A FACTOR(S) PRODUCED BY SERTOLI CELLS STIMULATES ANDROGEN BIOSYNTHESIS BY LEYDIG CELLS IN NEONATAL RATS

作     者：刘以训,KRISTINE D. DAHL 

作者机构：Laboratory of Reproductive Biology Institute of Zoology Academia Sinica Beijing Department of Reproductive Medicine M-025 University of California San Diego La Jolla CA 92093 USA 

出 版 物：《Science China Chemistry》 (中国科学:化学(英文版))

年 卷 期：1988年第31卷第7期

页      面：818-827页

核心收录：

基　　金：This work was supported by the Rockefeller Foundation and National Institute of Health Research Grant HD14084 

主　　题：Leydig cells Sertofi cells coculture factor testosterone production. 

摘      要：Using a coculture system, we have studied the local action of Sertoli cells on Leydig cell function. The results show that （ⅰ） both LH and FSH have equal potency to stimulate testosterone biosynthesis by fetal and neonatal testicular cells in an age-dependent manner, the maximum stimulation is observed between D3and D5. （ⅱ） An FSH-dependent factor（s） secreted by Sertoli cells increases the basal and/or LH-stimulated Leydig cell androgen production. （ⅲ） The Sertoli cell-stimulating factor（s） is not a steroid or other small molecule, but a heat-labile peptide.