Molecular diagnosis and treatment of drug-resistant hepatitis B virus

作     者：Jeong Han Kim Yong Kwang Park Eun-Sook Park Kyun-Hwan Kim 

作者机构：Digestive Disease CenterDepartment of Internal MedicineSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Department of Pharmacology and Center for Cancer Research and Diagnostic MedicineIBSTSchool of MedicineKonkuk UniversitySeoul 143-729South Korea Institute of Functional GenomicsKonkuk UniversitySeoul 143-729South Korea 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第19期

页      面：5708-5720页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：Supported by Konkuk University 

主　　题：Hepatitis B virus Drug-resistance Molecular diagnosis Antiviral treatment Chronic hepatitis B 

摘      要：Oral antiviral agents have been developed in the last two decades for the treatment of chronic hepatitis B(CHB).However,antiviral resistance remains an important challenge for long-term CHB *** of the clinically available oral antiviral agents are nucleoside or nucleotide analogues that target the activity of viral reverse transcriptase(RT),and all are reported to have resistant *** the hepatitis B virus(HBV)RT,like other viral polymerases,lacks proofreading activity,the emergence of drug-resistance occurs readily under selective pressure from the administration of antiviral *** molecular diagnosis of drug-resistant HBV is based on sequence variations,and current diagnostic methods include sequencing,restriction fragment polymorphism analysis,and ***,we will discuss the currently available molecular diagnosis tools,in vitro phenotypic assays for validation of drug-resistant HBV,and treatment options for drug-resistant HBV.