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Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction

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Journal of Geriatric Cardiology 2018年第4期15卷 290-297页

作者： Wen-Yao WANG kuo zhang Wei ZHAO A. Martin Gerdes Giorgio Iervasi Yi-Da TANG Departments of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Biomedtcal Sciences New York Institute of Technology-College of Osteopathic Medicine Northern Blvd. Old Westbury New York USA Clinical Physiology Institute Consiglio Nazionale delle Ricerche (CNR) Pisa Italy

Background Although thyroid hormone （TH） has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction （AMI）. Methods Consecutive 1091 hospitalized AMI patients in Fuwai hospital （Beijing, China） were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment： low-intensity （n = 221）, moderate-intensity （n = 712） and high-intensity （n = 158）. Lipid levels were measured after statin therapy lasting for 10-14 days. The association between TH, lipid profile levels and achievement of low-density lipoprotein cholesterol （LDL-C） lowering goals was explored in patients with AMI on statin therapy. Results By general linear analysis, a significant linear trend between free triiodothyronine （FT3） and LDL-C level （linear coefficient r = -0.082, P = 0.001） and FT3 and total cholesterol （TC） level （r = -0.105, P = 0.031） was observed in the moderate-intensity statin group. A more apparent linear trend was detected in the high-intensity statin group （for LDL-C： r = -0.113, P = 0.005; for TC： r = -0.172, P = 0.029, respectively）. However, no significant correlation was observed in the low-intensity statin group. Compared with the low-FT3 group （defined as FT3 〈 1.79 pg/mL）, the OR （95% CI） for attaining a LDL-C 〈 3.0mmol/L was found to be 2.217 （1.001–4.839） in the higher FT3 group （〉 2.95 pg/mL）. The OR （95% CI） for attaining the more intensive goal （LDL-C 〈 1.8mmol/L） was 2.836 （1.014–5.182）. Conclusions Our study reveals that variation in FT3 levels is related to the cholesterol-lowering responsiveness of statins in AMI patients. These findings suggest that low FT3 may be a factor responsible for lack of LDL-C goal attainment and patients’ poor responsiveness to statin treatment.

关键词： Acute myocardial infarction Free triiodothyronine Hypothyroid Statin

复合生物膜载体提高短程硝化-厌氧氨氧化工艺性能研究

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环境工程 2024年第1期42卷 16-23页

作者：孔领锐李心珏郑茹张阔刘思彤北京大学环境科学与工程学院北京100871

一段式短程硝化-厌氧氨氧化(PN/A)工艺作为一种自养生物脱氮技术使污水的低碳处理成为了可能。然而,维持稳定高效的短程硝化和保留厌氧氨氧菌的生物量仍然是PN/A工艺运行成功的主要挑战。采用层状硅酸盐矿物结合无纺布作为一种新型复合... 详细信息

一段式短程硝化-厌氧氨氧化(PN/A)工艺作为一种自养生物脱氮技术使污水的低碳处理成为了可能。然而,维持稳定高效的短程硝化和保留厌氧氨氧菌的生物量仍然是PN/A工艺运行成功的主要挑战。采用层状硅酸盐矿物结合无纺布作为一种新型复合生物膜载体,强化厌氧氨氧化菌的持留与PN/A工艺的脱氮效果,考察载体与微生物之间的吸附性能以及复合载体对菌群结构的影响。结果表明:加入复合生物膜载体的反应器的最高氮去除速率达131.4 mg/(L·d),显著高于仅有无纺布载体的对照组[97.2 mg/(L·d)]。表面热力学分析和扩展DLVO理论的研究表明,层状硅酸盐矿物与微生物群落形成了强烈相互吸引力,其表面丰富的金属阳离子可以通过静电引力与离子交换作用来增强菌群的吸附能力。研究制备的复合生物膜载体为PN/A工艺的快速启动和稳定运行提供了一种有效的方法。

关键词：污水生物脱氮短程硝化厌氧氨氧化复合载体层状硅酸盐矿物

In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition

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Chinese Chemical Letters 2020年第12期31卷 3107-3112页

作者： Ziming Chen kuo zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping zhang Hao Wang Lei Wang Faculty of Chemistry Northeast Normal UniversityChangchun 130024China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid *** an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of *** designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and *** formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of *** vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.

关键词： Self-assembly Integrinαvβ3 Peptide Anti-angiogenesis Tumor

鼠尾草酚调控Nrf2/HO-1信号通路介导成骨分化治疗骨质疏松症的研究

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中国医药导报 2024年第22期21卷 40-45,50页

作者：易艳梓来孟琪陈秀天江禹来张阔郑泽炜张庆文广州中医药大学第三临床医学院广东广州510112 广州中医药大学第三附属医院关节中心广东广州510106

目的研究鼠尾草酚对MC3T3-E1细胞氧化应激损伤状态下成骨分化的影响及其作用机制,阐述鼠尾草酚治疗骨质疏松症的潜力。方法MC3T3-E1细胞加入不同浓度(0.0、1.0、2.5、5.0、10.0、25.0、50.0、100.0μmol/L)的鼠尾草酚干预24 h,分析对成... 详细信息

