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Structural identification of active moiety in anti-tumor metastatic polysaccharide purified from fermented barley by sequential enzymatic hydrolysis

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Food Bioscience 2022年第6期50卷 139-149页

作者： Seung-U Son Han Wool Kim kwang-soon shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

The potent anti-cancer metastatic effects induced by the immunostimulatory activities of intravenously administered BF–I,an active polysaccharide purified from fermented barley,were previously *** study aimed to evaluate the anti-cancer metastatic effect of orally administered BF–I and elucidated the microstructure and active moiety of BF–I using sequential enzymatic *** experiments using Colon26-M3.1 carcinoma,prophylactic oral administration of BF–I potently suppressed lung cancer ***,gas chromatography-mass spectrometry analysis of partially methylated alditol acetate showed that BF–I comprised 15 different glycosyl linkages,including 4-linked Xylp(16.1%),terminal Araf(12.4%),4-linked Glcp(32.8%),3-linked Glcp(13.5%),3,6-linked Glcp(1.5%),and 3,6-linked Galp(5.3%).These glycosyl linkage combinations are typical for arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II *** clarify the microstructure,BF–I was sequentially degraded via linkage-specific enzymatic hydrolysis using five ***,the sugar composition,glycosyl linkage,and reactivity with theβ-glucosyl Yariv reagent were analyzed,along with sequencing based on tandem mass spectra of partially degraded fragment *** results confirmed that BF–I comprises a mixture of four different types of polysaccharides(arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II arabinogalactan)with similar molecular ***,different polysaccharides contribute significantly to cytokine(interleukin-6,-12,and tumor necrosis factor-α)secretion by peritoneal ***,the potent anti-cancer metastatic activity of BF–I is proposed to be related to the immunostimulatory activities of the four different types of polysaccharides.

关键词： Barley Polysaccharide structure Anti-cancer Enzymatic hydrolysis

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Effects of intravenous administration of polysaccharide purified from fermented barley on tumor metastasis inhibition via immunostimulating activities

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Food Bioscience 2022年第5期49卷 130-138页

作者： Seung-U Son Han Wool Kim Min Seung Park kwang-soon shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceGraduate SchoolKorea UniversitySeoul02841Republic of Korea

The present study was aimed that determine the effects of polysaccharide isolated from fermented barley about tumor metastasis inhibition via immune related factors such as complementary system,macrophages,natural killer(NK)cells,and cytotoxic T lymphocyte(CTL).To characterize the tumor inhibition effects through immunostimulation of polysaccharides purified from fermented barley,the active crude polysaccharide(BF-CP)was isolated from fermented barley and further fractionated into three purified polysaccharides(BF-I,-II,and-III)with different molecular weights through gel permeation ***-I was mainly composed of four monosaccharides,including xylose(32.90%),arabinose(26.71%),and glucose(33.43%).BF-I augmented the secretion of cytokines,such as interleukin(IL)-6,IL-12,and tumor necrosis factor-α,through peritoneal macrophages and potently activated the complement *** the experiment for NK cells and CTL activities,intravenous(i.v.)administration of BF-I significantly augmented the cytotoxicity of NK cells and CTL-mediated cytotoxicity against tumor *** addition,*** of BF-I potently inhibited tumor metastasis in a mouse model of lung cancer and tumor metastasis in mice with suppressed NK cell function through anti-asialo ***,BF-I shows potent tumor inhibition effects,and these effects are related to various immune factors such as macrophages,the complement system,NK cells,and ***,BF-I,the polysaccharide purified from fermented barley possess the new possibility for developing functional foods and medical ingredients.

关键词： Fermented barley Polysaccharide Immune system Anti-cancer

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Improvement effects of pectic polysaccharide isolated from Saururus chinensis leaves on dextran sulfate sodium-induced ulcerative colitis in BALB/c mice

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Food Bioscience 2022年第6期50卷 415-424页

作者： Seung-U Son A.Youn Nam So Min Kim YangKook Rho kwang-soon shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea PharmacoBio Co.Ltd. Seongnam13219Republic of Korea

In this study,the improvement effects of oral administration of polysaccharides isolated from Saururus chinensis on a DSS-induced ulcerative colitis mouse model were *** achieve this,***-derived crude polysaccharides(SCP)were extracted using hot water extraction and ethanol *** is composed primarily of eight monosaccharides,including galacturonic acid(46.6%),galactose(10.4%),arabinose(5.6%),and rhamnose(3.8%),that are typical sugar components of pectic *** administration of SCP recovered body weight loss and significantly alleviated various ulcerative colitis symptoms such as stool consistency,blood in stool,and blood in the ***,the DSS-treated group that exhibited a decrease in colon length,and SCP treatment significantly reduced colon length shortening in a dose-dependent *** of inflammatory factors such as interleukin-6,tumor necrosis factor-α,and myeloperoxidase were lower in the SCP-treated groups than they were in the DSS-treated *** contrast,Alcian blue-periodic acid Schiff staining revealed that SCP treatment effectively maintained the amount of mucus and goblet cells in the intestinal lumen compared to that in the DSS-treated *** short-chain fatty acid content decreased by DSS administration was recovered through oral administration of SCP,and the amount of butyric acid was significantly ***,the aforementioned results suggest that SCP isolated from *** is a potent candidate for use as a new health functional food and pharmaceutical ingredient for colitis treatment.

