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Storylines of family medicine Ⅻ:family medicine and the healthcare system

Family Medicine and community Health 2024年第S03期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M campbell Aerial R Petty Hima Ekanadham kurt c stange Rebecca S Etz William L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon c M Reece Joshua Freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical college NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA center for Family and community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA center for community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani college of Medicine TampaFloridaUSA Family and community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

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complex multimorbidity and health outcomes in older adult cancer survivors

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Family Medicine and community Health 2017年第2期5卷 129-138页

作者： David F.Warner Nicholas K.Schiltz kurt c.stange charles W.Given cynthia Owusu Nathan A.Berger Siran M.Koroukian Department of Sociology 711 Oldfather HallUniversity of Nebraska-Lincoln1400 R St.LincolnNE 68588USA Department of Epidemiology and Biostatistics School of MedicineWood BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA Department of Family Medicine and community Health Bolwell BuildingSchool of MedicineCase Western Reserve University11000 Euclid Ave.ClevelandOH 44106USA Department of Family Medicine Clinical CenterMichigan State University788 Service Rd.East LansingMI 48824USA Division of Hematology/Oncology Department of MedicineSchool of MedicineWolstein BuildingCase Western Reserve University10900 Euclid Ave.ClevelandOH 44106USA case comprehensive cancer center Wearn BuildingCase Western Reserve University11100 Euclid Ave.ClevelandOH 44106USA

Objective:To characterize complex multimorbidity among cancer survivors and evaluate the association between cancer survivorship,time since cancer diagnosis,and self-reported fair/poor health,self-rated worse health in 2 years,and 2-year ***:We used the 2010-2012 Health and Retirement *** survivors were indi-viduals who reported a(nonskin)cancer diagnosis 2 years or more before the *** defined complex multimorbidity as the co-occurrence of chronic conditions,functional limitations,and/or geriatric *** addition to descriptive analyses,we used logistic regression to evaluate the independent association between cancer survivor status and health *** also examined whether cancer survivorship differed by the number of years since ***:Among 15,808 older adults(age≥50 years),11.8%were cancer *** with cancer-free individuals,a greater percentage of cancer survivors had complex multimorbidity:co-occurring chronic conditions,functional limitations,and geriatric *** survivor-ship was significantly associated with self-reported fair/poor health,self-rated worse health in 2 years,and 2-year *** effects declined with the number of years since diagnosis for fair/poor health and mortality but not for self-rated worse ***:cancer survivor status is independently associated with more complex multi-morbidity,and with worse health *** effects attenuate with time,except for patient perception of being in worse health.

关键词： comorbidity functional limitations geriatric syndromes multimorbidity health status health decline mortality,cancer survivorship

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cultural adaptation and content validity of a chinese translation of the‘Person-centered Primary care Measure’:findings from cognitive debriefing

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Family Medicine and community Health 2020年第4期8卷 90-97页

作者： Emily Tsui Yee Tse cindy Lo Kuen Lam carlos King Ho Wong Weng Yee chin Rebecca S Etz Stephen J Zyzanski kurt c stange Department of Family Medicine and Primary care Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Family Medicine&Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA center for community Health Integration School of MedicineCase Western Reserve UniversityClevelandOhioUSA

Objectives To develop an equivalent chinese translation of the Person-centered Primary care Measure(PcPcM)and to establish its cultural adaptability and content validity through cognitive *** The original English PcPcM was first translated into chinese by double forward-translation by professional *** reconciliated chinese version was then doubly back-translated into English by two other professional translators blinded to the *** affirmation on its linguistic equivalence with the developers of the original English PcPcM,the reconciliated chinese PcPcM was sent for cognitive debriefing with 20 chinese-speaking primary care subjects by a trained interviewer using structured probing questions to collect their opinions on the clarity,comprehensibility and relevance of each item and response option in the *** Subjects were invited from a primary care clinic in Hong Kong to undergo the cognitive debriefing *** interviews were divided into four groups chronologically to allow revision of the items to be made in *** Ten males and 10 females above the age of 18 completed the cognitive *** were all cantonese-speaking chinese recruited by convenience *** with cognitive impairment,could not read chinese,too old or too sick to complete the interviews were excluded from the *** An average of 3.3 min(range 3-4 min)was required for the subjects to self-complete the *** items were generally perceived to be easily understood and *** were made to items with the content validity index(cVI)on clarity or understandingch round of the interviews or if a majority of the subjects suggested *** were made to two items in the chinese PcPcM throughout the whole cognitive debriefing process before the final version was *** average cVI on clarity of the chinese PcPcM items ranged from 0.75 to *** average cVI on un

关键词： translator interview validity

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The replication crisis and its relevance to Earth Science studies:case studies and recommendations

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Geoscience Frontiers 2024年第4期15卷 304-314页

