Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

作     者：Alisa A.Shaimardanova Valeriya V.Solovyeva Daria S.Chulpanova Victoria James Kristina V.Kitaeva Albert A.Rizvanov Alisa A. Shaimardanova;Valeriya V. Solovyeva;Daria S. Chulpanova;Victoria James;Kristina V. Kitaeva;Albert A. Rizvanov

作者机构：Institute of Fundamental Medicine and BiologyKazan Federal UniversityKazanRussia Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryThe Russian Academy of SciencesMoscowRussia School of Veterinary Medicine and ScienceUniversity of NottinghamSutton Bonington CampusLeicestershireUK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第4期

页      面：586-596页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financially supported by the Russian Government Program of Competitive Growth of Kazan Federal University supported by state assignment 20.5175.2017/6.7 of the Ministry of Education and Science of Russian Federation the President of the Russian Federation grant НШ-3076.2018.4 

主　　题：biomarkers cell-mediated therapy central nervous system diseases diagnosis exosomes extracellular RNAs extracellular vesicles microRNAs microvesicles neurodegenerative diseases 

摘      要：Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body *** many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic *** contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system *** vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain ***,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well *** attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative *** on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and *** to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the *** review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles.