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Towards a better understanding of antimicrobial resistance dissemination:what can be learnt from studying model conjugative plasmids?

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military medical Research 2022年第5期9卷 592-602页

作者： Zhen shen Christoph m.Tang Guang-Yu Liu Sir William Dunn School of Pathology University of OxfordOxfordOX13REUK Department of Laboratory medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China

Bacteria can evolve rapidly by acquiring new traits such as virulence,metabolic properties,and most importantly,antimicrobial resistance,through horizontal gene transfer(HGT).multidrug resistance in bacteria,especially in Gram-negative organisms,has become a global public health threat often through the spread of mobile genetic *** represents a major form of HGT and involves the transfer of DNA from a donor bacterium to a recipient by direct *** plasmids,a major vehicle for the dissemination of antimicrobial resistance,are selfish elements capable of mediating their own transmission through *** spread to and survive in a new bacterial host,conjugative plasmids have evolved mechanisms to circumvent both host defense systems and compete with co-resident *** mechanisms have mostly been studied in model plasmids such as the F plasmid,rather than in conjugative plasmids that confer antimicrobial resistance(AmR)in important human pathogens.A better understanding of these mechanisms is crucial for predicting the flow of antimicrobial resistance-conferring conjugative plasmids among bacterial populations and guiding the rational design of strategies to halt the spread of antimicrobial ***,we review mechanisms employed by conjugative plasmids that promote their transmission and establishment in Gram-negative bacteria,by following the life cycle of conjugative plasmids.

关键词： Horizontal gene transfer Antimicrobial resistance Conjugative plasmids Type IV secretion system Restriction-modification systems SOS response Entry exclusion Fertility inhibition

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Acetylation as a mechanism that regulates axonal regeneration

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Neural Regeneration Research 2015年第7期10卷 1034-1036页

作者： shen Lin George m.Smith Shriners Hospitals for Pediatric Research Center Department of Neuroscience Temple University

The capacity for adult axons to regenerate after injury is diminished compared with developing *** the case of central nervous system（CNS）axons,injury causes a total failure to *** failure is due to both the intrins... 详细信息

关键词： gene HDAC Acetylation as a mechanism that regulates axonal regeneration

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Network science meets algebraic topology

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National Science Review 2019年第6期6卷 1064-1065页

作者： Lingqing shen David m.Walker michael Small Department of mathematics Nanjing University Department of mathematics & Statistics University of Western Australia mineral Resources Commonwealth Scientific and Industrial Research Organisation

Network science is largely consumed with the study of graphs with heterogeneous degree: typically large graphs with no strong topological symmetry. Network science borrows approaches from statistical physics to understand this heterogeneous structure, in a manner quite distinct from the rich symmetry of the graphs that are studied by algebraic graph theorists. Shi et al. [1] move toward

关键词： Network science meets algebraic topology

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managing the surge:A comprehensive review of the entire disposal framework for retired lithium-ion batteries from electric vehicles

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Journal of Energy Chemistry 2024年第5期92卷 648-680页

作者： Ruohan Guo Feng Wang m.Akbar Rhamdhani Yiming Xu Weixiang shen Department of Engineering Technologies School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department of Chemistry and Biotechnology School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department mechanical and Product Design Engineering School of EngineeringSwinburne University of TechnologyMelbourne VIC 3122Australia

Anticipating the imminent surge of retired lithium-ion batteries(R-LIBs)from electric vehicles,the need for safe,cost-effective and environmentally friendly disposal technologies has *** paper seeks to offer a comprehensive overview of the entire disposal framework for R-LIBs,encompassing a broad spectrum of activities,including screening,repurposing and ***,we delve deeply into a thorough examination of current screening technologies,shifting the focus from a mere enumeration of screening methods to the exploration of the strategies for enhancing screening ***,we outline battery repurposing with associated key factors,summarizing stationary applications and sizing methods for R-LIBs in their second life.A particular light is shed on available reconditioning solutions,demonstrating their great potential in facilitating battery safety and lifetime in repurposing scenarios and identifying their techno-economic *** the realm of battery recycling,we present an extensive survey of pre-treatment options and subsequent material recovery ***,we introduce several global leading recyclers to illustrate their industrial processes and technical ***,relevant challenges and evolving trends are investigated in pursuit of a sustainable end-of-life management and disposal *** hope that this study can serve as a valuable resource for researchers,industry professionals and policymakers in this field,ultimately facilitating the adoption of proper disposal practices.

关键词： Lithium-ion battery Battery reproposing and recycling miaieiials recovery technologies Techno-economic issues End-of-life management Disposal framework

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等离子体聚合新进展的评述

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塑料 1983年第5期 31-43页

作者： m.shen A.T.Bell 金佑民

聚合物可以用有机的或有机金属的蒸气在辉光放电产生的等离子体中处理而获得。若改变压力、单体流率、功率等等离子体条件,不仅可形成膜,也可形成粉末和油状物。本文讨论聚合机理及反应条件对聚合速率的影响。并提出一个与实验很好地吻... 详细信息

聚合物可以用有机的或有机金属的蒸气在辉光放电产生的等离子体中处理而获得。若改变压力、单体流率、功率等等离子体条件,不仅可形成膜,也可形成粉末和油状物。本文讨论聚合机理及反应条件对聚合速率的影响。并提出一个与实验很好地吻合的动力学模型。等离子体聚合物质可由红外(IR),核磁共振(NmR),化学分析用电子光谱(ESCA)和其它分析技术来描述其特性。在此还发现聚合物是高度交联的、无定形的而且在其中所包含的官能团常常在单体中原先并不存在。还讨论这些膜的电性质。并指出等离子体聚合膜的某些可能的应用。

关键词：等离子体聚合流率高度交联聚合速率聚合物大分子化合物四氟乙烯全氟代烃单体辉光放电

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multivariate metal-organic frameworks

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National Science Review 2017年第3期4卷 296-298页

作者： Aasif Helal Zain H.Yamani kyle E.Cordova Omar m.Yaghi Center for Research Excellence in Nanotechnology(CENT) King Fahd University of Petroleum and Minerals Department of Chemistry University of California-Berkeley

Reticular chemistry is founded upon the principles of linking simple organic and inorganic building blocks through strong bonds to form extended,porous and crystalline solids,such as metal-organic frameworks(mOFs)[1].... 详细信息

关键词： mOFs mTV multivariate metal-organic frameworks that for of is were in SBU

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An Efficient,Energy Stable Scheme for the Cahn-Hilliard-Brinkman System

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Communications in Computational Physics 2013年第4期13卷 929-957页

作者： Craig Collins Jie shen Steven m.Wise Department of mathematics University of TennesseeKnoxvilleTN 37912USA Department of mathematics Purdue UniversityWest LafayetteIN 47907USA

We present an unconditionally energy stable and uniquely solvable finite difference scheme for the Cahn-Hilliard-Brinkman(CHB)system,which is comprised of a Cahn-Hilliard-type diffusion equation and a generalized Brinkman equation modeling fluid *** CHB system is a generalization of the Cahn-Hilliard-Stokes model and describes two phase very viscous flows in porous *** scheme is based on a convex splitting of the discrete CH energy and is *** equations at the implicit time level are nonlinear,but we prove that they represent the gradient of a strictly convex functional and are therefore uniquely solvable,regardless of time step *** to energy stability,we show that the scheme is stable in the time and space discrete ℓ^(∞)(0,T;H_(h)^(1))and ℓ^(2)(0,T;H_(h)^(2))*** also present an efficient,practical nonlinear multigrid method–comprised of a standard FAS method for the Cahn-Hilliard part,and a method based on the Vanka smoothing strategy for the Brinkman part-for solving these *** particular,we provide evidence that the solver has nearly optimal complexity in typical *** solver is applied to simulate spinodal decomposition of a viscous fluid in a porous medium,as well as to the more general problems of buoyancy-and boundary-driven flows.

