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Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles

Bone Research 2022年第2期10卷 310-325页

作者： Hsu-Wen Tseng Dorothée Girard kylie A.Alexander Susan m.millard Frédéric Torossian Adrienne Anginot Whitney Fleming Jules Gueguen marie-Emmanuelle Goriot Denis Clay Beulah Jose Bianca Nowlan Allison R.Pettit marjorie Salga François Genêt marie-Caroline Le Bousse-Kerdilès Sébastien Banzet Jean-Pierre Lévesque mater Research Institute-The University of Queensland WoolloongabbaQLDAustralia Institut de Recherche Biomédicale des Armées(IRBA) INSERM UMRS-MD1197 ClamartFrance INSERm UmRS-mD 1197 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance INSERm UmS-44 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance UPOH(UnitéPéri Opératoire du Handicap Perioperative Disability Unit)Physical and Rehabilitation Medicine departmentRaymond-PoincaréHospitalAssistance Publique-Hôpitaux de Paris(AP-HP)GarchesFrance Universitéde Versailles Saint Quentin en Yvelines UFR Simone Veil-SantéEND:ICAP INSERM U1179Montigny le BretonneuxFrance

The cells of origin of neurogenic heterotopic ossifications(NHOs), which develop frequently in the periarticular muscles following spinal cord injuries(SCIs) and traumatic brain injuries, remain unclear because skeletal muscle harbors two progenitor cell populations: satellite cells(SCs), which are myogenic, and fibroadipogenic progenitors(FAPs), which are mesenchymal. Lineage-tracing experiments using the Cre recombinase/Lox P system were performed in two mouse strains with the fluorescent protein Zs Green specifically expressed in either SCs or FAPs in skeletal muscles under the control of the Pax7 or Prrx1 gene promoter, respectively. These experiments demonstrate that following muscle injury, SCI causes the upregulation of PDGFRα expression on FAPs but not SCs and the failure of SCs to regenerate myofibers in the injured muscle, with reduced apoptosis and continued proliferation of muscle resident FAPs enabling their osteogenic differentiation into NHOs. No cells expressing Zs Green under the Prrx1 promoter were detected in the blood after injury, suggesting that the cells of origin of NHOs are locally derived from the injured muscle. We validated these findings using human NHO biopsies. PDGFRα+mesenchymal cells isolated from the muscle surrounding NHO biopsies could develop ectopic human bones when transplanted into immunocompromised mice, whereas CD56+myogenic cells had a much lower potential. Therefore, NHO is a pathology of the injured muscle in which SCI reprograms FAPs to undergo uncontrolled proliferation and differentiation into osteoblasts.

关键词： progenitor injuries muscles

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A Short Growing Season Negatively Affects Progeny Vigor in Jointed Goatgrass (<i>Aegilops cylindrica</i>)

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Agricultural Sciences 2015年第3期6卷 315-324页

作者： Lynn m. Ingegneri michael P. quinn Andrew G. Hulting Carol A. mallory-Smith Department of Crop and Soil Science Oregon State University Corvallis USA

Seed production and percent germination in jointed goatgrass were negatively affected by a shorter vernalization period in field studies conducted at Oregon State University. Our objective was to determine if a shorter growing season experienced by a maternal jointed goatgrass plant similarly affected seedling vigor in the progeny. Seed mass, percent germination, emergence, seedling height and biomass, including roots, were recorded or evaluated on progeny that were produced from three jointed goatgrass populations grown under a long or short growing season in a common garden experiment in eastern Oregon, an area where jointed goatgrass is known to commonly infest natural resources, including winter wheat. Seeds produced under a shorter growing season weighed less, were slower to germinate, and displayed lower percent germination compared with seeds produced under a long growing season. Seedlings from a short growing season were slower to emerge, and produced less shoot biomass compared to seedlings produced under a long growing season. Seedling roots and shoots were shorter when seeds were produced under a short growing season. A shorter growing season negatively affected jointed goatgrass seedling vigor. If resources for jointed goatgrass management are limited, strategies should focus on controlling plants that emerge in the fall, because they have the potential to produce more vigorous seedlings compared to plants that emerge in late winter or early spring.

