Gastric ghrelin in relation to gender,stomach topography and Helicobacter pylori in dyspeptic patients

作     者：Krystyna Stec-Michalska Sebastian Malicki Blazej Michalski Lukasz Peczek Maria Wisniewska-Jarosinska Barbara Nawrot 

作者机构：Department of Gastroenterology and Internal DiseasesMedical University of LodzPlac Hallera 190-647 LodzPoland Department of Bioorganic ChemistryCentre of Molecular and Macromolecular Studies of the Polish Academy of Sciences Sienkiewicza 11290-363 LodzPoland Ⅱ Department of CardiologyMedical University of Lodz1/5 Kniaziewicza St91-347 LodzPoland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第43期

页      面：5409-5417页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The Ministry of Science and Higher Education in Poland project N 402 307336 for 2009-2011 to Nawrot B and No.2 P05B 117 28 of Medical University of Lodz Poland(toStec-Michalska K 2008) 

主　　题：幽门螺杆菌 消化不良 胃粘膜 生长素 性别 地形 患者 ghrelin 

摘      要：AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori(H pylori)infection,bacterial cytotoxicity,topography and gender. METHODS:The study comprised 40 premenopausal women(19 H pylori positive)and 48 men(17 H pylori positive)with functional *** gastric biopsy specimens revealed normal mucosa or non-atrophic *** ghrelin concentration was determined by Enzyme linked immunosorbent *** cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction. RESULTS:In general,infection with H pylori causedan increase in gastric ghrelin level regardless of gender and stomach *** more hormone was present in both,noninfected and H pylori positive female samples,as compared to *** distribution of bacterial strains showed cagA(+)vacA s1m1 and cagA(-)vacA s2m2 genotypes as the most common infections in the studied population.A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative)strain-containing specimens from the antrum and corpus of both gender groups(without statistical significance). CONCLUSION:An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients,especially in those infected with cagA(-) strains,can exert a gastroprotective effect.