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Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercholesterolemic Men

Biomedical and Environmental Sciences 2008年第2期21卷 91-97页

作者： SOO YEON KIM SUN YOON SOO MI KWON kye sook park YANG CHA LEE-KIM Graduate School of Human Environmental Science Department of Food and Nutrition College of Human Ecology Yonsei Health Center Yonsei University 134 Shinchon-dong Sudaemun-ku 120-749 Seoul Korea

Objective To evaluate the effect of 3-month kale （Brassica oleracea acephala） juice supplementation on coronary artery disease risk factors among hypercholesterolemic men. Methods Thirty-two men with hypercholesterolemia （〉 200 mg/dL） were recruited after annual health examinations among the faculty and staff at university. The subjects consumed 150 mL of kale juice per day for a 12-week intervention period. Dietary and anthropometric assessments were performed and blood samples were collected to evaluate biochemical profiles before and after supplementation. Results Serum concentrations of HDL-cholesterol, and HDL- to LDL-cholesterol ratio were significantly increased by 27% （P〈0.0001） and 52% （P〈0.0001）, respectively. The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 10% （P=0.0007） and 24.2% （P〈0.0001）, respectively without affecting body mass index, waist and hip circumferences, or nutrient intakes after three months of supplementation. While there was no difference in the concentration of malondialdehyde, significant increase in glutathione peroxidase activity （P=0.0005） were accompanied by a significant increase in the serum selenium level （P=0.0132）. It was also found that the responses of these risk factors to kale juice administration were dependent on smoking status. Conclusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems, and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia.

关键词： Kale juice Hyperlipidemia Coronary artery disease Lipid profile Antioxidant system

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Preparation of Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_2 powders for cathode material in secondary battery by solid-state method

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Rare Metals 2006年第Z2期25卷 184-188页

作者： park sook Hee KANG Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

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Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease

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World Journal of Gastroenterology 2010年第20期16卷 2496-2503页

作者： Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh park Jee Young Han Young Chae Chu kye sook Kwon Eun Joo Kim Department of Pathology College of Medicine Inha University7-206 Shin-heung-Dong 3 GaJoong-GuIncheon 400-711South Korea Gastroenterology College of Medicine Inha University7-206 Shinheung-Dong 3 GaJoong-GuIncheon 400-711South Korea Department of Nano and Bio Research Daegu Gyeongbuk Institute of Science and TechnologyDeocksan-dong 110Daegu 700-742South Korea

AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and ***: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic *** features of ITB and CD were reviewed,and eight pathologic parameters were *** cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,*** assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy ***: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with *** sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,*** PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy *** the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combi

关键词： Intestine Tuberculosis Crohn’s disease Histopathology Polymerase chain reaction Kit IS6110 MPB64

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Environmental influence in the forested area toward human health: incorporating the ecological environment into art psychotherapy

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Journal of Mountain Science 2020年第4期17卷 992-1000页

作者： Ju-hyoung LEE Ji-sook park Sunnam CHOI Department of Forest Resources and Landscape Architecture Yeungnam UniversityGyeongsan 38541South Korea Department of Art Therapy Yeungnam UniversityGyeongsan 38541South Korea

This study on the development of a psychotherapy program based on the relationship between forests and human health focused on actively considering the natural ecological environment. This study categorized and compared an art psychotherapy program that simply moved to an outdoor space and a forest-art therapy program that actively utilized the forest environment as a medium. The characteristics of the natural environment, such as openness, change, and diversity, shortened the amount of time participants took to develop a rapport and open up and played a vital role in recovering mental health. After a bold attempt at integrating forest environment and art psychotherapy by going beyond outdoor art therapy, there were significant results pertaining to improvements in mental disorders in today’s society, including stress vulnerabilities, depression, anxiety, and aggression. The research results verified that the developed forest-art therapy method had greater efficacy in relation to both the Stress Vulnerability-Interpersonal Sensitivity Scale and the Stress Vulnerability-Self-Regulation Scale.

