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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 36-36页

作者： kearney M.T. Fox k.A.A. Lee A.J. 郭宁 Department of Cardiology Kings College Bessemer Road Lond on SE5 9PJ United Kingdom Dr.

Objectives: To explore the relation between non invasive measures of cardiac function and sudden cardiac death, as well as the development and utility of an index integrating these variables to identify patients at increased risk of this mode of death. Design: Uk HEART(United kingdom heart failure evaluation and a ssessment of risk trial) was a prospective study conducted between December 1993 and April 2000. The study was specifically designed to identify non invasive m arkers of death and mode of death among patients with chronic heart failure. Set ting: 8 Uk general hospitals. Main outcome measures: Death and mode of death. Re sults: 553 patients aged a mean (SD) of 63(10) years, in New York Heart Associat ion functional class 2.3(0.02), recruited prospectively. After 2365 patient yea rsfollow up, 201 patients had died (67 suddenly). Predictors of sudden death w ere greater cardiothoracic ratio, QRS dispersion, QT dispersion corrected for ra te(QTc) across leads v1 v6 on the 12 lead ECG, and the presence of nonsustained ventricular tachycardia. The hazard ratio and 95%confidence intervals (CI) of sudden death for a 10%increase in cardiothoracic ratio was 1.43 (95%CI 1.20 to 1.71), for a 10%increase in QRS dispersion 1.11 (95%CI 1.04 to 1.19), for the presence of non sustained ventricular tachycardia 2.03(95%CI 1.27 to 3.25), a nd for a 10%increase in QTc dispersion across leads v1-v6 1.03 (95%CI 1.00 to 1.07) (all pved from these four factors performed well in identifying patients specifically at increased risk of sudden death. Conclusion s: Results show that an index derived from three widely available non invasive investigations has the potential to identify ambulant patients with chronic hear t failure at increased risk of sudden death. This predictive tool could be used to target more sophisticated investigations or interventions aimed at preventing sudden death.

关键词：慢性心力衰竭持续性室速心功能离散度心脏性猝死死亡模式综合性医院评估试验心胸比率功能检查

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维普期刊数据库

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他汀类药物治疗预防冠心病死亡不同指南方案的有效性和效率:模拟性研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 1-1页

作者： Manuel D.G. kwong k. Tanuseputro P. 郭俊 Institute for Clinical Evaluative Sciences G106-2075 Bayview Avenue Toronto Ont. M4N 3M5 Canada

目的:在加拿大人群中检查旨在降低冠心病死亡的他汀类药物治疗不同指南方案的可能效果。设计:6个国家或国际指南方案(加拿大、澳大利亚、新西兰、美国、英国学会联会和欧洲学会)中筛查和治疗建议的模拟结果。地点:加拿大。

关键词：冠心病死亡他汀类药物模拟性加拿大人方案建议样本量死亡人数

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L—异亮氨酸发酵对氧需求的研究

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生物技术 1998年第1期8卷 26-28页

作者：刘勇陈雅丽张长铠李昆峰山东大学微生物技术国家重点实验室济南250100

L—异亮氨酸主要用于医药和食品行业,是人体八种必需氨基酸之一.合理地供氧L—异亮氨酸产酸多,杂氨基酸量低.以钝齿棒杆菌(Corynebacterium Crenatum)为菌株,在71自动控制发酵罐中分批培养,在1.0—1.5vvm通气量范围内,测得了L—异亮氨... 详细信息

L—异亮氨酸主要用于医药和食品行业,是人体八种必需氨基酸之一.合理地供氧L—异亮氨酸产酸多,杂氨基酸量低.以钝齿棒杆菌(Corynebacterium Crenatum)为菌株,在71自动控制发酵罐中分批培养,在1.0—1.5vvm通气量范围内,测得了L—异亮氨酸发酵的多项参数,并对它们之间的关系及控制手段进行综合分析,提出了工业发酵过程中继续提高发酵水平的依据.

