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Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Neural Regeneration Research 2020年第4期15卷 586-596页

作者： Alisa A.Shaimardanova valeriya v.Solovyeva Daria S.Chulpanova victoria James kristina v.kitaeva Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry The Russian Academy of SciencesMoscowRussia School of veterinary Medicine and Science University of NottinghamSutton Bonington CampusLeicestershireUK

Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body *** many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic *** contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system *** vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain ***,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well *** attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative *** on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and *** to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the *** review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles.

关键词： biomarkers cell-mediated therapy central nervous system diseases diagnosis exosomes extracellular RNAs extracellular vesicles microRNAs microvesicles neurodegenerative diseases

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Electroluminescence from pure resonant states in hBN-based vertical tunneling junctions

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Light(Science & Applications) 2024年第8期13卷 1557-1564页

作者： Magdalena Grzeszczyk kristina vaklinova Kenji Watanabe Takashi Taniguchi Konstantin SNovoselov Maciej Koperski Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Defect centers in wide-band-gap crystals have garnered interest for their potential in applications among optoelectronic and sensor ***,defects embedded in highly insulating crystals,like diamond,silicon carbide,or aluminum oxide,have been notoriously difficult to excite electrically due to their large internal *** address this challenge,we realized a new paradigm of exciting defects in vertical tunneling junctions based on carbon centers in hexagonal boron nitride(hBN).The rational design of the devices via van der Waals technology enabled us to raise and control optical processes related to defect-to-band and intradefect *** fundamental understanding of the tunneling events was based on the transfer of the electronic wave function amplitude between resonant defect states in hBN to the metallic state in graphene,which leads to dramatic changes in the characteristics of electrons due to different band structures of constituent *** our devices,the decay of electrons via tunneling pathways competed with radiative recombination,resulting in an unprecedented degree of tuneability of carrier dynamics due to the significant sensitivity of the characteristic tunneling times on the thickness and structure of the *** enabled us to achieve a high-efficiency electrical excitation of intradefect transitions,exceeding by several orders of magnitude the efficiency of optical excitation in the sub-band-gap *** work represents a significant advancement towards a universal and scalable platform for electrically driven devices utilizing defect centers in wide-band-gap crystals with properties modulated via activation of different tunneling mechanisms at a level of device engineering.

关键词： carbide tunneling defect

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Coulometric sizing of nanoparticles： Cathodic and anodic impact experiments open two independent routes to electrochemical sizing of Fez04 nanoparticles

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Nano Research 2013年第11期6卷 836-841页

作者： kristina Tschulik Baptiste Haddou Dario Omanovi Neil v. Rees Richard G. Compton Department of Chemistry Physical & Theoretical Chemistry Laboratory Oxford University South Parks Road Oxford OXI 3QZUnited Kingdom Center for Marine and Environmental Research Ruder Boskovic Institute P. O. Box 180 I0001 Zagreb Croatia

Anodic particle coulometry （APC） is a recently established method of sizing individual metal nanoparticles by oxidising them during their impact on a micro electrode. Here it is demonstrated that the application of APC can be extended to sizing of metal oxide nanoparticles, such as Fe304 magnetite nanoparticles. Additionally, a new route to electrochemical nanoparticle sizing is introduced-- cathodic particle coulometry （CPC）. This method uses the reduction of impacting nanoparticles, e.g., metal oxide nanoparticles, and is demonstrated to yield correct size information for Fe304 nanoparticles. The combination of these two independent electrochemical methods of nanoparticle sizing, allows for purely electrochemical sizing of single nanoparticles and simultaneous verification of the obtained results.

