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Large Deformation Analysis and Synthesis of Elastic Closed-loop Mechanism Made of a Certain Spring Wire Described by Free Curves

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 756-762页

作者： IWATSUKI Nobuyuki kosaki Takashi Department of Mechanical Sciences and Engineering Graduate School of Science and EngineeringTokyo Institute of Technology

Recently novel mechanisms with compact size and without many mechanical elements such as bearing are strongly required for medical devices such as surgical operation devices. This paper describes analysis and synthesis of elastic link mechanisms of a single spring beam which can be manufactured by NC coiling machines. These mechanisms are expected as disposable micro forceps. Smooth Curvature Model（SCM） with 3rd order Legendre polynomial curvature functions is applied to calculate large deformation of a curved cantilever beam by taking account of the balance between external and internal elastic forces and moments. SCM is then extended to analyze large deformation of a closed-loop curved elastic beam which is composed of multiple free curved beams. A closed-loop elastic link is divided into two free curved cantilever beams each of which is assumed as serially connected free curved cantilever beams described with SCM. The sets of coefficients of Legendre polynomials of SCM in all free curved cantilever beams are determined by taking account of the force and moment balance at connecting point where external input force is applied. The sets of coefficients of Legendre polynomials of a nonleaded closed-loop elastic link are optimized to design a link mechanism which can generate specified output motion due to input force applied at the assumed dividing point. For example, two planar micro grippers with a single pulling input force are analyzed and designed. The elastic deformation analyzed with proposed method agrees very well with that calculated with FEM. The designed micro gripper can generate the desired pinching motion. The proposed method can contribute to design compact and simple elastic mechanisms without high calculation costs.

关键词： elastic link mechanism closed-loop spring beam large deformation analysis smooth curvature model force balance equation synthesi

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A comparison of lignin-degrading enzyme activities in forest floor layers across a global climatic gradient

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Soil Ecology Letters 2020年第4期2卷 281-294页

作者： Kazumichi Fujii Yuji Nakada Kiwamu Umezawa Makoto Yoshida Makoto Shibata Chie Hayakawa Yoshiyuki Inagaki Takashi kosaki Ryan Hangs Forestry and Forest Products Research Institute Tsukuba 305-8687Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyTokyo 183-8509Japan Faculty of Agriculture Kindai UniversityNara 631-8505Japan Niigata Agro-Food University Niigata 959-2702Japan Faculty of Agriculture Utsunomiya UniversityUtsunomiya 321-8505Japan Faculty of International Communication Aichi UniversityNagoya 453-8777Japan Department of Soil Science Saskatchewan UniversitySaskatchewan S7N 5A8Canada

Rapid litter turnover in tropical forests and during summer seasons might be due to increases in ligninolytic enzyme activities during warmer *** compared ligninolytic enzyme activity[lignin peroxidase(LiP),manganese peroxidase(MnP),and laccase(Lac)]in the organic layers of forest soils across a global climate *** expected,MnP activities in fresh litter layers increased with increasing air *** Mn/lignin ratios correlate positively with MnP activity and more rapid litter turnover in warmer *** contrast,LiP and Lac activities are regulated by site-specific *** activity is commonly observed in less acidic fresh litter layers,while LiP activity localizes in acidified and lignin-rich deeper organic *** widespread occurrence of MnP and an increase in MnP activities in warmer climates support efficient lignin degradation in the tropics and during summer *** Mn/lignin ratios in fresh litter could be an indicator of lignin degradability by MnPproducing fungi across global climate gradients.

关键词： Acidification Ligninolysis Litter decomposition Manganese White-rot fungi

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First cases of MPV17 related mitochondrial DNA depletion syndrome with compound heterozygous mutations in p.R50Q/p.R50W:a case report

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Hepatoma Research 2020年第1期6卷 1-10页

作者： Shuichiro Umetsu Ayano Inui Sohya Kobayashi Masaru Shimura Tomoko Uehara Hajime Uchida Rie Irie Tsuyoshi Sogo Haruki Komatsu Takako Yoshioka Kei Murayama Kenjiro kosaki MureoKasahara Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu HospitalKanagawa 230-0012Japan Department of Metabolism Chiba Children’s HospitalChiba 266-0007Japan Center for Medical Genetics Keio University School of MedicineTokyo 160-8582Japan Department of Transplantation Surgery National Center for Child Health and DevelopmentTokyo 157-8535Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatrics Toho University Sakura Medical CenterChiba 285-8741Japan Department of Pathology National Center for Child Health and DevelopmentTokyo 157-8535Japan