关键词：异亮氨酸发酵氧需求

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铕(Ⅲ)的β—双酮—邻菲绕啉混配配合物的合成、晶体结构和红外光谱

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无机化学学报 1987年第4期 1-11页

作者：王加赋章士伟吴瑾光陈滇徐光宪北京大学化学系

合成了1,3-二苯基-4-乙酰吡唑酮-5[Hl)PAP=C17H14N2O2]邻菲绕啉[phen=C12H8N2]配铕的混配合物Eu（DPAP）3·（o-phen）;并测定、讨论其晶体结构和150—4000cm-1范围的红外光谱。晶体Eu（DPAP）3（o-phen）属单斜晶系;空间群为C26h—C2/c;Z=8;晶胞参数a=23.021（15）,b=22.988（11）,c=23.549（9）,β=109.27（4）°,v=11761（10）;F（000）=4527.00,μ=11.28cm-1（Mo靶）。

关键词：铕β—双酮邻菲绕啉螯合物合成结构红外光谱

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用16×0.75准直单元及375 ms旋转时间的多探头CT检测冠状动脉狭窄

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 53-53页

作者： Achenbach S. Ropers D. Pohle F.-k. 潘闽 Department of Internal Medicine II(Cardiology) University of Erlangen-NürnbergUlmenweg 18 91054 Erlangen Germany

Aims: Insufficient spatial and temporal resolutions have limited image quality and accuracy of multidetector CT(MDCT) for coronary artery visualization and detection of stenoses. We assessed the accuracy of a new 16-slice scanner with 370 ms rotation and 0.75 mm collimation for detection of coronary stenoses using an analysis approach based on coronary artery segments. Methods and results: Fifty consecutive patients scheduled for diagnostic coronary angiography in stable clinical condition and sinus rhythm were enrolled. All patients with a heart rate >60 b.p.m. received 100 mg atenolol p.o. and up to four doses of 5 mg metoprolol i.v. before the scan. MDCT was performed using 16×0.75 mm collimation, 120 kv , and ECG-gated tube current modulation. Ninety millilitres of contrast agent w as injected intravenously. MDCT images were visually analysed using the 16-segm ent coronary artery model of the American Heart Association and compared with in vasive, quantitative coronary angiography in a blinded fashion. A significant st enosis was assumed if the diameter reduction was ≥50%. Mean heart rate was 58 b.p.m. during MDCT. After exclusion of two patients with not fully evaluable dat a sets, MDCT correctly identified at least one coronary stenosis in all 25 patie nts with significant coronary lesions in angiography and correctly demonstrated the absence of stenoses in 19/23 patients(sensitivity 100%, specificity 83%). Sensitivity and specificity for all 50 patients were 93 and 83%, respectively. On a per-segment basis, nine coronary segments distal of total occlusions and 1 28 coronary segments with a reference diametervaluable due to c alcification or motion artefact. In the remaining 635 segments, 50/53 stenoses w ere detected by MDCT(sensitivity 94%, specificity 96%, negative predictive val ue 99%, positive predictive value 69%). Conclusion: Increasing temporal and sp atial

关键词：冠状动脉狭窄 CT ms 多探头准直

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房颤导管消融后膈神经损伤的特征及结局:一项多中心研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 52-52页

作者： Sacher F. Monahan k.H. Thomas S.P. 马超 Hpital Cardiologique du Haut-Lévêque UniversitéBordeaux II Bordeaux-Pessac France Dr.

