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Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 653-658页

作者： Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi hae Lim Kim kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le Interdisciplinary Program of Biomodulation Myongji UniversityYonginGyeonggi 17058Republic of Korea Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityYonginGyeonggi 17058Republic of Korea Teazen Co. B-606 Acrotower230 Sinim-daeroDongan-guAnyang-siGyeonggi-do 14067Republic of Korea Department of Food Science&Biotechnology Shin Ansan UniversityAnsanGyeonggi 15435Republic of Korea' Division of Bioscience and Bioinformatics Myongji UniversityYonginGyeonggi 17058Republic of Korea Department of Biotechnology Chonnam National UniversityYeosuChonnam 59626Republic of Korea

Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer.

关键词： Immune system enhancement Cyclophosphamide Cornus officinalis Sieb Et Zucc Eriobotrya japonica Lindley Olive leaves

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Linking individual attributes and host specialization in brood parasitic cuckoos

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Avian Research 2022年第2期13卷 145-151页

作者： Sue-Jeong Jin hae-Ni Kim Geun-Won Bae Jin-Won Lee Jeong-Chil Yoo Korea Institute of Ornithology Kyung Hee UniversitySeoul02447Republic of Korea Department of Biology Kyung Hee UniversitySeoul02447Republic of Korea

Generalist avian brood parasites vary considerably in their degree of host specialization(e.g.,number of hosts);some parasitize the nests of just a few host species,whereas others exploit more than 100 *** factors,including habitat range,habitat type,and geographic location,have been suggested to account for these ***,inter-specific differences in individual attributes,such as personality and plasticity,have rarely been considered as potential factors of such variation,despite their potential relationship to,for example,range *** cage experiments,we tested the hypothesis that parasitic species exploiting more host species may be more active and *** this end,we quantified behaviors exhibited by two Cuculus cuckoos(Common Cuckoo *** and Oriental Cuckoo ***)that vary greatly in their number of host ***,we evaluated exploratory behavior displayed by birds in the cage,such as the number of movements,head-turning,wing-flapping,and *** Common Cuckoo,which has a higher number of host species,tended to exhibit higher levels of exploratory behaviors than the Oriental *** study showed that the two cuckoo species exhibited different exploratory levels,as predicted by the differences in their number of *** studies regarding the causality between individual attributes and host specialization with improved experimental methodology would greatly enhance our understanding of the role of individual characteristics in the coevolution of avian brood parasites and their hosts.

关键词： Brood parasitism Common Cuckoo Individual attributes Number of hosts Oriental Cuckoo

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Reduced interface energy loss in non-fullerene organic solar cells using room temperature-synthesized SnO2 quantum dots

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Journal of Materials Science & Technology 2020年第17期52卷 12-19页

作者： In Su Jin Minwoo Park Jae Woong jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Department of Chemical and Biological Engineering Sookmyung Women's UniversitySeoul 04310Republic of Korea

We herein report the room temperature synthesis of colloidal SnO2 quantum dots and their application in non-fullerene organic solar cells as an excellent electron transport *** thiourea-assisted hydrolysis at room temperature affords the nanocrystalline SnO2 quantum dots with a diameter of 3-4 *** utilization of the SnO2 quantum dots as an electron transporting layer effectively reduces the interfacial trap density and charge recombination in the solar cell devices,leading to not only the reduced energy loss but also excellent photocurrent *** optimized organic solar cells employing SnO2 quantum dots with polyethylenimine ethoxylated achieves power conversion efficiencies up to 12.023%with a VOC,a JSC,and a FF of 0.89 V,18.89 mA cm^–2,and *** work suggest that the SnO2 quantum dot is a promising electron transporting material to construct efficient organic solar cells for practical *** work also demonstrates the key strategy for thiourea-assisted hydrolysis to synthesize fine and nanocrystalline SnO2 quantum dots.

关键词： Energy loss Organic solar cells Interface SnO2 Quantum dots

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FEA technique of hot plate forming process using cell-typed die with cooling device

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中国有色金属学会会刊：英文版 2012年第S3期22卷 831-837页

作者： jung-Min LEE In-Kyu LEE kyung-Hun LEE Dae-Soon KIM Byung-Min KIM Dongnam Regional Division Korea Institute of Industrial Technology School of Mechanical Engineering Pusan National University Industrial Technology Division Hyundai Heavy Industries

Hot plate forming using a cell-typed die is a process for forming a large thick plate with a spherical shape for the manufacture of a large spherical LNG ***-typed upper and lower dies made of a framework of steel plates fitted to make a grid pattern are used in this process,and an air-cooling device is separately installed inside the lower die.A finite element analysis (FEA) technique was developed,which included hot forming,air flow,cooling and thermal deformation analysis for the hot plate forming process using the cell-typed ***,the convective and interface heat transfer coefficients were used to reproduce analytically the effects of the cooling device in the hot plate forming analysis.A small-scale model test of the process was conducted to verify the FEA *** analysis results show that the curvature of the final plate agrees well with that of the designed experiment within a maximum relative error of 0.03% at the corner of the plate.

