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Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

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Efficient photovoltaic effect in graphene/h-BN/silicon heterostructure self-powered photodetector

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Nano Research 2021年第6期14卷 1967-1972页

作者： Ui Yeon Won Boo Heung Lee Young Rae Kim Won Tae kang Ilmin Lee Ji Eun Kim Young hee Lee Woo Jong Yu Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Center for Integrated Nanostructure Physics Institute for Basic Science(IBS)Suwon16419Republic of Korea

Graphene(Gr)/Si-based optoelectronic devices have attracted a lot of academic attention due to the simpler fabrication processes,low costs,and higher performance of their two-dimensional(2D)/three-dimensional(3D)hybrid interfaces in Schottky junction that promotes electron-hole ***,due to the built-in potential of Gr/Si as a photodetector,the Iph/Idark ratio is often hindered near zero-bias at relatively low illumination *** is a major drawback in self-powered *** this study,we have demonstrated a self-powered van der Waals heterostructure photodetector in the visible range using a Gr/hexagonal boron nitride(h-BN)/Si structure and clarified that the thin h-BN insertion can engineer asymmetric carrier transport and avoid interlayer coupling at the *** dark current was able to be suppressed by inserting an h-BN insulator layer,while maintaining the photocurrent with minimal decrease at near *** a result,the normalized photocurrent-to-dark ratio(NPDR)is improved more than 104 ***,both Iph/Idark ratio and detectivity,increase by more than 104 times at−0.03 V drain *** proposed Gr/h-BN/Si heterostructure is able to contribute to the introduction of next-generation photodetectors and photovoltaic devices based on graphene or silicon.

关键词： graphene hexagonal boron nitride van der Waals heterostructure self-powered Research

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Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes

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光学学报 2003年第S1期23卷 715-716页

作者： Sung-Bum Park Seung Goo kang Sang Bae Lee Chang-hee Lee KAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 KoreaCurrent affiliation: Samsung Electronics Co. Ltd. Suwon KoreaXL Photonics Inc.Daejeon KoreaKIST Seoul KoreaKAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 Korea

We demonstrate a bidirectional WDM self-healing ring network for hub/remote nodes with one fiber. In this network, self-healing can be achieved within 8 ms. The transmission capacity can be doubled in the operating st... 详细信息

关键词： WDM on in Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes for dBm

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Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors——8 cases: A case report

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World Journal of Gastroenterology 2019年第16期25卷 2010-2018页

作者： Jwa Hoon Kim Min-hee Ryu Young Soo Park Hyun Jin Kim Hyojung Park Yoon-Koo kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Pathology Asan Medical Center University of Ulsan College of Medicine Department of Radiology Asan Medical Center University of Ulsan College of Medicine

BACKGROUND Intra-abdominal desmoid tumors(DTs) can mimic recurrence or progression of gastrointestinal stromal tumors(GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate *** SUMMARY All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intraabdominal DTs:(1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST;(2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib;(3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and(4) a lesion showing mild or no hypermetabolic activity on 18 fluorodeoxyglucose-positron emission tomography,contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically *** Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.

关键词： Desmoid tumor Gastrointestinal stromal tumor Radiology Surgicalresection Imatinib mesylate Case report

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Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound

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World Journal of Gastroenterology 2010年第8期16卷 1034-1038页

作者： Sang-Woo Cha Sae hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung hee Jung Anna Kim Min Koo Lee Hyun Young Han Dong Wook kang Division of Gastroenterology Department of Internal Medicine Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Surgery Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Radiology Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Pathology Eulji University College of Medicine Eulji University Hospital

Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected.

关键词： Pancreatic pseudocyst Lipids Endosonog-raphy

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Freezing and thawing effects of sand-silt mixtures on elastic waves

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Research in Cold and Arid Regions 2013年第4期5卷 418-424页

作者： MinGu kang JongChan Kim Jung-hee Park Jong-Sub Lee School of Civil Environmental and Architectural Engineering Korea University

Freezing and thawing during the winter season change soil properties such as density. The density change in the particulate media influences soil stiffness. In addition, freezing of partially or fully saturated soils changes the soil matrix from a particulate media to a continuum. The goal of this study is to investigate the cyclic freezing and thawing effects on elastic waves. Sand-silt mixtures with 10% silt fraction in weight and 40% saturation are prepared. The sand-silt mixtures are placed in a nylon cell, onto which a pair of bender elements and a pair of piezoelectric disk elements are installed for the measurement of shear and compressional waves, respectively. The temperature of the mixtures decreases from 20 ℃ to -10 ℃ to freezing. The frozen sample is gradually thawed at room temperature （20 ℃）, These freezing-thawing processes are repeated three times. The test result shows that the shear and compressional wave velocities significantly increase when the specimen is frozen. When the temperature is greater than 0 ℃, the elastic wave velocities are lower during thawing than during freezing due to soil structure change. This study demonstrates that soil strucre change during the winter season may be effectively estimated from elastic waves.