Objectives: The purpose of this study was to characterize the occurrence of phrenic nerve injury(PNI) and its outcome after radiofrequency(RF) ablation of atrial fibrillation(AF). Background: It is recognized that extra-myocardial damage may develop owing to penetration of ablative energy. Methods: Between 1997 and 2004, 3,755 consecutive patients underwent AF ablation at five centers. Among them, 18 patients(0.48%; 9 male, 54±10 years) had PNI(16 right, 2 left). The procedure consisted of pulmonary vein(Pv) isolation in 15 patients and anatomic circumferential ablation in 3 patients, with additional left atrial lesions(n=11) and/or superior vena cava(SvC) disconnection(n=4). Results: Right PNI occurred during ablation of right superior Pv(n=12) or SvC disconnection(n=3). Left PNI occurred during ablation at the left atrial appendage. Immediate features were dyspnea, cough, hiccup, and/or sudden diaphragmatic elevation in 9, and in the remaining the diagnosis was made after ablation owing to dyspnea(n=7) or on routine radiographic evaluation(n=2). Four patients(22%) were asymptomatic. Complete recovery occurred in 12 patients(66%). Recovery occurred within 24 h in the two patients with left PNI and in one patient with right PNI occurring with SvC disconnection. In the other nine patients, right PNI recovery occurred after 4±5 months(1 to 12 months) with respiratory rehabilitation. After a mean follow-up of 36±33 months, six patients have persistent PNI(three with partial and three with no recovery). Conclusions: In this multicenter experience, PNI was a rare complication(0.48%) of AF ablation. Ablation of the right superior Pv, SvC, and left atrial appendage were associated with PNI. Complete(66%) or partial(17%) recovery was observed in the majority.

关键词：导管消融膈神经电隔离左心耳上腔静脉呼吸困难呼吸状况持久性临床症状

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维普期刊数据库

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印度南部农村人口眼外伤发生的Andhra Pradesh眼病研究

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 52-52页

作者： krishnaiah S. Nirmalan P.k. Shamanna B.R. 刘瑛 L.v.Prasad Eye Institute HyderabadIndia

Objective:To determine the prevalence of ocular trauma and proportion of blindness and visual impairment due to ocular trauma in a rural population of southern ***:Population-based cross-sectional epidemiological ***:A total of 7771 subjects of all ages,representative of the rural population of Andhra ***:The subjects underwent a detailed interview and comprehensive ocular evaluation as part of the population-based Andhra Pradesh Eye Disease *** Outcome:An eye was considered to be blind due to trauma if best-corrected distance visual acuity was worse than 6/60 and the cause was attributed to ocular ***:A total of 824(10.6%) subjects gave a history of ocular trauma in either eye,including 76(1.0%) persons reporting trauma in both *** overall age-and gender-adjusted prevalence of history of eye injury in this rural population was 7.5%(95% confidence interval [CI],7.0%-8.1%) .Men were more likely to have an eye injury than women(odds ratio [OR],2.1 [95% CI,1.8-2.5]) .After adjusting for gender and other demographic factors,ocular trauma was significantly more frequent among laborers(OR,1.5 [95% CI,1.2-1.7]) when compared with other occupational *** adjusting for gender,injury with vegetable matter such as a thorn,branch of a tree,plant secretion,etc.(n=373 [45.3% ]) was the major cause of trauma reported in this *** majority of the eye injuries occurred at the workplace(n=461 [55.9% ]) ,followed by home(n=179 [21.7% ]) .The majority of those affected(n=806 [97.8% ]) did not wear any eye protection at the time of trauma.A significant proportion(n=307 [43.1% ]) of subjects who sought treatment for an eye injury went to an *** was responsible for unilateral blindness in 39 subjects,an age-and gender-adjusted prevalence of 0.6%(95% CI,0.4%-0.8%) .Conclusions:Most ocular injuries in this rural population occurred at the workplace,suggesting the need to explore workplace strateg

关键词：眼外伤性别致盲眼损伤 Andhra Pradesh 眼病农村人口

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I型毛发-鼻-指(趾)综合征发生纵向v形甲营养不良

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 3-3页

作者： Itin P.H. Eich G. Fistarol S.k. 刘安 Department of Dermatology Kantonsspital Aarau CH- 5001 Aarau Switzerland

Trichorhinophalangeal syndrome (TRPS) is a rare genodermatosis with growth retardation, craniofacial abnormalities, alopecia and brachyphalangia. Three subtypes with considerable clinical overlap can be separated. Numerous nail changes have been documented in this syndrome. We observed a 19- year- old female with typical TRPS I who developed unique v- shaped longitudinal nail dystrophies on both hands. TRPS belongs to the spectrum of ectodermal dysplasias, and therefore it is not surprising that cutaneous adnexal structures are involved in different ways.