关键词： nanoparticle sizing Fe3O4 anodic particle coulometry cathodic particle coulometry impact experiments metal oxide nanoparticles

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Technosols on mining wastes in the subarctic: Efficiency of remediation under Cu-Ni atmospheric pollution

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International Soil and Water Conservation Research 2019年第3期7卷 297-307页

作者： Marina v.Slukovskaya viacheslav I.vasenev kristina v.Ivashchenko Dmitry v.Morev Svetlana v.Drogobuzhskaya Liubov A.Ivanova Irina P.Kremenetskaya I.v.Tananaev Institute of Chemistry and Technology of Rare Elements and Mineral Raw Materials Kola Science CentreRussian Academy of Sciences184209Academgorodok 26aApatityMurmansk RegionRussia Department of Landscape Design and Sustainable Ecosystems RUDN University117198Miklykho-Maklaya str.8MoscowRussia Institute of Physicochemical and Biological Problems in Soil Science Russian Academy of Sciences142290Institutskaya str.2PushchinoMoscow RegionRussia Department of Ecology Russian State Agrarian University-Moscow Timiryazev Agricultural Academy127550Timiryazevskaya str.49MoscowRussia N.A.Avrorin Polar-Alpine Botanical Garden-Institute Kola Science CentreRussian Academy of Sciences184209Academgorodok 18aApatityMurmansk RegionRussia

Tne copper-nickel factory's emissions in the Murmansk region,Russia,led to the degradanon of plant cover and topsoil with the subsequent formation of industrial *** this study,the industrial barrens were remediated by means of Technosol engineering,when grasses were sown on the two different types of mining wastes (carbonatite and serpentinite-magnesite) covered by hydroponic *** serpentinite-magnesite waste was significantly different from the carbonatite waste in the content of silicon (Si) and manganese (Mn),pH,and *** wastes had an alkaline pH level and high content of calcium (Ca) and magnesium (Mg).The vegetation and Technosol properties at the remediated sites were analyzed in 2017 and compared to the initial state (2010 year) to assess the efficiency of the long-term *** quality and sustainability of Technosols based on the serpentinite-magnesite wastes were substantially higher compared to the carbonatite-based *** and a projective cover of the grass community depended on Si content in the original mining waste and were found to be higher in the serpentinite-magnesite *** content of organic carbon and its fractions,microbial biomass and basal respiration after seven years of Technosol evolution was comparable to natural *** parameters were directly related to plant cover state and were inversely proportional to copper (Cu) content in *** Technosol development led to the reduction of nickel (Ni) and Cu migration in soil-plant ecosystems due to neutralization and adsorption properties of mining wastes and phytostabilization by underground parts of grass *** Technosol development in its early stage of pedogenesis indicates the efficiency of applied remediation technology to the degraded acidic soil under the conditions of industrial atmospheric pollution.

关键词： Industrial barrens Metals Phytostabilization Soil organic carbon Basal respiration Pedogenesis

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Bv(RI )c photometric study of three variable PMS stars in the field of v733 Cephei

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Research in Astronomy and Astrophysics 2020年第12期20卷 221-228页

作者： Sunay Ibryamov Evgeni Semkov Stoyanka Peneva kristina Gocheva Department of Physics and Astronomy University of Shumen115Universitetska Str.9700 ShumenBulgaria Institute of Astronomy and National Astronomical Observatory Bulgarian Academy of Sciences72Tsarigradsko Shose Blvd.1784 SofiaBulgaria

This paper reports results from the first long-term Bv(RI)c photometric CCD observations of three variable pre-main-sequence stars collected during the period from February 2007 to January 2020. The investigated stars are located in the field of the PMS star v733 Cep within the Cepheus OB3 association. All stars from our study show rapid photometric variability in all-optical passbands. In this paper, we describe and discuss the photometric behavior of these stars and the possible reasons for their variability. In the light variation of two of the stars, we found periodicity.

关键词： stars:pre-main sequence stars:variables:T Tauri,Herbig Ae/Be techniques:photometric methods:observational,data analysis stars:individual(2MASS J22534654+6234582,2MASS J22533629+6231446,2MASS J22531578+6235262)

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Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis

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Cellular & Molecular Immunology 2011年第4期8卷 296-304页

作者： Cecilia Carnrot Kajsa E Prokopec kristina Rasbo Mikael CI Karlsson Sandra Kleinau Department of Cell and Molecular Biology Uppsala UniversityUppsalaSweden Department of Medicine Unit of Clinical Allergy ResearchThe Karolinska InstituteSolnaSweden

Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully *** show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to *** CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B *** CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B *** was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B ***,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B ***,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive *** data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA.