关键词： compressional waves freezing frozen soil shear stiffness shear waves thawing

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Development of annulus fibrosus tissue construct with hydrogel coils containing pre-conditioned mesenchymal stem cell

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Journal of Materials Science & Technology 2021年第4期63卷 27-34页

作者： Yon Jin Chuah Yingnan Wu Mei Ling Shirlynn Cheong Yan Qing Chia Ching Ann Tee Hwan Tak hee Chenjie Xu Yuejun kang Dong-An Wang School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang Drive637459Singapore Lee Kong Chian School of Medicine Nanyang Technological University59 Nanyang Drive636921Singapore Pinnacle Spine&Scoliosis Centre 3 Mount ElizabethMount Elizabeth Medical Centre228510Singapore Faculty of Materials and Energy Institute for Clean Energy and Advanced MaterialsSouthwest UniversityChongqing 400715China Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina National Dental Centre of Singapore 5 Second Hospital Ave168938Singapore

Low back pain associated with degenerative disc diseases has been a major health concern that brings suffering to the patients physically and *** existing therapeutic strategies provide shortterm relief of symptoms rather than treatment of the underlying *** of an engineered tissue for disc regeneration is still in its infancy due to the limited autologous healthy disc cell source from the *** is also challenging to mimic the complexity of micro-architecture in the native disc tissue that determine their unique structural *** date,simple tissue models that mimic the annulus fibrosus(AF)micro-environment for understanding the potential of mesenchymal stem cells(MSCs)in AF tissue engineering are still *** this study,the assembly of a coiled hydrogel microfiber has shown its capability to encapsulate MSCs and create an engineered tissue model that mimics the multiple lamellae of native *** this model,we investigated the potential of MSCs that were previously induced by ascorbic acid(AA).Compared to non-induced MSCs,AA-induced MSCs exhibited significant increase in AF-associated biomarkers during later development in the engineered AF tissue model and also encouraged collagen accumulation through the down-regulated catabolic gene MMP1 and upregulated anti-catabolic gene ***,AA-induced MSCs exhibited a Col2/Col1 ratio closer to that of a native AF *** results suggested that AA-induced MSCs could be a potential cell source for AF tissue engineering and this established tissue model may provide a simple tool for successful AF tissue engineering strategies in the future.

关键词： closer stem strategies

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A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents

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Journal of Magnesium and Alloys 2021年第6期9卷 2195-2207页

作者： Kwang-hee Cheon Cheonil Park Min-Ho kang Suhyung Park Jinyoung Kim Seol-Ha Jeong Hyoun-Ee Kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon-si 03083Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon-si 14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Biodegradable stents made of magnesium(Mg)and its alloys have been developed to minimize persistent inflammation or in-stent restenosis,which are the main problems for permanent ***,their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure,which remains an important unsolved clinical ***,we demonstrate a new strategy for solving this problem by combining poly(ether imide)(PEI)coating and subsequent tantalum(Ta)ion *** PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying *** ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg *** extremely short processing time(<30 s)permits preservation of the PEI coating’s corrosion protection ability and sirolimus loading *** addition,a Ta-implanted skin layer that forms on the topmost surface of the PEI coating plays an effective role in not only preventing a rapid release of sirolimus from the surface but also improving the PEI coating’s surface *** on in vitro cellular response and blood compatibility tests,Ta ion implantation leads to the improvement of endothelial cell adhesion/proliferation and suppression of platelet adhesion/activation regardless of sirolimus *** results indicate that the combination of PEI coating and Ta ion implantation has significant innovative potential to provide excellent vascular compatibility and prevent in-stent restenosis and thrombosis.