Mutations in MPV17 lead to severe mitochondrial DNA depletion syndrome(MTDPS).All known p.R50W variants in MPV17 are *** homozygous variant p.R50Q in MPV17 among patients with Navajo neurohepatopathy is known to allow longer survival,although heterozygous variants p.R50Q have not been *** is the first clinical report in compound heterozygosity MPV17 mutation(p.R50W/p.R50Q).Three siblings were admitted due to multiple hepatic nodules;none presented neurological ***,they suffered from severe hypoglycemia and cyclic *** diagnosis of MPV17-related MTDPS was confirmed by detection of a compound heterozygous MPV17 mutation(p.R50W/p.R50Q),and striking reduction of hepatic mitochondrial *** patient developed pediatric-onset of hepatocellular ***,all patients survived for extended periods,including two patients who received liver transplantation,which contrasted the high mortality rate associated with p.R50W mutations,as previously *** p.R50Q mutation might be associated with longer survival and improved liver transplantation outcomes.

关键词： Mitochondrial DNA depletion syndrome MPV17 compound heterozygous mutation liver transplantation

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CYP3A5 and MDR1 Polymorphisms are Associated with Calcineurin Inhibitor-related Neurotoxicity after Allogenic Stem Cell Transplantation in Children

CYP3A5 and MDR1 Polymorphisms are Associated with Calcineuri...

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第五届亚洲儿科研究大会

作者： Masakatsu Yanagimachi Takuya Naruto Reo Tanoshima Hiromi Kato Tomoko Yokosuka Hisaki Fujii Hiroaki Goto Tatsuhiko Yagihashi Kenjiro kosaki Shumpei Yokota Department of Pediatrics Yokohama City University School of Medicine

＜正＞Calcineurin inhibitors such as cyclosporine（CsA） and tacrolimus（FK506） are widely used as prophylactics and for treatment of graft-versus-host disease（GVHD） after hematopoietic stem cell transplantation（HSCT）.One severe side effect of these calcineurin inhibitors is *** substances are substrates for CYP3A5 and P-glycoprotein,the product of multidrug resistance gene （MDR1）.The effect of the polymorphisms,such as CYP3A5 6986G＞A,MDR1 1236C＞T,2677G＞A/T and

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Successful Cord Blood Transplantation for a CHARGE Syndrome with CHD7 Mutation Showing Characteristic Triad of DiGeorge Syndrome Including Hypoparathyroidism

Successful Cord Blood Transplantation for a CHARGE Syndrome ...

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第五届亚洲儿科研究大会

作者： Hidetoshi Takada Hirosuke Inoue Masataka Ishimura Takeshi Kusuda Takako Goto Masayuki Ochiai Tadamune Kinjo Jun Muneuchi Yasushi Takahata Kenjiro kosaki Toshiro Hara Department of Pediatrics Graduate School of Medical SciencesKyushu University

＜正＞Charge syndrome is a distinctive syndrome of multiple congenital anomalies including coloboma,congenital heart defects,choanal atresia,retarding of growth,developmental delay,genital abnormalities,ear anomalies,...

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聚丙烯薄膜在高温区的电击穿

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电力电容器与无功补偿 1986年第1期 80-83页

作者： M.Nagao M.Fukuma N.Ohsachi M.kosaki M.Ieda 宋明兰丰桥工业大学日本名古屋大学

研究了聚丙烯薄膜在高温区施加直流电压击穿。在室温以上,环氧树脂模注样品的电击穿,热过程起着支配作用。对非模注样品,电气机械变形过程也起着重要作用,这种作用由在施加电压的情况下样品表面反射的激光图样的变化得到证实。

关键词：予应力极性聚丙烯薄膜环氧树脂万能胶环氧化物聚丙烯膜电气强度击穿强度绝缘性能电击穿放电高温区

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可乐定在有延髓头端腹外侧区神经血管接触的原发性高血压患者中的效能

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中华高血压杂志 2010年第11期18卷 1075-1075页

作者：张玲玉叶鹏 Sakuma T Morimoto S Aota Y Takahashi N Toyoda N kosaki a Maehara M Tanigawa N Ikeda K Sawada S Iwasaka T

延髓头端腹外侧区(rostral ventrolateral medutla,RVLM)是调节交感神经活性的重要中枢。若干个临床研究表明,RVLM的神经血管接触(neurovascular contact,NVC)与原发性高血压之间有相关性。RVLM的微血管减压(microvascular decompression,MVD)可降低有RVLM神经血管接触的高血压患者的血压。因此,MVD可能可作为降低这类高血压患者血压的一种有效治疗措施。[第一段]

关键词：原发性高血压患者延髓头端腹外侧区神经血管可乐定效能交感神经活性 RVLM 微血管减压

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