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AN APPLICATION OF RITT-WU＇S ZeRO DeCOMPOSITION ALGORITHM TO THe PSeUDO NULL BeRTRAND TYPe CURVeS IN MINKOWSKI 3-SPACe

2012年中国科协海峡两岸青年科学家学术活动月——第九届海峡两岸细胞生物学学术研讨会

作者： Wei-Qi He Yan-Ning Qiao Ya-Jing Peng Juan-Min Zha Chen-Hai Zhang Chen Chen Cai-Ping Chen Pei Wang Xiao Yang Chao-Jun Li kristine e.kamm James T.Stull 朱敏生 Model Animal Research Center and MOe Key Laboratory of Model Animal for Disease Study Nanjing University The School of Medicine Nanjing University Department of Geratology the First Hospital Affiliated with the Nanjing Medical University State Key Laboratory of Proteomics Genetic Laboratory of Development and DiseaseInstitute of Biotechnology Department of Physiology University of Texas Southwestern Medical CenterDallasTXUSA

Smooth muscles can be classified into phasic and tonic subtypes based on their different contractile properties,but the molecular determinants that define phasic and tonic subtypes remain *** generated smooth muscle-s... 详细信息

关键词： MYPT1,smooth muscle phasic tonic Ca2+ sensitivity

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Journal of Systems Science & Complexity 2011年第2期24卷 358-366页

作者： kamm ILARSLAN Mehmet YILDIRIM Faculty of Arts and Sciences Department of Mathematics K~mkkalc University Yahgihan 71450 KirikkaleTurkiye

The Bertrand curves were first studied using a computer by Wu （1987）. The same problem was studied using an improved version of Ritt-Wu＇s decomposition algorithm by Chou and Gao （1993）. This paper investigates th... 详细信息

关键词： Bertrand curves mechanical theorem proving Minkowski space pseudo-null curve Ritt-Wu's method.

Vascularization in interconnected 3D printed Ti-6Al-4V foams with hydrogel matrix for biomedical bone replacement implants

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Science China Materials 2018年第4期61卷 565-578页

作者： Victor L.Correa kristine M.Garza Lawrence e.Murr Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso Department of Biological Sciences University of Texas at El Paso

Vascularization on newly implanted metal orthopedic implants has remained a challenge in the field of tissue engineering. To address this challenge, in this research,an interconnected foam structure of Ti-6 Al-4 V was microfabricated by electron beam melting(eBM) technique. The foam in question has a density of 1.77 g cm-3 with 60% porosity and a tensile strength of 18 GPa. An extracellular matrix based hydrogel was added as an aqueous matrix to the *** mimetic stress has been closely related to many wound healing biomedical applications as it increases survival and proliferation molecular signals. To that end, increased expression of hypoxia-inducible factor-1α(Hif-1α) and vascular endothelial growth factor(VeGF) in the aqueous hydrogel matrix was achieved by the addition of a hypoxia mimetic deferoxamine mesylate(DFM). In this study, the formation of an endothelial network was achieved in a hydrogel matrix in the presence of the before mentioned 3 D printed metal foam. Cellular viability, fluorescent microscopy and scanning electron microscopy imaging analysis demonstrate that pre-osteoblasts undergo proliferation and also attach efficiently to the foam when exposed to DFM. Human umbilical vascular endothelial cells(HUVeCs) were grown in an extracellular matrix-like 3 D hydrogel and a hypoxia-like stress was achieved. This research demonstrates that pre-osteoblast cells undergo cell differentiation and increase the production of hydroxyapatite on exposure to the hypoxia mimetic molecule. This proposed approach encompasses an ideal prototype for a completely living implanted structure for future orthopedic implants.

关键词： Ti-6Al-4V electron beam melting angiogenesis deferoxamine mesylate hydrogel vascularization

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Geology without national boundaries The 1 ： 5 Million International Geological Map of europe and Adjacent Areas IGMe 5000

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episodes 2006年第1期29卷 39-42页

作者： kristine Asch Federal Institute for Geosciences and Natural Resources （BGR）GeRMANY

The International Geological Map of europe and Adjacent Areas （IGMe 5000） is a major european geological GIS project being managed and implemented by the German Geological Survey （Federal Institute for Geosciences and Natural Resources, BGR） under the umbrella of the Commission for the Geological Map of the World （CGMW）. It is a collaborative european project that to date involves 48 Geological Surveys and is supported by a network of scientific advisors. The original aims of the project have now been achieved： to develop a Geographic Information System （GIS） containing up-to-date harmonised lithological and geochronological data of europe, and to print a geological map （Figure 1） of the preQuaternary on-shore and, for the first time at this scale, off-shore areas of europe （see Asch, 2003, for a full account.）

关键词：地质图地理信息系统国家边界地质勘测 GIS

’emulsion locks’ for the containment of hydrocarbons during surfactant flushing

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Journal of environmental Sciences 2020年第4期32卷 98-109页

作者： kristine Lamont Alejandro GMarangoni erica Pensini University of Guelph School of Engineering50 Stone Road EastGwelph ONNIG 2W1Canada University of Guelph Food Science Department50 Stone Road EastGuelph ONNIG 2WlCanada

Reversible double water in oil in water(W/O/W)emulsions were developed to contain subsurface hydrocarbon spills during their remediation using surfactant *** emulsions were prepared by emulsifying CaCl2 solutions in canola oil,and subsequently by emulsifying the W/O emulsions in aqueous sodium alginate *** formation of double emulsions was confirmed with confocal and optical *** double emulsions reversed and gelled when mixed with the surfactants sodium dodecyl sulfate(SDS)and cocamidopropyl betaine(CPB).Gels can act as’emulsion locks’to prevent spreading of the hydrocarbon plume from the areas treated with surfactant flushing,as shown in sand column *** rheology was used to quantify the viscoelastic moduli increase(gelation)upon mixing the double emulsion with SDS and *** was more effective than CPB in gelling the double *** and SDS could adsorb at the interface between water and model hydrocarbons(toluene and motor oil),lowering the interfacial tension and rigidifying the interface(as shown with a Langmuir trough).Bottle tests and optical microscopy showed that SDS and CPB produced W/O and O/W emulsions,with either toluene or motor oil and *** emulsification of motor oil and toluene in water with SDS and CPB facilitated their flow through sand columns and their *** recovery from sand columns was quantitated using Gas-Chromatography MassSpectroscopy(GC-MS).The data show that SDS and CPB can be used both for surfactant flushing and to trigger the gelation of’emulsion locks’.ethanol also gelled the emulsions at100 mL/L.