关键词： Saururus chinensis Pectic polysaccharide DSS-Induced ulcerative colitis Anti-Inflammatory

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed kwang-soon Ahn Jun-Seok Ha Uk Sim Hyeyoung shin soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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Formulation of corrosion rate of magnesium alloys using microstructural parameters

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Journal of Magnesium and Alloys 2020年第1期8卷 134-149页

作者： Ahmad Bahmani Srinivasan Arthanari kwang Seon shin Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826Korea

Up to the date of writing this article,a quantitative analysis between corrosion rate and combined microstructural parameters including composition,grain size,and precipitations has not been ***,a literature review was carried out on these parameters to understand the quantitative effect of each one on the corrosion rate of Mg and Mg ***,using the available data in the literature and several experimental results,a new model was developed to predict the corrosion rate,through microstructural *** model suggests that by using ultra-fined grains,alloying compounds with low Volta-potential difference relative to the matrix and a low fraction of secondary phase,a very low corrosion rates of materials are achievable.

关键词： Corrosion rate Magnesium Grain size Volta-potential

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Corrosion behavior of Mg-Mn-Ca alloy:Influences of Al,Sn and Zn

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Journal of Magnesium and Alloys 2019年第1期7卷 38-46页

The effects of different elements including Al,Sn and Zn with ability of solution hardening on corrosion behavior of a Mg alloy have been *** microstructure was analyzed and the electrochemical and immersion techniques were used for corrosion *** kelvin probe force microscopy(SKPFM)was utilized to analyze the volta-potential distribution on the *** was found that all additives reduced the corrosion resistance;however,Zn decreased the corrosion resistance less than Al and *** corrosion rate was quantitatively explained through volta-potential difference and the second phase fraction.

关键词： Magnesium alloy Extrusion Corrosion rate Volta-potential Secondary phase

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Microstructure evolution and mechanical properties of Ti-B-N coatings deposited by plasma-enhanced chemical vapor deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 722-728页

作者： Jung Ho shin kwang Soo CHOI Tie-gang WANG kwang Ho KIM Roman NOWAK National Core Research Center for Hybrid Materials Solution Pusan National University School of Materials Science and Engineering Pusan National University State Key Laboratory of Corrosion and Protection Institute of Metal ResearchChinese Academy of Sciences School of Chemical Technology Aalto University

Ternary Ti-B-N coatings were synthesized on AISI 304 and Si wafer by plasma-enhanced chemical vapor deposition (PECVD) technique using a gaseous mixture of TiCl4,BCl3,H2,N2,and *** virtue of X-ray diffraction analysis,X-ray photoelectron spectroscopy,scanning electron microscope,and high-resolution transmission electron microscope,the influences of B content on the microstructure and properties of Ti B N coatings were investigated *** results indicated that the microstructure and mechanical properties of Ti-B-N coatings largely depend on the transformation from FCC-TiN phase to HCP-TiB2 *** increasing B content and decreasing N content in the coatings,the coating microstructure evolves gradually from FCC-TiN/a-BN to HCP-TiB2 /a-BN via FCC-TiN+HCP-TiB2/*** highest microhardness of about 34 GPa is achieved,which corresponds to the nanocomposite Ti-63%B-N (mole fraction) coating consisting of the HCP-TiB2 nano-crystallites and amorphous BN *** lowest friction-coefficient was observed for the nanocomposite Ti-41%B-N (mole fraction) coating consisting of the FCC-TiN nanocrystallites and amorphous BN

关键词： Ti-B-N coating plasma-enhanced chemical vapor deposition (PECVD) nanocomposite coating hardness friction coefficient

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Electrochemical corrosion behavior of acid treated strip cast AM50 and AZX310 magnesium alloys in 3.5 wt.% NaCl solution

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Journal of Magnesium and Alloys 2017年第3期5卷 277-285页

作者： Srinivasan Arthanari Rajendran Nallaiyan shin kwang Seon Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Chemistry Anna UniversityChennai 600025TamilnaduIndia

The influence of acid treatments on the surface morphology and electrochemical corrosion behavior of strip-cast AM50 and AZX310 alloys have been studied in the present *** alloys were acid treated using H_(3)PO_(4)(AT-1),HF(AT-2)and HNO3(AT-3)for different treatment durations viz.,60,300 and 600 *** acid treatments produced a surface layer consisting of corresponding magnesium salts of the acids and were confirmed from the X-ray diffraction(XRD),scanning electron microscopy(SEM)and energy dispersive X-ray analysis(EDAX).AT-1 treatment produced cracked and network porous morphology for AM50 and AZX310 alloys respectively andAT-3 treatment exhibited dense creaked surface layer formation while AT-2 does not produce any significant change in the *** studies revealed that,the acid treatment significantly altered the corrosion process by altering anodic and cathodic reaction rates of AM50 and AZX310 *** HNO3(AT-3)treatment was effective compared to other treatments to control the corrosion rate in the studied treatment *** surface morphology and chemical composition of surface layer produced during the treatment was correlated to explain the corrosion results.

