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A comparative study to evaluate the effect of limited access dressing on diabetic ulcers

Plastic and Aesthetic Research 2015年第1期2卷 266-271页

作者： Thittamaranahalli Muguregowda Honnegowda Pramod Kumar krishnananda Prabhu Ashwini Kumar Pragna Rao E.G.Padmanabha Udupa Shobha Kamath Antony Sylvan D’Souza krishna kishore mahato Department of Plastic Surgery and Burns Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Plastic Surgery King Abdulaziz Specialist HospitalSakaka 42421Al-JoufSaudi Arabia Department of Biochemistry Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Forensic Medicine Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Anatomy Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Biophysics School of Life SciencesManipal 576104KarnatakaIndia

Aim:Emerging evidence favors the important role of antioxidants,matrix metalloproteinases(MMPs),and nitric oxide(NO)in the healing of diabetic *** is a lack of substantial evidence regarding the effects of negative pressure on antioxidants,MMPs and NO in chronic wounds associated with ***:A total of 55 type 2 diabetic patients with leg ulcers were divided into 2 groups:a limited access dressing(LAD)group(n=27)and a conventional dressing group(n=28).Levels of hydroxyproline,total protein,MMP-2 and MMP-9,NO and antioxidants including reduced glutathione(GSH)and the oxidative biomarker malondialdehyde(MDA)were measured in the granulation tissue at days 0 and *** in levels between the LAD and conventional groups were determined by the Student’s ***:After 10 days of treatment,the LAD *** dressing group showed increase in the levels of hydroxyproline(mean±standard deviation=55.2±25.1 vs.29.2±1,P<0.05),total protein(12.8±6.5 vs.8.34±3.2,P<0.05),NO(1.13±0.52 vs.0.66±0.43,P<0.05),GSH(7.0±2.4 vs.6.6±2.2,P<0.05)and decrease in MMP-2(0.47±0.33 vs.0.62±0.30,P<0.05),MMP-9(0.32±0.20 vs.0.53±0.39,P<0.05)and MDA(6.8±2.3 vs.10.4±3.4,P<0.05).Conclusion:When compared to conventional dressings,LAD induces biochemical changes by significantly increasing the levels of hydroxyproline,total protein,NO and antioxidants levels,and significantly reducing MMPs(MMP-2 and MMP-9)and an oxidative biomarker in diabetic *** biochemical changes are thought to favor diabetic wound healing.

关键词： Antioxidants diabetic wounds hydroxyproline limited access dressing matrix metalloproteinases nitric oxide reactive oxygen species and oxidative stress biomarker total protein

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A novel control strategy of a variable-speed doubly-fed-induction-generator-based wind energy conversion system

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Clean Energy 2024年第1期8卷 153-170页

作者： Shibani Prasad Mohapatra Pradipta kishore Dash Department of Electrical Engineering Siksha O Anusandhan Deemed to be UniversityBhubaneswar-751030OdishaIndia Multidisciplinary Research Cell Siksha O Anusandhan Deemed to be UniversityBhubaneswar-751030OdishaIndia

This paper aims to address the issue of control of a variable-speed wind turbine based on doubly-fed induction generators. In this work,an effort is made to extract the maximum efficiency from a doubly-fed induction generator-based variable-speed wind turbine by controlling the rotor current. In the first step, a maximum power point tracking technique is used to extract the maximum power from theturbine. Then a stator-flux-oriented vector control strategy is employed to control the rotor-side current. Subsequently, a grid voltagevector-oriented control strategy is used to control the grid-side system of the grid-connected generator. Considering the nonlinearityand parameter uncertainty of the system, an active disturbance rejection controller with a sliding-mode-based extended-state observeris developed for the above-mentioned control strategies. Furthermore, the stability of the controller is tested and the performance of thecontroller is compared with the classical proportional-integral controller based on disturbance rejection, robustness and tracking capability in a highly non-linear wind speed variation scenario. Modelling, control and comparison are conducted in the MATLAB®/Simulink®environment. Finally, a real-time hardware set-up is presented using the dSPACE ds-1104 R&D processing board to validate the controlscheme. From the result of the experiments, it is seen that the proposed controller takes 10-15 control cycles to settle to its steady-statevalues, depending on the control loop, whereas the conventional proportional-integral controller takes 60-75 control cycles. As a result,the settling time for the proposed control scheme is shorter than that of the proportional-integral controller.