关键词： cell-typed die hot plate forming spherical LNG tank heat transfer coefficient

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Simultaneously enhanced efficiency and ambient stability of inorganic perovskite solar cells by employing tetramethylammonium chloride additive in CsPbI2Br

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Journal of Materials Science & Technology 2022年第7期102卷 224-231页

作者： In Su Jin Bhaskar Parida Jae Woong jung Department of Advanced Materials Engineering for Information and Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Integrated Education Institute for Frontier Materials(BK21 Four) Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

Although all-inorganic perovskites possess suitable bandgap and thermal stability for photovoltaic ap-plications,the unstable film morphologies,and poor moisture stabilities lag behind the organic-inorganic hybrid ***,we demonstrate that high qualityα-CsPbI_(2 ) Br films with improved phase sta-bility,high crystallinity,and pinhole-free film morphology was achieved by employing tetramethylammo-nium chloride(TMACl)as an *** a result,the TMACl-added CsPbI_(2) Br films exhibited high power conversion efficiency of 14.12%with an open-circuit voltage of 1.19 V,a short-circuit current density of 15.08 mA/cm^(2),and a fill factor of *** importantly,the TMACl addition imparts hydrophobicity to the film surface of CsPbI_(2) Br,which delivered excellent stability up to 30 days in the ambient condition and thermal stability at 85℃ for 156 h,***,the TMACl-added device also exhibited excellent PCE of 27.16%under indoor light source(1000 lux),which presents a promising approach for designing stable but high performance all-inorganic perovskite solar cells.

关键词： Inorganic perovskite solar cells CsPbI2Br Additive Tetramethylammonium chloride Efficiency

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Increased risk of atrial fibrillation in patients with inflammatory bowel disease: A nationwide population-based study

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World Journal of Gastroenterology 2019年第22期25卷 2788-2798页

作者： You-jung Choi Eue-Keun Choi kyung-Do Han Jiesuck Park Inki Moon Euijae Lee Won-Seok Choe So-Ryoung Lee Myung-Jin Cha Woo-Hyun Lim Seil Oh Department of Internal Medicine Seoul National University HospitalSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 03083South Korea Department of Internal Medicine Seoul National University Boramae Medical CenterSeoul 07061South Korea

BACKGROUND Inflammatory bowel disease (IBD), a chronic inflammatory disease of the gastrointestinal tract, could play a role in the pathophysiology of atrial fibrillation (AF). AIM To investigate the association between IBD and AF development. METHODS We performed a population-based cohort study using records in the Korean National Health Insurance Services database between 2010 and 2014. A total of 37696 patients with IBD (12349 with Crohn’s disease and 25397 with ulcerative colitis) were identified. The incidence rate of newly diagnosed AF in patients with IBD was compared with that in a 3 times larger cohort of 113088 age- and sex-matched controls without IBD. RESULTS During 4.9 ± 1.3 years of follow-up, 1120 patients newly diagnosed with AF (348 in the IBD group and 772 in controls) were identified. After adjustments using multivariable Cox proportional hazards, patients with IBD were at a 36%[95% confidence interval (CI) 20%-54%] higher risk of AF than controls. The association between IBD and the development of AF was stronger in younger than in older patients. Patients without cardiovascular risk factors showed a higher risk of AF primarily. Additionally, patients receiving immun-omodulators [Hazard ration (HR) 1.46, 95%CI 1.31-1.89], systemic corticosteroids (HR 1.37, 95%CI 1.10-1.71), or biologics agents (HR 2.38, 95%CI 1.51-3.75) were at higher risk of AF than patients without them. CONCLUSION IBD significantly increased the risk of AF, and the impact of IBD on developing AF was in patients with moderate to severe disease.

关键词： Atrial fibrillation Inflammatory bowel disease Colitis, Ulcerative Crohn's disease

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Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders

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World Journal of Gastroenterology 2017年第18期23卷 3330-3337页

作者： Soo-kyung Lim Seung Jin Yoo Dae Lim Koo Chae A Park Han Jun Ryu Yong Jin jung Ji Bong Jeong Byeong Gwan Kim Kook Lae Lee Seong-Joon Koh Department of Internal Medicine Seoul National University College of MedicineSeoul National University Boramae Hospital Department of Neurology Seoul National University Boramae HospitalSeoul National University College of Medicine

