoon JUNG Jae-Kwon LEE kyung-Jun HAN Jae-Moon PARK Hyung-Gil seo Jong-Soo Samsung Ship Model Basin(SSMB) Marine Research InstituteSamsung Heavy IndustriesScience TownDaejeon 305-380Korea

Tip vortex cavitation noise of marine propeller became primary concems to reduce hazardous environmental impacts from commercial ship or to keep the underwater surveillance of naval ships. The investigations of the tip vortex and its induced noise are normally conducted through the model test in a water cavitation tunnel. However the Reynolds number of model-test is much smaller than that of the full-scale, which subsequently results in the difference of tip vortex cavitation inception. Hence, the scaling law between model- and full-scales needs to be identified prior to the prediction and assessment of propeller noise in full scale. From previous researches, it is generally known that the incipient caivtation number of tip vortex can be represented as a power of the Reynolds number. However, the power exponent for scaling, which is the main focus of this research, has not been clearly studied yet. This paper deals with the estimation of scaling exponent based on tip vortex cavitation inception test in both full- and model-scale ships. Acoustical measurements as well as several kind of signal processing technique for an inception criterion suggest the scaling exponent as 0.30. The scaling value proposed in this study shows slight difference to the one of most recent research. Besides, extrapolation of model-ship noise measurement using the proposed one predicts the full-scale noise measurement with an acceptable discrepancy.

关键词： tip vortex cavitation underwater radiated noise scaling exponent

Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun seo Da Hyun Lee Yu seol Lee kyung Joo Cho Hye Jung Park Hye won Lee Beom kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

Graphene-GaN Schottky diodes

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Nano Research 2015年第4期8卷 1327-1338页

作者： seongjun Kim Tae Hoon seo Myung Jong Kim Keun Man song Eun-kyung Suh Hyunsoo Kim School of Semiconductor and Chemical Engineering Semiconductor Physics Research Center Chonbuk National University Jeonju 561-756 Republic of Korea Soft Innovative Materials Research Center Korea Institute of Science and Technology Jeonbuk 561-905 Republic of Korea Korea Advanced Nano Fab Center Suwon 443-700 Republic of Korea

The electrical characteristics of graphene Schottky contacts formed on undoped GaN semiconductors were investigated. Excellent rectifying behavior with a rectification ratio of -10^7 at ±2 V and a low reverse leakage current of 1.0 × 10^-8 A/cm^2 at -5 V were observed. The Schottky barrier heights, as determined by the thermionic emission model Richardson plots, and barrier inhomogeneity model, were 0.90, 0.72, and 1.24 ± 0.13 eV, respectively. Despite the predicted low barrier height of -0.4 eV at the graphene-GaN interface, the formation of excellent rectifying characteristics with much larger barrier heights is attributed to the presence of a large number of surface states （1.2 x 1013 states/cm2/eV） and the internal spontaneous polarization field of GaN, resulted in a significant upward surface band bending or a bare surface barrier height as high as of 2.9 eV. Using the S parameter of 0.48 （measured from the work function dependence of Schottky barrier height） and the mean barrier height of 1.24 eV, the work function of graphene in the Au/graphene/GaN stack could be approximately estimated to be as low as 3.5 eV. The obtained results indicate that graphene is a promising candidate for use as a Schottky rectifier in GaN semiconductors with n-type conductivity.

关键词： graphene GaN Schottky diode Schottky barrier height Fermi level pinning

Relaxation of rabbit cavernous smooth muscle to 17β-estradiol: a non-genomic, NO-independent mechanism

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Asian Journal of Andrology 2004年第2期6卷 127-131页

作者： Sae-Chul Kim kyung-Kun seo Soon-Chul Myung Moo Yeol Lee Department of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Physiology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim: To investigate whether estrogen was involved in relaxation of rabbit cavernous smooth muscle. Methods: Relaxation response of the rabbit cavernous smooth muscles to 17β-estradiol (0.3, 3, 30 and 300 nmol/L) were observed in vitro. The response of the muscle strips to estrogen after incubation with either actinomycin D (10μmol/L) or L-NAME (10μmol/L) were also evaluated. Inside-out mode of patch clamp in a single smooth muscle cell was applied to investigate the Maxi-K channel activities. Results: Estrogen caused a dose-dependent relaxation of the strips precontracted with norepinephrine. The maximal response was noted about 10 minutes after treatment. The estrogen-induced relaxation was prevented by neither actinomycin D nor L-NAME, suggesting that the response was not mediated by gene transcription or nitric oxide (NO). Application of 17β-estradiol increased the Maxi-K channel activities. Conclusion: 17β-estradiol may be involved in relaxation of rabbit cavernous smooth muscles via a non genomic and NO independent mechanism. 17β-estradiol stimulates Maxi-K channel of the rabbit cavernous myocyte.