关键词： arthritis B cells collagen type II ELISpot marginal zone mice

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Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning

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神经科学通报:英文版 2023年第8期39卷 1309-1326页

作者： Qian Lv kristina Zeljic Shaoling Zhao Jiangtao Zhang Jianmin Zhang Zheng Wang School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental HealthIDG/McGovern Institute for Brain ResearchPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China School of Health and Psychological Sciences CityUniversity of LondonLondon EC1V 0HBUK Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 101408China Tongde Hospital of Zhejiang Province(Zhejiang Mental Health Center) Zhejiang Ofce of Mental HealthHangzhou 310012China School of Biomedical Engineering Hainan UniversityHaikou 570228China

Machine learning approaches are increasingly being applied to neuroimaging data from patients with psychiatric disorders to extract brain-based features for diagnosis and *** goal of this review is to discuss recent practices for evaluating machine learning applications to obsessive-compulsive and related disorders and to advance a novel strategy of building machine learning models based on a set of core brain regions for better performance,interpretability,and ***,we argue that a core set of co-altered brain regions(namely‘core regions’)comprising areas central to the underlying psychopathology enables the efficient construction of a predictive model to identify distinct symptom dimensions/clusters in individual ***-driven and data-driven approaches are further introduced showing how core regions are identified from the entire *** demonstrate a broadly applicable roadmap for leveraging this core set-based strategy to accelerate the pursuit of neuroimaging-based markers for diagnosis and prognosis in a variety of psychiatric disorders.

关键词： Psychiatric disorders Obsessive-compulsive disorder Core region Magnetic resonance imaging Machine learning Neuroimaging-based diagnosis

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Retrospective review of total neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 857-865页

作者： Laila Babar veli Bakalov Stephen Abel Obaid Ashraf Gene Grant Finley Moses S Raj kristina Lundeen Dulabh K Monga Alexander v Kirichenko Rodney E Wegner Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiation Oncology Allegheny General HospitalPittsburghPA 15212United States Department of Medical Oncology Allegheny General HospitalPittsburghPA 15212United States

BACKGROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal *** this approach,maChT administration can be delayed for several months,leading to concern for distant *** counteract this,a novel treatment approach known as total neoadjuvant therapy(TNT)has gained popularity,in which patients receive both maChT and nCRT prior to *** utilized the National Cancer Database to examine temporal trends in TNT usage,and any potential effect on *** To study the temporal trends in the usage of TNT and evaluate its efficacy compared to neoadjuvant *** We queried the National Cancer Database for patients with locally advanced rectal cancer,Stage II-III,from 2004-2015 treated with nCRT or *** was defined as maChT initiated≥90 d prior to nCRT *** survival was calculated from the date of diagnosis to the date of last contact or death using Kaplan-Meier curves to present the cumulative probability of survival,with logrank statistics to assess *** cox regression was used to identify predictors of survival and propensity score analysis accounted for *** We identified 9066 eligible patients,with 8812 and 254 patients receiving neoadjuvant chemoradiation followed by maChT and TNT,*** involvement,stage III disease,and treatment in recent years were predictive of TNT *** was greater use of TNT with more advanced stage,specifically>1 node involved(odds ratio[OR]=2.88,95%confidence interval[CI]:2.11-3.93,Pvant chemoradiation arms had a similar 5-year survival at 76%and 78%*** analysis with propensity score de

关键词： Total neoadjuvant therapy Neoadjuvant chemoradiation Multi-agent chemotherapy Locally advanced rectal cancer National cancer database Colorectal cancer Retrospective review Gastrointestinal oncology Temporal trends Surgical excision

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Efficient reversible CO/CO_(2) conversion in solid oxide cells with a phase-transformed fuel electrode

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Science China Materials 2021年第5期64卷 1114-1126页