关键词： doubly-fed induction generator variable-speed wind turbine vector control active disturbance rejection controller stability analysis

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Pre‑hatch thermal manipulation of embryos and post‑hatch baicalein supplementation mitigated heat stress in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1071-1085页

作者： Sadid Al Amaz Ajay Chaudhary Prem Lal mahato Rajesh Jha Birendra Mishra Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawai’i at ManoaAgSci 2161955 East‑West RdHonoluluHI 96822USA

Background High environmental temperatures induce heat stress in broiler chickens,affecting their health and pro-duction *** dietary,managerial,and genetics strategies have been tested with some success in mitigating heat stress(HS)in *** novel HS mitigation strategies for sustaining broiler production is critically *** study investigated the effects of pre-hatch thermal manipulation(TM)and post-hatch baica-lein supplementation on growth performance and health parameters in heat-stressed *** Six hundred fertile Cobb 500 eggs were incubated for 21 *** candling on embryonic day(ED)10,238 eggs were thermally manipulated at 38.5℃ with 55%relative humidity(RH)from ED 12 to 18,then transferred to the hatcher(ED 19 to 21,standard temperature)and 236 eggs were incubated at a controlled temperature(37.5℃)till *** hatch,180-day-old chicks from both groups were raised in 36 pens(n=10 birds/pen,6 replicates per treatment).The treatments were:1)Control,2)TM,3)control heat stress(CHS),4)thermal manipulation heat stress(TMHS),5)control heat stress supplement(CHSS),and 6)thermal manipulation heat stress supplement(TMHSS).All birds were raised under the standard environment for 21 d,followed by chronic heat stress from d 22 to 35(32–33℃ for 8 h)in the CHS,TMHS,CHSS,and TMHSS groups.A thermoneutral(22–24℃)environment was maintained in the Control and TM *** was constant(50%±5%)throughout the *** the data were analyzed using one-way ANOVA in R and GraphPad software at P<0.05 and are presented as mean±*** stress significantly decreased(P<0.05)the final body weight and ADG in CHS and TMHS groups compared to the other *** TM significantly increased(P<0.05)the expression of heat shock protein-related genes(HSP70,HSP90,and HSPH1)and antioxidant-related genes(GPX1 and TXN).TMHS birds showed a significant increment(P<0.05)in total cecal volatile fatty acid(VFA)concentration compared to the CHS bird

关键词： Baicalein Growth performance Gut microbiota Heat stress Thermal manipulation

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Implications of MMP-12 in the pathophysiology of ischaemic stroke

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Stroke & Vascular Neurology 2024年第2期9卷 97-107页

作者： krishna Kumar Veeravalli Cancer Biology and Pharmacology University of Illinois College of Medicine at PeoriaPeoriaIllinoisUSA

This article focuses on the emerging role of matrix metalloproteinase-12(MMP-12)in ischaemic stroke(IS).MMP-12 expression in the brain increases dramatically in animal models of IS,and its suppression reduces brain damage and promotes neurological,sensorimotor and cognitive functional ***,MMP-12 could represent a potential target for the management of *** article provides an overview of MMP-12 upregulation in the brain following IS,its deleterious role in the post-stroke pathogenesis(blood-brain barrier disruption,inflammation,apoptosis and demyelination),possible molecular interactions and mechanistic insights,its involvement in post-ischaemic functional deficits and recovery as well as the limitations,perspectives,challenges and future directions for further *** to testing any MMP-12-targeted therapy in patients with acute IS,additional research is needed to establish the effectiveness of MMP-12 suppression against IS in older animals and in animals with *** article also examines the clinical implications of suppressing MMP-12 alone or in combination with MMP-9 for extending the currently limited tissue plasminogen activator therapy time *** of MMP-12 is expected to have a profound influence on the therapeutic management of IS in the future.