To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call *** this cross-sectional observation study, using the Rome III Questionnaire and Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 doctors with 24 hour-on-call *** the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48 (28.2%) had FGIDs. Overall prevalence of irritable bowel syndrome (IBS) and functional dyspepsia (FD) were 16.5% and 17.1%, respectively, with 5.3% exhibiting both. Sleep scores (PSQI) (8.79 ± 2.71 vs 7.30 ± 3.43, P = 0.008), the presence of serious psychosocial alarm (83.3% vs 56.6%, P = 0.004), and the proportion of doctors who experienced over two months of recent on-call work (81.2% vs 68.9%, P = 0.044) were significantly different between individuals with or without FGIDs. Multivariate analysis revealed that presenting serious psychosocial alarm was an independent risk factor for prevalence of FD (OR = 5.47, 95%CI: 1.06-28.15, P = 0.042) and poor sleep quality (PSQI ≥ 6) was a predictor of IBS (OR = 4.17, 95%CI: 1.92-19.02, P = 0.016).CONCLUSIONPhysicians should recognize the role of sleep impairment and psychological stress in the development of FGIDs and a comprehensive approach should be considered to manage patients with FGIDs.

关键词： Psychosocial stress Sleep 24 hour-on-call shift Doctors Functional gastrointestinal disorders

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The Performance Improvement of BASK System for Giga-Bit MODEM Using the Fuzzy System

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International Journal of Communications, Network and System Sciences 2010年第5期3卷 441-445页

作者： Ki-Hwan Eom Kyo-Hwan Hyun kyung-Kwon jung 不详

In this paper we propose an automatic bandwidth control method for the performance improvement of Binary Amplitude Shift Keying (BASK) system for Giga-bit Modem in millimeter band. To improve the performance of the BASK system with a fixed bandwidth, the proposed method is to adjust a bandwidth of low pass filter in receiver using the fuzzy system. The BASK system consists of a high speed shutter of the transmitter and a counter and a repeater of receiver. The repeater consists of four stage converters, and a converter is constructed with a low pass filter and a limiter. The inputs to the fuzzy system are the reminder and integral of remainder of counter, and output is a bandwidth. We used a Viterbi algorithm to find the optimum detection from output of the counter. Simulation results show that the proposed system improves the performance compared to the fixed bandwidth.

关键词： BASK Giga-Bit MODEM Bandwidth Low Pass Filter Fuzzy System

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福岛核事故泄漏进入海洋的137Cs对中国近海影响的模拟与预测

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科学通报 2014年第34期59卷 3416-3423页

作者：赵昌乔方利王关锁夏长水 jung kyung Tae 国家海洋局第一海洋研究所青岛266061 Korea Institute of Ocean Science and Technology Ansan-Si 426-744 Korea

2011年3月日本福岛第一核电站遭受海啸侵袭,引起大量放射性物质泄漏进入海洋和大气,进入大气通道的放射性物质大部分沉降于海洋上,其中进入大气中的137Cs(总量约13 PBq)有38.5%沉降于日本东部海域,对海洋造成二次污染.本文在POM环流模... 详细信息

2011年3月日本福岛第一核电站遭受海啸侵袭,引起大量放射性物质泄漏进入海洋和大气,进入大气通道的放射性物质大部分沉降于海洋上,其中进入大气中的137Cs(总量约13 PBq)有38.5%沉降于日本东部海域,对海洋造成二次污染.本文在POM环流模式中引入放射性物质在海洋中的输运、沉降和衰变的控制方程,建立了一个准全球放射性物质数值模式,模拟并预测了福岛核事故泄漏的放射性物质137Cs的长期输运情况,分析了该泄漏物质通过海洋途径进入中国近海的过程.结果表明:福岛核事故泄漏的137Cs于2013年开始对中国近海海域造成影响,其浓度和影响范围在未来5~6年将逐渐增加,2018年前后黄东海和南海北部的137Cs浓度达到最高值.南海中南部浓度小于黄东海和南海北部,且最大浓度出现时间滞后于其他海域,所有中国近海海区137Cs浓度达到最大值后在自身衰减的作用下逐渐降低;137Cs在中国近海的浓度小于外海,在黑潮外部海域由于黑潮的强流屏障作用会形成一个137Cs浓度高值区;137Cs在中国近海浅水海域上下混合均匀,在深水区上层水体的137Cs(上400 m)浓度要明显大于下层,在南海200~400 m层水体形成一个高值区.

关键词：福岛核事故 137Cs 放射性物质模式中国近海

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Risedronate Inhibition of Matrix Metalloproteinase-2 Expression in Osteosarcoma Cell Line

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中国肺癌杂志 2009年第6期12卷 664-665页

作者： Kim Yang kyung Sung Taek jung Taek Rim YOON The Brain Korea 21 Project Center for Biomedical Human Resources Department of Orthopaedic Surgery Chonnam National University Medical School

Background and objective Osteosarcoma is a high-malignant bone tumor and is the most frequent malignant bone tumor in children and adolescents. Significant proportions of the

关键词：肺癌恶性肿瘤炎症 β-七叶皂甙钠

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