作者： Stephen J.Puetz Kent c.condie kurt Sundell Nick M.W.Roberts christopher J.Spencer Slah Boulila Qiuming cheng 475 Atkinson Dr Suite 704HonoluluHI 96814USA New Mexico Institute of Mining and Technology SocorroNM 87801USA Idaho State University PocatelloID 83209USA Geochronology and Tracers Facility British Geological SurveyKeyworthNottingham NG125GGUK Queen’s University Department of Geological Sciences and Geological EngineeringKingstonOntario K7L 3N6Canada Sorbonne Université CNRSInstitut des Sciences de la Terre ParisParisFrance State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

Numerous scientific fields are facing a replication crisis,where the results of a study often cannot be replicated when a new study uses independent *** issue has been particularly emphasized in psychology,health,and medicine,as incorrect results in these fields could have serious consequences,where lives might be at *** other fields have also highlighted significant replication problems,the Earth Sciences seem to be an *** paucity of Earth Science research aimed at understanding the replication crisis prompted this ***,this work aims to fill that gap by seeking to replicate geological results involving various types of *** identify and discuss 11 key variables for replicating U-Pb age distributions:independent data,global sampling,proxy data,data quality,disproportionate non-random sampling,stratigraphic bias,potential filtering bias,accuracy and precision,correlating time-series segments,testing assumptions and divergent analytical methods,and analytical *** while this work primarily focuses on U-Pb age distributions,most of these factors(or variations of them)also apply to other geoscience ***,some of the discussions involve time-series consisting ofεHf,δ18O-zircon,14c,10Be,marineδ13c,and marineδ*** then provide specific recommendations for minimizing adverse effects related to these factors,and in the process enhancing prospects for replicating geological results.

关键词： Replication crisis Replicability Independent data Global time-series Globality index Filtered data

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Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania c.Muntau kurt Hecher Anke Diemert Petra clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University children’s Hospital UKEHamburgGermany computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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The Plant cell Surface

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Journal of Integrative Plant Biology 2010年第2期52卷 126-130页

作者： Anne-Mie c. Emons kurt V. Fagerstedt The Editor of this Special Issue Plant cell Biology Droevendaalsesteeg 1 Wageningen University 6708 PB Wageningen The Netherlands The Editor of this Special Issue Plant Biology PO Box 65 FI-00014 Helsinki University Finland

Multicellular organization and tissue construction has evolved along essentially different lines in plants and animals. Since plants do not run away, but are anchored in the soil, their tissues are more or less firm and stiff. This strength stems from the cell walls, which encase the fragile cytoplasm, and protect it. Properties of plant cell walls translate into properties of plant tissue. For instance, the cellulose microfibril angle in the different layers of walls of individual cells is a determinant of mechanical functions, which are useful to the plant itself. It also determines material properties of tissues and their potential industrial use. Indeed, plant cell walls determine the industrial value of a range of plant products including paper, timber, foodstuff, fodder, spun fibers, coatings, renewable polymers and future nanocomposites. cell walls and their biosynthesis is a very active field of plant research.

关键词： cell The Plant cell Surface

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Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication

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World Journal of Gastroenterology 2016年第15期22卷 4071-4072页

作者： Hakan Demirci Kadir Ozturk Omer kurt Department of Gastroenterology Gulhane Military Medical Academy 06010 Ankara Turkey

We read the article "Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori(H. pylori) eradication: A prospective singlecenter study from china" written by Wang et al with great interest. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins c and E were not excluded.

关键词： Helicobacter pylori Erdication rates Telephone based education

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Evaluation of growth characteristics of Aspergillus parasiticus inoculated in different culture media by shortwave infrared(SWIR) hyperspectral imaging

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 69-83页

作者： Xuan chu Wei Wang Xinzhi Ni Haitao Zheng Xin Zhao Hong Zhuang kurt c.Lawrence chunyang Li Yufeng Li chengjun Lu college of Engineering China Agricultural University Beijing 100083P.R.China college of Mechanical and Electrical Engineering Zhongkai University of Agriculture Engineering Guangzhou 510225 P.R.China crop Genetics and Breeding Research Unit USDA-ARS 2747 Davis RoadTiftonGA 31793USA college of Food Science&Nutritional Engineering china Agricultural University Beijing 100083PR.China Quality&Safety Assessment Research Unit U.S.National Poultry Research center USDA-ARS 950 College Station Rd.AthensGA 30605USA Quality&Safety Assessment Research Unit USDA-ARS AthensGA 30605USA Institute of Food Science and Technology Jiangsu Academy of Agricultural Sciences Nanjing 210014 P.R.China Multidisciplinary Initiative center Institute of High Energy Physics chinese Academy of Sciences Beijing 100049 P.R.China Lingang Experimental Middle School Linyi 276624 P.R.China