关键词： involvement alone directions

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An inverse analysis of fluid flow through granular media using differentiable lattice Boltzmann method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2077-2090页

作者： Qiuyu Wang krishna Kumar Department of Civil Architectural and Environmental EngineeringUniversity of Texas at AustinAustin78712-2100USA

This study presents a method for the inverse analysis of fluid flow *** focus is put on accurately determining boundary conditions and characterizing the physical properties of granular media,such as permeability,and fluid components,like *** primary aim is to deduce either constant pressure head or pressure profiles,given the known velocity field at a steady-state flow through a conduit containing obstacles,including walls,spheres,and *** lattice Boltzmann method(LBM)combined with automatic differentiation(AD)(AD-LBM)is employed,with the help of the GPU-capable Taichi programming language.A lightweight tape is used to generate gradients for the entire LBM simulation,enabling end-to-end *** AD-LBM approach accurately estimates the boundary conditions for complex flow paths in porous media,leading to observed steady-state velocity fields and deriving macro-scale permeability and fluid *** method demonstrates significant advantages in terms of prediction accuracy and computational efficiency,making it a powerful tool for solving inverse fluid flow problems in various applications.

关键词： Inverse problem Fluid flow Granular media Automatic differentiation(AD) Lattice Boltzmann method(LBM)

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Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

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Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： Amit Kumar Singh krishna Pramanik Amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： Scaffold Biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering

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Seismic evaluation of frequency influence and resonant behavior for lead rubber bearing isolated rigid rectangular liquid tanks

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 973-994页

作者： Jyoti Ranjan Barik kishore Chandra Biswal Department of Civil Engineering National Institute of Technology RourkelaOdisha 769008India

The seismic behavior of a partially filled rigid rectangular liquid tank is investigated under short-and longduration ground motions.A finite element model is developed to analyze the liquid domain by using four-noded quadrilateral *** competency of the model is verified with the available *** studies are conducted for the dynamic parameters of the base-isolated tank,using a lead rubber bearing to evaluate the optimum damping and time period of the *** application of base isolation has reduced the total and impulsive hydrodynamic components of pressure by 80 to 90 percent,and base shear by 15 to 95 percent,depending upon the frequency content and duration of the considered *** sloshing amplitude of the base-isolated tank is reduced by 18 to 94 percent for most of the short-duration earthquakes,while it is increased by 17 to 60 percent for the majority of the long-duration ***,resonance studies are carried out through a long-duration harmonic excitation to obtain the dynamic behavior of non-isolated and isolated tanks,using a nonlinear sloshing *** seismic responses of the base-isolated tank are obtained as higher when the excitation frequency matches the fundamental sloshing frequency rather than the isolator frequency.

关键词： lead rubber bearing frequency domain resonant inputs long-duration excitation

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Preserving environmental quality of ecotourism sites through community participation in Purulia District of West Bengal,India

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Regional Sustainability 2024年第3期5卷 111-123页

作者： Piyall CHATTERJEE Soumyendra kishore DATTA Department of Economics the University of Burdwan West Bengal734013India