关键词： Magnesium Pretreatment Corrosion Acid treatment Polarization

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Preparation of human decellularized peripheral nerve allograft using amphoteric detergent and nuclease

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Neural Regeneration Research 2021年第9期16卷 1890-1896页

作者： Joo-Yul Bae Suk Young Park Young Ho shin shin Woo Choi Jae kwang Kim Department of Orthopedic Surgery University of Ulsan College of MedicineGangneung Asan HospitalGangneung-siKorea Department of Orthopedic Surgery University of Ulsan College of MedicineAsan Medical CenterSeoulKorea

Animal studies have shown that amphoteric detergent and nuclease(DNase I and ribonuclease A) is the most reliable decellularization method of the peripheral nerve. However, the optimal combination of chemical reagents for decellularization of human nerve allograft needs further investigation. To find the optimal protocol to remove the immunogenic cellular components of the nerve tissue and preserve the basal lamina and extracellular matrix and whether the optimal protocol can be applied to larger-diameter human peripheral nerves, in this study, we decellularized the median and sural nerves from the cadavers with two different methods: nonionic and anionic detergents(Triton X-100 and sodium deoxycholate) and amphoteric detergent and nuclease(3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate(CHAPS), deoxyribonuclease I, and ribonuclease A). All cellular components were successfully removed from the median and sural nerves by amphoteric detergent and nuclease. Not all cellular components were removed from the median nerve by nonionic and anionic detergent. Both median and sural nerves treated with amphoteric detergent and nuclease maintained a completely intact extracellular matrix. Treatment with nonionic and anionic detergent decreased collagen content in both median and sural nerves, while the amphoteric detergent and nuclease treatment did not reduce collagen content. In addition, a contact cytotoxicity assay revealed that the nerves decellularized by amphoteric detergent and nuclease was biocompatible. Strength failure testing demonstrated that the biomechanical properties of nerves decellularized with amphoteric detergent and nuclease were comparable to those of fresh controls. Decellularization with amphoteric detergent and nuclease better remove cellular components and better preserve extracellular matrix than decellularization with nonionic and anionic detergents, even in large-diameter human peripheral nerves. In Korea, cadaveric studies are not yet l

关键词： median nerve sural nerve nuclease detergent human decellularized nerve graft

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Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer

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World Journal of Gastroenterology 2020年第44期26卷 7022-7035页

作者： Chinock Cheong Jun Sang shin kwang Wook Suh Department of Surgery Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

BACKGROUND Preoperative chemoradiotherapy(CRT)is a standard treatment modality for locally advanced rectal ***,CRT alone cannot improve overall *** 20%of patients with CRT-resistant tumors show disease ***,predictive factors for treatment response are needed to identify patients who will benefit from *** theorized that the prognosis may vary if patients are classified according to pre-to post-CRT changes in carcinoembryonic antigen(CEA)*** To identify patients with locally advanced rectal cancer for preoperative chemoradiotherapy based on carcinoembryonic antigen *** We retrospectively included locally advanced rectal cancer patients who underwent preoperative CRT and curative resection between 2011 and *** were assigned to groups A,B,and C based on pre-and post-CRT serum CEA levels:Both>5;pre>5 and post≤5;and both≤5 ng/mL,*** compared the response to CRT based on changes in serum CEA *** operating characteristic curve analysis was performed to determine optimal cutoff for neutrophil–lymphocyte ratio and platelet–lymphocyte *** logistic regression analysis was used to evaluate the prognostic factors for pathologic complete response(pCR)/good *** The cohort comprised 145 patients;of them,27,43,and 65 belonged to groups A,B,and C,respectively,according to changes in serum CEA levels before and after ***-(P<0.001)and post-CRT(P<0.001)CEA levels and the ratio of downstaging(P=0.013)were higher in Groups B and C than in Group *** ratio of pathologic tumor regression grade 0/1 significantly differed among the groups(P=0.003).Group C had the highest number of patients showing pCR(P<0.001).Most patients with pCR showed pre-and post-CRT CEA levels<5 ng/mL(P<0.001,P=0.008).Pre-and post-CRT CEA levels were important risk factors for pCR(OR=18.71;95%CI:4.62–129.51,P<0.001)and good response(OR=5.07;95%CI:1.92–14.83,P=0.002),***-CRT

关键词： Rectal cancer Neoadjuvant chemoradiation therapy Carcinoembryonic antigen levels Prognostic factor Change in serum carcinoembryonic antigen Response of chemoradiotherapy

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