目的研究鼠尾草酚对MC3T3-E1细胞氧化应激损伤状态下成骨分化的影响及其作用机制,阐述鼠尾草酚治疗骨质疏松症的潜力。方法MC3T3-E1细胞加入不同浓度(0.0、1.0、2.5、5.0、10.0、25.0、50.0、100.0μmol/L)的鼠尾草酚干预24 h,分析对成骨细胞增殖的影响,选择最佳的鼠尾草酚干预浓度进行后续实验。将细胞分为对照组(不做任何处理)、模型组(250.0μmol/L H_(2)O_(2)干预)、鼠尾草酚低浓度组(250.0μmol/L H_(2)O_(2)+2.5μmol/L鼠尾草酚)、鼠尾草酚高浓度组(250.0μmol/L H_(2)O_(2)+5.0μmol/L鼠尾草酚),各组细胞干预24 h。比较各组活性氧(ROS)、丙二醛(MDA),碱性磷酸酶(ALP)活性,矿化面积比例,Runx2、Osterix、COL1A mRNA表达及Nrf2、HO-1、SOD2 mRNA和蛋白表达。结果选择2.5、5.0μmol/L鼠尾草酚进行后续实验。与对照组比较,模型组ROS、MDA含量及Nrf2、HO-1 mRNA和蛋白表达升高;ALP活性,矿化面积比例,Runx2、Osterix、COL1A mRNA及SOD2 mRNA和蛋白表达降低(P0.05)。结论鼠尾草酚可通过激活Nrf2/HO-1信号通路调控MC3T3-E1细胞的氧化应激状态,进而促进成骨分化,减轻骨质疏松进程中骨代谢失衡。

关键词：鼠尾草酚骨质疏松症成骨分化 Nrf2/HO-1信号通路

Damage quantitative assessment of spacecraft in a large-size inspection

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Frontiers of Information Technology & Electronic Engineering 2022年第4期23卷 542-554页

作者： kuo zhang Jianliang HUO Shengzhe WANG Xiao zhang Yiting FENG School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu611731China Norla Institute of Technical Physics Chengdu610041China

To ensure the safety and reliability of spacecraft during multiple space missions,it is necessary to conduct in-situ nondestructive detection of the spacecraft to judge the damage caused by the hypervelocity impact of micrometeoroids and orbital debris(MMOD).In this paper,we propose an innovative quantitative assessment method based on damage reconstructed image mosaic ***,a Gaussian mixture model clustering algorithm is applied to extract images that highlight damage ***,a mosaicking scheme based on the ORB feature extraction algorithm and an improved M-estimator SAmple Consensus(MSAC)algorithm with an adaptive threshold selection method is proposed which can create large-scale mosaicked images for damage ***,to create the mosaicked images,the damage characteristic regions are segmented and *** location of the damage area is determined and the degree of damage is judged by calculating the centroid position and the perimeter quantitative *** efficiency and applicability of the proposed method are verified by the experimental results.

关键词： Hypervelocity impact Damage information extraction Image mosaicking Damage localization Quantitative assessment

Current Tracking on Effectiveness and Mechanisms of Acupuncture Therapy: A Literature Review of High-Quality Studies

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Chinese Journal of Integrative Medicine 2020年第4期26卷 310-320页

作者： YANG Fu-ming YAO Lin WANG Shen-jun GUO Yi XU Zhi-fang zhang Chien-Hung zhang kuo FANG Yu-xin LIU Yang-yang Acupuncture Research Center Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Acu-moxibustion and Tuina Changchun University of Traditional Chinese MedicineJilin(130000)China Department of Acu-moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China

The scientific evidenee of acupuncture studies has been improved in recent years,and one of the important manifestations is that more and more acupuncture clinical trials and mechanism researches have been published in the source periodicals of Science Citation Index(SCI).This study summarized the dominant diseases of acupuncture focusing on of acupuncture efficacy and mechanisms,and discussed the existing problems,highlight!ng the directi on of future developme *** clinical studies were published in journals with journal impact factor(JIF)score of 10 or above,and majority of the basic researches had JIF scores of 5 to *** above literature were further divided according to the International Classification of Diseases(ICD).The most concerned diseases in these articles were neurological diseases,musculoskeletal system and connective tissue diseases,tumor and digestive system *** therapeutic effect and mechanism of acupuncture on each kind of disease were *** results showed that the therapeutic effect of acupuncture on nerve injury focused on the anti-oxidation pathway,neuroprotective and anti-inflammatory *** antiinflammatory effect also played an important role in the treatme nt of musculoskeletal *** an algesic effect was underlined in most of these *** trials were well carried out on acupuncture curative effect of tumor complications and side effects of chemo-radiotherapy,but the potential mechanisms have not been ***-visceral reflex was suggested to be strongly associated with the effects of acupuncture changing the motor activity of the gastrointestinal *** magnetic resonance imaging studies indicated that non-specific effects play important roles in acupuncture *** of evidenee have pointed out that the regulation of neuro-endocrine-immune networks may be a common switch of acupuncture on different nerve system diseases.