作者： Yihang Li Manish Singh Zechao Zhuang Yifu Jing Fengjiao Li kristina Maliutina Chuanxin He Liangdong Fan College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Key Lab of Optoelectronic Devices and Systems of Ministry of Education/Guangdong ProvinceShenzhen UniversityShenzhen 518060China Department of Chemistry Division for Pure and Applied BiochemistryNaturvetarvägen 1422362Lund UniversitySweden Department of Chemistry Tsinghua UniversityBeijing 100084China Shenzhen Key Laboratory of New Lithium-ion Batteries and Mesoporous Materials Shenzhen UniversityShenzhen 518060China

The reversible solid oxide cell(RSOC)is an attractive technology to mutually convert power and chemicals at elevated ***,its development has been hindered mainly due to the absence of a highly active and durable fuel ***,we report a phase-transformed CoFe-Sr_(3)Fe_(1.25)Mo_(0.75)O_(7)-δ(CoFe-SFM)fuel electrode consisting of CoFe nanoparticles and Ruddlesden-Popper-layered Sr_(3)Fe_(1.25)Mo_(0.75)O_(7)-δ(SFM)from a Sr_(2)Fe_(7/6)Mo_(0.5)Co_(1/3)O_(6)-δ(SFMCo)perovskite oxide after annealing in hydrogen and apply it to reversible CO/CO_(2)conversion in *** CoFeSFM fuel electrode shows improved catalytic activity by accelerating oxygen diffusion and surface kinetics towards the CO/CO_(2)conversion as demonstrated by the distribution of relaxation time(DRT)study and equivalent circuit model fitting ***,an electrolyte-supported single cell is evaluated in the 2:1 CO-CO_(2)atmosphere at 800℃,which shows a peak power density of 259 mW cm^(-2)for CO oxidation and a current density of-0.453 A cm^(-2)at 1.3 v for CO_(2)reduction,which correspond to 3.079 and3.155 m L min-1cm^(-2)for the CO and CO_(2)conversion rates,*** importantly,the reversible conversion is successfully demonstrated over 20 cyclic electrolysis and fuel cell switching test modes at 1.3 and 0.6 *** work provides a useful guideline for designing a fuel electrode through a surface/interface exsolution process for RSOC towards efficient CO-CO_(2)reversible conversion.

关键词： reversible solid oxide cells CO-CO_(2)conversion perovskite oxide phase transformation cyclic test

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Modifying light–matter interactions with perovskite nanocrystals inside antiresonant photonic crystal fiber

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Photonics Research 2021年第8期9卷 1462-1469页

作者： ANDREY A.MACHNEv ANATOLY P.PUSHKAREv PAvEL TONKAEv ROMAN E.NOSKOv kristina R.RUSIMOvA PETER J.MOSLEY SERGEY v.MAKAROv PAvEL B.GINZBURG IvAN I.SHISHKIN School of Electrical Engineering Tel Aviv UniversityTel Aviv 69978Israel Department of Physics and Engineering ITMO UniversitySaint Petersburg 197101Russia Centre for Photonics and Photonic Materials Department of PhysicsUniversity of BathBath BA27AYUK Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia

Structured environments are employed in a plethora of applications to tailor dynamics of light–matter interaction processes by modifying the structure of electromagnetic *** promising example of such a system is antiresonant photonic crystal fibers(AR-PCFs),which allow light–analyte interactions in a very long *** we probe contribution of microstructuring and nontrivial mode hierarchy on light–matter interactions in AR-PCFs by investigating lifetime shortening of perovskite(CsPbBr3)nanocrystals grown to fiber *** crystals have been deposited using a wet chemistry approach and then excited by a supercontinuum source in the 450–500 nm *** spectra have been measured and analyzed via the time-correlated single photon counting(TCSPC)technique,unravelling contributions of core and cladding *** lifetime imaging inside an AR-PCF enables mapping input of various electromagnetic channels into light–matter interaction *** results pave the way for tailoring the dynamics of high-order quantum processes,promoting the concept of AR-PCF as a light-driven reactor.

关键词： fiber light resonant

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