关键词： Caryopses Crop Rotation Germination Growing Degree Days Seedling Vigor Seeds Vernalization Winter Annual

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Computational Quantum Chemistry II. The Group Theory Calculator

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2005年

作者： Charles m. quinn Patrick W. Fowler and David B. Redmond (Auth.)

来源：畅想之星图书光盘版（南... 评论

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Enewetak环礁(西部赤道太平洋)上-更新世灰岩的淡水成岩作用

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海洋地质前沿 1992年第10期 20-21页

作者： T.m.quinn 文丽

本文的主题是关于Enewctak环礁与上-更新世快速而频繁的海平面波动之间的动态效应关系。作者采用定量的地层模式来评估浅海碳酸盐对海平面变化、沉降、沉积和成岩作用的反应;应用水体-岩石在大气淡水成岩环境中相互作用的定量模式,综合... 详细信息

本文的主题是关于Enewctak环礁与上-更新世快速而频繁的海平面波动之间的动态效应关系。作者采用定量的地层模式来评估浅海碳酸盐对海平面变化、沉降、沉积和成岩作用的反应;应用水体-岩石在大气淡水成岩环境中相互作用的定量模式,综合考虑灰岩的组构、同位素和微量元素特征来限定Enewetak环礁上-更新世的成岩历史。

关键词：淡水成岩作用方解石化作用 Enewetak 太平洋

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Discovery of tanshinone derivatives with anti-mRSA activity via targeted bio-transformation

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Synthetic and Systems Biotechnology 2016年第3期1卷 187-194页

作者： Wenni He miaomiao Liu Pei Huang Wael m.Abdel-mageed Jianying Han Jeramie D.Watrous Don D.Nguyen Wenzhao Wang Fuhang Song Huanqin Dai Jingyu Zhang Ronald J.quinn Tanja Grkovi Houwei Luo Lixin Zhang Xueting Liu Key Laboratory of Pathogenic microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Department of Chemistry&Biochemistry University of California San DiegoLa JollaCA 92093United States Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Pharmacognosy Faculty of PharmacyAssiut UniversityAssiut 71526Egypt Department of Natural Products China Pharmaceutical UniversityNanjing 210009China Graduate University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Eskitis Institute Griffith UniversityBrisbaneQLD 4111Australia

Two potent anti-mRSA tanshinone glycosides(1 and 2)were discovered by targeted microbial biotransformation,along with rapid identification via mS/mS *** reactions including dehydrogenation,demethylations,reduction,glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus mucor rouxianus AS *** addition,tanshinosides B(2)showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with mIC values of 0.78 mg/*** is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.

关键词： Biotransformation Glycosylation Tanshinone IIA mucor rouxianus

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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厦门港和员当湖表层沉积物中的石油烃和多环芳香烃

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海洋环境科学 2003年第4期22卷 49-53页

作者：欧寿铭郑建华郑金树 James G.quinn 厦门市环境保护科学研究所福建厦门361006 国家海洋局第三海洋研究所福建厦门361005 美国罗得岛大学海洋研究生院

2002年4月厦门港沿岸设9个站,员当湖设两个站采集表层沉积物,用有机溶剂萃取,硅胶柱色层分离,气相色谱-质谱联机带SIm数据采集系统对样品的石油烃类(m/Z=55),多环芳香烃类进行分析,结果显示员当湖石油烃和多环芳香烃质量分数分别高达139... 详细信息

2002年4月厦门港沿岸设9个站,员当湖设两个站采集表层沉积物,用有机溶剂萃取,硅胶柱色层分离,气相色谱-质谱联机带SIm数据采集系统对样品的石油烃类(m/Z=55),多环芳香烃类进行分析,结果显示员当湖石油烃和多环芳香烃质量分数分别高达1397和1376.5ng/g。厦门港船只活动,厦门港四周工业废水、车辆燃油滴漏是石油烃和多环芳香烃污染的主要来源。

关键词：厦门港表层沉积物石油烃类多环芳香烃类

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The predictive value of SS-16 in clinically diagnosed Parkinson’s disease patients:comparison with ^(99m)Tc-TRODAT-1 SPECT scans