关键词： 17β-estradiol cavernous smooth muscles Maxi-K channel relaxation

Effect of prenatal antioxidant intake on infants' respiratory infection is modified by a CD14 polymorphism

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World Journal of Pediatrics 2017年第2期13卷 173-182页

作者： seo Ah Hong Eun Lee Sung Ok Kwon kyung won Kim Youn Ho Shin Kang Mo Ahn Eun-Jin Kim Jeom-Gyu Lee Se-Young Oh Soo-Jong Hong ASEAN Institute for Health Development Mahidol UniversitySalayaPhutthamonthonNakhonpathomThailand Department of Pediatrics Inje University Haeundae Paik HospitalBusanKorea Department of Food and Nutrition Research Institute of Human EcologyKyung Hee UniversitySeoulKorea Department of Pediatrics Severance Children's HospitalCollege of MedicineYonsei UniversitySeoulKorea Department of Pediatrics CHA Medical CenterCHA University School of MedicineSeoulKorea Department of Pediatrics Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Allergy and Respiratory Diseases Korea National Institute of HealthOsong Health Technology Administration ComplexKorea Department of Pediatrics Childhood Asthma Atopy CenterEnvironmental Health CenterAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic *** hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of ***:This study included 550 *** the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study,prenatal maternal diet was assessed by administering a food frequency ***' cord blood was genotyped for CD14 (rs2569190),TLR4 (rs1927911),and GSDMB (rs4794820) polymorphisms by the TaqMan ***:Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430).In children with TT genotype at rs2569190,a higher prenatal intake of vitamins A and C,fruits,and total FV decreased RTI risk (P-trend <0.05),while in infants with TC+CC genotype,a higher prenatal intake of fruit increased RTI risk (P-trend <0.05).When analyzing the 3 genotypes,children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30,respectively].In children with CC genotype at rs1927911,RTI risk showed a dose-response association with a higher prenatal intake of vitamin C (P for interaction<0.05).A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction<0.05).Conclusion:Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14,TLR4,and GSDMB polymorphisms.

关键词： antioxidants CD14 fruit polymorphism respiratory tract infection

PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer： a retrospective study

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Asian Journal of Andrology 2017年第4期19卷 458-462页

作者： Sung Han Kim Weon seo Park Bo Ram Park Jungnam Joo Jae Young Joung Ho kyung seo Jinsoo Chung Kang Hyun Lee Department of Urology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Pathology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Statistics Biometric Research Branch Clinical Research Coordination Center Research Institute and Hospital of National Cancer Center Goyang Korea.

Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry （IHC） to determine the prognostic values of multiple tissue biomarkers in hormone-na＇l＇ve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections. The Cox proportional hazard model was used to determine the predictive risk factors for biochemical recurrence （BCR） of prostate cancer. During a median 44-month follow-up, 128 （25.1%） patients developed BCR. A multivariate regression analysis revealed that Ki-67 （hazard ratio [HR]. 1.60, P = 0.033）, PSCA （HR： 0.42, P 〈 0.001）, and Cox-2 （HR： 2.05, P = 0.003） were the only significant prognostic tissue markers of BCR. Resection margin status （HR： 1.67, P = 0.010）, pathologic pTO/l/2 stage （vs pT3/4; HR： 0.20, P = 0.002）, preoperative PSA levels （HR.. 1.03, P 〈 0.001）, biopsied （HR： 1.30, P = 0.022） and pathologic （HR： 1.42, P = 0.005） Gleason scores, and prostate size （HR： 0.97, P = 0.003） were significant clinicopathologic factors. The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for BCR in patients with clinically localized prostate cancer following radical prostatectomy.

