Improvement effects of pectic polysaccharide isolated from Saururus chinensis leaves on dextran sulfate sodium-induced ulcerative colitis in BALB/c mice
作者机构：Department of Food Science and BiotechnologyKyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health SystemDepartment of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea PharmacoBio Co.Ltd.Seongnam13219Republic of Korea
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2022年第50卷第6期
页 面：415-424页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by the PharmacoBio Assistantship 2019 supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2020R1F1A1070996)
主 题：Saururus chinensis Pectic polysaccharide DSS-Induced ulcerative colitis Anti-Inflammatory
摘 要：In this study,the improvement effects of oral administration of polysaccharides isolated from Saururus chinensis on a DSS-induced ulcerative colitis mouse model were *** achieve this,***-derived crude polysaccharides(SCP)were extracted using hot water extraction and ethanol *** is composed primarily of eight monosaccharides,including galacturonic acid(46.6%),galactose(10.4%),arabinose(5.6%),and rhamnose(3.8%),that are typical sugar components of pectic *** administration of SCP recovered body weight loss and significantly alleviated various ulcerative colitis symptoms such as stool consistency,blood in stool,and blood in the ***,the DSS-treated group that exhibited a decrease in colon length,and SCP treatment significantly reduced colon length shortening in a dose-dependent *** of inflammatory factors such as interleukin-6,tumor necrosis factor-α,and myeloperoxidase were lower in the SCP-treated groups than they were in the DSS-treated *** contrast,Alcian blue-periodic acid Schiff staining revealed that SCP treatment effectively maintained the amount of mucus and goblet cells in the intestinal lumen compared to that in the DSS-treated *** short-chain fatty acid content decreased by DSS administration was recovered through oral administration of SCP,and the amount of butyric acid was significantly ***,the aforementioned results suggest that SCP isolated from *** is a potent candidate for use as a new health functional food and pharmaceutical ingredient for colitis treatment.
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