The growth characteristics of Aspergillus parasitic us incubated on two culture media were ex-amined using shortwave infrared(SWIR,1000-2500 nm)hyperspectral imaging(HSI)in this *** images of the *** colonies growing on rose bengal medium(RBM)and maize agar medium(MAM)were recorded daily for 6 *** growth phases of *** were indicated through the pixel number and average spectra of *** score plot of the first principal component(Pc1)and Pc2,four growth zones with varying mycelium densities were *** characteristic wavelengths(1095,1145,1195,1279,1442,1655,1834 and 1929 nm)were selected from Pc1 loading,average spectra of each colony as well as each growth zone.F urthermore,support vector machine(S VM)classifier based on the eight wavelengths was built,and the classification accuracies for the four zones(from outer to inner zones)on the colonies on RBM were 99.77%,9935%,99.75%and 99.60%and 99.77%,9939%,99.31%and 98.22%for colonies on *** addition,a new score plot of Pc2 and Pc3 was used to differ-entiate the colonies incubated on RBM and MAM for 6 *** characteristic wavelengths of 1067,1195,1279,1369,1459,1694,1834 and 1929 nm were selected from the loading of Pc2 and *** on them,a new SVM model was developed to diferentiate colonies on RBM and MAM with accuracy of 100.00%and 9999%,*** conclusion,SWIR hyperspectral image is a powerful tool for evaluation of growth characteristics of *** incubated in diferent culture media.

关键词： Aspergilus parasiticus growth characteristics characteristic wavelengths shortwave infrared(SWIR)hyperspectral imaging

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Petrogenesis of the ükapili Granitoid and its Mafic Enclaves in Elmal Area (Nigde, central Anatolia, Turkey)

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Acta Geologica Sinica(English Edition) 2013年第3期87卷 738-748页

作者： Hüseyin kurt Kerim KOAK Kürsad ASAN Mustafa KARAKAS Department of Geological Engineering Seluk University central Anatolia Directorate of Mineral Research and Exploration

The Late cretaceous Uckapth Granitoid including mafic microgranular enclaves intruded into metapelitic and metabasic rocks, and overlain unconformably by Neogene ignimbrites in the Ni^de area of Turkey. It is mostly granite and minor granodiorite in composition, whereas its enclaves are dominantly gabbro with a few diorites in composition. The Uckapdl Granitoid is composed mainly of quartz, K-feldspar, plagioclase, biotite, muscovite and minor amphibole while its enclaves contain mostly plagioclase, amphibole, minor pyroxene and biotite. The Uckapth Granitoid has calcalkaline and peraluminous （AJcNK= 1.0-1.3） geochemical characteristics. It is characterized by high LILE/HFSE and LREE/HREE ratios （（La/Lu）N 3-33）, and has negative Ba, Ta, Nb and Eu anomalies, resembling those of comsion granitoids. The {）fkaplh Granitoid has relatively high STSr/S6Sr0） ratios （0.711189--0.716061） and low eNd（t） values （-5.13 to -7.13）, confirming crustal melting. In contrast, the enclaves are tholeiitic and metaluminous, and slightly enriched in LILEs （K, Rb） and Th, and have negative Ta, Nb and Ti anomalies; propose that they were derived from a subduction-modified mantle source. Based on mineral and whole rock chemistry data, the Uckapth granitoid is H-（hybrid） type, post-collision granitoid developed by mixing/mingllng processes between crustal melts and mantle-derived mafic magmas.

关键词： H-type granitoid mafic enclave geochemistry central Anatolia Turkey

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Pharmacologic rationale for treatments of peritoneal surface malignancy from colorectal cancer

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World Journal of Gastrointestinal Oncology 2010年第1期2卷 19-30页

作者： PaulH Sugarbaker kurt Vander Speeten O Anthony Stuart Washington cancer Institute Washington Hospital Center Department of Surgical Oncology Ziekenhuis Oost-Limburg Schiepse Bos 6

The peritoneal surfaces of the abdomen and pelvis are important sites for the dissemination of gastrointestinal and gynecologic malignancy. Transcoelomic dissemination of cancer cells gives rise to carcinomatosis, which, without special treatment, is a fatal manifestation of these diseases. To treat peritoneal carcinomatosis, cytoreductive surgery removes gross disease plus perioperative intraperitoneal and perioperative intravenous chemotherapy eradicates microscopic residual disease and chemical compatibilities. chemotherapy agents are administered either by the intraperitoneal or intravenous route, based on their pharmacologic properties. A peritoneal-plasma barrier, which retards the clearance of high molecular weight chemotherapy from the peritoneal cavity, results in a large exposure of small cancer nodules on abdominal and pelvic surfaces. Tissue penetration of the intraperitoneal chemotherapy is facilitated by moderate hyperthermia (41-42℃). Targeting of intravenous chemotherapy to the peritoneal surface is facilitated by the intraperitoneal heat. A constant dose of chemotherapy agent and volume of carrier solution, based on body surface area, allows prediction of systemic drug exposure and systemic toxicity. Timing of the hyperthermic chemotherapy as a scheduled part of the surgical procedure to uniformly expose all peritoneal surfaces is crucial to success.

关键词： Intraperitoneal chemotherapy 5-fluorouracil Doxorubicin Mitomycin c Peritoneal-plasma barrier Appendiceal cancer colorectal cancer Peritoneal mesothelioma Ovarian cancer

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