关键词： acupuncture clinical trials mechanism anti-inflammation neuro-endocrine-immune network

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聚天冬氨酸盐产品马铃薯减肥增效作用

浙江农业科学 2024年第8期65卷 1806-1809页

作者：范占权刘双虎张阔李华帅焦永康河北协同化学有限公司河北石家庄050000

为了提高马铃薯种植过程中对肥料的利用率、减少植物生长调节剂的使用、改善马铃薯薯块的品质,该研究采用田间试验的方式,研究了在减施肥料20%条件下,施用专用型聚天冬氨酸盐肥料增效剂在马铃薯种植过程的减肥增效效果。结果表明,在增... 详细信息

为了提高马铃薯种植过程中对肥料的利用率、减少植物生长调节剂的使用、改善马铃薯薯块的品质,该研究采用田间试验的方式,研究了在减施肥料20%条件下,施用专用型聚天冬氨酸盐肥料增效剂在马铃薯种植过程的减肥增效效果。结果表明,在增效剂施用量为15 kg·hm^(-2)、减少肥料使用20%条件下,3种专用型增效剂促进了光合产物的合成和转运,最终马铃薯增产5.86%~9.47%,并能有效地改善马铃薯的商品性,证明了专用型聚天冬氨酸增效剂能有效地减少肥料用量和增加马铃薯产量的特性,尤其以T2处理最为明显。同时,施用聚天冬氨酸类增效剂能有效改善马铃薯薯块的品质。

关键词：聚天冬氨酸盐马铃薯减肥增效

维普期刊数据库博看期刊

Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia—Nuclear FactorκB Signaling Pathway

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Chinese Journal of Integrative Medicine 2021年第12期27卷 933-939页

作者： zhang kuo ZHAO Xue YANG Tao zhang Yan-fang YAN Ya-wen XU Zhi-fang GONG Yi-nan LIU Yang-yang GUO Yong-ming GUO Yi Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin(300072)China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin(301617)China Affiliated Hospital of Municipal Institute of Traditional Chinese Medicine of Changzhi City Shanxi Province(046000)China Sanhuai Road Community Health Service Center Tanggu StreetBinhai New AreaTianjin(300451)China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China

Objective To identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture(MA).Method A three-step study was conducted,the experiment 1 was a genome-wide analysis of the tissue at acupoint Zusanli(ST 36),including 12 Wistar rats which were divided into control,control+MA1,and control+MA7 *** the experiment 2,the paw withdrawal latency(PWL),immunohistochemistry and Western blot analysis of phospho-nuclear factor kappa B(NFκB)p65(p-p65),phospho-NFκB p50(p-p50)at ST 36 were performed on rats of saline,saline+MA,and complete Freund’s adjuvant(CFA)+MA groups(n=6).In experiment 3,24 rats were divided into saline+DMSO,CFA+DMSO,CFA+DMSO+MA,and CFA+BAY 11–7082+MA groups,the PWL and immunofluorescence assay of NFκB p65 at ST 36 was ***(1)The gene:inhibitor of NFκB(Nfkbia),interleukin-1β(Il1b),interleukin-6(Il6),chemokine c-x-c motif ligand 1(Cxcl1),monocyte chemoattractant protein-1(MCP-1/Ccl2)expressions in the control+MA7 group were significantly increased(P<0.05 or P<0.01),and the expression of NFκB p65(Rela),NFκB p50(Nfkb1)were increased in the control+MA7 group(P<0.05).(2)CFA+MA groups showed increased PWL from day 1 to 7(P<0.01 ***),and the Western blot results were consistent with immunohistochemistry,the expression of NFκB p-p65 and NFκB p-p50 were significantly increased in the MA-related groups compared with control and CFA groups(P<0.05).(3)Compared with the CFA+DMSO+MA group,the PWL of the CFA+BAY 11–7082+MA group decreased significantly and continued until day 5 and 7(P<0.05 and P<0.01,respectively),and the NFκB p65 expression of CFA+BAY 11–7082+MA was significantly reduced compared with CFA+DMSO+MA(P<0.01).Conclusion Local NFκB signaling cascade in acupoint caused by MA is an important step in initiating the analgesic effect,which would provide new evidence for the initiation of MA-effect and improve the understanding of the scientific basis of acupuncture analgesia.

关键词： manual acupuncture acupoint analgesia nuclear factor kappa B

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Recycling Big

China Today 2006年第10期55卷 78-79页

作者： By zhang kuo

Agrand ceremony was held on May 31 this year to mark the opening of the China Qingyuan Recycling Resource Demon-stration Base in Guangdong Province＇s Qingyuan City. The base was established after winning approval from the State Development and Reform Commission, the Ministry of Commerce, the State Environmental Protection Administration and three other relevant ministries. It reflects China＇s efforts in constructing a recyclable economy. The base is also a provincial-level demonstration program for building an energy- and resourcesaving society and part of the Ministry of Commerce＇s endeavors to build a modern recycling industry system.

关键词：中国循环经济产业结构经济战略