关键词： biomarker immunohistochemistry prostatectomy recurrence tissue microarray

Carbon and nitrogen storage in an age-sequence of Pinus densiflora stands in Korea

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Science China(Life Sciences) 2010年第7期53卷 822-830页

作者： NOH Nam-Jin SON Yowhan LEE Sue-Kyoung seo kyung-won HEO Su-Jin1 YI Myong-Jong PARK Pil-Sun KIM Rae-Hyun SON Yeong-Mo LEE Kyeong-Hak Division of Environmental Science and Ecological Engineering Korea University Korea Forest Research Institute Department of Forest Resources Kangwon National University Department of Forest Sciences Seoul National University

The carbon(C) and nitrogen(N) storage capabilities of Pinus densiflora in six different stand ages(10,27,30,32,44,and 71 years old) were investigated in *** sample trees were destructively harvested and 12 were *** from the above and belowground tree components,coarse woody debris(CWD),forest floor,and mineral soil(0-30 cm) were *** biomass was highest in the 71-year-old stand(202.8 t ha-1) and lowest in the 10-year-old stand(18.4 t ha-1).C and N storage in the mineral soil was higher in the 71-year-old stand than in the other stands,mainly due to higher soil C and N ***,the total ecosystem C and N storage(tree+forest floor+CWD+soil) was positively correlated with stand age:increasing from a minimum in the 10 year old stand(18.8 t C ha-1 and 1.3 t N ha-1) to a maximum in the 71-year-old stand(201.4 t C ha-1 and 8.5 t N ha-1).The total ecosystem C storage showed a similar sigmoidal pattern to that of tree C storage as a function of the age-sequence,while N storage in the CWD,forest floor and mineral soil showed no significant temporal *** results provide important insights that will increase our understanding of C and N storage in *** stands and our ability to predict changes according to stand age in the region.

关键词： age-sequence allometric equation biomass carbon nitrogen Pinus densiflora stand age

High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices

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Neural Regeneration Research 2010年第18期5卷 1365-1372页

作者： Don-Kyu Kim Young Chul Yoon Soo Ahn Chae kyung Mook seo Tai Ryoon Han Si-Hyun Kang Department of Physical Medicine and Rehabilitation Chung-Ang University College of Medicine Department of Neurology Chung-Ang University College of Medicine Department of Pediatrics Chung-Ang University College of Medicine Department of Physical Medicine and Rehabilitation Seoul National University

Repetitive transcranial magnetic stimulation （rTMS） has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer＇s disease. However, the precise mechanisms of its clinical effects remain unknown. β-amyloid （Aβ） exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer＇s disease. Therefore, it has been hypothesized that the neuroprotective effects of rTMS are related to the mechanisms of protection against Aβ neurotoxicity. Organotypic hippocampal slices were prepared from 8-day old, Sprague Dawley rats. The tissue slices were exposed to 100 μmol/L Al3142 since day 12 in vitro with and without high-frequency （20 Hz） magnetic stimulation. Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei （NeuN） protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine （BrdU） immunohistochemistry. Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage. Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure （P 〈 0.05） and significantly reduced the number of damaged cells in the hippocampal slices （P 〈 0.05）. However, lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences These findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity.

关键词： organotypic hippocampus amyloid beta-protein magnetic stimulation nerve degeneration/metabolism nerve degeneration/pathology organ culture techniques rats, Sprague Dawiey

Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

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Asian Journal of Andrology 2012年第2期14卷 320-324页

作者： Mee-Young Lee In-Sik Shin Chang-seob seo Nam-Hun Lee Hye-kyung Ha Jong-Keun Son Hyeun-Kyoo Shin Herbal Medicine EBM Research Center Korea institute of Oriental MedicineExporo 483Yusung-guDaejeon 305-811Koreaand Coilege of Pharmacy Yeungnam UniversityGyonsan 712-749Korea

Benign prostatic hyperplasia （BPH） is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract （MFME） improves BPH, using the testosterone propionate （TP）-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP （3 mg kg-1） dissolved in corn oil, for 4 weeks. MFME was administered daily by oral garage at a dose of 200 mg kg-1 for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight （prostate/body weight ratio） was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone （DHT） in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound（s） responsibility for inducing the protective effect against BPH and determine its mechanism of action,

关键词： benign prostatic hyperplasia dihydrotestosterone Melandrium firmum (S. et Z.)RoHRB prostate testosterone