关键词： Forest therapy Human health Healing forest Art therapy Forest environment

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Esophageal mucosal metastasis from adenocarcinoma of the distal stomach

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World Journal of Gastroenterology 2013年第23期19卷 3699-3702页

作者： Sung-Ho Ki Seok Jeong In Suh park Don Haeng Lee Jung Il Lee kye sook Kwon Hyung Gil Kim Yong Woon Shin Division of Gastroenterology Department of Internal Medicine Pohang St. Mary's HospitalPohang 790-825 South Korea Division of Gastroenterology Department of Internal Medicine Inha University School of MedicineIncheon 400-711 South Korea Department of Pathology Inha University School of MedicineIncheon 400-711 South Korea Center for Advanced Medical Education by BK21 Project Inha University School of Medicine Utah-Inha DDS and Advanced Therapeutics Research CenterIncheon 400-711 South Korea

Dissemination of gastric cancer may usually occur by direct spread through the perigastric tissues to adjacent organ, lymphatic spread, and hematogenous spread. We report a rare case of gastric cancer with mucosal metastastic lesion on the upper esophagus that was diagnosed by endoscopy and endosonography. A biopsy of the esophageal mass was performed and the pathologic findings with immunohistochemical stain for Mucin-5AC are proved to be identical to that of gastric adenocarcinoma, suggesting metastasis from main lesion of the gastric cancer. The lesion could not be explained by lymphatic or hematogenous spread,and its metastasis mechanism is considered to be different from previous studies. We suggest that the gastroesophageal reflux of cancer cells could be one of the possible metastatic pathways for metastasis of esophagus from an adenocarcinoma of the stomach.

关键词： Stomach cancer Neoplasm metastasis Esophagus

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Seroprevalence of Helicobacter pylori in female Vietnamese immigrants to Korea

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World Journal of Gastroenterology 2012年第6期18卷 517-521页

作者： Su Jung Baik Sun Young Yi Hye sook park Bo Hyun park Department of Internal Medicine Ewha Medical Research InstituteSchool of MedicineEwha Womans University911-1 MokdongSeoul 158-710South Korea Department of Preventive Medicine Ewha Medical Research InstituteSchool of MedicineEwha Womans University911-1 MokdongSeoul 158-710South Korea

AIM： To investigate the seroprevalence of Helicobacter pylori （H. pylorl） and its relationship to nutritional fac- tors in female Vietnamese immigrants to Korea. METHODS： A total of 390 female immigrants from Vietnam and 206 Korean male spouses participated in the study. Blood samples from 321 female immigrants and 201 Korean male spouses were analyzed for H. py- Iori antibodies. Data on age, sex, alcohol consumption, smoking status, dietary nutritional factors and gastro- intestinal symptoms were collected using question- naires. The daily intakes of the following nutrients were estimated： energy, protein, niacin, lipid, fiber, calcium, iron, sodium, potassium, zinc, folate, cholesterol, and vitamins A, B1, B2, B6, C and E. RESULTS： The prevalence of H. py/ori positivity was lower in the immigrants than in age-matched Koreanfemales （55.7% vs 71.4%, respectively; P 〈 0.0001） and the domestic population of Vietnam. The preva- lence of H. pylori positivity among married couples was 31.7% for both spouses. There were no statistically sig- nificant differences in the incidence of smoking, amount of alcohol consumed, or nutritional factors between the H. pylori-positive and negative groups. CONCLUSION： The prevalence of H. pylori positivity was lower among female Vietnamese immigrants than among Korean females. Nutritional factors did not differ between the H. pylori-positive and negative groups.

关键词： Vietnam Immigration South Korea Helico-bacter pylori Diet

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Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

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Energy & Environmental Materials 2024年第5期7卷 86-94页

作者： Hyunji park Hyojin kye Jong-Sung Lee Young-Chang Joo Dong Joo Min Bong-Gi Kim Soo Young park Ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials(LSOM) Department of Materials Science and EngineeringResearch Institute of Advanced Materials(RIAM)Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)92 Chudong-roBongdong-eupWanju-gunJeonbuk 55324Korea Department of Organic and Nano System Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University567 Baekje-daeroDeokjin-guJeonjuJeonbuk 54896Korea

Most organic electrode materials(OEMs)for rechargeable batteries employ n-type redox centers,whose redox potentials are intrinsically limited<3.0 V versus Li^(+)/***,p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***,we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole(DEICZ)as a novel p-type OEM,exhibiting stable plateaus at high discharge potentials of 3.44 and 4.09 V versus Li^(+)/***,the second redox potential of DEICZ is within the stable electrochemical *** mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements,including density functional theory calculations,ex situ electron spin resonance,and X-ray photoelectron ***,hybridization with single-walled carbon nanotubes(SWCNT)improves the cycle stability and rate performance of DEICZ owing to theπ-πinteractions between the SWCNT and co-planar molecular structure of DEICZ,preventing the dissolution of active materials into the *** DEICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability,even performing well at 100-C ***,we demonstrate its potential for flexible batteries after applying 1000 bending stresses to the composite electrode.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

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Precise control of surface oxygen vacancies in ZnO nanoparticles for extremely high acetone sensing response

