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Comprehensive use of the Gutenberg–Richter law and geotomography for improving seismic hazard evaluation in hard coal mines

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International Journal of Coal Science & Technology 2023年第1期10卷 48-59页

作者： Józef Dubiński krystyna stec Jacek Krupanek Central Mining Institute 40-166 KatowicePoland Polish Mining Group Ltd. Mine MysłowiceWesołaPoland

Mining-induced seismicity occurs in numerous underground mines worldwide where extraction is conducted at great depths or in areas characterised by complex tectonic *** is accompanied by rock bursts,which result in the loss of working functionality and the possibility of accidents among *** issue of a constant and reliable seismic hazard evaluation is of key signifcance for both the safety of miners and the stability of *** on its improvement is directed at developing new interpretive solutions and *** nature of the presented solution is the complex interpretation of seismological data that characterise rock mass seismicity and of underground measurement results in the form of a map presenting the longitudinal wave propagation velocity distribution in the rock surrounding the mined coal *** solution was tested in hard coal mines located in the Upper Silesian Coal *** mines are equipped with a modern seismological system enabling the constant monitoring of seismicity together with hazard level evaluation as well as with seismic apparatus for conducting periodic measurements of the seismic wave propagation velocity before the mining *** seismic hazard evaluation criteria were determined based on the obtained results,involving the anomaly of the Gutenberg–Richter law“b”value and the maximum longitudinal seismic wave propagation velocity in the roof *** obtained experience and the result validation of this new comprehensive hazard evaluation method confrm its practical usefulness and indicate the directions of improvement for the solution in question.

关键词： Induced seismicity Rock bursts Mine seismology Gutenberg-Richter law Seismic geotomography

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Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第1期11卷 17-21页

作者： krystyna stec-Michalska Slawomir Antoszczyk Grazyna Klupinska Barbara Nawrot Clinic of Gastroenterology and Internal Diseases Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences

AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with ***: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori ***: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of ***: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach ca

关键词： Gastric cancer Helicobacter pylori infection FHIT protein

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Gastric ghrelin in relation to gender,stomach topography and Helicobacter pylori in dyspeptic patients

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World Journal of Gastroenterology 2009年第43期15卷 5409-5417页

作者： krystyna stec-Michalska Sebastian Malicki Blazej Michalski Lukasz Peczek Maria Wisniewska-Jarosinska Barbara Nawrot Department of Gastroenterology and Internal Diseases Medical University of LodzPlac Hallera 190-647 LodzPoland Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences Sienkiewicza 11290-363 LodzPoland Ⅱ Department of Cardiology Medical University of Lodz1/5 Kniaziewicza St91-347 LodzPoland

AIM： To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylor/（H pylori） infection, bacterial cytotoxicity, topography and ***： The study comprised 40 premenopausal women （19 H pylori positive） and 48 men （17 H pylori positive） with functional dyspepsia. All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis. Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay. The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain ***： In general, infection with H pylori caused an increase in gastric ghrelin level regardless of gender and stomach topography. Significantly more hormone was present in both, non-infected and H pylori positive female samples, as compared to males. The distribution of bacterial strains showed cagA（＋） vacA slml and cagA（-） vacA s2m2 genotypes as the most common infections in the studied population. A tendency to higher ghrelin levels was observed in less cytotoxic （cagA negative） strain-containing specimens from the antrum and corpus of both gender groups （without statistical significance）. CONCLUSION： An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA（-） strains, can exert a gastroprotective effect.

关键词： Dyspepsia Gastric ghrelin Helicobacterpylori Gender

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