关键词： Remediation emulsion Hydrocarbons Surfactant Rheology Langmuir trough

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Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility

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Myosin light chain kinase is central to smooth muscle contra...

A FACTOR(S) PRODUCeD BY SeRTOLI CeLLS STIMULATeS ANDROGeN BIOSYNTHeSIS BY LeYDIG CeLLS IN NeONATAL RATS

中国遗传学会“发育、遗传和疾病”研讨会

作者： Robert Feil kristine e. kamm James T.Stull Interfakultres Institut für Biochemie(IFIB) Signaltransduktion-Transgene Modelle Universitt Tübingen Hoppe-Seyler-Str.4 72076 Tübingen Germany Department of Physiology UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390 USA Department of Physiology UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas TX 75390 USA

Smooth muscle contractility is essential for maintaining various physiological activities and adaptive responses to stresses imposed by pathological *** signaling networks define many potential mechanisms for initiating smooth muscle contraction with or without myosin regulatory light chain（RLC）phosphorylation by myosin light chain kinase（MLCK）.Here we provide direct loss-of-function evidence in adult mice that shows the primary importance of *** deletion of MLCK in adult smooth muscle results in severe gut dysmotility,characterized by weak peristalsis,dilation of the digestive tract and reduction of feces excretion and food *** muscles show a loss of RLC phosphorylation and force development induced by *** kinase knockout also markedly reduced RLC phosphorylation and force development with acetylcholine which also activates Ca-sensitizing *** conclude that MLCK and its phosphorylation of RLC are required physiologically for smooth muscle contraction and essential for normal gastrointestinal motility.

关键词： Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility

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Science China Chemistry 1988年第7期31卷 818-827页

作者：刘以训,kristine D. DAHL Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing Department of Reproductive Medicine M-025 University of California San Diego La Jolla CA 92093 USA

Using a coculture system, we have studied the local action of Sertoli cells on Leydig cell function. The results show that （ⅰ） both LH and FSH have equal potency to stimulate testosterone biosynthesis by fetal and neonatal testicular cells in an age-dependent manner, the maximum stimulation is observed between D3and D5. （ⅱ） An FSH-dependent factor（s） secreted by Sertoli cells increases the basal and/or LH-stimulated Leydig cell androgen production. （ⅲ） The Sertoli cell-stimulating factor（s） is not a steroid or other small molecule, but a heat-labile peptide.

关键词： Leydig cells Sertofi cells coculture factor testosterone production.

Connections Between Insomnia and Cognitive Aging

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Neuroscience Bulletin 2020年第1期36卷 77-84页

作者： Claire e.Sexton Konstantina Sykara elissaios Karageorgiou Jenny Zitser Talita Rosa kristine Yaffe Yue Leng Global Brain Health Institute Memory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoCAUSA Department of Psychiatry University of OxfordOxfordUK Neurological Institute of Athens AthensGreece Department of Psychiatry Neurology and EpidemiologyUniversity of CaliforniaSan FranciscoCAUSA

Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental ***,the relationship between insomnia and cognitive health is not well ***,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive *** are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter *** the interventional literature is still in its infancy,there is some indication that treatment may have an impact on ***-powered studies examining sources of heterogeneity are warranted.

关键词： Insomnia Sleep Dementia Cognition

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A Pressure Relaxation Closure Model for One-Dimensional, Two-Material Lagrangian Hydrodynamics Based on the Riemann Problem

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Communications in Computational Physics 2010年第5期7卷 927-976页

作者： James R.kamm Mikhail J.Shashkov Applied Physics Division Los Alamos National LaboratoryLos AlamosNM 87545USA Theoretical Division Los Alamos National LaboratoryLos AlamosNM 87545USA

Despite decades of development, Lagrangian hydrodynamics of strengthfree materials presents numerous open issues, even in one dimension. We focus on theproblem of closing a system of equations for a two-material cell under the assumptionof a single velocity model. There are several existing models and approaches, eachpossessing different levels of fidelity to the underlying physics and each exhibitingunique features in the computed solutions. We consider the case in which the changein heat in the constituent materials in the mixed cell is assumed equal. An instantaneous pressure equilibration model for a mixed cell can be cast as four equations infour unknowns, comprised of the updated values of the specific internal energy andthe specific volume for each of the two materials in the mixed cell. The unique contribution of our approach is a physics-inspired, geometry-based model in which theupdated values of the sub-cell, relaxing-toward-equilibrium constituent pressures arerelated to a local Riemann problem through an optimization principle. This approachcouples the modeling problem of assigning sub-cell pressures to the physics associated with the local, dynamic evolution. We package our approach in the frameworkof a standard predictor-corrector time integration scheme. We evaluate our model using idealized, two material problems using either ideal-gas or stiffened-gas equationsof state and compare these results to those computed with the method of Tipton andwith corresponding pure-material calculations.

关键词： Lagrangian hydrodynamics compressible flow multi-material flow pressure relaxation