关键词：甲营养不良遗传性皮肤病秃发生长发育迟缓皮肤附属器外胚层发育不良双手指甲病谱文献报道

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维普期刊数据库

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伴近视和红色盲的X连锁视锥细胞功能障碍综合征

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 61-61页

作者： Michaelides M Johnson S Bradshaw k. D.M. Hunt 白芳 Institute of Oph thalmology University College London 11- 43 Bath Street London EC1V 9EL Un ited Kingdom Dr.

Purpose: To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. Participants: Affected and unaffected members of 4 British nonconsanguineous families. Methods: Subjects underwent both detailed clinical examination and psychophysical testing. After informed consent was obtained, blood samples were taken for DNA extraction, and molecular genetic analysis was performed. The strategy for molecular analysis was to amplify the coding regions of the long and middle wavelength-sensitive cone opsin genes and the upstream locus control region by polymerase chain reaction and to examine these fragments for mutations by sequencing of DNA. Results: The phenotype was almost identical in all 4 families, consisting of moderate to high myopia, astigmatism, moderately reduced acuity, and normal fundi. Electroretinography showed abnormal cone but normal rod responses. Psychophysical testing showed a selective impairment of long cones in combination with well-preserved middle cone and short cone function. There was no evidence to suggest that the phenotype was progressive. Molecular analysis of the X-linked opsin gene array in the 4 families indicated that affected males have inherited the same X-chromosome from their mother. In 2 families, a long/middle hybrid gene was detected. In a third family, the commonly described deleterious Cys203Arg amino acid substitution was identified in both the long and middle opsin genes. In the fourth family, the only abnormality was absence of a middle opsin exon 2; the cause of the protanopia in this family is uncertain. Conclusions: The Xlinked cone dysfunction syndrome associated with myopia and dichromacy described here has many similarities to Bornholm eye disease, a condition previously mapped to Xq28. Except for the Cys203Arg substitution in one family, no alterations in the opsin gene array were identified that could underlie t

关键词：视锥细胞红色盲近视屈光不正功能障碍综合征综合病症

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乳腺癌BRCA1和BRCA2携带者患卵巢癌的风险

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 54-54页

作者： Metcalfe k.A Lynch H.T Ghadirian P 蔡国青

To estimate the risk of ovarian cancer after a primary diagnosis of breast can cer among women with a BRCA1 or BRCA2 mutation and to identify host and treatmen t-related factors that might modify the risk. Patients were 491 women with stag e I or stage II breast cancer, diagnosed from 1975 to 2000 and for whom a BRCA1 or BRCA2 mutation had been identified. Patients were followed from the initial d iagnosis of breast cancer until either ovarian cancer, prophylactic oophorectomy , death, or 2002. The medical treatment records and pathology documents were rev iewed. Information that was abstracted from the medical charts included date of breast cancer diagnosis, stage of disease, use of chemotherapy, use of radiation therapy, usage of tamoxifen, oophorectomy, recurrence, second malignancy, and v ital status. The 10-year actuarial risk of ovarian cancer after breast cancer w as 12.7%for BRCA1 carriers and 6.8%for BRCA2 carriers (P = 0.03). The use of t amoxifen (OR = 1.79; P = 0.16) and chemotherapy (OR = 0.59; P = 0.15) did not si gnificantly impact on the risk of subsequent ovarian cancer. Twenty-five percen t of the deaths in women with stage I breast cancer were due to a subsequent ova rian cancer. The high incidence of ovarian cancer suggests that oophorectomy sho uld be recommended in female BRCA1 and BRCA2 mutation carriers with a diagnosis of breast cancer, especially those with stage I disease. Breast cancer systemic therapy did not significantly alter the risk of ovarian cancer.

关键词： BRCA BRCA2 携带者卵巢切除患病风险他莫西芬病理学资料性治疗信息汇总

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