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Translational Neurodegeneration 2016年第1期5卷 126-130页

作者： Wenyan Kang Fangyi Dong Dunhui Li Thomas J.quinn Shengdi Chen Jun Liu Department of Neurology&Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Neurology Ruijin Hospital North affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Radiation Oncology Beaumont Health SystemRoyal OakMI 48073USA

Background:Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease(PD)from patients with non-Parkinsonian *** previous study indicated that the“Sniffin’Sticks”odor identification test(SS-16)acts as a valid instrument for olfactory assessment in Chinese PD *** aim of the study was to compare the efficacy of the two methods in diagnosing ***:Fifty-two PD patients were involved in this study and underwent single photon emission computed tomography(SPECT)imaging using the labeled dopamine transporter radiotracer ^(99)mTc-TRODAT-1 to assess nigrostriatal dopaminergic *** function was assessed with the“Sniffin’Sticks”odor identification test(SS-16)in all patients who received DAT-SPECT *** analysis(SPSS version 21)was carried out to determine the diagnostic accuracy of SS-16 as well as its correlation with ^(99)mTc-TRODAT-1 SPECT,its positive predictive value(PPV),and negative predictive value(NPV).Results:We identified a negative correlation between SS-16 and DAT SPECT(Kappa=0.269,p=0.004).By using the ^(99)mTc-TRODAT-1 uptake results as the gold standard,the sensitivity and specificity of SS-16 was 56.8 and 37.5%,***,the negative and positive predictive values were calculated as 13.6 and 83.3%,***:SS-16 would not be used as a diagnostic tool for early stage PD *** results of SS-16 would not exclude the diagnosis of *** tests are needed for validation.

关键词： Parkinson’s disease DAT-SPECT SS-16

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带楔形减振器的货车转向架

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铁道车辆译丛 1964年第2期 5-7页

作者： F.P.quinn D.m.Young 蒋荃生

本文叙述了这样一种铁路货车转向架,在转向架内采用了一种新的装置,以减少摇枕相对侧架的振动。当转向架沿曲线运动时,摇枕相对侧架倾斜后以恢复到正常的垂直位置。这种装置的主要特点是:1.摇枕和摩擦靴间具有最大的接触面积,在弹簧压... 详细信息

本文叙述了这样一种铁路货车转向架,在转向架内采用了一种新的装置,以减少摇枕相对侧架的振动。当转向架沿曲线运动时,摇枕相对侧架倾斜后以恢复到正常的垂直位置。这种装置的主要特点是:1.摇枕和摩擦靴间具有最大的接触面积,在弹簧压力的作用下摩擦靴紧紧靠着摇枕和侧架主柱;2.在上述转向架中采用了具有最大行程和容量的摩擦靴张紧弹簧;3.摩擦靴能迫使摇枕和支持摇枕的侧架之间经常保持垂直关系。这些特点从下面的详细说明和附图中将很明显。图1是中央垂直断面附近侧架的部分正视图,是表示这种装置的详图。

关键词：侧架立柱腹板摩擦面摇枕楔形

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Pseudoceramines A-D,new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp

Pseudoceramines A-D,new antibacterial bromotyrosine alkaloid...

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2011年全国药物化学学术会议——药物的源头创新

作者：尹胜 Rohan A.Davis Todd Shelper melissa L.Sykes Vicky m.Avery mikael Elofsson Charlotta Sundin Ronald J.quinn School of Pharmaceutical Sciences Sun Yat-Sen University Eskitis Institute Griffith UniversityBrisbaneQLD 4111Australia Laboratories for Chemical Biology Umea Umea Centre for Microbial ResearchLaboratories for Molecular Infection Medicine Sweden and Department of ChemistryUmea UniversitySE-90187 UmeaSweden

Bioassay guided fractionation of the CHCI/meOH extract of Australian marine sponge Pseudoceratina *** in the purification of four new bromotyrosine alkaloids, pseudoceramines A-D(1-4),along with a known natural produc... 详细信息

关键词： sponge Pseudoceratina sp. bromotyrosine alkaloids antibiotics

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