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Journal of Advanced Ceramics 2022年第5期11卷 769-783页

作者： Jihyun LEE Youngmoon CHOI Byoung Joon park Jeong Woo HAN Hyun-sook LEE Jong Hyeok park Wooyoung LEE Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biological Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea

ZnO has been studied intensely for chemical sensors due to its high sensitivity and fast ***,we present a simple approach to precisely control oxygen vacancy contents to provide significantly enhanced acetone sensing performance of commercial ZnO nanopowders.A combination of H_(2)O_(2)treatment and thermal annealing produces optimal surface defects with oxygen vacancies on the ZnO nanoparticles(NPs).The highest response of~27,562 was achieved for 10 ppm acetone in 0.125 MH_(2)O_(2)treated/annealed ZnO NPs at the optimal working temperature of 400℃,which is significantly higher than that of reported so far in various acetone sensors based on metal oxide semiconductors(MOSs).Furthermore,first-principles calculations indicate that pre-adsorbed O formed on the surface of H_(2)O_(2)treated ZnO NPs can provide favorable adsorption energy,especially for acetone detection,due to strong bidentate bonding between carbonyl C atom of acetone molecules and pre-adsorbed O on the ZnO *** study demonstrates that controlling surface oxygen vacancies by H_(2)O_(2)treatment and re-annealing at optimal temperature is an effective method to improve the sensing properties of commercial MOS materials.

关键词： gas sensors acetone metal oxide semiconductors(MOSs) ZnO nanoparticles(NPs) H_(2)O_(2)treatment

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Molecular diagnosis and treatment of drug-resistant hepatitis B virus

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World Journal of Gastroenterology 2014年第19期20卷 5708-5720页

作者： Jeong Han Kim Yong Kwang park Eun-sook park Kyun-Hwan Kim Digestive Disease Center Department of Internal MedicineSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine IBSTSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Institute of Functional Genomics Konkuk UniversitySeoul 143-729South Korea

Oral antiviral agents have been developed in the last two decades for the treatment of chronic hepatitis B(CHB).However,antiviral resistance remains an important challenge for long-term CHB *** of the clinically available oral antiviral agents are nucleoside or nucleotide analogues that target the activity of viral reverse transcriptase(RT),and all are reported to have resistant *** the hepatitis B virus(HBV)RT,like other viral polymerases,lacks proofreading activity,the emergence of drug-resistance occurs readily under selective pressure from the administration of antiviral *** molecular diagnosis of drug-resistant HBV is based on sequence variations,and current diagnostic methods include sequencing,restriction fragment polymorphism analysis,and ***,we will discuss the currently available molecular diagnosis tools,in vitro phenotypic assays for validation of drug-resistant HBV,and treatment options for drug-resistant HBV.

关键词： Hepatitis B virus Drug-resistance Molecular diagnosis Antiviral treatment Chronic hepatitis B

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A 75 kDa glycoprotein isolated from Cudrania tricuspidata Bureau induces colonic epithelial proliferation and ameliorates mouse colitis induced by dextran sulfate sodium

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Chinese Journal of Natural Medicines 2021年第1期19卷 46-55页

作者： park Jeong-Bae Kim Do-Wan Lim kye-Tack Oh Sejong Lee Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610South Korea Division of Animal Science Chonnam National UniversityGwangju 61186South Korea

Cudrania tricuspidata Bureau(CTB),a species of the Moraceae plant,has been used as a bruise recovery *** study aimed to determine whether the 75 kDa phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease(IBD).We found that CTB glycoprotein significantly induces the proliferation of human colon epithelial HT-29 cells by activating protein kinase *** glycoprotein stimulated the phosphorylation of c-Jun N-terminal kinase and transcription factor nuclear factor-κB,which are responsible for the expression of cell-cycle-related proteins(CDK2,CDK4,cyclin D1 and cyclin E)during its promotion of cell *** colitis was induced in mice by adding dextran sulfate sodium to their drinking water at a concentration of 4%(W/V)for seven *** found that CTB glycoprotein ameliorates the pathological process of IBD and lowers the disease activity index score,which was composed of body weight change,diarrhea,and hematochezia in ICR mice treated with dextran sulfate ***,we suggest that CTB glycoprotein has the ability to prevent IBD by promoting cell proliferation signaling events via the activation of PKC,JNK and NF-κB in colon epithelial cells.

关键词： Cell cycle Cell proliferation Colon epithelial cells Cudrania tricuspidata Glycoprotein Inflammatory bowel disease Protein kinase C

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