The importance of valuing environmental resources,especially in ecotourism sites,has become increasingly important over the last two *** is now considered as an important source of livelihood of local stakeholders in backward ***,the preservation of ecotourism sites through community participation seems very important to maintain continued flow of *** study aimed at recognizing the importance of community participation for the preservation of ecotourism *** this,this study executed a survey based on non-probability sampling in two ecotourism sites(Garpanchkot and Baranti)covering 100 respondents in Purulia District,West Bengal of *** central issue of this study was to assess the tendency of community participation for the conservation of ecotourism sites and find the optimum condition for offering participatory labour *** study showed that the participation of young people is high,and the majority of respondents are aware of the importance in protecting ecotourism *** respondents were too poor to offer money,the contingent valuation method(CVM)was used to elicit their willingness to pay(WTP)participatory labour time for the conservation of ecotourism ***’age,income,education level,caste,and their perceived environmental quality had significant relationship with their WTP participatory labour time by applying the ordinary least square(OLS)*** was found that the mean WTP participatory labour time of each respondent in a month is approximately 3.64 *** significance of this study is that community participation can improve the sense of belonging,trust,and credibility of ecotourism sites,making them more appreciative of the value and protection of these sites.

关键词： Ecotourism site conservation Community participation Local stakeholders Willingness to pay Participatory labour time Ordinary least square(OLS)model Contingent valuation method(CVM)

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Enhanced saturation magnetization in La^(3+) doped NiCo ferrites prepared by sol-gel auto-combustion method

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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy krishna Reddy C.V. Department of Physics Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physics Government PolytechnicRayachotiA.P516269India

Lanthanum doped nickel-cobalt nano ferrites with chemical formula Ni_(0.5)Co_(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto combustion *** basic structural properties were determined by X-ray diffraction method and the formation of single phased spinel ferrite was *** crystalline size decreased from 25 to 11 nm and lattice parameter a increases with increase of La *** surface morphology of these ferrites was observed by field-emission scanning electron microscopy(FESEM) and agglomerated irregular grains are observed with increase of the rare earth element La ***-dispersive X-ray spectroscopy(EDX) result confirms the presence of the required *** Fourier transform infrared spectroscopy(FTIR) spectrum indicates the formation of the spinel ferrite structure with M-O *** direct band measurements from ultraviolet-visible spectroscopy(UV-Vis) spectroscopy indicate that the direct band gap decreases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then increases to 1.28 eV for x=*** room temperature magnetic properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanced saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually decreased for x=0.15 and x=*** the remanent magnetization and coercivity also follow the same trend.

关键词： Ferrites Sol-gel auto combustion La doping Magnetic properties Rare earths

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Improved Energy Management Strategy for Prosumer Buildings with Renewable Energy Sources and Battery Energy Storage Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 381-392页

作者： Pavitra Sharma krishna Kumar Saini Hitesh Datt Mathur Puneet Mishra Department of Electrical&Electronics Engineering Birla Institute of Technology&SciencePilaniIndia IEEE

The concept of utilizing microgrids(MGs)to convert buildings into prosumers is gaining massive popularity because of its economic and environmental *** pro-sumer buildings consist of renewable energy sources and usually install battery energy storage systems(BESSs)to deal with the uncertain nature of renewable energy ***,because of the high capital investment of BESS and the limitation of available energy,there is a need for an effective energy management strategy for prosumer buildings that maximizes the profit of building owner and increases the operating life span of *** this regard,this paper proposes an improved energy management strategy(IEMS)for the prosumer building to minimize the operating cost of MG and degradation factor of ***,to estimate the practical operating life span of BESS,this paper utilizes a non-linear battery degradation *** addition,a flexible load shifting(FLS)scheme is also developed and integrated into the proposed strategy to further improve its *** proposed strategy is tested for the real-time annual data of a grid-tied solar photovoltaic(PV)and BESS-powered AC-DC hybrid MG installed at a commercial ***,the scenario reduction technique is used to handle the uncertainty associated with generation and load *** validate the performance of the proposed strategy,the results of IEMS are compared with the well-established energy management *** simulation results verify that the proposed strategy substantially increases the profit of the building owner and operating life span of ***,FLS enhances the performance of IEMS by further improving the financial profit of MG owner and the life span of BESS,thus making the operation of prosumer building more economical and efficient.

关键词： Prosumer building battery energy storage system(BESS) battery degradation factor demand response energy management microgrid solar photovoltaic(PV)system

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