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Current status of the biliary tract malformation

World Journal of Clinical Pediatrics 2024年第2期13卷 100-103页

作者： krishna.kumar govindarajan Department of Pediatric Surgery JIPMERPondicherryPondicherry 605006India

The choledochal cyst(CC)can be better termed as biliary tract malformation because of the close association of embryology and etiology in the causation of *** to Babbitt's postulation of reflux,damage and dilatation,reflux was not demonstrable as the causative factor in all varieties of *** pressure in the biliary system,otherwise termed ductal hypertension,is put forth as an alternative to explain the evolution of *** forme fruste type,which does not find a place in the standard classification,typifies the ductal hypertension *** a closer,in-depth review would be able to highlight this apt terminology of biliary tract malformation.

关键词： Choledochal cyst Biliary tract Biliary dilatation Ductal hypertension Common channel Pancreatobiliary malunion

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Biliary atresia: Where do we stand now?

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World Journal of Hepatology 2016年第36期8卷 1593-1601页

作者： krishna.kumar govindarajan Department of Pediatric Surgery Jawaharlal Institute of Postgraduate Medical Education and Research

The pathway from clinical suspicion to establishing the diagnosis of biliary atresia in a child with jaundice is a daunting task. However, investigations available help to point towards the correct diagnosis in reasonable time frame. Imaging by Sonography has identified several parameters which can be of utility in the diagnostic work up. Comparison of Sonography with imaging by Nuclear medicine can bring out the significant differences and also help in appropriate imaging. The battery of Biochemical tests, available currently, enable better understanding of the line-up of investigations in a given child with neonatal cholestasis. Management protocols enable standardized care with optimal outcome. The place of surgical management in biliary atresia is undisputed, although Kasai procedure and primary liver transplantation have been pitted against each other. This article functions as a platform to bring forth the various dimensions of biliary atresia.

关键词：胆汁的闭锁新生的 cholestasis Kasai 过程新生的黄疸 Hyperbilirubinemia

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Optoelectronic and electrochemical behaviour of γ-CuI thin films prepared by solid iodination process

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Progress in Natural Science:Materials International 2019年第5期29卷 533-540页

作者： Karthik kumar Chinnakutti Vengatesh Panneerselvam Durai govindarajan Ajith kumar Soman Kuppusami Parasuraman Shyju Thankaraj Salammal Centre of Excellence for Energy Research Sathyabama Institute of Science and Technology Centre for Nanoscience and Nanotechnology Sathyabama Institute of Science and Technology

A simple and efficient solid iodination method has been proposed for the fabrication of p-type γ-CuI thin *** structural,morphological,optical,electrical and electrochemical properties have been investigated in order to serve as an effective hole-transporting layer in solid-state solar *** fabricated films exhibited p-type conductivity with resistivity of 7.0×10;Ωcm,the hole concentration of ～1.13×10;cm;and the mobility of 18.34 cm;V;s;.The cyclic voltammetry result shows a maximum specific capacitance of 43 mF/cm;at a scan rate of 10 mV/*** cyclic stability and capacitance retention were found to be 99.7%.These findings demonstrate that γ-CuI film can be a potential candidate for multiple applications,such as a hole transporting material for solid-state solar cells and electrochemical supercapacitor.

关键词： Copper iodide Solid iodination Hole mobility Cyclic voltammetry

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Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells

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Genes & Diseases 2019年第2期6卷 159-166页

作者： R.L.Babu M.Naveen kumar Rajeshwari H.Patil K.M.Kiran kumar K.S.Devaraju govindarajan T.Ramesh S.Chidananda Sharma Department of Bioinformatics and Biotechnology Akkamahadevi Women’s UniversityJnanashakthi CampusVijayapura586108KarnatakaIndia Department of Microbiology and Biotechnology Bangalore UniversityJnana BharathiBengaluru560056KarnatakaIndia Department of Biochemistry Karnatak UniversityDharwad580003KarnatakaIndia Department of Biology Center for Biotechnology and Biomedical SciencesNorfolk State UniversityNorfolkVAUSA

Activator protein-1(AP-1)transcription factor is a key component of many signal transduction pathways involved in the regulation of cellular processes and controls rapid responses of mammalian cells when exposed to the variety of *** phorbol 12-myristate 13-acetate and Forskolin(Fo)are well-known kinase activators/stimulators of Protein Kinase C(PKC)and Protein Kinase A(PKA)***,these kinases are found to be present in transitional points of many cell signaling pathways,especially those involved in *** stimulating effect of PKC and PKA on the expression of AP-1 factors in MCF-7 breast cell proliferation is not well ***,the role of PKC by PMA treatment and the role of PKA by using Fo in MCF-7 cells is ***,cells treated with PMA showed increased cell proliferation,while Fo had no effect,but inhibited the PMA induced *** RT-PCR results showed the PMA induced c-Jun,c-Fos and Fra-1 expressions compared to control and ***,Fo in combination with PMA,inhibit the PMA induced above mRNA expressions where Fo alone has no *** blot studies validated the c-Jun expressions in PMA treated MCF-7 ***,PMA increases the mRNA expression of Cyclin-E1,Cyclin-D1,and CDK-4,whereas Fo decreases their ***,mitogenic effect of PMA and inhibitory action of Fo on MCF-7 cells is probably enhanced via activation of AP-1 factors and concomitant action of cell cycle regulators in the downstream singling cascade.

关键词： AP-1 transcription factor Cell cycle Forskolin MCF-7 cells Phorbol esters

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