关键词： Cahn-Hilliard equation Stokes equations Brinkman equation finite difference methods nonlinear multigrid convex splitting energy stability

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Investigating low dispersion isotope dissolution Lu-Hf garnet dates via in situ Lu-Hf geochronology,Kanchenjunga Himal

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Geoscience Frontiers 2024年第3期15卷 137-145页

作者： kyle P.Larson John m.Cottle mark Button Brendan Dyck Iva Lihter Sudip Shrestha Department of Earth Environmental and Geographic SciencesUniversity of British ColumbiaOkanaganKelownaCanada Department of Earth Science University of CaliforniaSanta BarbaraUSA Fipke Laboratory for Trace Element Research University of British ColumbiaOkanaganKelownaCanada

Re-examination of three specimens from the Kanchenjunga Himal of Nepal via in situ Lu-Hf garnet geochronology yields evidence of multiple garnet growth *** analyses from grain cores in two specimens define Paleozoic regressions whereas analyses from grain rims in the same specimens define low-precision regressions consistent with the timing of Himalayan *** dates contrast with previously published low dispersion,ca.290 ma isotope dissolution(ID)Lu-Hf garnet dates for the same *** of Lu and spot age distribution in representative grains from the specimens examined yields calculated dates that approximate the Permian-age regressions through the original ID *** findings demonstrate that it is possible to generate low dispersion ID Lu-Hf data from multigenerational garnet with significantly different-age growth events when approximately equal proportions of the different age reservoirs are included in multi-component aliquots.

关键词： Lu-Hf geochronology In situ Lu-Hf geochronology Kanchenjunga Himal

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Cross-talk between the thyroid and liver:A new target for nonalcoholic fatty liver disease treatment

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World Journal of Gastroenterology 2013年第45期19卷 8238-8246页

作者： Yue-Ye Huang Aaron m Gusdon shen Qu Department of Endocrinology and metabolism Shanghai 10th People’s Hospital School of Medicine Tongji University Department of Neurology and Neuroscience Weill Cornell Medical College New York NY 10065 United States Department of Endocrinology and metabolism Nanjing Medical University

Nonalcoholic fatty liver disease(NAFLD)has been recognized as the most common liver metabolic disease,and it is also a burgeoning health problem that affects one-third of adults and is associated with obesity and insulin resistance *** hormone(TH)and its receptors play a fundamental role in lipid metabolism and lipid accumulation in the *** is found that thyroid receptor and its isoforms exhibit tissue-specific expression with a variety of ***β1 is predominantly expressed in the brain and adipose tissue and TRβ2 is the major isoform in the liver,kidney and *** have different functions and play important roles in lipid ***,there are many studies on the treatment of NAFLD with TH and its *** review here that thyroid hormone and TR are a potential target for pharmacologic *** metabolism and lipid accumulation can be regulated and reversed by TH and its analogues.

关键词： Thyroid hormone Thyroid hormone receptor Nonalcoholic fatty liver disease Obesity

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Sustainable Resource Use in Enhancing Agricultural Development in China

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Engineering 2018年第5期4卷 588-589页

作者： Jianbo shen Fusuo Zhang Kadambot H.m. Siddique National Academy of Agriculture Green Development Center for Resources Environment and Food Security College of Resources and Environmental SciencesChina Agricultural University Beijing 100193 China Hackett Professor and Director of the UWA Institute of Agriculture The University of Western Australia Perth WA 6001 Australia

1. IntroductionChina is entering an impressive era of grain production since its reform and opening up in 1978. At present, China feeds 22% of the world population with only 9% of the world＇s arable land [1]. Thus, China has become a leader in the global fight against hunger[2] . Grain production has increased dramatically, from about 3 × 10^8t in 1978 to 6.21 × 10^8t in 2016, which is an annual increase rate of 9% [3].

关键词：改革开放中国粮食安全农业

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