关键词： Magnesium stent Biodegradability Tantalum Plasma immersion ion implantation Multifunctionality

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Tail spillover effects between cryptocurrencies and uncertainty in the gold,oil,and stock markets

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Financial Innovation 2023年第1期9卷 2339-2365页

作者： Walid Mensi Mariya Gubareva hee‑Un Ko Xuan Vinh Vo Sang Hoon kang Department of Economics and Finance College of Economics and Political ScienceSultan Qaboos UniversityMuscatOman Institute of Business Research University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam Universidade de Lisboa Lisbon School of Economics and Management(ISEG)Research Centre in Economic and Organisational Sociology(SOCIUS)/Research in Social Sciences and Management(CSG)Rua Miguel Lupi 201249‑078 LisbonPortugal Korea Housing and Urban Guarantee Corporation BusanKorea Institute of Business Research and CFVG University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam PNU Business School Pusan National UniversityBusanRepublic of Korea

This study investigates tail dependence among five major cryptocurrencies,namely Bitcoin,Ethereum,Litecoin,Ripple,and Bitcoin Cash,and uncertainties in the gold,oil,and equity *** the cross-quantilogram method and quantile connectedness approach,we identify cross-quantile interdependence between the analyzed *** results show that the spillover between cryptocurrencies and volatility indices for the major traditional markets varies substantially across quantiles,implying that diversification benefits for these assets may differ widely across normal and extreme market *** normal market conditions,the total connectedness index is moderate and falls below the elevated values observed under bearish and bullish market ***,we show that under all market conditions,cryptocurrencies have a leadership influence over the volatility *** results have important policy implications for enhancing financial stability and deliver valuable insights for deploying volatility-based financial instruments that can potentially provide cryptocurrency investors with suitable hedges,as we show that cryptocurrency and volatility markets are insignificantly(weakly)connected under normal(extreme)market conditions.

关键词： Cryptocurrency Uncertainty indices Quantile spillover Crossquantilogram

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Potentially inappropriate prescribing of cardiovascular system and antiplatelet/anticoagulant drugs among elderly patients:a Korean population-based national study

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Journal of Geriatric Cardiology 2021年第5期18卷 327-337页

作者： Jongyeon Kim Euna Han hee-Jin Hwang Hyeonseok Cho Young-Sang Kim Hyejin Chun Jinkwon Kim Yon Chul Park Hye-Young kang Department of Pharmaceutical Medicine and Regulatory Sciences Colleges of Medicine and PharmacyYonsei UniversityIncheonSouth Korea College of Pharmacy Yonsei Institute of Pharmaceutical SciencesYonsei UniversityIncheonSouth Korea Department of Family Medicine Catholic Kwandong University International St.Mary’s HospitalIncheonSouth Korea Department of Family Medicine CHA Bundang Medical CenterCHA UniversitySeongnamSouth Korea Department of Neurology Yongin Severance HospitalYonsei University College of MedicineYonginSouth Korea Department of Family Medicine Wonju Severance Christian HospitalWonjuSouth Korea

OBJECTIVES To investigate the prevalence of potentially inappropriate prescribing(PIP)for cardiovascular system(CVS)and antiplatelet/anticoagulant(AP/AC)drugs among Korean elderly patients,using the Screening Tool of Older Persons’Prescriptions(STOPP)criteria version 2 and to identify the risk factors related to *** The 2016 National Aged Patient Sample data,comprising National Health Insurance claim records for a random sample of 20%of patients aged≥65 years,were used to calculate PIP prevalence of outpatient *** criteria including drugdisease interactions,PIP prevalence per indication was *** Among 1,274,148 elderly patients and 27,062,307 outpatient prescription claims,100,085 patients(7.85%)and 341,664 claims(1.27%)had one or more *** most frequent PIP was“nonsteroidal antiinflammatory drug with concurrent antiplatelet agent(s)without protonpump inhibitor prophylaxis”in the claimlevel(0.97%)and patientlevel(6.33%)analyses.“Betablocker with bradycardia”(16.47%of claims)and“angiotensin receptor blockers in patients with hyperkalaemia”(23.89%of claims)showed the highest PIP prevalence per *** regression analysis revealed that,among the patient and health care provider characteristics,female,older age,more severe comorbidities,polypharmacy,higher level of healthcare organization,and specialty of prescriber were significantly associated with a higher risk of *** Our findings of a high prevalence of PIP for CVS and AP/AC drugs among the elderly suggest that an effective strategy is urgently needed to improve the prescription practices of these drugs.

关键词： drugs patients prescription

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